Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: An analyte sensor apparatus including a sensing portion including one or more electrodes including a working electrode and one or more contacts for electrically connecting the sensor portion to control circuitry (e.g., a printed circuit board assembly, PCBA); and a circuit comprising the one or more contacts; wherein the circuit detects an electrical connection between the control circuitry without requiring exposure of the sensing portion to a fluid.

Abstract: The present disclosure describes systems and methods of estimating sedation level of a patient using machine learning. For example, the integration of multiple QEEG features into a single sedation level estimation system using machine learning could result in a significant improvement in the predictability of the levels of sedation, independent of the sedative drug used. The present disclosure advantageously allows for the incorporation of large numbers of QEEG features and machine learning into the next-generation monitors of sedation level. Different QEEG features may be selected for different sedation drugs, such as propofol, sevoflurane and dexmedetomidine groups. The sedation level estimation system can maintain a high performance for detecting MOAA/S, independent of the drug used.

Abstract: Disclosed are systems and methods of a health monitoring device comprising: a flexible circuit, an absorbent product, and, a processing unit. The flexible circuit comprises: an electrochemical biosensor, a color sensor, an LED, and, a moisture sensor. The electrochemical biosensor comprises a plurality of reference electrodes. The processing unit comprises: a GPS antenna, a power unit, a BLUETOOTH® low energy transceiver, a GPS transceiver, a microcontroller, and, an accelerometer. The processing unit is electronically coupled to the flexible circuit. The methods comprise: obtaining health data from health monitoring device; recording the health data on the memory unit; transmitting the health data to a data communication device; and, displaying the health data on the data communication device.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: A system SY for determining a tissue type TY of a tissue region TR is provided in which the distal ends OFDE1..n of at least three optical fibers define a plurality of intersecting optical paths IOP1..k within the tissue region TR. A tissue signal Q1..k indicative of a tissue type TY for the respective optical path IOP1..k is generated from said spectral measurement data SMD corresponding to each of the plurality of intersecting optical paths IOP1..k. Each tissue signal Q1..k is compared with a reference threshold QRT for the tissue type, and with an average of the tissue signals QMA. At least a portion of the tissue region is identified as the tissue type TY if i) every tissue signal Q1..k in the tissue region TR indicates that its corresponding tissue is not the tissue type TY in the comparison with the reference threshold QRT and ii) at least one of the tissue signals Q1..k in the tissue region TR lies between the average QMA of the tissue signals Q1..

Abstract: An implantable micro-biosensor includes at least one counter electrode, a first working electrode, a chemical reagent layer, and at least one second working electrode. The chemical reagent layer reacts with an analyte to product a product, such that a first sensing section of the first working electrode is driven to perform a measurement action. A second sensing section of the second working electrode is driven to perform an interference-eliminating action to consume interference. The second working electrode cooperates with the counter electrode to permit the counter electrode to be driven to perform a regeneration action to regenerate silver halide.

Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.

Abstract: A medical device for transcutaneously inserting an insertable element into a body tissue. The medical device includes an insertable element and an insertion cannula for subcutaneously inserting the insertable element. The insertable element includes an in vivo distal end for subcutaneous insertion and an ex vivo proximal end. The insertion cannula has a lumen configured to receive the insertable element that is fully or partially enclosed by a wall of the insertion cannula. The wall comprises at least one shape memory alloy wherein the insertion cannula is stored in a first shape configuration and is configured to be transformable into a second shape configuration for insertion.

Abstract: An implantable micro-biosensor a substrate, a first electrode, a second electrode, a third electrode, and a chemical reagent layer. The first electrode is disposed on the substrate and used as a counter electrode. The second electrode is disposed on the substrate and spaced apart from the first electrode. The third electrode is disposed on the substrate and used as a working electrode. The chemical reagent layer at least covers a sensing section of the third electrode so as to permit the third electrode to selectively cooperate with the first electrode or the first and second electrodes to measure a physiological signal in response to the physiological parameter of the analyte.

Abstract: The present invention provides a micro biosensor for reducing a measurement interference when measuring a target analyte in the biofluid, including: a substrate; a first working electrode configured on the surface, and including a first sensing section; a second working electrode configured on the surface, and including a second sensing section which is configured adjacent to at least one side of the first sensing section; and a chemical reagent covered on at least a portion of the first sensing section for reacting with the target analyte to produce a resultant. When the first working electrode is driven by a first working voltage, the first sensing section measures a physiological signal with respect to the target analyte. When the second working electrode is driven by a second working voltage, the second conductive material can directly consume the interferant so as to continuously reduce the measurement inference of the physiological signal.

Abstract: Disclosed herein are combined devices and methods of manufacturing such combined devices. The combined devices disclosed herein include an analyte sensor including a sensor probe; an infusion set hub including a cannula; and a flexible base. The analyte sensor and infusion set hub are attached to the flexible base such that movement of one of the analyte sensor and the infusion set hub is substantially not transferred to the other one of the analyte sensor and the infusion set hub.

Abstract: Systems, methods and graphical user interfaces for visualizing analyte measurements using animation are presented. For instance, a system for continuously monitoring analyte concentration in a physiological fluid includes a sensor, a transmitter, at least one processor and a display. The display is for outputting a graphical user interface. The display is controlled by the at least one processor to display, using the graphical user interface, historical analyte concentration levels and a trend indication animation. The trend indication animation comprises at least one visual element configured by the at least one processor to have a periodic motion between a first position and a second position on the display in one of a plurality of trend directions. The trend direction of the periodic motion between the first and second positions indicates whether the analyte concentration is increasing or decreasing and the rate of change of the analyte concentration level.

Abstract: An analyte monitoring system may include an analyte sensor, two or more devices including a display device and a second device, and a transceiver. The transceiver may be configured to (i) receive measurement information from the analyte sensor, (ii) establish a connection with the display device while being connected with no other device of the two or more devices, (iii) convey first information to the display device while connected with the display device, (iv) establish a connection with the second device while being connected with no other device of the two or more devices, and (v) convey or receive second information to or from the second device while connected with the second device. The display device may be configured to (i) receive the first information from the transceiver and (ii) display an analyte level based on at least the first information.

Abstract: The present disclosure pertains to a method and system for determining the blood pressure dip of a subject based on features extracted from information generated by an on-body sensor system. The on-body sensor system includes a photoplethysmographic (PPG) sensor and a motion sensor. Blood pressure variation is captured throughout the day and utilized along with determinations of whether a subject is asleep or awake. The blood pressure determinations collected throughout the day, along with determinations of sleep periods, are used to determine a blood pressure dip for the day the on-body sensor system is worn.

Abstract: A device and a signal processing method that can monitor human memory performance by recognizing and characterizing high-gamma (65-250 Hz) and beta (14-30 Hz) band oscillations in the left Brodmann Area 40 (BA40) of the brain that correspond with the strength of memory encoding or correct recall. The signal processing method detects high-gamma and beta band oscillations in the electrical signals recorded from left BA40, and quantifies the spectral content, power, duration, onset, and offset of the oscillations. The oscillation's properties are used to classify the subject's memory performance on the basis of a comparison with the subject's prior human memory performance and the properties of the corresponding oscillations. A report of the subject's current memory performance can be utilized in a closed loop brain stimulation device that serves the purpose of enhancing human memory performance.

Abstract: An apparatus for obtaining a target signal spectrum includes: a spectrum measurer configured to measure a plurality of spectra from an object; and a processor configured to obtain a difference spectrum matrix by subtracting a reference spectrum from each of the plurality of spectra, and to obtain a spectrum of a target signal based on the obtained difference spectrum matrix.

Abstract: The present disclosure concerns a plethysmograph. The plethysmograph comprises a housing defining a test cavity configured to enclose a test subject. The plethysmograph further comprises an optical filter providing a spectrally restricted optical access to the test cavity from an exterior of the housing, the optical filter being configured to at least partially transmit light in a transmission band ranging from about 560 nm to about 750 nm; and to at least partially block light in a blocking band ranging from about 380 nm to about 560 nm.

Abstract: There is provided a system for measuring a property of a sample that comprises a test strip for collecting the sample; a diagnostic measuring device configured to receive the test strip and measure a concentration of an analyte in the sample received on the test strip; and the diagnostic measuring device further comprising a processor programmed to execute an analyte correction for correcting a measurement of the sample due to one or more interferents, comprising: calculating an interferent impedance measurement including a magnitude measurement and a phase measurement using a switched capacitor accumulator to measure a phase angle; and adjusting the measurement of the analyte in the sample using that the calculated interferent impedance measurement.