Abstract: This invention relates to a catalyst composition for a producing process of an unsaturated carboxylic acid salt and its derivatives from carbon dioxide and olefin, wherein the catalyst composition in the present invention has been proved to be effective in catalyzing the carboxylation of carbon dioxide and olefin, wherein said catalyst composition comprises: a) a palladium metal complex as shown in structure (I); wherein, R1, R2, R3, and R4 independently represents a group selected from hydrogen atom, halogen atom, alkyl group, alkyl halide group, alkoxy group, amine group, optionally from alkenyl group, alkynyl group, phenyl group, benzyl group, or cylic hydrocarbon group comprising hetero atom; R5 represents group selected from alkyl group or phenyl group; b) a ligand selected from organophosphorus compound; c) a base selected from sodium tert-butoxide, sodium isopropoxide, sodium 2,6-dimethylphenolate, sodium 2,6-difluorophenolate, sodium 2-methylphenolate, or sodium 2-fluorophenol); and d
Type:
Grant
Filed:
November 23, 2018
Date of Patent:
March 2, 2021
Assignee:
PTT GLOBAL CHEMICAL PUBLIC COMPANY LIMITED
Abstract: The present invention specifically relates to novel salt and crystalline form of haloacetic acid and its process of preparation. The invention more particularly relates to novel crystalline form dichloroacetate tromethamine salt and its process of preparation. The present invention more specifically relates to the dichloroacetate tromethamine salt, its process and its use for the treatment of various diseases and/or disorders.
Abstract: The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.
Type:
Grant
Filed:
March 27, 2017
Date of Patent:
February 16, 2021
Assignee:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors:
Craig Thomas, Carlos Zarate, Ruin Moaddel, Todd Gould, Panos Zanos, Patrick Morris
Abstract: The present invention relates to: a novel transition metal compound; a preparation method therefor; a composition for depositing a transition metal-containing thin film, containing the same; a transition metal-containing thin film using the composition for depositing a transition metal-containing thin film; and a method for preparing a transition metal-containing thin film. The transition metal compound of the present invention has high thermal stability, high volatility, and high storage stability, and thus a transition metal-containing thin film having high-density and high-purity can be easily prepared by using the same as a precursor.
Type:
Grant
Filed:
April 6, 2017
Date of Patent:
February 9, 2021
Assignee:
DNF CO., LTD.
Inventors:
Myong Woon Kim, Sang Ick Lee, Won Mook Chae, Sang Jun Yim, Kang Yong Lee, A Ra Cho, Sang Yong Jeon, Haeng Don Lim
Abstract: The invention describes hydrosoluble iron (III) oxyhydroxide complexes prepared from different sources of iron, amino acids and carboxylic acids. The iron (III) complexes have no undesirable residual taste and can be used as supplementation forms for the prevention or treatment of iron deficiency anemia in humans or animals and pharmaceutical or food compositions containing them.
Type:
Grant
Filed:
November 5, 2015
Date of Patent:
February 9, 2021
Assignee:
NPA—NÚCLEO DE PESQUISAS APLICADAS LTDA
Inventors:
Ricardo Da Silva Sercheli, Nelson Henriques Fernandes, Nelson Henriques Fernandes Filho
Abstract: A lanthanum compound, a method of synthesizing a thin film, and a method of manufacturing an integrated circuit device, the compound being represented by Formula 1 below, wherein, in Formula 1, R1 is a hydrogen atom or a C1-C4 linear or branched alkyl group, R2 and R3 are each independently a hydrogen atom or a C1-C5 linear or branched alkyl group, at least one of R2 and R3 being a C3-C5 branched alkyl group, and R4 is a hydrogen atom or a C1-C4 linear or branched alkyl group.
Abstract: The present invention provides a process for the preparation of N-phenoxyisopropyl ethanolamine of Formula (II) and its conversion to Phenoxybenzamine of Formula (I) or pharmaceutically acceptable salts thereof.
Abstract: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L1, n and p are defined herein. The compounds of formula (X) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
February 2, 2021
Assignee:
Novartis AG
Inventors:
Luis Brito, Delai Chen, Gabriel Grant Gamber, Andrew Geall, Kevin Love, Thomas Zabawa, Frederic Zecri
Abstract: A method for manufacturing an amino group-containing organosilicon compound of the following formula (1): wherein each R1 independently represents an alkyl group having 1 to 10 carbon atoms, etc., each of R2 and R3 represents a functional group of the following formula (4), etc., m represents an integer of 1 to 3, and n represents an integer of 1 to 12, wherein an asterisk * represents a bond with an adjacent atom, p represents an integer of 1 to 12, and q represents an integer of 1 to 10, the method comprising: (A) reacting an amine compound of the following formula (2): wherein R2 and R3 mean the same as above with a halogen group-containing organosilicon compound of the following formula (3): wherein X represents a chlorine atom, etc., and R1 and n mean the same as above; (B) removing an amine hydrohalide produced in the step (A), by liquid-liquid separation; and (C) neutralizing an organic layer obtained in the step (B), using a base which amounts 0.1 to 0.
Abstract: A method of separating a metal organic framework (MOF) from a solution and associated apparatus. The method comprises: providing a MOF containing solution; contacting the MOF containing solution with an acoustic reflector surface such that, any high frequency ultrasound applied within the MOF containing solution reflects off the acoustic reflector surface; and applying a high frequency ultrasound of at least 20 kHz to the MOF containing solution. The MOF material is substantially separated from solution as aggregated sediment that settles out of solution.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
January 26, 2021
Inventors:
Marta Rubio Martinez, Pablo Juliano, Thomas Leong, Matthew Roland Hill, Kok Seng Lim
Abstract: Provided is a desulfurizer for removing a sulfur compound contained in a fluid, comprising a desulfurization agent for removing the sulfur compound from the fluid and a housing which contains the desulfurization agent and the inside of which the fluid flows through. The desulfurization agent includes a metal organic framework. The metal organic framework has copper ions and organic ligands. The organic ligands include 1,3,5-benzenetricarboxylic acid and 1,3-benzenedicarboxylic acid.
Abstract: The present invention concerns a process for the preparation of pure aniline, comprising the steps of a) providing a crude aniline fraction containing up to 20.000% by weight of phenol; b) dividing the crude aniline fraction from step a) into a first partial stream and a second partial stream; c) distilling the first partial stream from step b) in a first distillation column and distilling the second partial stream from step b) in a second distillation column, wherein the first distillation column is operated at a higher head pressure than the second distillation column, with the proviso that each of the first distillation column and the second distillation column is operated at a head pressure in the range from 1.0 mbar(abs.) to 500 mbar(abs.
Type:
Grant
Filed:
October 16, 2019
Date of Patent:
January 12, 2021
Assignee:
Covestro Deutschland AG
Inventors:
Michael Merkel, Friedhelm Steffens, Murat Kalem, Peter Lehner
Abstract: The present invention relates to a method for manufacturing a catalyst for synthesizing a fatty acid methyl or ethyl ester and a method for manufacturing a fatty acid methyl or ethyl ester using the catalyst. It provides a method for manufacturing a solid catalyst by mixing the oxides of manganese as active catalytic material and the soda lime glass as carrier wherein the content of the oxides of manganese is in the range of 0.1 w % to 70 w %, molding the mixture to spherical or cylindrical shape and sintering the molded catalyst. It also provides a method for manufacturing fatty acid methyl or ethyl ester with high purity by reacting fatty acid or a mixture of oil and fatty acid with methanol or ethanol by placing the solid catalyst in the reactor.
Abstract: A versatile, highly efficient process for the preparation of acylphosphines such as mono- and bisacylphosphines via reaction of phosphines (PH3 and higher homologues) or silylated phosphines with acylhalides in the presence of at least one lewis acid. Further a novel acyl phosphines obtainable by the process.
Type:
Grant
Filed:
September 18, 2017
Date of Patent:
January 12, 2021
Assignees:
ETH ZÜRICH, THE UNIVERSITY OF BRISTOL
Inventors:
Hansjörg Grützmacher, Paul Gerard Pringle, Mark Bispinghoff
Abstract: The present invention relates to bi- and trinuclear metal complexes and to electronic devices, in particular organic electroluminescent devices, containing these complexes.
Type:
Grant
Filed:
August 28, 2017
Date of Patent:
January 12, 2021
Inventors:
Philipp Stoessel, Christian Ehrenreich, Philipp Harbach, Anna Hayer
Abstract: The present invention relates to a 1,1-diborylalkyl-1-metal compound including one metal group together with two identical boron groups at the sp3 carbon center, and its use. Specifically, the present invention relates to development of novel organic reactions, synthesis of functional molecules, and synthesis of new drugs by applying the novel 1,1-diboryl-1-metal substituted alkyl compounds to various molecular libraries which could not be synthesized by conventional methodologies.
Abstract: The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.
Type:
Grant
Filed:
December 17, 2015
Date of Patent:
January 5, 2021
Assignee:
Biophore India Pharmaceuticals Pvt. Ltd.
Abstract: A tin compound, tin precursor compound for atomic layer deposition (ALD), a method of forming a tin-containing material film, and a method of synthesizing a tin compound, the tin compound being represented by Chemical Formula (I): wherein R1, R2, Q1, Q2, Q3, and Q4 are each independently a C1 to C4 linear or branched alkyl group.
Abstract: 4-(dialkylchlorosilyl)butyronitriles are prepared by high yield by reacting a mixture of technical grade allyl cyanide with dialkylchlorosilanes in the presence of a catalyst of transition group 8 of the Periodic Table of the Elements, wherein the reaction is conducted such that a stoichiometric excess of the dialkylchlorosilane is present together with the catalyst in the reaction mixture, into which the allyl cyanide is metered.
Abstract: Method for the production of tetrakis(trihydrocarbylphosphane)palladium(0) in organic solvent, whereby 50 to 100% by weight of the organic solvent consist of at least one polar-aprotic solvent, characterised in that a) at least one palladium compound selected from the group consisting of palladium(II) compounds and palladium(IV) compounds that are soluble in the organic solvent is reacted with b) at least one base, selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal hydrogen carbonates, alkali metal-C1-C4-alcoholates, ammonium carbonate, ammonium hydrogen carbonate, alkaline earth metal hydroxides, alkaline earth metal carbonates, alkaline earth metal hydrogen carbonates, alkaline earth metal-C1-C4-alcoholates, and alkylamines with a total of 2 to 12 carbon atoms; c) at least one trihydrocarbylphosphane; and d) at least one organic reducing agent that is different from the remaining components that are used in the method.
Type:
Grant
Filed:
August 17, 2016
Date of Patent:
December 29, 2020
Assignee:
HERAEUS DEUTSCHLAND GMBH & CO. KG
Inventors:
Florian Eweiner, Walter Lässig, Richard Walter