Patents Examined by Craig D Ricci
  • Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin O-acyl transferase (GOAT) inhibitors
    Patent number: 11136337
    Abstract: The present invention relates to compounds of general formula I, wherein the groups R1 and R2 are defined as in claim 1, which have valuable pharmacological properties, in particular bind to ghrelin O-acyl transferase (GOAT) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular obesity.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: October 5, 2021
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Trieselmann, Cedrickx Godbout, Viktor Vintonyak
  • PAC-1 combination therapy
    Patent number: 11129830
    Abstract: Compositions and methods for the induction of cancer cell death. The compositions and methods of using them include use of compositions in therapy for the treatment of cancer and for the selective induction of apoptosis in cancer cells. The drug combinations described herein can be synergistic and can have lower neurotoxicity effects than the same amounts of other compounds and combinations of compounds and can be effective when a particular cancer has become resistant to previously administered therapies.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: September 28, 2021
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Jessie Peh
  • Fumarate analogs and uses thereof
    Patent number: 11129819
    Abstract: Aspects of the present disclosure include compounds that find use for the treatment of a variety of autoimmune and inflammatory diseases and disorders. Embodiments of the present disclosure also relate to pharmaceutical compositions that include these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: September 28, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Matthew Duncton, Somasekhar Bhamidipati, Jiaxin Yu, Ihab Darwish, Rajinder Singh
  • Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides
    Patent number: 11123416
    Abstract: The invention relates to the compositions of synthetic oligo-?-(1?6)-2-amino-2-deoxy-D-glu-copyranosides conjugated to carriers, and methods for making and use same.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: September 21, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
  • Compounds, compositions, and methods for treating diseases
    Patent number: 11117870
    Abstract: The present application is directed, in part, to compounds, and/or pharmaceutically acceptable salts or solvates thereof, and/or pharmaceutical compositions thereof, for modulating the activity of Sigma I receptor. The present application is further directed, in part, to methods for treating and/or preventing cancer using compounds disclosed herein, and/or pharmaceutically acceptable salts or solvates thereof, and/or pharmaceutical compositions thereof.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: September 14, 2021
    Assignee: Drexel University
    Inventors: Felix Kim, Joseph Salvino
  • Compositions of coenzyme Q10 and methods of use
    Patent number: 11116246
    Abstract: In an embodiment, a nutritional supplement including, about 0.5 mg to about 4 mg of folate, about 6.25 mg to about 50 mg of vitamin B-6, about 250 mcg to about 2000 mcg of vitamin B-12, about 75 mg to about 600 mg of coenzyme Q10 (CoQ10), about 1250 IU to about 10,000 IU of vitamin D3, about 25 mg to about 200 mg of magnesium, about 25 mg to 200 mg of N-acetyl-L-cysteine, about 5 mg to about 40 mg pyrroloquinoline quinone disodium (PQQ), about 25 mg to about 200 mg of curcumin extract, about 25 mg to about 200 mg of resveratrol, about 25 mg to about 200 mg berberine, about 12.5 mcg to about 100 mcg of chromium, and about 12.5 mcg to about 100 mcg of selenium. In an additional embodiment, the aforementioned nutritional supplement in a nutritional kit that further includes an omega-3 supplement.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: September 14, 2021
    Assignee: GM Pharmaceuticals, Inc.
    Inventor: Odes W. Mitchell
  • Artificial platelets for treating catastrophic bleeding
    Patent number: 11112145
    Abstract: Artificial dense granules composed of a sterically stabilized liposome shell encapsulating a polyphosphate nanoparticle core are provided as are methods for their production and use in the treatment of a severe hemorrhagic event.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: September 7, 2021
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Ying Liu, Alexander Donovan
  • Mono- and di-amidine endo-exonuclease inhibitors and methods for inhibiting endo-exonuclease activity
    Patent number: 11103468
    Abstract: Compounds useful in inhibiting endo-exonuclease activity and treating cancer have the formula (I) wherein R3 is selected from the group consisting of loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or a halogen; R4 is selected from the group consisting of H, loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or a halogen; and wherein R5 is a loweralkyl; or formula (II) wherein R1 is selected from the group consisting of loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or halogen; R2 is selected from the group consisting of H, loweralkyl, oxyalkyl, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, aminoalkyl or halogen; and wherein R5 is a loweralkyl comprising a linear carbon chain of at least two carbons connecting the first “O” to the second “O”.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: August 31, 2021
    Inventor: Terry Chow
  • Methods and compositions for modulating muscle and bone loss
    Patent number: 11103001
    Abstract: The present disclosure comprises methods and compositions comprising an extracted mineral element composition to modulate muscle and/or bone loss, or deleterious muscle tone change.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: August 31, 2021
    Assignee: CORE INTELLECTUAL PROPERTIES HOLDINGS, LLC
    Inventors: Luke Blotsky, Krys Bojanowski
  • Personal care compositions comprising polymers derived from vinyl alcohol ethers and applications thereof
    Patent number: 11103437
    Abstract: The invention provides a personal care composition comprising polymers having the structure: wherein Q, R1, a, b, and c are described herein. The invention further provides hair care compositions comprising the polymers. Particularly, the hair care composition is a hair styling composition that provides hairstyle retention at a relative humidity exceeding about 40 percent. The invention furthermore provides a method of providing hairstyle retention to hair at a relative humidity exceeding about 40 percent, the method comprising applying to hair the hair care composition as described herein.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 31, 2021
    Assignee: ISP INVESTMENTS LLC
    Inventors: Osama M. Musa, Ezat Khosravi, Peter Andrew King, Allwyn Colaco
  • Esters for treatment of ocular inflammatory conditions
    Patent number: 11096919
    Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and/or strip and/or a contact lens.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: August 24, 2021
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Annabelle Gallois-Bernos, Frank F. Molock, Jr., Carrie L. Davis, Kathrine Osborn Lorenz, James K. Young, Kristy L. Canavan, Fang Lu
  • Sodium chlorite compositions with enhanced anti-microbial efficacy and reduced toxicity
    Patent number: 11096958
    Abstract: Disclosed are antiseptic compositions for disinfecting tissues, in particular for ocular use. Methods and compositions disclosed herein include sodium chlorite, optionally in combination with a surfactant.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: August 24, 2021
    Assignee: Allergan, Inc.
    Inventors: James A. Burke, Richard S. Graham, Corine Ghosn, Alexandra Almazan, Michael Engles, Lakshmi Rajagopalan
  • Spiro-lactam NMDA receptor modulators and uses thereof
    Patent number: 11077094
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: August 3, 2021
    Assignee: Aptinyx Inc.
    Inventors: John A. Lowe, III, M. Amin Khan
  • Method for diagnosis, prognosis and determination of treatment for cutaneous t-cell lymphoma
    Patent number: 11067577
    Abstract: The present invention relates to biomarkers associated with CTCL, including TOX, PLS3, KIR3DL2, GATA3 and RUNX3, where increased expression, relative to normal control, of one or more of TOX, PLS3, KIR3DL2, and/or GATA3 is associated with CTCL and decreased expression of RUNX3, relative to normal control, is associated with CTCL. One or more of these biomarkers may be used to diagnose CTCL and/or design and monitor treatment.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: July 20, 2021
    Assignee: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Larisa J. Geskin, Brittany Lynn O'Neill Dulmage, Louis D. Falo, Jr.
  • Long acting multi-specific molecules and related methods
    Patent number: 11065342
    Abstract: This invention relates to multi-specific molecules, such as long acting multi-specific antibodies. Also disclosed are relates methods.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: July 20, 2021
    Assignee: SHENZHEN ENDURING BIOTECH, LTD.
    Inventors: Shu-min Liu, Dechun Wu
  • Use of cannabidiol in the treatment of epilepsy
    Patent number: 11065209
    Abstract: The present disclosure relates to the use of cannabidiol (CBD) for the treatment of Tuberous Sclerosis Complex (TSC). In particular the TSC is treatment resistant and is characterised by generalised seizures or focal seizures with impairment. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).
    Type: Grant
    Filed: January 12, 2021
    Date of Patent: July 20, 2021
    Assignee: GW Research Limited
    Inventors: Geoffrey Guy, Stephen Wright, Elizabeth Thiele
  • Solid forms of substituted benzoxaborole and compositions thereof
    Patent number: 11066424
    Abstract: The present invention relates to solid forms of a substituted benzoxaborole compound, specifically crystalline forms of a compound of formula I, compositions comprising crystalline forms of the compound of formula (I), and methods of their use.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 20, 2021
    Assignee: Boragen, Inc.
    Inventors: Chun Yu Liu, Marissa Caroline Aubrey, Yong-Kang Zhang, Michael Samuels
  • External wound-healing agent, and external wound-healing material
    Patent number: 11058660
    Abstract: A method of healing an external wound involves applying an external wound-healing agent to an external wound, or bringing the external wound-healing agent applied to a substrate into contact with an external wound, wherein the external wound-healing agent includes, as an active ingredient, at least one compound of a glycerol alkyl ester represented by defined Formula (I) or a diglycerol alkyl ester represented by defined Formula (II). In a further embodiment, the method involves bringing a fiber aggregate or a film into contact with an external wound, wherein the fiber aggregate or the film each includes a thermoplastic resin and at least one compound of the glycerol alkyl ester or the diglycerol alkyl ester.
    Type: Grant
    Filed: December 31, 2018
    Date of Patent: July 13, 2021
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Naosuke Kunimoto, Kenichi Suzuki, Kouya Kojima, Akira Hasegawa, Yasufumi Tsuchiya, Jun Kamada, Satoshi Yamasaki, Goro Kuwamura, Daisuke Hasegawa
  • Use of cytochrome bc1 complex inhibitor in preparing pharmaceutical composition
    Patent number: 11058690
    Abstract: A use of an inhibitor of the cytochrome bc1 complex for preparing a pharmaceutical composition which treats diseases related to smooth muscle spasms, inflammatory diseases, and relieves pain.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: July 13, 2021
    Assignee: BEIJING WEILANZHIYUAN MEDICAL TECHNOLOGY CO., LTD.
    Inventor: Yuwen Cong
  • Diagnosing and treating colorectal cancer
    Patent number: 11060148
    Abstract: Methods for predicting risk of developing colorectal cancer, for treating colorectal cancer, and reducing risk of developing colorectal cancer.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 13, 2021
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Matthew Meyerson, Aleksandar Kostic