Patents Examined by Craig Ricci
  • Treatment of intrahepatic cholestatic diseases
    Patent number: 9486428
    Abstract: Treatment of intrahepatic cholestatic diseases by therapy with MBX-8025 or an MBX-8025 salt.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: November 8, 2016
    Assignee: CymaBay Therapeutics, Inc.
    Inventors: Pol Boudes, Charles A. McWherter
  • Methods and compositions relating to synthetic beta-1,6 glucosamine oligosaccharides
    Patent number: 9474806
    Abstract: The invention relates to the compositions of synthetic oligo-?-(1?6)-2-amino-2-deoxy-D-glucopyranosides conjugated to carriers, and methods for making and use same.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: October 25, 2016
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Gerald B. Pier, Nikolay Nifantiev, Yury Tsvetkov, Marina Gening
  • Tricyclic pyrrolopyridine compound, and JAK inhibitor
    Patent number: 9475813
    Abstract: To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof: wherein the respective substituents are defined in detail in the specification, and R1 is a C1-6 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, the ring A is C3-11 cycloalkane or the like, L1 is a C1-6 alkylene group or the like, and R4 is NRaRb or the like.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: October 25, 2016
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Keiji Takahashi, Tsuneo Watanabe, Keishi Hayashi, Kazunori Kurihara, Takanori Nakamura, Akio Yamamoto, Takuya Nishimura, Toshihiko Kamiyama, Yuuki Hidaka
  • Compounds and compositions for the treatment of parasitic diseases
    Patent number: 9469645
    Abstract: The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: October 18, 2016
    Assignee: Novartis AG
    Inventors: Arnab K. Chatterjee, Advait S. Nagle, Tao Wu, David C. Tully, Kelli L. Kuhen
  • Sulfonyl-substituted bicyclic compounds as PPAR modulators for the treatment of non-alcoholic steatohepatitis
    Patent number: 9463189
    Abstract: Disclosed herein are new methods of treatment of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and other fibrotic diseases of the liver in a subject by modulating PPAR? with sulfonyl-substituted bicyclic compounds and compositions as pharmaceuticals.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: October 11, 2016
    Assignee: BPV Holdings, LLC
    Inventors: Mausumee Guha, Paul Grint
  • Influenza A virus inhibition
    Patent number: 9464075
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: October 11, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Fluorinated ethoxylated polyurethanes
    Patent number: 9464160
    Abstract: The present invention comprises fluorinated ethoxylated polyurethanes of formula [Rf—(X)n—(CH2CHR1—O)m—CH2CH2—O—C(O)—NH]p-A, wherein Rf is a C1 to C6 perfluoroalkyl; X is a divalent radical; n is 0 or 1; R1 is H or C1 to C4 alkyl; m is 1 to 20; p is a positive integer of at least 2; and A is the residue of a polyisocyanate, and methods for altering surface behavior of liquids using such compounds.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: October 11, 2016
    Assignee: THE CHEMOURS COMPANY FC, LLC
    Inventors: Michael Henry Ober, Kathleen L. Kanetsky, Allison Mary Yake
  • Inhibition of influenza M2 proton channel
    Patent number: 9453005
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: September 27, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Inhibitors of HIV replication
    Patent number: 9447116
    Abstract: The present invention relates to novel 2,3,4-substituted 5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridine compounds and pharmaceutically acceptable salts thereof, to compositions containing such compounds and to the use of such compounds as inhibitors of HIV replication.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: September 20, 2016
    Assignee: ViiV Healthcare UK Limited
    Inventors: Andrew Simon Bell, Iain Brian Gardner, Karl Richard Gibson, David Cameron Pryde, Florian Michel Wakenhut
  • Imidazo-, pyrazolopyrazines and imidazotriazines and their use
    Patent number: 9434731
    Abstract: The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: September 6, 2016
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Stephan Siegel, Andreas Wilmen, Susanne Röhrig, Niels Svenstrup, Mark Jean Gnoth, Stefan Heitmeier, Ulrich Rester, Adrian Tersteegen, Michael Gerisch
  • Pesticide formulation with streaming birefringence
    Patent number: 9426987
    Abstract: A pesticide composition exhibiting streaming birefringence and methods for making the pesticide composition are disclosed. In one embodiment, the pesticide composition comprises an active ingredient and a surfactant adjuvant.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: August 30, 2016
    Assignee: HUNTSMAN PETROCHEMICAL LLC
    Inventors: Curtis M. Elsik, Joe C. Arzola, Howard M. Stridde, Alan J. Stern
  • Oligomer modified diaromatic substituted compounds
    Patent number: 9421204
    Abstract: The invention relates to (among other things) oligomer modified diaromatic substituted compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over non-oligomer modified diaromatic substituted compounds.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: August 23, 2016
    Assignee: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Bo-Liang Deng
  • Methods of treating hepatic encephalopathy
    Patent number: 9421195
    Abstract: The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin. The instant application also provides methods for determining if a subject has a neurological condition or hepatic encephalopathy by determining the critical flicker frequency and/or the venous ammonia level of the subject at two or more time points. The invention further provides methods for treating these subjects.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: August 23, 2016
    Assignee: Salix Pharmaceuticals, Ltd
    Inventors: William Forbes, Kunal Merchant, Enoch Bortey, Audrey Shaw
  • Methods of treating Parkinson's disease
    Patent number: 9415025
    Abstract: Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve providing therapeutically effective amounts of such compositions to subjects in need thereof.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: August 16, 2016
    Assignees: The Hospital for Sick Children, McMaster University
    Inventors: Don J. Mahuran, Michael B. Tropak, Justin D. Buttner, Jan E. Blanchard, Eric D. Brown
  • Methods for treating inflammatory conditions
    Patent number: 9408844
    Abstract: The present invention relates to compounds and pharmaceutically acceptable salts thereof and formulations comprising tenilsetam or pharmaceutically acceptable salts thereof that are useful in modulating inflammation. In particular, the compounds or pharmaceutically acceptable salts thereof are useful for treating or preventing a disease or disorder involving inflammation, including, but not limited to, delayed type hypersensitivity and contact hypersensitivity.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: August 9, 2016
    Assignee: Melior Discovery, Inc.
    Inventors: Andrew Reaume, Heather Hain, Michael S. Saporito
  • Method for treating pain syndrome and other disorders
    Patent number: 9402848
    Abstract: The present invention provides the use of certain compounds to treat peripheral or central pain syndrome and other disorders associated with the T-type calcium ion channels.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: August 2, 2016
    Assignee: VM Therapeutics LLC
    Inventor: Jay Jie-Qiang Wu
  • Drug entrapment efficiency and sustained drug release of chloramphenicol loaded polymeric-iron nanoparticles
    Patent number: 9393313
    Abstract: This invention harvests nanocomposite which enable targeted delivery of antibiotics. Biodegradable and biocompatible polymer such as diethylaminoethyl-cellulose (DEAE-Cellulose) are used in combination with iron, which contributes its magnetic characteristics to the nanocomposite. The nanoparticles produced could be used as carriers for releasing chloramphenicol at the targeted site for sustained release.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 19, 2016
    Inventors: Muhammad Akhyar Farrukh, Adarsh Shams, Muhammad Khaleeq-ur- Rahman
  • Crystalline salts of a potent HCV inhibitor
    Patent number: 9382240
    Abstract: This invention relates to novel tris(hydroxymethyl)aminomethane, choline and N-methyl-D-glucamine salt forms of the following Compound (1) and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: July 5, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bing-Shiou Yang, Ka Yip
  • Buprenorphine-wafer for drug substitution therapy
    Patent number: 9370512
    Abstract: The present invention relates to oral pharmaceutical dosage forms comprising buprenorphine with the dosage form releasing buprenorphine instantly upon oral, preferably sublingual, application of the dosage form. The present invention also relates to the use of such dosage forms for treating pain in a human or animal or for drug substitution therapy in drug-dependent human subjects.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: June 21, 2016
    Assignee: PURDUE PHARMA L.P.
    Inventors: Alexander Oksche, William Heath, Timothy Holden, Derek A. Prater, Richard S. Sackler, Malcolm Walden
  • Prolylcarboxypeptidase inhibitors
    Patent number: 9365539
    Abstract: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: June 14, 2016
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Jeffrey J. Hale, Jinlong Jiang, Dong-Ming Shen, Zhi-Cai Shi, Min Shu, Zhicai Wu, Cangming Yang