Patents Examined by Criares
  • Methods for inhibiting bone resorption
    Patent number: 6586457
    Abstract: The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: July 1, 2003
    Assignees: Merck & Co., Inc., Merck Frosst Canada & Co.
    Inventors: Shun-Ichi Harada, Mohamed MacHwate, Gideon A. Rodan, Marc Labelle, Kathleen Metters, Robert N. Young
  • Methods of treatment using an epithelial sodium channel blocker and an inhibitor of the mineralocorticoid receptor
    Patent number: 6586416
    Abstract: Co-administration of a channel blocking epithelial sodium channel (ENaC) blocker in conjunction with a mineralocorticoid receptor inhibitor makes it possible to achieve desired lowering of blood pressure with use in the range of 20% to 75% or less of the presently used dosage of the mineralocorticoid receptor inhibitor (MRI), thus avoiding many of the deleterious side effects usually associated with administration of an MRI. As little as 10% of the usual dosage of MRI may, in some cases, be efficacious. The most commonly used ENaC blocker now in use is amiloride. The most commonly used inhibitors of the mineralocorticoid receptor are precursors of canrenone.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: July 1, 2003
    Inventor: James K. Bubien
  • Method for producing calcium pantothenate
    Patent number: 6582940
    Abstract: A method for preparing nondeliquescent crystalline calcium pantothenate which comprises the steps of: (1) stirring a supersaturated aqueous solution containing calcium pantothenate in a ratio of 60% (W/W) or more, for example, by using a grinder mill, to obtain a crystal suspension; and (2) drying the suspension. A nondeliquescent crystalline calcium pantothenate which is substantially free from an organic solvent can be efficiently prepared.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: June 24, 2003
    Assignee: Daiichi Fine Chemical Co., Ltd.
    Inventors: Norikazu Takahashi, Tomoko Nozaki, Sotohiko Eimori, Motoo Shiba
  • 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol and estrogen formulations
    Patent number: 6583170
    Abstract: The present invention relates to new formulations containing one or more estrogens and 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structure below: and related methods of treatment for providing tissue selective estrogenic activity while minimizing undesirable side effects of estrogen treatment or therapy, such as excessive estrogenic uterine stimulation.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: June 24, 2003
    Assignee: Wyeth
    Inventors: James Harrison Pickar, Barry Samuel Komm
  • Cosmetic product
    Patent number: 6579517
    Abstract: The present invention relates to a cosmetic composition which comprises at least one crosslinked, water-soluble or water-dispersible polyurethane formed from A) at least one polyurethane prepolymer having terminal isocyanate groups, and B) at least one polymer having isocyanate-reactive groups selected from hydroxyl, primary and secondary amino and/or carboxyl groups, at least one of components A) and/or B) being soluble or dispersible in water and at least one of components A) and/or B) comprising at least one siloxane group, and the salts thereof.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: June 17, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Son Nguyen Kim, Axel Sanner, Volker Schehlmann
  • Use of physiologically acceptable vanadium compounds, salts and complexes
    Patent number: 6579540
    Abstract: Use of a physiologically acceptable vanadium compound, salt or complex as active component in the preparation of a pharmaceutical composition for the prophylactic treatment of secondary injury of tissue, said secondary injury being induced by primary injury of mainly surrounding tissue, in particular surrounding tissue, and being the result of a traumatic event.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: June 17, 2003
    Assignee: Gho'st Holding B.V.
    Inventor: Conradus Ghosal Gho
  • Assessment of concentration of inhalational compounds in the brain
    Patent number: 6579511
    Abstract: This invention directs to a method of assessing the concentration of an inhalational compound in the brain of a subject. The method includes administering a gas containing the compound into a subject to fill the pulmonary functional residual capacity, which is defined as the remaining lung volume at the end of an unforced respiration. The method also includes measuring an inspired compound concentration (Cl′) and an expired compound concentration (Ce′) after having filled the functional residual capacity with the gas. Therefore, a mixed venous compound concentration (Cb′) can be assessed based on the formula Cb′=[Ci′(M−1)+Ce′]/M, in which M is an alveolar membrane factor for the compound; and a brain compound concentration (Cb) can be assessed based on the formula Cb=(Ce′+Cb′)/2.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 17, 2003
    Inventor: Chung-Yuan Lin
  • Remedies for arthrosis deformans
    Patent number: 6576668
    Abstract: An object of the present invention is to find further new pharmacological actions of useful mercaptoacylcysteine derivatives. The present invention relates to therapeutic agents for osteoarthritis comprising compounds represented by the following general formula [I] or salts thereof as active ingredients. In the formula, “A” is lower alkylene. The lower alkylene is exemplified by straight-chain or branched alkylene having one to six carbon atoms such as methylene, ethylene, (dimethyl)methylene or (diethyl)methylene.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: June 10, 2003
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Hiroyuki Aono, Miwa Takai
  • Pharmaceutical or dietetic preparation for improvement of fertility and sperm quality
    Patent number: 6576634
    Abstract: A composition for improving the fertility of a male, and/or for improving the quality of the semen produced by a male includes at least one source of folic acid, preferably 0.05-8 mg; at least one source of zinc, preferably 5-50 mg; and optionally one or more of vitamin B12, magnesium, betaine, choline, SAM, vitamin B2, and Vitamin B6; and/or optionally one or more carriers, excipients and/or adjuvants.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: June 10, 2003
    Assignee: N.V. Nutricia
    Inventors: Regine Patricia Maria Steegers-Theunissen, Robert Johan Joseph Hageman, Arie Nieuwenhuizen
  • Method of inhibiting angiogenesis using active vitamin D analogues
    Patent number: 6573256
    Abstract: Methods utilizing active vitamin D analogs for the inhibition of angiogenesis associated with malignant and neoplasmic cells. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to inhibit the angiogenesis of malignant cells, inducing the apoptosis of malignant cells, and regressing the growth of tumorous cells.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: June 3, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Cream utilizing capsaicin
    Patent number: 6573302
    Abstract: A cream comprising: a topical carrier wherein the topical carrier comprises a member selected from the group comprising lavender oil, myristal myristate, and other preservatives including, hypericum perforatum arnica montana capric acid; and 0.01 to 1.0 wt. % capsaicin; 2 to 10 wt. % an encapsulation agent selected from the group comprising colloidal oatmeal hydrogenated lecithin, dipotassium glycyrlhizinate and combinations thereof; esters of amino acid; a light scattering element having a particle size up to 100 nm.; and a histidine.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: June 3, 2003
    Assignee: Medical Merchandising, Inc.
    Inventors: Stephen D. Holt, Teresa Leigh Barr
  • Cyclic AMP-specific phosphodiesterase inhibitors
    Patent number: 6569885
    Abstract: Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: May 27, 2003
    Assignee: Icos Corporation
    Inventors: Timothy J. Martins, Kerry W. Fowler, Carmen C. Hertel, Amy Oliver
  • Solubilization of flavonols
    Patent number: 6569446
    Abstract: A method of increasing the solubility in water of a flavonol component of a flavonol-containing composition, the method including the steps of providing a flavonol-containing composition, providing an anthocyanin-containing composition and mixing the two compositions.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: May 27, 2003
    Assignee: The Howard Foundation
    Inventor: Alan N. Howard
  • Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
    Patent number: 6569895
    Abstract: Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: May 27, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Xiong Cai, Aberra Fura, Changgeng Qian
  • Treatment of multiple sclerosis (MS) and other demyelinating conditions using lofepramine in combination with L-phenylalanine, tyrosine or tyrptophan and possibly a vitamin B12 compound
    Patent number: 6569850
    Abstract: Method for treating multiple sclerosis or encephalomyelitis by administering to a patient a combination of a tricyclic antidepressant drug and tyrosine or phenylalanine or both.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: May 27, 2003
    Inventor: Cari Loder
  • Method of treating malignancy associated hypercalcemia using active vitamin D analogues
    Patent number: 6566353
    Abstract: Methods utilizing active vitamin D analogs for the treatment of malignancy-associated hypercalcemia. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to alleviate hypercalcemia, lower serum parathyroid hormone related protein (PTHrP) levels.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: May 20, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Hemorrhoidal compositions and method of use
    Patent number: 6565850
    Abstract: The present invention is directed to gel compositions useful in the preparation of medicated gel products. Such medicated gel products are suitable for use in the treatment of anorectal disorders such as hemorrhoids. Also disclosed is a method for the treatment of such anorectal disorders using the claimed medicated gel products.
    Type: Grant
    Filed: April 5, 1995
    Date of Patent: May 20, 2003
    Inventor: Amparo Blanco
  • Skin care product containing retinoids and phytoestrogens in a dual compartment package
    Patent number: 6565864
    Abstract: A stable skin care product containing a first composition comprising about 0.001% to about 10% of a retinoid; a second composition comprising about 0.001% to about 10% of a phytoestrogen; a first compartment for storing the first composition; and a second compartment for storing the second composition, the first and second compartments being joined together.
    Type: Grant
    Filed: November 7, 2001
    Date of Patent: May 20, 2003
    Assignee: Unilever Home & Personal Care USA, a division of Conopco, Inc.
    Inventors: Sreekumar Pillai, Stewart Paton Granger, Ian Richard Scott, David Joseph Pocalyko
  • Intraperitoneal administration of adenosine for the treatment of prevention of gastrointestinal of systemic diseases
    Patent number: 6566371
    Abstract: A method for preventing or treating gastrointestinal or systemic diseases in a mammalian subject, comprising: the step of administering a therapeutically effective amount of a composition comprising adenosine or a prodrug thereof into the peritoneal cavity of said subject at a dose that does not achieve pharmacologically active levels in the aortic arterial plasma of said subject.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: May 20, 2003
    Assignee: University of Pittsburgh
    Inventor: Edwin K. Jackson
  • Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y
    Patent number: 6562862
    Abstract: A method of inhibiting a physiological disorder associated with an excess of neuropeptide Y or its symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula wherein R1 and R3 are independently hydrogen,  or  wherein Ar is optionally substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.
    Type: Grant
    Filed: October 20, 1994
    Date of Patent: May 13, 2003
    Assignee: Eli Lilly and Company
    Inventors: Robert F. Bruns, Jr., Donald R. Gehlert, J. Jeffry Howbert, William H. W. Lunn