Patents Examined by D. B. Springer
  • Patent number: 4837338
    Abstract: N-methyl pyrrolidone solvent (hereinafter NMP) used to extract aromatic components from lubricating oil distillates is purified by contacting the solvent with activated alumina.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: June 6, 1989
    Assignee: Exxon Research and Engineering Company
    Inventors: Bordan W. Krupay, Lloyd E. Reid
  • Patent number: 4829074
    Abstract: Compounds of the formula: ##STR1## The compounds are useful as pesticides, particularly insecticides.
    Type: Grant
    Filed: February 24, 1986
    Date of Patent: May 9, 1989
    Assignee: Imperial Chemical Industries PLC
    Inventor: Michael J. Bushell
  • Patent number: 4820841
    Abstract: Disclosed herein is a novel chromogenic compound of the formula: ##STR1## wherein R represents an alkyl group of 6 to 12 carbon atoms or benzyl group, and ring A and ring B in the quinolyl group may be substituted, a color forming composition containing said chromogenic compound, and pressure- or heat-sensitive recording paper based on said color forming composition.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: April 11, 1989
    Assignee: Yamada Chemical Co., Ltd.
    Inventors: Hideaki Fujisaki, Kouzou Mizuno, Yukihiko Sueto, Katsuhiko Tsunemitsu
  • Patent number: 4816465
    Abstract: Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.
    Type: Grant
    Filed: January 13, 1987
    Date of Patent: March 28, 1989
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Michel Fortin, Odile Le Martret, Francoise Delevallee
  • Patent number: 4808212
    Abstract: Oxime esters of substituted quinoline-8-carboxylic acids of the formula ##STR1## where X is hydrogen, C.sub.1 -C.sub.4 -alkyl or halogen, Z is hydrogen or methyl, R.sup.1 is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkoxymethyl, C.sub.1 -C.sub.4 -alkoxyethyl, C.sub.1 -C.sub.4 -alkylthiomethyl, C.sub.1 -C.sub.4 -alkylthioethyl, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.3 -C.sub.6 -alkenyl or C.sub.5 -C.sub.8 -cycloalkyl, each of which is unsubstituted or bears up to 3 methyl substituents, hydrogen, cyano, acetyl, benzoyl, unsubstituted benzyl or phenyl, or benzyl or phenyl bearing up to 3 substitutents selected from the group consisting of halogen, cyano, trifluoromethyl, C.sub.1 -C.sub.4 -haloalkyloxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkyl, hydroxy, dimethylamino or acetamino, R.sup.2 is hydrogen if R.sup.1 is not hydrogen, R.sup.2 further denotes C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.4 -alkoxymethyl, chloromethyl, azolylmethyl, 1,1-dimethoxymethyl, cyano, C.sub.
    Type: Grant
    Filed: December 22, 1986
    Date of Patent: February 28, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Plath, Karl Eicken, Bernd Zeeh, Ulrich Eichenauer, Helmut Hagen, Rolf-Dieter Kohler, Norbert Meyer, Bruno Wuerzer
  • Patent number: 4806558
    Abstract: Novel diarylacetylenes of the formula I ##STR1## where A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meanings stated in the description, are useful for the treatment of dermatological disorders.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: February 21, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Heiner Wuest, Fritz-Frieder Frickel, Axel Nuerrenbach
  • Patent number: 4801595
    Abstract: The invention concerns compounds of formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; R.sub.2 represents hydrogen or lower alkyl; A represents an alkylene, oxoalkylene or hydroxyalkylene chain each having 2 to 6 carbon atoms, R.sub.3 and R.sub.4 may be in the same or different rings and independently represent hydrogen, lower alkyl, lower alkoxy, amino or halogen and one of X and Y represents nitrogen the other represents CR.sub.5 wherein R.sub.5 is one of the values for R.sub.3 or R.sub.5 is the bond to the NHCO group; or a pharmaceutically acceptable salt thereof, which compounds possess antihypertensive activity while exhibiting reduced CNS depressant properties. Also disclosed are processes for preparing the compounds and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: January 31, 1989
    Assignee: John Wyeth & Brother Limited
    Inventors: John L. Archibald, Terence J. Ward, Janet C. White
  • Patent number: 4800212
    Abstract: Compounds of formula (I) or when a compound of formula (I) contain a salifiable group, a pharmaceutically acceptable salt thereof: ##STR1## wherein: R.sub.1 -R.sub.7 and X are as defined, are useful as anti-hypertensive agents.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: January 24, 1989
    Assignee: Beecham Group p.l.c.
    Inventors: John M. Evans, Geoffrey Stemp
  • Patent number: 4800227
    Abstract: A one-step method for the reductive amination of a heterocyclic to produce a nitrogen-containing heterocyclic. The feedstock is contacted with a mixed metal catalyst in which the metal comprises palladium and one of ruthenium, rhodium or rhenium.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: January 24, 1989
    Assignee: Phillips Petroleum Company
    Inventor: Michael S. Matson
  • Patent number: 4797148
    Abstract: Quinoline derivatives of the formula ##STR1## where R.sup.1, X, Y and Z have the meanings given in the disclosure, herbicides containing these compounds as active ingredients, and a process for combating unwanted plant growth.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: January 10, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Helmut Hagen, Ulrich Eichenauer, Peter Plath, Norbert Meyer, Bruno Wuerzer
  • Patent number: 4795754
    Abstract: A new compound, 3-(1H-tetrazol-5-yl)oxanilic acid and pharmaceutically acceptable salts thereof are herein disclosed, which can be prepared by reacting 3-(1H-tetrazol-5-yl)aniline with a compound represented by the general formula: A--CO--CO--B (wherein A and B may be identical with or different from one another and represent hydroxyl group, a halogen atom or a lower alkoxy group) and then optionally hydrolyzing the resultant product. The compound presents an excellent histamine and SRS-A release inhibitory effect and is hydrophilic or soluble in water. Therefore, the compound is very suitable to form, in particular, an aqueous pharmaceuticals for treatment or prevention of allergic diseases such as bronchial asthma, rhinitis and conjunctivitis.
    Type: Grant
    Filed: August 7, 1987
    Date of Patent: January 3, 1989
    Assignee: Wakamoto Pharmaceutical Co., Ltd.
    Inventors: Shohei Sawaki, Yasuhiro Ootake, Terumasa Hashimoto, Tooru Abe, Yoshihiro Horio
  • Patent number: 4794181
    Abstract: The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same of different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.
    Type: Grant
    Filed: January 16, 1986
    Date of Patent: December 27, 1988
    Assignee: Hoechst-Roussel Pharmaceuticals, Inc.
    Inventors: Richard C. Effland, Joseph T. Klein, Larry Davis
  • Patent number: 4794180
    Abstract: A process for producing fine-grained .beta.-HMX wherein a solution of .beta.-HMX is treated in a .gamma.-lactone in a temperature range of between 5.degree. and 15.degree. C. with toluene, and the desired fine and very pure .beta.-HMX crystals are precipitated. The resultant crystals have grain sizes of down to 5 .mu.m and exhibit an extremely small proportion of other modifications or forms of HMX. An additional aspect of the process resides in providing the very fine .beta.-HMX with a coating of a thermoplastic polymer. In this procedure, the .beta.-HMX particles, after having been separated from toluene, are made into a slurry in water and combined under agitation at temperatures of between 25.degree. and 60.degree. C. with a solution or suspension or emulsion of the thermoplastic polymer. During this step, granules are formed which can be separated after distillation of the solvent.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: December 27, 1988
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Klaus Heinemeyer, Klaus Redecker, Ulrich Sassmannshausen
  • Patent number: 4792611
    Abstract: Cyclic N-hydroxyimide compounds derived from tartaric acid are provided which exhibit strong metal ion chelating ability, making them useful as detergent additives, in boiler water systems, as reaction intermediates, etc. A detergent composition containing N-hydroxyimide compounds as detergent additives is also disclosed.
    Type: Grant
    Filed: August 12, 1984
    Date of Patent: December 20, 1988
    Assignee: American Cyanamid Company
    Inventor: Stephen F. Donovan
  • Patent number: 4792560
    Abstract: This invention relates to new chemical compounds possessing valuable pharmaceutical activity, particularly as lipoxygenase inhibitors possessing anti-inflammatory and anti-allergic properties.
    Type: Grant
    Filed: February 19, 1986
    Date of Patent: December 20, 1988
    Assignee: Rorer Pharmaceutical Corporation
    Inventor: Fu-chih Huang
  • Patent number: 4792559
    Abstract: 5-aminopentanenitrile compounds of the formula: ##STR1## in which: Ar represents ##STR2## in which: R.sub.1 is hydrogen, halogen trifluoromethyl or C.sub.1 -C.sub.5 -alkoxy, andR.sub.2 and R.sub.3, which are identical or different, each are hydrogen or C.sub.1 -C.sub.5 -alkoxy or together form --O--CH.dbd.CH--O-- or --O--CH.sub.2 --O--; or together form with the phenyl ring to which they are bound a benzoxazolyl, benzothiazolyl, benzothiadiazolyl or quinolyl radical;R is C.sub.3 -C.sub.15 -alkyl or ##STR3## in which: X is S or SO.sub.2 and Z is hydrogen, chlorine or C.sub.1 -C.sub.5 -alkyl or C.sub.1 -C.sub.5 -alkoxy;R' is C.sub.1 -C.sub.5 -alkyl, andAr' represents ##STR4## in which: R'.sub.1 is C.sub.1 -C.sub.5 -alkyl andR'.sub.2 is hydrogen or C.sub.1 -C.sub.4 -alkyl; and moreover when R is ##STR5## Ar' may be ##STR6## in which Y is C.sub.1 -C.sub.5 alkoxy andY' is hydrogen or C.sub.1 -C.sub.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: December 20, 1988
    Assignee: ADIR et Compagnie
    Inventors: Gilbert Regnier, Yves-Michel Gargouil, Jean-Paul Vilaine
  • Patent number: 4792609
    Abstract: An indoline derivative of the formula (I) ##STR1## in which R.sup.1 denotes H or C.sub.1 -C.sub.8 -alkyl;R.sup.2 and R.sup.3 are identical or different and denote C.sub.1 -C.sub.8 -alkyl;R.sup.4 -R.sup.9 are identical or different and denote H, C.sub.1 -C.sub.8 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or phenyl-C.sub.1 -C.sub.4 -alkyl, or R.sup.5 and R.sup.6 connected together to form a further C.sub.5 -C.sub.6 ring, andR.sup.10 denotes H or one or more radicals selected from the group consisting of C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.5 -C.sub.6 -cycloalkyl, phenyl-C.sub.1 -C.sub.4 -alkyl and carb-C.sub.1 -C.sub.8 -alkoxy radicals, or halogen atoms. Such indoline derivative is useful as a UV absorber.
    Type: Grant
    Filed: May 21, 1986
    Date of Patent: December 20, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Scholl, Otto Exner, Peter Finkel, Hermann Perrey
  • Patent number: 4791210
    Abstract: 5-Methyltetrazole can be produced by reacting acetonitrile with an alkali azide or ammonium azide in high purity and a yield of above 98% by using a trialkyl amine as the solvent or suspension agent and by using the associated hydrochloride of the amine as the catalyst.
    Type: Grant
    Filed: October 13, 1987
    Date of Patent: December 13, 1988
    Assignee: Dynamit Nobel Aktiengesellschaft
    Inventors: Gunter Bison, Johannes Schlupp, Josef Winterscheid, Klaus Thewalt
  • Patent number: 4791204
    Abstract: Compositions comprising(a) a pyrrolopyrrole of formula I ##STR1## wherein A and B are identical or different alkyl, aralkyl, aryl or heterocyclic aromatic radicals, R.sub.1 and R.sub.2 are hydrogen atoms, unsubstituted or substituted alkyl radicals, and also alkenyl, alkynyl, aralkyl, cycloalkyl, carbamoyl, alkylcarbamoyl, arylcarbamoyl, alkoxycarbonyl, aryl, alkanoyl or aroyl groups, and X is an --O-- or --S-- atom, and(b) a pyrrolopyrrole of the above formula I that contains at least one group of formula --SO.sub.3 L, --CO.sub.2 L, --PO.sub.3 (L).sub.2, --N(R.sub.4)(R.sub.5 ), ##STR2## oder --NHCOR wherein L is --H, a group of formula M.sub.n.sup.+n or N.sup.+ H(R.sub.3)(R.sub.4)(R.sub.5), M is a monovalent, divalent or trivalent metal cation, n is 1, 2 or 3, R.sub.3 R.sub.4 and R.sub.5 are each independently --H or alkyl, aralkyl, C.sub.5 -C.sub.6 cycloalkyl or aryl radicals, or R.sub.4 and R.sub.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: December 13, 1988
    Assignee: Ciba-Geigy Corporation
    Inventors: Max Jost, Abul Iqbal, Alain C. Rochat
  • Patent number: 4788294
    Abstract: Process for the production of 4-alkoxy-3-pyrrolin-2-ones, which are preferred intermediate products for the production of cerebrally-active pharmaceutical products.
    Type: Grant
    Filed: March 14, 1988
    Date of Patent: November 29, 1988
    Assignee: Lonza Ltd.
    Inventors: Laurent Duc, John McGarrity, Thomas Meul