Patents Examined by D. B. Springer
  • Cleavable cross-linking reagent
    Patent number: 4647671
    Abstract: An alkali-cleavable heterobifunctional cross-linking analytical reagent is provided in the form of a compound having the structure ##STR1## in which R.sub.1 and R.sub.2 is each an alkylene group having from 2 to 4 carbon atoms.
    Type: Grant
    Filed: January 25, 1985
    Date of Patent: March 3, 1987
    Inventor: Martin A. Schwartz
  • Octa- and deca-hydroquinoline intermediates
    Patent number: 4647667
    Abstract: A 1-substituted-3-permissibly-substituted-6 (or 7)-oxodecahydroquinoline is converted to the corresponding 7 (or 6)-formyl derivative. The 6-oxo-7-formyl compound, upon treatment with hydrazine, is cyclized to a tautomeric mixture of 5-substituted-7-permissibly-substituted-4,4a,5,6,7,8,8a,9-octahydro-1H(and 2H)-pyrazolo[3,4-g]quinolines.
    Type: Grant
    Filed: September 16, 1985
    Date of Patent: March 3, 1987
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • N-(dichlorofluoromethylthio)-3,4-dimethylmaleimide and its use as a fungicide
    Patent number: 4645776
    Abstract: The new compound N-(dichlorofluoromethylthio)-3,4-dimethylmaleimide can be prepared by reacting 3,4-dimethylmaleimide with dichlorofluoromethanesulphenyl chloride in the presence of an acid-binding agent. N-(dichlorofluoromethylthio)-3,4-dimethylmaleimide is an active compound in microbicidal agents.
    Type: Grant
    Filed: April 9, 1985
    Date of Patent: February 24, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Engelbert Kuhle, Wilfried Paulus, Hermann Genth
  • Pyrrole compounds for detecting the presence of hydrolytic analytes
    Patent number: 4645842
    Abstract: A novel compound useful in detecting leukocytes, esterase and protease in a test sample. The compound has the structure ##STR1## in which: A is an acid residue, R is lower alkyl, aryl, carboxyl, carboxyl ester, amido or cyano, R* is H or lower alkyl, and X is O, S, or NR', in which R' is H, lower alkyl or aryl.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: February 24, 1987
    Assignee: Miles Laboratories, Inc.
    Inventors: Paul F. Corey, Frederick E. Ward, Kin F. Yip, Meitak T. Yip
  • Process for the preparation of N-arylhalopyrrolid-2-ones
    Patent number: 4645843
    Abstract: Production of N-arylhalopyrrolidones by intramolecular cyclization of an .alpha.-halogen-N-2-alkenylamide is conducted in the presence of a copper-containing catalyst and a primary or secondary aliphatic amine.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: February 24, 1987
    Assignee: Stauffer Chemical Company
    Inventors: Michael D. Broadhurst, Richard D. Gless, Jr.
  • Herbicidal 5-amino-3-oxo-4-(3-substituted-phenyl)-4-pyrroline and derivatives thereof
    Patent number: 4643762
    Abstract: 5-Amino-3-oxo-4-(substituted-phenyl)-4-pyrroline and derivatives thereof. The compounds generally exhibit both pre-emergence and post-emergence phytotoxicity and are useful as herbicides and also plant growth regulating agents at low dosages.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: February 17, 1987
    Assignee: Chevron Research Company
    Inventor: Carl E. Ward
  • Process for the extraction of amino acids from an aqueous phase
    Patent number: 4644067
    Abstract: A process for the extraction of aromatic (e.g., phenyl-containing) amino acids from an aqueous phase (solution) containing them, comprising combining the aqueous phase with a tenside of the formulaR--U--SO.sub.3 XwhereinR is alkyl or cycloalkyl each of 4-18 carbon atoms; or phenyl or naphthyl, each optionally substituted by alkyl groups, and having up to 18 carbon atoms total.U is a carbon-to-sulfur bond or an oxygen atom, andX is an alkali metal ion;acidifying the aqueous phase to a pH value of 2.0-2.5; andextracting the aqueous phase with an alcohol, a ketone, or a carboxylic acid alkyl ester, each containing 4-6 carbon atoms.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: February 17, 1987
    Assignee: Schering Aktiengesellschaft
    Inventors: Alfred Weber, Detlef Wilke, Johannes Kurzidim, Mario Kennecke
  • Process for the preparation of 4(3H)-quinazolinones
    Patent number: 4644065
    Abstract: A new process for the preparation of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones from anthranilic acid derivatives is described herein. Additional reactants used in the process are 4-aminotetrazole and a trialkoxymethane or the reaction can be carried out using the imidic ester obtained from these two compounds.
    Type: Grant
    Filed: May 15, 1984
    Date of Patent: February 17, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Anna P. Vinogradoff
  • 6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones
    Patent number: 4642345
    Abstract: Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase inhibitors, and peripheral vasodilators. They are orally active and useful in the prophylaxis and treatment of asthma. A preferred compound is 4-[(4-chlorophenyl)methyl]-6,7-dihydro-3H-imidazo[1,2-a]-purin-9(4H)-one.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: February 10, 1987
    Assignee: Mead Johnson & Company
    Inventor: Davis L. Temple, Jr.
  • 3(2-quinolinylalkoxy)phenols
    Patent number: 4642347
    Abstract: There are disclosed compounds of the formula ##STR1## wherein Z is CR or N, when n=1; or Z is O, S, or NR, when n=0; n is 0 or 1; p is 1-10; R.sup.1 is hydrogen, loweralkyl, loweralkoxy or halo; R.sup.2 is hydrogen, loweralkyl, loweralkoxy or halo; or R.sup.1 and R.sup.2 taken together form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like.
    Type: Grant
    Filed: May 21, 1985
    Date of Patent: February 10, 1987
    Assignee: American Home Products Corporation
    Inventors: Anthony F. Kreft, III, Thomas W. Pattison, John H. Musser
  • Crystallization method for HMX and RDX
    Patent number: 4638065
    Abstract: The present invention relates to a method for the recrystallization of the high explosives HMX and RDX. According to the invention, the explosive is dissolved in a low molecular weight, liquid (at room temperature) lactone, after which the degree of saturation of the solution obtained, is changed by either lowering the temperature or by diluting with water.This method produces, depending on the crystallization method chosen, .beta.-HMX crystals or RDX crystals of either 50-1500 .mu.m or 5-50 .mu.m median particle diameter respectively.
    Type: Grant
    Filed: March 26, 1985
    Date of Patent: January 20, 1987
    Assignee: Aktiebolaget Bofors
    Inventors: Leif Svensson, Jan-Olof Nyqvist, Lars Westling
  • Process for decomposing N-oxide derivatives producing 5-vinyl-2-pyrrolidones
    Patent number: 4632994
    Abstract: New process for preparing olefinic lactams by decomposing the corresponding N,N-dimethyl-N-oxides in a suitable solvent in the presence of a base at a temperature of at least 100.degree. C.
    Type: Grant
    Filed: November 4, 1983
    Date of Patent: December 30, 1986
    Assignee: Gruppo Lepetit S.p.A.
    Inventor: Aldo Trani
  • Process for the preparation of pyrrolidone derivatives
    Patent number: 4629797
    Abstract: A process for preparing compounds (1) ##STR1## where Y is NR.sup.1 R.sup.2 or OR, R.sup.1 and R.sup.2 are hydrogen or C.sub.1-3 alkyl, and R is C.sub.1-3 alkyl, which comprises protecting the hydroxy group of a compound (2) ##STR2## cyclising the product under basic conditions and removing the protecting group.
    Type: Grant
    Filed: March 29, 1985
    Date of Patent: December 16, 1986
    Assignee: I.S.F. Societa per Azioni
    Inventors: Mario Pinza, Ugo C. Pfeiffer
  • Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines
    Patent number: 4626591
    Abstract: A process for preparing 1-alkyl-6-oxodecahydroquinolines in 5 steps--a quaternization, hydrogenation, two organometallic reductions and hydrolysis of the thus formed enol ether--from 6-alkyloxyquinoline and intermediates useful therein.
    Type: Grant
    Filed: April 19, 1985
    Date of Patent: December 2, 1986
    Assignee: Eli Lilly and Company
    Inventor: John M. Schaus
  • Use of oxindole compounds for the treatment of epilepsy
    Patent number: 4624963
    Abstract: Oxindole compounds of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.1', R.sup.2', R.sup.3', R.sup.4, R.sup.5 and R.sup.6 have the meanings given, and physiologically acceptable salts thereof, for the treatment of epilepsy and their use for the preparation of a medicament for the treatment of epilepsy are described.
    Type: Grant
    Filed: April 9, 1985
    Date of Patent: November 25, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hansjorg Kruse, Heinz Kuch
  • Antimicrobial peptide
    Patent number: 4623733
    Abstract: Novel peptide B-52653 having the formula: ##STR1## which is produced by cultivating a microorganism belonging to the genus Streptomyces and being capable of producing B-52653 in a culture medium, whereby B-52653 is elaborated and accumulated in the cultured broth and is recovered.B-52653 is useful as a germicide or disinfectant, and a possibility of the present substance as an antifibrotic agent is suggested.
    Type: Grant
    Filed: July 10, 1984
    Date of Patent: November 18, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Eiji Higashide, Satoshi Horii
  • Method for oxidizing alkyl groups on pyridine, quinoline and benzene ring compounds to carboxylic acids under basic conditions
    Patent number: 4623726
    Abstract: There is provided a novel process for the preparation of carboxylic acids from alkyl groups under basic conditions utilizing oxides of copper, cobalt and silver.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: November 18, 1986
    Assignee: American Cyanamid Company
    Inventor: William A. Daniels
  • Method for production of maleimides
    Patent number: 4623734
    Abstract: A method for the production of maleimides, which comprises subjecting maleinamic acids to ring-closure imidation in an organic solvent capable of forming an azeotrope with water in the presence of an acid catalyst at a temperature in the range of 120.degree. to 250.degree. C. while removing the formed water in the form of an azeotrope with said organic solvent and thereafter purifying the produced maleimides.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: November 18, 1986
    Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.
    Inventors: Yuichi Kita, Kentaro Sakamoto, Masao Baba, Atsushi Okubo
  • 8-hydroxy-quinoline derivatives for the protection of cultivated plants
    Patent number: 4623727
    Abstract: A process for the protection of cultivated plants against harmful effects of aggressive agricultural chemicals by the use of compounds of the formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 independently of one another are each hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, nitro or cyano,R.sub.4, R.sub.5 and R.sub.6 independently of one another are each hydrogen, halogen or C.sub.1 -C.sub.3 -alkyl,A is any one of the groups --CH.sub.2 --, --CH.sub.2 --CH.sub.2 -- or --CH(CH.sub.3)--, andZ is cyano, or amidoxime which can be acylated on the oxygen atom,including acid addition salts and metal complexes thereof.
    Type: Grant
    Filed: February 11, 1983
    Date of Patent: November 18, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Adolf Hubele
  • Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
    Patent number: 4622399
    Abstract: Herein is disclosed bicyclic-substituted aminoethanol derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for treating hypertension in a mammal.
    Type: Grant
    Filed: May 23, 1985
    Date of Patent: November 11, 1986
    Assignee: American Home Products Corporation
    Inventors: Andre A. Asselin, Danilo A. Crosilla, Leslie G. Humber