Patents Examined by D. C. Jacobson
  • Patent number: 5451521
    Abstract: This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by modification of one or more specific proteolytic cleavage sites encompassing the arginine residues at positions 226, 336, 562, 740, 776, 1313, 1648, or 1721. The variants possess similar procoagulant activity to that of human Factor VIII:c.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: September 19, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Debra D. Pittman, John J. Toole, Jr.
  • Patent number: 5436136
    Abstract: Novel upstream activation sites of the yeast PHO5 gene are used to produce inducible yeast hybrid promoters. The yeast hybrid promoters can be used to control transcription of a polypeptide coding region foreign to yeast in a yeast expression vector.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: July 25, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Albert Hinnen, Bernd Meyhack
  • Patent number: 5434074
    Abstract: A herpes virus proteinase has been found to be encoded by a member of a family of four nested genes in simian cytomegalovirus. Another member of the nested genes encodes the assembly protein precursor, which is a substrate for the proteinase. Homologous genes are found in other herpes viruses. Cleavage sites recognized by the proteinase are identified in cytomegalovirus and are found to be highly conserved in other herpes viruses. Substrates, inhibitors, assay kits, and methods of assaying are provided which rely on the proteinase and its activity.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: July 18, 1995
    Inventors: D. Wade Gibson, Anthony R. Welch