Patents Examined by D. Carr
  • Contaminant reduced marine oil
    Patent number: 6469187
    Abstract: Process for the preparation of oil of marine origin with reduced content of polychlorinated dioxins, furans, biphenyls and polycyclic aromatic hydrocarbons. The oil obtainable by the process has combined concentrations of polychlorinated dioxins, furans and biphenyls in a range from 0.05-6 (ng TEQ/kg oil) and is used in foodstuffs or pharmaceutical formulations.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: October 22, 2002
    Assignee: Merck Patent GmbH
    Inventors: Charles W. Craven, Tommy Morrison
  • Process for preparing polyether polyols
    Patent number: 6469218
    Abstract: The invention is directed to a process for preparing a polyether polyol by the polyaddition of an alkylene oxide on to a starter compound containing active hydrogen atoms under basic catalysis in the presence of phosphonium cations.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: October 22, 2002
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ornulf Rexin, Rolf Mülhaupt
  • Oils with heterogenous chain lengths
    Patent number: 6465401
    Abstract: Oils containing a triacylglycerol polyol ester and a non-glycerol polyol ester are described, as well as methods of making such oils. Methods for improving lubrication properties of a vegetable oil also are described.
    Type: Grant
    Filed: January 19, 2000
    Date of Patent: October 15, 2002
    Assignee: Cargill Incorporated
    Inventors: Dharma R. Kodali, Scott C. Nivens
  • Isomer enriched CLA compositions
    Patent number: 6465666
    Abstract: Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:1 are desirable for a wide variety of nutritional, therapeutic and pharmacologic uses.
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: October 15, 2002
    Assignee: Conlinco, Inc.
    Inventors: Daria Jerome, Carl Skarie
  • Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for treatment of dry eye
    Patent number: 6462061
    Abstract: Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: October 8, 2002
    Assignee: Alcon Universal Ltd.
    Inventor: David B. Belanger
  • Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
    Patent number: 6458854
    Abstract: Phospholipid-HETE derivatives, compositions and methods of use are disclosed. The compounds are particularly useful for treating dry eye.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: October 1, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Gustav Graff, Peter G. Klimko
  • Lipophilic diesters of chelating agents
    Patent number: 6458837
    Abstract: The invention discloses stable diesters of chelating agents of divalent metal ions, processes for their preparation and pharmaceutical compositions thereof. Most preferred compounds according to the present invention are stable lipophilic diesters comprising a covalent conjugate of a BAPTA and a pharmaceutically acceptable alcohol. The diesters are useful in a method for treating a condition or disease related to an excess of divalent metal ions, and in particular for the treatment of a condition or disease related to elevated levels of intracellular calcium ions, such as in brain or cardiac ischemia, stroke, epilepsy, Alzheimer's disease or cardiac arrhythmia and in open heart surgery.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: October 1, 2002
    Assignee: D-Pharm Ltd.
    Inventors: Alexander Kozak, Israel Shapiro
  • Carboplatin analogs for cancer treatment
    Patent number: 6458832
    Abstract: The synthesis and the use of a series of carboplatin analogs is disclosed. These carboplatin analogs may be represented by cis-Pt(II)L1L2, wherein each of L1 and L2, independently, is the carboxylate of phosphatidylserine, an &agr;-amino acid, a &bgr;-amino acid, or a derivative thereof, wherein each ligand is bidentate with —NH2 and —COO− as the binding sites. The complexes can be used in the treatment of cancer.
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: October 1, 2002
    Assignee: Unitech Pharmaceuticals, Inc.
    Inventor: Jiajiu Shaw
  • Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
    Patent number: 6458853
    Abstract: Phospholipid-HETE derivatives, compositions and methods of use are disclosed. The compounds are particularly useful for treating dry eye.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: October 1, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Gustav Graff, Peter G. Klimko
  • Process for the codimerization of fatty substance dienes and olefins that are catalyzed by nickel complexes
    Patent number: 6452029
    Abstract: A nickel catalytic system that makes it possible to obtain branched compounds from fatty substances by reacting simple olefins on polyunsaturated esters, which may or may not be conjugated, is described. The compounds that are obtained may be hydrogenated and used as lubricant bases or may be transformed according to known procedures into compounds of acid, alcohol, amine or amide type, used in varied applications.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: September 17, 2002
    Assignee: Institut Francais du Petrole
    Inventors: Gérard Hillion, Hélène Olivier, Katja Siepen, Dominique Commereuc, Robert Stern
  • Refining of glyceride oils by treatment with silicate solutions and filtration
    Patent number: 6448423
    Abstract: This invention relates to the refining of glyceride oils in the food industry. More particularly, this invention is directed to the removal of free fatty acids and soapstock from oils during refining. The method and apparatus of the invention contact the crude glyceride oil with an agglomerating agent, preferably a soluble silicate solution, such that the contaminants agglomerate in a discrete phase. This discrete phase is separated from the liquid oil phase through physical separation means, preferably filtration.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: September 10, 2002
    Assignee: The Texas A&M University System
    Inventors: Ernesto Hernandez, Steve J. Rathbone
  • Chromogenic compound
    Patent number: 6448422
    Abstract: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 10, 2002
    Assignee: Eli Lilly and Company
    Inventors: Patrick Irving Eacho, Patricia Sue Foxworthy-Mason, Richard Waltz Harper, Ho-Shen Lin, Jose Eduardo Lopez, Michael Enrico Richett
  • Process for the codimerization of polyunsaturated fatty substances and olefins by iron complexes
    Patent number: 6444831
    Abstract: To obtain branched compounds from fatty substances, simple olefins are reacted on polyunsaturated esters, which may or may not be conjugated, in the presence of an iron catalytic system, whereby the products that are obtained, primarily mono-addition compounds, can be hydrogenated and transformed into various compounds that can be used in particular as a base for surfactants, emulsifiers, emollients, lubricants or heavy metal salts.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: September 3, 2002
    Assignee: Institut Francais du Petrole
    Inventors: Ingrid Bach, Gérard Hillion, Héléne Olivier
  • Amino alcohol derivatives, method of producing said derivatives and medicaments containing them
    Patent number: 6444832
    Abstract: Compounds of formula I in which R1 denotes hydrogen or methyl R2 denotes lower straight-chained or branched alkyl with 1 to 10 carbon atoms R3 denotes hydrogen or lower alkyl n denotes 0-12 R4 denotes alkyl, alkenyl or alkinyl with 6 to 24 carbon atoms, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of osteoporosis.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: September 3, 2002
    Inventors: Angelika Esswein, Lothar Kling, Ulrike Leser, Walter-Gunar Friebe
  • Method for producing fatty acid methyl ester and equipment for realizing the same
    Patent number: 6440057
    Abstract: Method for producing fatty acid methyl ester, including compounding saturated and unsaturated higher fatty substances from at least one of vegetable and animal with an alkaline solution dissolved in alcohol to form a mixture. The method also includes emulsifying the mixture to reach a chemical balance state in a reaction section, wherein fats are transesterified into fatty acid methyl ester, wherein border surfaces of the mixture are enlarged by dynamic turbulence in the reaction section and the transesterification is performed under pressure, and wherein the pressure is reduced during transesterification. The method further includes after reaching a chemical balance state, separating residues from the fatty acid methyl ester in a phase separation section. Apparatus for producing fatty acid methyl ester.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: August 27, 2002
    Assignee: ENERGEA Umwelttechnologie GmbH
    Inventors: Nurhan Ergün, Peter Panning
  • Diacetylenics containing adjacent triple bonds
    Patent number: 6440056
    Abstract: This invention pertains to a process for preparing diacetylenics, to diacetylenic compounds and to reduced diacetylenic compounds. The process includes the steps of reacting coupling an acetylenic acid in presence of cupric chloride in Ethylamine and hydroxylamine hydrochloride to form a diacetylenic diacid; reacting the diacetylenic diacid with a lithium compound, trimethylsilyl chloride and hydrochloric acid to form a diacetylenic compound; and reducing the diacetylenic compound to a reduced diacetylenic compound.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: August 27, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Alok Singh, Paul Schoen, Dan Zabetakis, Joel M. Schnur
  • Use of organic acid esters in dietary fat
    Patent number: 6441206
    Abstract: The invention concerns dietary fat compositions that contain the hydroxy acid or dicarboxylic acid or amino acid esters of a phytosterol and/or phytostanol, or the mixed esters formed with the alcohols, polyols or polyol (C2 . . . C22)-fatty acid esters of dicarboxylic acids or hydroxy acids, or the (C2 . . . C22)-fatty acid esters of hydroxy acids.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: August 27, 2002
    Assignee: Raisio Benecol Ltd.
    Inventors: Hannu Mikkonen, Elina Heikkilä, Erkki Anttila, Anneli Lindeman
  • Fatty analogues for the treatment of obesity, hypertension and fatty liver
    Patent number: 6441036
    Abstract: The present invention relates to novel fatty acid analogous of the general forumla I: CH3—[CH2]m—[xi—CH2]n—COOR, as defined in the specification, which can be used for the treatment and/or prevention of obesity, fatty liver and hypertension. Further, the invention relates to a nutritional composition comprising such fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal. The invention also relates to a method for improving the quality of product such as meat, milk and eggs.
    Type: Grant
    Filed: January 27, 2001
    Date of Patent: August 27, 2002
    Assignee: Thia Medica AS
    Inventor: Rolf Berge
  • Method for treating organic acid-treated phosphatides
    Patent number: 6441209
    Abstract: This invention relates to improved methods for treating organic acid-treated phosphatides. More particularly, this invention relates to improved methods comprising providing a phosphatide-containing material obtained from organic acid refining of vegetable oil, adjusting the pH of the phosphatide-containing material to form a neutralized phosphatide, and drying the neutralized phosphatide for a time sufficient to produce a dried phosphatide containing hydrolyzed lecithin.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: August 27, 2002
    Assignee: IP Holdings, L.L.C.
    Inventors: Dick Copeland, W. Maurice Belcher
  • Preparation of microbial polyunsaturated fatty acid containing oil from pasteurized biomass
    Patent number: 6441208
    Abstract: The present invention discloses a microbial polyunsaturated fatty acid(PUFA)-containing oil with a high triglyceride content and a high oxidative stability. In addition, a method is described for the recovery of such oil from a microbial biomass derived from a pasteurized fermentation broth, wherein the microbial biomass is subjected to extrusion to form granular particles, dried and the oil then extracted from the dried granules using an appropriate solvent.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: August 27, 2002
    Assignee: DSM N.V.
    Inventors: Hendrik Louis Bijl, Johannes Hendrik Wolf, Albert Schaap, Johannes Martinus Jacobus Visser