Patents Examined by D. D. Carr
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Patent number: 5399731Abstract: The invention relates to a process for the production of the fatty acid esters of lower monovalent alcohols by transesterification of fatty acid glycerides in the presence of basic catalysts. The process according to the invention is characterized in that the transesterification is carried out in the presence of 0.025 to 0.045 mols of an alkali or alkaline earth metal compound, preferably sodium hydroxide, potassium hydroxide, sodium or potassium alcoholate, based on 100 g of fatty acid glyceride and the subsequent purification of the fatty acid esters is effected by the addition of 0.3 to 3.0 percent of water by hydration and separation of the catalyst residues and other impurities.Type: GrantFiled: March 10, 1992Date of Patent: March 21, 1995Assignee: Vogel & Noot Industrieanlagenbau Gesellschaft m.b.H.Inventor: Theodor Wimmer
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Patent number: 5391782Abstract: In the production of highly concentrated pastes of .alpha.-sulfofatty acid alkyl ester alkali metal salts by reaction of fatty acid alkyl esters with gaseous SO.sub.3, subsequent after-reaction in liquid phase and neutralization with aqueous alkali hydroxide solutions, the sulfonation product and aqueous alkali metal hydroxide solution are introduced during neutralization into an aqueous phase initially containing 0 to 55% by weight washing-active substance at a pH value in the range from 2 to 8 and washing-active substance contents of 60 to 70% by weight are established.Type: GrantFiled: November 23, 1992Date of Patent: February 21, 1995Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Dietmar Colignon, Erich Dorra, Guenter Panthel, Wolfgang Schmidt, Norbert Wrede
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Patent number: 5391786Abstract: Light-colored ester sulfonates can be obtained by sulfonation of fatty acid lower alkyl esters and subsequent working up providing fatty acid esters having a low content of oxo compounds and unsaturated compounds are used in the sulfonation stage.Type: GrantFiled: October 14, 1992Date of Patent: February 21, 1995Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Bernd Fabry, Ulrich Kratzel, Wolfgang Schmidt, Guenter Kreienfeld
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Patent number: 5386045Abstract: A process for producing alkoxylated mono-, di-, and tri-esters in which a starting material ester and an alkylene oxide are reacted in the presence of selected calcium based catalysts.Type: GrantFiled: August 5, 1992Date of Patent: January 31, 1995Assignee: Vista Chemical CompanyInventors: Upali Weerasooriya, Donald T. Robertson, John Lin, Bruce E. Leach, Cynthia L. Aeschbacher, Tonyette S. Sandoval
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Patent number: 5382677Abstract: In the production of highly concentrated pastes of .alpha.-sulfofatty acid alkyl ester alkali metal salts by reaction of fatty acid alkyl esters with gaseous SO.sub.3, subsequent after-reaction in liquid phase and neutralization with aqueous alkali hydroxide solutions, the sulfonation product and aqueous alkali metal hydroxide solution are introduced during neutralization into an aqueous phase initially containing at least 55% by weight washing-active substance at a pH value in the range from 2 to 8 and washing-active substance contents of 60 to 70% by weight are established.Type: GrantFiled: November 24, 1992Date of Patent: January 17, 1995Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Dietmar Colignon, Erich Dorra, Guenter Panthel, Wolfgang Schmidt, Norbert Wrede
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Patent number: 5352673Abstract: The present invention provides prodrugs that serve as useful therapeutics for various disease states and conditions mediated by underlying specific hydrolytic enzyme activity. The prodrugs hereof (additionally) impart a physiologically bioactive component thus providing prodrug compounds that are capable of imparting dual effect systemically.Type: GrantFiled: June 10, 1991Date of Patent: October 4, 1994Inventor: Edward A. Dennis
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Patent number: 5352811Abstract: Preparaing alkanoyloxytetradecanoic acids by asymmetric allylboration, acylation, and oxidation of homoallylic alcohols in the operational presence of a phase transfer catalyst.Type: GrantFiled: July 22, 1992Date of Patent: October 4, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventor: Prabhakar K. Jadhav
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Patent number: 5312932Abstract: Process for the continuous production of partial glyceride sulfates comprising the steps ofA. continuously reacting partial glycerides with gaseous sulfur trioxide,B. subjecting the resulting acidic sulfonation products to ageing, andC. neutralizilng the aged acidic sulfonation products with an aqueous base in the presence of a buffer.Type: GrantFiled: August 3, 1993Date of Patent: May 17, 1994Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Ansgar Behler, Uwe Ploog, Bernd Fabry, Frank Clasen
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Patent number: 5298638Abstract: A process for removal of sulfur-containing compounds from fatty materials is disclosed, in which the fatty material is contacted with a silica hydrogel. Use of this adsorptive process prior to hydrogenation improves oil quality and decreases hydrogenation times.Type: GrantFiled: May 5, 1992Date of Patent: March 29, 1994Assignee: W. R. Grace & Co.-Conn.Inventors: Gabriella J. Toeneboehn, William A. Welsh
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Patent number: 5296597Abstract: The present invention is directed towards a series of secondary and tertiary amide derivatives of Partricin A & Partricin B attached at the C-18 carboxyl group. The compounds can be used in the treatment of hypercholesteremia and hyperlipemia conditions, of steroidal imbalances, and as antifungal and antiprotozoan agents.Type: GrantFiled: November 14, 1990Date of Patent: March 22, 1994Assignee: SPA Societa' Prodotti Antibiotici S.P.A.Inventors: Tiberio Bruzzese, Franco Ottoni, Giuseppe Ghielmetti
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Patent number: 5296621Abstract: The invention provides a process for the isolation of hydroxy fatty acid derivatives from Convolvulaceae plants like Ipomoea batatas and Ipomoea orizabensis by extracting parts of said plants like leaves, stems, seeds and in particular roots and tubers thereof, with an organic solvent, removing the solvent for at least the main part from the extract, dispersing the obtained residue into water, subjecting the obtained dispersion to a single hydrolysis step and recovering the released hydroxy fatty acids, like 11-hydroxy palmitic acid and 3,11-hydroxy myristic acid from the aqueous dispersion by means of an extraction agent. The obtained hydroxy fatty acid may be used in the synthesis of specific organic compounds like lactones or in the preparation of products having purgative properties and of thickeners for lubricating greases respectively.Type: GrantFiled: December 14, 1992Date of Patent: March 22, 1994Assignee: Unilever Patent Holdings B.V.Inventors: Robert Roos, Jan Bakker
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Patent number: 5288896Abstract: The present invention is a novel compound which is a 3,5-di-t-butyl-4-hydroxyphenylmethylhydroxylamine or derivative thereof and a pharmaceutically acceptable acid addition or base salt thereof, pharmaceutical composition and methods of use therefor. The invention compounds are now found to have activity as inhibitors of one or both of cyclooxygenase and 5-lipoxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.Type: GrantFiled: January 15, 1992Date of Patent: February 22, 1994Assignee: Warner-Lambert CompanyInventors: Thomas Capiris, David T. Connor, Jagadish C. Sircar
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Patent number: 5278326Abstract: Novel pharmaceutically useful compounds which lower blood cholesterol levels and are beta-ketoamides, oximes, amines, and hydroxyl derivatives thereof.Type: GrantFiled: March 18, 1991Date of Patent: January 11, 1994Assignee: Warner-Lambert CompanyInventors: Corinne E. Augelli-Szafran, Bruce D. Roth
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Patent number: 5264597Abstract: The invention relates to a process for refining glyceride oil comprising the steps of contacting the oil with amorphous silica, wherein said silica is selected from the group of precipitated amorphous silicas having a surface area of at least 400 m.sup.2 /g in pores with a diameter from at least 2 nm. Preferably said precipitated amorphous silicas have a pore volume in the range of about 1.3 to 2.5 ml/g, in pores having a pore diameter in the range of 3.6 to 1000 nm.Type: GrantFiled: June 15, 1992Date of Patent: November 23, 1993Assignee: Van den Bergh Foods, Co., Division of Conopco, Inc.Inventors: Josef P. Van Dalen, Jannes G. Lammers, Derek Aldcroft
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Patent number: 5248799Abstract: The invention relates to a method for refining glyceride oil, comprising the steps of:i) acidifying the oil with an acid;ii) partially neutralizing the acidified oil with alkali;iii) contacting the partially neutralized oil with an amorphous silica; andiv) removing solids from the glyceride oil.Preferably, water is removed from the mixture comprising the glyceride oil and the amorphous silica before any solids are removed.Type: GrantFiled: September 25, 1991Date of Patent: September 28, 1993Assignee: Unilever Patent Holdings B.V.Inventor: Luis O. F. Schmutzler
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Patent number: 5248798Abstract: The invention refers to a novel method for the preparation of 8-hydroxyoctanoic acid by reaction of 6-chlorohexanol with a dialkyl malonate ester, thermal decarboxylation of the malonic acid derivative and isolation of the 8-hydroxyoctanoic acid as the free acid or as an alkali metal salt.Type: GrantFiled: July 22, 1991Date of Patent: September 28, 1993Assignee: Natterman, A. & Cie. GmbHInventors: Bernd R. Gunther, Rainer Losch, Hans Lautenschlager, Klaus Steiner
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Patent number: 5237080Abstract: Alkoxylation products of at least one of ethylene oxide, propylene oxide, and butylene oxide and at least one C.sub.10-22 carboxylic acid mono-, di-, or tri-glyceride which is of natural origin or is obtained from natural origin wherein in the 9, 10 position, the 13, 14 position, or in both positions of the carboxylic acid the following unit is present ##STR1## in which R is a hydrogen atom, an OH group or an OR.sup.1 group,R.sup.1 is a C.sub.9-18 alkyl group, a C.sub.9-18 alkenyl group or a ##STR2## group, and R.sup.2 is a hydrogen atom, a C.sub.1-21 alkyl group or a C.sub.2-21 alkenyl group.The invention also relates to compositions containing the above alkoxylation products in place of alkoxylated castor oil normally present in the compositions, and to a process for preparing the alkoxylation products.Type: GrantFiled: January 14, 1992Date of Patent: August 17, 1993Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Peter Daute, Gerhard Stoll
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Patent number: 5227506Abstract: The invention relates to acyloxymethyl esters of bisphosphonic acids, halo-bisphosphonic acids and hydroxy-bisphosphonic acids which exhibit oral bioavailability and are useful in the treatment of disturbances involving calcium or phosphate metabolism, in particular, the treatment and prevention of diseases involving bone resorption, especially osteoporosis, Paget's disease, malignant hypercalcemia, and metastatic bone disease.Type: GrantFiled: July 12, 1990Date of Patent: July 13, 1993Assignee: Merck & Co., Inc.Inventors: Walfred S. Saari, Paul S. Anderson
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Patent number: 5225581Abstract: An electrocatalytic process for hydrogenating an unsaturated fatty acid, triglyceride, or mixtures thereof as an oil or fat is described. Current is passed through a cathode and hydrogen is generated in situ on the high surface area, low hydrogen overvoltage catalytic material used as the cathode in a reactor containing a liquid reaction medium (electrolyte) comprised of oil and/or fat, water and/or an organic solvent (e.g. t-butanol), and a supporting electrolyte salt. Typical catalytic cathodes comprise a granular or powdered Raney metal or an alloy thereof, platinum black, ruthenium black, or finely divided carbon powder containing platinum, palladium, or ruthenium. Typical supporting electrolyte salts include sodium p-toluenesulfonate, tetraethylammonium p-toluenesulfonate, and sodium or potassium phosphate monobasic.A novel partially hydrogenated oil or fat product is obtained when the above process is carred out at temperatures less than 75.degree. C.Type: GrantFiled: June 14, 1990Date of Patent: July 6, 1993Assignee: Tulane Educational FundInventor: Peter N. Pintauro
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Patent number: 5223621Abstract: Transvinylation process between vinyl acetate or vinyl propionate and a carboxylic acid of general formula (I),RCOOH (I)in which R represents a substituted or non-substituted alkyl, cycloalkyl, aralkyl or aromatic radical, in the presence of a palladium catalyst, in which the catalyst is obtained in situ, by reacting, in the reaction medium, a derivative of palladium chosen from the group constituted by palladium II acetate, nitrate or hydroxide and palladium deposited on charcoal, with a tertiary amine chosen from the group constituted by 2,2'-bipyridyl, orthophenanthroline or tetramethylethylenediamine, that the quantity of palladium used, expressed in gram-atom of palladium II per 100 moles of carboxylic acid of general formula (I) is between 0.005 and 1 and that the quantity of amine is greater than 1 and less than 10 moles per gram-atom of palladium II used and use for the preparation of certain products.Type: GrantFiled: January 6, 1992Date of Patent: June 29, 1993Assignee: Societe Francaise HoechstInventors: Jean-Claude Vallejos, Yani Christidis