Patents Examined by D. G. Rivers
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Patent number: 4816458Abstract: Substituted 2,3-dihydro-6-substituted-pyrimido[2,1-f]purine-4,8(1H,9H)-diones, their tautomers and salts, are disclosed for use as antihyperproliferative skin disease agents.Methods for their preparation and use are described.Type: GrantFiled: December 19, 1986Date of Patent: March 28, 1989Assignee: Schering CorporationInventors: Daniel M. Solomon, James J. Kaminski
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Patent number: 4749706Abstract: Stereoisomerically pure forms of normorphine analogs which have superior analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl-substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent.Type: GrantFiled: March 24, 1986Date of Patent: June 7, 1988Assignee: SRI InternationalInventors: John A. Lawson, Joseph I. DeGraw, Gilda H. Loew
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Patent number: 4739053Abstract: Novel 2H-v-triazolo[4,5-d]pyrimidines of the general formula ##STR1## where R.sup.1 and R.sup.2 independently of one another are each alkyl, unsubstituted or substituted phenyl or phenalkyl, or ##STR2## is a saturated 5-membered or 6-membered heterocyclic ring, X is alkyl, halogen or phenyl n is 0, 1 or 2, and A is ##STR3## hydrogen, halogen, cyano, thiocyano, alkoxy, alkoxyalkoxy, unsubstituted or substituted phenoxy, phenylalkoxy, alkylthio, phenylthio, --S--(CH.sub.2).sub.m --COO-alkyl, where m is from 1 to 4, alkylcarbonyl, benzoyl, carboxyl, carboalkoxy, alkylsulfonyl, phenylsulfonyl, an N-imidazole, benzimidazole, 1,2,3-triazole, benzotriazole, 2-mercaptobenzothiazole, 2-mercaptobenzimidazole, 2-mercaptothiazole or 2-mercapto-1,3,4-thiadiazole radical, or a radical of the formula ##STR4## where R.sup.4 is H or C.sub.1 -C.sub.4 -alkyl, p is from 2 to 5 and R.sup.5 and R.sup.6 are each C.sub.1 -C.sub.Type: GrantFiled: March 6, 1986Date of Patent: April 19, 1988Assignee: BASF AktiengesellschaftInventors: Bernhard Albert, Gerhard Hoffmann, Peter Neumann
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Patent number: 4614743Abstract: The compound 4,7-dimethyl-2-(4-pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidin-5(4H)-one and the pharmaceutically acceptable salts thereof are analgesic and anti-inflammatory agents. Methods for preparing and using the compound and salts are described.Type: GrantFiled: December 27, 1983Date of Patent: September 30, 1986Assignee: Schering CorporationInventors: Richard E. Chipkin, Joseph T. Witkowski
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Patent number: 4610987Abstract: Imidazoquinazolin-2-one compounds having platelet aggregation inhibitory activity is disclosed. These compounds have high water-solubility and reduced influences on the circulatory system and are useful for treatment and prophylaxis of intravascular thromboembolism and temporary ischemia as well as prevention of thrombus upon use of prosthetic apparatus.Type: GrantFiled: July 16, 1984Date of Patent: September 9, 1986Assignee: Daiichi Seiyaku Co., Ltd.Inventor: Fumiyoshi Ishikawa
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Patent number: 4579847Abstract: Amino derivatives of benzylidene-Pyrrolo[2,1-b] Quinazolines are provided, together with pharmaceutical compositions containing them. The compounds and the compositions have pharmaceutical utility and are particularly useful as anti allergy agents.Type: GrantFiled: December 14, 1984Date of Patent: April 1, 1986Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Gianfederico Doria, Carlo Passarotti, Maria L. Corno
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Patent number: 4555579Abstract: Angiotensin converted enzyme inhibitor activity if exhibited by compounds having the formula ##STR1## and salts thereof wherein R.sub.1 is hydrogen, aryl, or heteroaryl; R.sub.2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino;R.sub.3 is hydrogen, alkyl, or aminoalkyl;R.sub.4 and R.sub.5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R.sub.4 and R.sub.5 taken together are oxo, ethylenedithio or propylenedithio;one of R.sub.6 and R.sub.7 is ##STR2## and the other is hydrogen, alkyl or arylalkyl; R.sub.8 is hydrogen, alkl or aryl;R.sub.9 is hydrogen or alkyl;n is 0 or an integer of 1 to 8;m is 0 or 1; andA is --(CH.sub.2).sub.p --wherein p is 0 or 1, --NH--, or --O--.Type: GrantFiled: March 24, 1983Date of Patent: November 26, 1985Assignee: E. R. Squibb & Sons, Inc.Inventor: George C. Rovnyak
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Patent number: 4355185Abstract: 2-Mercaptoalkylsulphides and 2-mercaptoalkylethers are obtained by the hydrazinolysis of 3-thiaalkylisothiuronium salts and 3-oxaalkylisothiuronium salts.Type: GrantFiled: August 25, 1980Date of Patent: October 19, 1982Assignee: Agfa-Gevaert AktiengesellschaftInventors: Peter Bergthaller, Peter Wenzl
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Patent number: 4324920Abstract: Disclosed is a process for the preparation of otho-(hydrocarbylthio)-phenols, having at least one hydrogen on a carbon atom ortho to a hydroxy group, with hydrocarbyl disulfides in the presence of catalytic amounts of aluminum phenoxide.Type: GrantFiled: July 28, 1980Date of Patent: April 13, 1982Assignee: Ethyl CorporationInventors: Bonnie G. McKinnie, Paul F. Ranken
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Patent number: 4323572Abstract: Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.Type: GrantFiled: February 6, 1981Date of Patent: April 6, 1982Assignee: American Home Products CorporationInventors: Christopher A. Demerson, Leslie G. Humber, Jean-Marie Ferland
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Patent number: 4204868Abstract: A photolithographic plate, method for preparation thereof, and salt compound useful in the preparation, the method involving the treatment of a metallic silver image on a substrate with a homogeneously stable acidic aqueous salt solution comprising a ferricyanide anion for oxidizing the metallic silver and an organic cation capable of forming a water-insoluble, inherently oleophilic complex with oxidized silver, the cation being derived from a protonatable nitrogen-substituted hydrocarbon compound containing a formal imine group therein which is in resonant association with adjacent groups within the hydrocarbon compound.Type: GrantFiled: November 7, 1977Date of Patent: May 27, 1980Assignee: Minnesota Mining and Manufacturing CompanyInventor: David R. Boston
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Patent number: 4144393Abstract: 3-Acetoxymethyl cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure ##STR1## where R is thienyl, furyl or phenyl; R.sup.a is C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl or phenyl, and R.sup.b is hydrogen, carboxy, C.sub.2 -C.sub.5 carbalkoxy or any of the groups designated for R.sup.a, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce .beta.-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly high in vitro activity against strains of Escherichia coli. Haemophilus influenzae and Proteus organisms; and also shown unusually high activity against Pseudomonas organisms.Type: GrantFiled: March 18, 1976Date of Patent: March 13, 1979Assignee: Glaxo Laboratories LimitedInventors: Janice Bradshaw, Martin C. Cook, Gordon I. Gregory
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Patent number: 4144392Abstract: Cephalosporin antibiotics having the formula: ##STR1## (where R is thienyl, furyl or phenyl; R.sup.a is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl or phenyl, and R.sup.b is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, carboxy or C.sub.2-5 alkoxycarbonyl, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; R.sup.13 is C.sub.1 -C.sub.6 alkyl, C.sub.3-7 cycloalkyl, phenylalkyl, phenyl or naphthyl, thiadiazolyl, diazolyl, triazolyl, tetrazolyl, thiazolyl, thiatriazolyl, oxazolyl, oxadiazolyl, pyridyl, pyrimidyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, triazolopyridyl or purinyl, and n is 0, 1 or 2 and their physiologically acceptable derivatives exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce .beta.-lactamases.Type: GrantFiled: June 15, 1976Date of Patent: March 13, 1979Assignee: Glaxo Laboratories LimitedInventors: Janice Bradshaw, Martin C. Cook, Gordon I. Gregory
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Patent number: 4104400Abstract: Imidazo[2,1-b]thiazole derivatives are provided having the structure ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or carboxy, and R.sup.2 is hydrogen, lower alkyl or phenyl.In addition, a method is provided for treating or inhibiting helminthiasis by parenterally, perorally or topically administering a pharmaceutical composition containing such imidazo[2,1-b]thiazole derivatives. Pharmaceutical compositions for use in the above method are also provided.Type: GrantFiled: July 8, 1977Date of Patent: August 1, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frank Lee Weisenborn, Rudiger D. Haugwitz, Frederic Peter Hauck
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Patent number: 4064247Abstract: Thiazolo[3,4-b]isoquinoline derivatives of the general formula: ##STR1## wherein A represents 3-pyridyl, 4-pyridyl or 5-isoquinolyl and, when A represents 3-pyridyl, X.sub.1 represents hydrogen, halogen, dimethylamino or cyano, X.sub.2 represents hydrogen or fluorine and X.sub.3 represents hydrogen or nitro, at least two of X.sub.1, X.sub.2 and X.sub.3 representing hydrogen, or X.sub.1 X.sub.2 together represent methylenedioxy and X.sub.3 represents hydrogen, and when A represents 4-pyridyl or 5-isoquinolyl, X.sub.1, X.sub.2 and X.sub.3 each represent hydrogen, and non-toxic pharmaceutically acceptable acid addition salts thereof, possess useful pharmacodynamic properties, in particular analgesic and antipyretic activity. This invention relates to new therapeutically useful thiazolo[3,4-b]isoquinoline derivatives, to processes for their preparation and to pharmaceutical compositions containing them.Type: GrantFiled: August 5, 1976Date of Patent: December 20, 1977Assignee: Rhone-Poulenc IndustriesInventors: Daniel Farge, Alain Jossin, Gerard Ponsinet, Daniel Reisdorf
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Patent number: 4028372Abstract: This invention relates to novel compounds of the isoindoline series. More particularly, the present invention relates to certain novel 1-imino-3-(2-oxo-4-thioxo-5-thiazolidinylidene)isoindolines, 1-imino-3-(2,4-dithioxo-5-thiazolidinylidene)isoindolines, water-insoluble pigments prepared therefrom, and to methods for their preparation.Type: GrantFiled: November 19, 1975Date of Patent: June 7, 1977Assignee: Sterling Drug Inc.Inventors: Nathan N. Crounse, Nicholas A. Ambrosiano
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Patent number: 4025626Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and an ureidoalkyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.Type: GrantFiled: December 9, 1975Date of Patent: May 24, 1977Assignee: SmithKline CorporationInventor: David A. Berges
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Patent number: 4025525Abstract: Allantoin compound with a metal salt of 2-pyrrolidone-5-carboxylic acid has a solubility which is from 2.5 to 4 times greater than that of pure allantoin. The compound has almost the same pharmacological effect as allantoin itself and is harmless, and therefore it can be used in medicines, cosmetics, creams, ointments, etc.Type: GrantFiled: September 16, 1975Date of Patent: May 24, 1977Assignee: Kawaken Fine Chemicals Co., Ltd.Inventors: Hirohide Takayama, Ippei Yoshimura
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Patent number: 4025520Abstract: A process for the dehydrohalogenation of a 7-halo- or a 1,7-dihalodihydrocodeinone dialkyl ketal of the general formula (I): ##STR1## in which R represents an alkyl group containing from 1 to 6 carbon atoms, X represents hydrogen or chlorine or bromine and Y represents chlorine or bromine which comprises subjecting the ketal to the action of a base in the presence of a polar aprotic solvent. The process has utility in facilitating the production of codeine.Type: GrantFiled: March 28, 1975Date of Patent: May 24, 1977Assignee: Macfarlan Smith LimitedInventors: Edward Leon Grew, Nigel David Vaughan Wilson
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Patent number: 4022897Abstract: Compounds of the formula ##STR1## wherein R may be hydrogen or a straight or branched chain alkyl radical of from 1 to 10 carbon atoms, aryl of from 6 to 10 carbon atoms, or aralkyl of from 7 to 10 carbon atoms;Y may be hydrogen, alkyl of from 1 to 4 carbons, CF.sub.3, F, Cl, or Br; andZ may be hydrogen or as defined hereinafter.These compounds are useful as central nervous system stimulants or more specifically in enhancing performance or as mood elevators.Type: GrantFiled: April 17, 1975Date of Patent: May 10, 1977Assignee: E. R. Squibb & Sons, Inc.Inventors: Harry Louis Yale, John T. Sheehan