Patents Examined by D M Mach
  • Asymmetric conjugate addition reaction using a chiral additive
    Patent number: 5998625
    Abstract: This invention relates to a process for the preparation of a key intermediate using an chiral additive to effect an asymmetric conjugate addition.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: December 7, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Richard D. Tillyer, David M. Tschaen, Feng Xu
  • 4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
    Patent number: 5972961
    Abstract: The present invention provides novel 4-aryl-3-aminoquinolin-2-one derivatives having the general formula ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K.sup.+ channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: October 26, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Piyasena Hewawasam, John E. Starrett, Jr., Stephen G. Swartz
  • Substituted hydroisoquinoline derivatives and their use as pharmaceuticals
    Patent number: 5968949
    Abstract: According to the present invention, there is provided a compound, or a solvate or salt thereof of formula (I): ##STR1## Substituted hydroisoquinoline derivatives are potent and selective delta opioid agonists and antagonists and are of potential therapeutic utility as inter alia analgesics.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham S.p.A.
    Inventors: Giulio Dondio, Silvano Ronzoni
  • Substituted 6- and 7-aminotetrahydroisoquinolinecarboxylic acids
    Patent number: 5962471
    Abstract: Compounds of the formula I ##STR1## are suitable for the preparation of pharmaceuticals for the prophylaxis and therapy of disorders involving increased activity of matrix-degrading metalloproteinases.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Manfred Schudok