Patents Examined by D M Seaman
  • Hepatitis C virus inhibitors
    Patent number: 9227940
    Abstract: Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R?, B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: January 5, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alan Xiangdong Wang, Li-Qiang Sun, Sing-Yuen Sit, Ny Sin, Paul Michael Scola, Yan Chen
  • Secondary alcohol quinolinyl modulators of ROR?t
    Patent number: 9221804
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: December 29, 2015
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Kristi A. Leonard, Kent Barbay, James P. Edwards, Kevin D. Kreutter, David A. Kummer, Umar Maharoof, Rachel Nishimura, Maud Urbanski, Hariharan Venkatesan, Aihua Wang, Ronald L. Wolin, Craig R. Woods, Anne Fourie, Xiaohua Xue, Maxwell D. Cummings
  • 2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition
    Patent number: 9212144
    Abstract: Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: December 15, 2015
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Maris A. Cinelli
  • Modulators of methyl modifying enzymes, compositions and uses thereof
    Patent number: 9206128
    Abstract: Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: December 8, 2015
    Assignee: Constellation Pharmaceuticals, Inc.
    Inventors: Brian K. Albrecht, James Edmund Audia, Andrew S. Cook, Alexandre Gagnon, Jean-Christophe Harmange, Christopher G. Nasveschuk
  • Compound, optical resolution method, and derivative of an optical isomer of an amino acid
    Patent number: 9193684
    Abstract: Disclosed is a compound represented by chemical formula (1): or chemical formula (2):
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 24, 2015
    Assignees: SHISEIDO COMPANY, LTD., KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Masashi Mita, Kenji Hamase, Tsubasa Oyama
  • Reactivators of organophosphorous inhibited acetylcholinesterase
    Patent number: 9162983
    Abstract: The present invention relates to organophosphate-inhibited acetylcholinesterase (AChE) reactivators with central nervous system (CNS) bioavailability and their associated methods of preparation including their use for treatment of exposure to AChE inhibitors such as an organophosphate (OP) insecticides and nerve agents.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 20, 2015
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: William E. Bauta, William R. Cantrell, Jr., Michael W. Tidwell
  • Methods of using a methylxanthine compound
    Patent number: 9155741
    Abstract: The invention relates to compositions and methods for treating various diseases or medical conditions by administering a methylxanthine compound. Specifically, the invention relates to compositions and methods for treating cytochrome oxidase (CcOX) mediated diseases or medical conditions by administering compositions comprising a methyl xanthine compound.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: October 13, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Clifford S. Deutschman, Richard J. Levy
  • Process for the preparation of Roflumilast
    Patent number: 9145365
    Abstract: The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 29, 2015
    Assignee: Mylan Laboratories Ltd.
    Inventors: Priyesh Vijaykar, Dattatrey Kokane, Sushant Gharat, Dhananjay Shinde, Manojkumar Bindu, Vinayak Gore
  • Benzimidazole compound crystal
    Patent number: 9145389
    Abstract: A novel crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole or a salt thereof of the present invention is useful for an excellent antiulcer agent.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: September 29, 2015
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Akira Fujishima, Isao Aoki
  • Maleate salts of (E)-N-{4-[3-Chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
    Patent number: 9139558
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: September 22, 2015
    Assignee: Wyeth LLC
    Inventors: Quinhong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
    Patent number: 9139530
    Abstract: The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 22, 2015
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawiec, Yuchuan Gong, Yushi Feng, Martin Trudeau
  • MIF inhibitors and their uses
    Patent number: 9133164
    Abstract: The invention relates to MIF inhibitors; compositions comprising an effective amount of a MIF inhibitor; and methods for treating or preventing diseases associated with MIF.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: September 15, 2015
    Assignee: INNOV88 LLC
    Inventors: Anderson Gaweco, John Walker, Joseph B. Monahan, Jerry W. Cubbage, Jeffery Carroll
  • Antibacterial quinoline derivatives
    Patent number: 9133167
    Abstract: The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: September 15, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jerome Emile Georges Guillemont, Magali Madeleine Simone Motte, David Francis Alain Lancois, Wendy Mia Albert Balemans
  • Process for producing 4-carbonyloxyquinoline derivatives
    Patent number: 9126934
    Abstract: An objective of the present invention is to provide a process for producing 4-carbonyl oxyquinoline derivatives useful as agricultural and horticultural pesticides and fungicides. The objective can be attained by a process for producing 4-carbonyl oxyquinoline derivatives represented by general formula (1), the process including reacting a quinolone derivative with a halogenated compound or an acid anhydride in the presence of a phase transfer catalyst and a base.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: September 8, 2015
    Assignees: NIPPON KAYAKU CO., LTD., MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Shizuo Shimano, Akinori Morikawa, Kenichi Yamamoto, Hiroki Hotta, Kazumi Yamamoto, Nozomu Nakanishi, Nobuto Minowa
  • Boron-containing diacylhydrazines
    Patent number: 9127024
    Abstract: The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 8, 2015
    Assignee: Intrexon Corporation
    Inventors: Sheela K. Chellappan, Robert E. Hormann, Inna Shulman
  • Quinoline derivatives and MELK inhibitors containing the same
    Patent number: 9120749
    Abstract: The present invention directs a compound represented by formula (I).
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: September 1, 2015
    Assignee: ONCOTHERAPY SCIENCE, INC.
    Inventors: Yo Matsuo, Shoji Hisada, Yusuke Nakamura, Feryan Ahmed, Raymond Huntley, Joel R. Walker, Helene Decornez
  • Process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one via a novel intermediate
    Patent number: 9108918
    Abstract: The present invention is concerned with a process for preparing 5-(2{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: August 18, 2015
    Assignee: ALMIRALL, S.A.
    Inventors: Iolanda Marchueta Hereu, Enrique Moyes Valls
  • Cysteinyl leukotriene antagonists
    Patent number: 9102665
    Abstract: The present invention relates to novel cysteinyl leukotriene (specifically LTD4) antagonists, mainly to quinolin, quinoxaline or benz[c]thiazole derivatives represented by the general formula (I), or the pharmaceutically acceptable salt thereof, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders related to cysteinyl leukotriene, in mammals, more specially in humans.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: August 11, 2015
    Assignee: Sun Pharma Advanced Research Company Ltd.
    Inventors: Rajendrasinh Rathod, Tushar Bhatt, Kiritkumar Joshi, Binaka Dole, Kadiyala V. S. N. Murty, Rajamannar Thennati
  • Substituted naphthyridine and quinoline compounds as MAO inhibitors
    Patent number: 9102674
    Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: August 11, 2015
    Assignee: Dart NeuroScience (Cayman) Ltd.
    Inventors: Jillian Basinger, Graeme Freestone, Varsha Gupta, Alan Kaplan, Chi-Ching Mak, Benjamin Pratt, Vincent Santora, Dipanjan Sengupta, Lino Valdez
  • Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-y1)-acetic acid esters
    Patent number: 9102658
    Abstract: The invention relates to a process for the preparation of a compound of formula (I) wherein R1 is C1C6 alkyl or benzyl by reacting a compound of formula (II) wherein R1 is as defined for formula (I) with 2-quinoline carboxaldehyde. The process is suitable for use on an industrial scale.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: August 11, 2015
    Assignee: Atopix Therapeutics Limited
    Inventors: Jacques Tonnel, Tony Pintus, Alain Burgos