Patents Examined by D. Margaret Seaman
  • Pyrazolo[1,5-a]pyridine-3-carboxylic acids as EphB and VEGFR2 kinase inhibitors
    Patent number: 7795273
    Abstract: The invention relates to novel pyrazolo[1,5-a]pyridine-3-carboxylic acid compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: September 14, 2010
    Assignee: Novartis AG
    Inventors: Patricia Imbach, Philipp Holzer, Pascal Furet
  • Ether derivatives
    Patent number: 7795437
    Abstract: The present invention relates to ether derivatives according to general formula I, and to their pharmaceutically-acceptable salts, which may be used in treating or preventing cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, or psychoses comprising paranoia and delusions.
    Type: Grant
    Filed: October 22, 2007
    Date of Patent: September 14, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Luca Claudio Gobbi, Georg Jaeschke, Olivier Roche, Rosa Maria Rodriguez Sarmiento, Lucinda Steward
  • Graftable hindered amine light stabilizers
    Patent number: 7790897
    Abstract: The invention describes novel compound of the formula I, wherein the general symbols are as defined in claim 1, as stabilizers for protecting organic materials, in particular synthetic polymers, against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: September 7, 2010
    Assignee: Ciba Specialty Chemicals Corp.
    Inventors: Hans-Rudolf Meier, Gerrit Knobloch
  • Modified carbocyanine dyes and their conjugates
    Patent number: 7790893
    Abstract: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: September 7, 2010
    Assignee: Life Technologies Corporation
    Inventors: Wai-Yee Leung, Ching-Ying Cheung, Stephen Yue
  • Mycobacterial inhibitors
    Patent number: 7790894
    Abstract: The present invention relates to novel substituted quinoline derivatives according to the general Formula (I) and pharmaceutically acceptable addition salts thereof, wherein the variable moieties are as defined in the specification. The invention also relates to a method of treating of mycobacterial diseases through administration of the claimed compounds and a process for preparing the claimed compounds.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: September 7, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Jérôme Emile Georges Guillemont, Elisabeth Therese Jeanne Pasquier, David Francis Alain Lancois
  • RNA-selective probes for live cell imaging of nuclear structure and function
    Patent number: 7790896
    Abstract: The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: September 7, 2010
    Assignee: New York University
    Inventors: Young-Tae Chang, Qian Li, Gustavo Rosania
  • Inhibitors of VEGF receptor and HGF receptor signaling
    Patent number: 7790729
    Abstract: The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: September 7, 2010
    Assignee: Methylgene Inc.
    Inventors: Oscar Mario Saavedra, Stephen William Claridge, Lijie Zhan, Franck Raeppel, Arkadii Vaisburg, Stephane Raeppel, Robert Deziel, Michael Mannion, Nancy Z. Zhou, Ljubomir Isakovic
  • Quinoline derivatives as potassium ion channel openers
    Patent number: 7790895
    Abstract: The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: September 7, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nareshkumar Jain, Jiayi Xu, Zhihua Sui
  • Metalloprotein inhibitors
    Patent number: 7786316
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Grant
    Filed: July 15, 2009
    Date of Patent: August 31, 2010
    Assignee: The Regents of The University of California
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same
    Patent number: 7786306
    Abstract: The present invention provides a method of resolving piperdin-yl-alkylene-alcohols, in high yield at high enantiomeric purity, for example 2-piperidin-2-yl-ethanol.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: August 31, 2010
    Assignee: Schering Corporation
    Inventors: Frank Xing Chen, Maria M. Tamarez, Ji Xie
  • Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors
    Patent number: 7781590
    Abstract: The present invention comprises peridinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Jean Jeunesse
  • Indolylmaleimide derivatives
    Patent number: 7781438
    Abstract: A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Jürgen Wagner, Maurice Van Eis, Peter Von Matt, Jean-Pierre Evenou, Walter Schuler
  • Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters
    Patent number: 7781601
    Abstract: A method for the production of 6,6,6-trihalo-3,5-dioxohexanic acid esters of formula (I): in addition to the enols thereof and <I>E</I> and <I>Z</I> isomers, wherein X independently represents fluorine, chlorine or bromine and R1 represents alkyl, cycloalkyl, aryl or aralkyl. A method for the production of enol ethers of formula (Ib): and the enols thereof (E and Z isomers) wherein X and R1 have the above-mentioned meanings.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: August 24, 2010
    Assignee: Basel
    Inventors: Paul Hanselmann, Wolfgang Wenger
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7781454
    Abstract: Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: August 24, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Neville J. Anthony, Robert Gomez
  • Composition for treating bone disorders
    Patent number: 7781418
    Abstract: Disclosed is a new composition of matter, substantially enantiomerically pure (1R,6S)-2-Azabicyclo-[4.3.0]nonane-8,8-diphosphonic acid, methods of preparing this new composition of matter, a pharmaceutical composition comprising the new composition, and administration of the composition in methods of treating bone disorders such as osteoporosis, osteolytic bone metastasis, rheumatoid arthritis and osteoarthritis.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: August 24, 2010
    Assignee: Isis Innovation Ltd.
    Inventors: Frank Hallock Ebetino, Robert Kenneth Boeckman, Jr., Xinyi Song
  • Enantiomers of 3-heteroaryl-8H-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors
    Patent number: 7781456
    Abstract: This invention relates to novel enantiomers useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: August 24, 2010
    Assignee: Neurosearch A/S
    Inventors: Dan Peters, David Tristram Brown, Börje Egestad, Sinikka Marjatta Taurio, legal representative, Eva Dam, David Spencer Jones, Brian Frøstrup, Elsebet Østergaard Nielsen, Gunnar M. Olsen, John Paul Redrobe
  • Quantitative method of determining beryllium or a compound thereof in a sample
    Patent number: 7781589
    Abstract: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: August 24, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: T. Mark McCleskey, Deborah S. Ehler, Kevin D. John, Anthony K. Burrell, Gavin E. Collis, Edel M. Minogue, Benjamin P. Warner
  • Aminopyridine-derivatives
    Patent number: 7781453
    Abstract: The compounds of Formula (I) in which R1, R2, R3 and R4 have the meanings as given in the description are novel effective iNOS inhibitors.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: August 24, 2010
    Assignee: Altana Pharma AG
    Inventor: Thomas Fuchss
  • Fluorinated cyclic compound, polymerizable fluoromonomer, fluoropolymer, resist material comprising the same, and method of forming pattern with the same
    Patent number: 7781602
    Abstract: The present invention relates to a novel fluorine-containing cyclic compound that is derived from a norbornadiene and hexafluoroacetone and has an oxacyclopentane structure. This compound may be represented by the following formula (1) or (2). Furthermore, the present invention relates to a fluorine-containing polymer compound prepared by a polymerization or copolymerization using this fluorine-containing cyclic compound or its derivative. By using such fluorine-containing polymer compound, it is possible to provide a superior resist material and a fine pattern forming process using the same.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: August 24, 2010
    Assignee: Central Glass Company, Limited
    Inventors: Haruhiko Komoriya, Shinichi Sumida, Katsunori Kawamura, Satoru Kobayashi, Satoru Miyazawa, Kazuhiko Maeda
  • Carbostyril compound
    Patent number: 7777038
    Abstract: The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.
    Type: Grant
    Filed: September 26, 2005
    Date of Patent: August 17, 2010
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Takeshi Kuroda, Takahito Yamauchi, Tomoichi Shinohara, Kunio Oshima, Chiharu Kitajima, Hitoshi Nagao, Tae Fukushima, Takahiro Tomoyasu, Hironobu Ishiyama, Kazuhide Ohta, Masaaki Takano, Takumi Sumida