Abstract: Compounds corresponding to the formula: ##STR1## wherein A represents --(CH.sub.2).sub.2 or --(C.tbd.C)--;n is equal to 0, 1 or 2;R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl;R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl;R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring.Application of these compounds in pharmacy and cosmetics.
Type:
Grant
Filed:
May 10, 1989
Date of Patent:
September 29, 1992
Assignee:
Centre International de Recherches Dermatologiques (CIRD)
Inventors:
Braham Shroot, Christopher Hensby, Jean Maignan, Gerard Lang, Michel Colin
Abstract: Imidazole derivatives and a process for the preparation thereof.The imidazole derivatives have remarkable antiulcer properties and are of the following formula: ##STR1## where X is an anion of pharmaceutically acceptable acids; a is 1, 2, 3, 4 or 5; b is 1, 2, 3, 4, 5, 6 or 7; c is 1, 2, 3 or 4; d is twice a minus c; and n is 0, 1, 2 or 3.The process for the preparation thereof is based on reacting cimetidine and a zinc compound containing the anion X.
Type:
Grant
Filed:
May 23, 1989
Date of Patent:
October 23, 1990
Assignee:
Laboratorios Vinas, S.A.
Inventors:
Amparo S. Sanfeliu, Lucia S. Tuero, Maria J. Delgado de Molina Gonzalez, Antonio B. Vinas