Patents Examined by Dale R Miller
  • Bladder instillation composition with increased storage stability and containing chondroitin sulfate (4.5 mg/ml), hyaluronic acid (16 mg/ml) and phosphate buffer (PH 6.1 to 7.9), for the treatment of cystitis
    Patent number: 11351113
    Abstract: The invention relates to a combination drug with increased storage stability containing chondroitin sulfate (4.5 mg/ml), hyaluronic acid (16 mg/ml), a phosphate buffer (pH 6.1 to 7.9) and an electrolyte (e.g., an alkali salt, e.g., sodium chloride) for the treatment inflammations of the urogenital tract, in particular of the bladder, in particular for the treating cystitis, and to an instillation kit containing said drug.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: June 7, 2022
    Assignee: FARCO-PHARMA GMBH
    Inventor: Andreas Meier
  • Composite vitamin composition promoting gastrointestinal system motility
    Patent number: 11351171
    Abstract: Disclosed are composite compositions of B vitamins and C vitamins and the use of same in the preparation of a drug or health food for treating and/or preventing gastrointestinal conditions diseases related to deficiency of the gastrointestinal system motility. The composition comprises a vitamin B composition or an analogue or a derivative thereof and a vitamin C or an analogue or a derivative thereof.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: June 7, 2022
    Assignee: Zensun (Shanghai) Science & Technology, Co., Ltd.
    Inventor: Mingdong Zhou
  • Tobramycin compound conjugates and derivative compositions
    Patent number: 11344566
    Abstract: Disclosed herein are compositions comprising tobramycin or a tobramycin derivative that exhibit improvements in permeation of corneal cells, retention in corneal cells, or both. Such compositions can comprise tobramycin or tobramycin derivative(s) complexed to an agent which facilitates improved permeation of corneal cells, retention in corneal cells, or both. The invention also relates to a process of preparing such compositions.
    Type: Grant
    Filed: May 22, 2021
    Date of Patent: May 31, 2022
    Assignee: Somerset Therapeutics, LLC
    Inventors: Mandar V Shah, Veerappan Subramanian, Ilango Subramanian
  • Phytochemical-antibiotic combination for the treatment of a bacterial infection
    Patent number: 11331330
    Abstract: The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of tulathromycin and gallic acid for the treatment of a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection or a disease, disorder or condition arising from a Mannheimia haemolytica and/or Pasteurella multocida bacterial infection.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: May 17, 2022
    Assignee: University of Saskatchewan
    Inventors: Meena Kishor Sakharkar, Jian Yang
  • 2'-fucosyllactose for the prevention and treatment of coronavirus-induced inflammation
    Patent number: 11324766
    Abstract: The invention provides compositions and methods for utilizing oligosaccharides, such as isolated human milk oligosaccharides, to attenuate a respiratory pathogen infection-induced host inflammation and/or to promote recovery from a respiratory pathogen infection-induced host inflammation in a subject.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 10, 2022
    Assignee: Glycosyn LLC
    Inventors: Ardythe L. Morrow, David S. Newburg, John M. McCoy
  • Rapid-acting insulin formulation comprising a substituted anionic compound
    Patent number: 11324808
    Abstract: A composition in aqueous solution includes insulin and at least one substituted anionic compound chosen from substituted anionic compounds consisting of a backbone formed from a discrete number u of between 1 and 8 (1?u?8) of identical or different saccharide units, linked via identical or different glycoside bonds, the saccharide units being chosen from the group consisting of hexoses, in cyclic form or in open reduced form, said compound comprising partially substituted carboxyl functional groups, the unsubstituted carboxyl functional groups being salifiable. A pharmaceutical formulation including the composition is also set forth.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: May 10, 2022
    Assignee: Adocia
    Inventors: Gérard Soula, Bertrand Alluis
  • Synergistic nutritional compositions for promoting axonal regeneration
    Patent number: 11311565
    Abstract: The invention disclosed herein relates to a novel synergistic nutritional composition for promoting axonal regeneration. Particularly, the present invention provides potent nutritional composition comprising synergistic exogenous blend of agmatine (decarboxylated L-arginine) and inosine monophosphate (IMP) and salts thereof, which are present in a weight ratio of 1:0.05 to 1:2 along with pharmaceutically acceptable excipients. The instant synergistic nutritional composition is useful for treating diseases or disorders related to traumatic injury in the central nervous system such as brain or spinal cord injury, optic nerve lesions.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: April 26, 2022
    Assignee: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Rajaram Samant, Rajendra Prasad Tongra
  • Method and composition for preventing and treating viral infections
    Patent number: 11311563
    Abstract: A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a patient at risk of or diagnosed with a viral infection a composition including therapeutically effective amounts of a helicase ATPase inhibitor, a sialidase enzyme inhibitor, an ICAM-1 inhibitor and gallic acid which each also down regulate the immune response. The composition may further include a permeation enhancer.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: April 26, 2022
    Assignee: GLOBAL BIOLIFE INC.
    Inventor: Daryl Thompson
  • Efficient tobramycin compound conjugate compositions
    Patent number: 11298368
    Abstract: Disclosed herein are compositions comprising tobramycin or a tobramycin derivative that exhibit improvements in permeation of corneal cells, retention in corneal cells, or both. Such compositions can comprise tobramycin or tobramycin derivative(s) complexed to an agent which facilitates improved permeation of corneal cells, retention in corneal cells, or both. The invention also relates to a process of preparing such compositions.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: April 12, 2022
    Assignee: SOMERSET THERAPEUTICS, LLC.
    Inventors: Mandar V. Shah, Veerappan Subramanian, Ilango Subramanian
  • Production method for acidic xylooligosaccharide, and acidic xylooligosaccharide
    Patent number: 11286272
    Abstract: The present invention provides a reduced-cost method for producing an acidic xylooligosaccharide, the method including a depolymerization step of depolymerizing a plant-derived raw material and a deacetylation step of adding a base to a solution of the product of the depolymerization step to achieve a pH of 11 or higher. The present invention further provides an acidic xylooligosaccharide having an acetyl group content of 0 to 5.0 mass %. The acidic xylooligosaccharide of the present invention, which has an acetyl group content of 0 to 5.0 mass %, can be used as a starting material in a production method to thereby obtain pentosan polysulfate with a high yield.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 29, 2022
    Assignee: OJI HOLDINGS CORPORATION
    Inventors: Kotaro Ishikawa, Takuro Kashiwamura, Takuya Kato, Toru Koga, Suguru Ishikawa
  • Synthetic composition for microbiota modulation
    Patent number: 11278558
    Abstract: The invention relates to a method and composition for modulating the microbiota in the gastro-intestinal tracts of non-infant humans, particularly for increasing the abundance of Bifidobacterium longum and/or Bifidobacterium bifidum in the gut microbiota of non-infant humans.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 22, 2022
    Assignee: Glycom A/S
    Inventors: Louise Kristine Vigsnæs, Bruce McConnell
  • Health supplement
    Patent number: 11278562
    Abstract: A kit for supporting health of a user throughout the user's menstrual cycle may include at least two daily supplements of a first type, and at least two daily supplements of a second type, the second type different from the first type, wherein the daily supplements of the first type and the daily supplements of the second type are packaged in a single kit according to menstrual cycle phase. A method for supporting health of a user throughout the user's menstrual cycle may include providing at least two daily supplements of a first type, providing at least two daily supplements of a second type, and instructing the user to ingest the daily supplements of the first type during at least two days of a first time period of the menstrual cycle, and to ingest the daily supplements of the second type during at least two days of a second time period of the menstrual cycle.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: March 22, 2022
    Assignee: DR SARI'S, INC.
    Inventor: Sari Eitches
  • Combinations including ABX196 for the treatment of cancer
    Patent number: 11278552
    Abstract: An antitumor pharmaceutical combination includes (i) a compound ABX196 and (ii) at least one chemotherapeutic agent and/or at least one immunotherapeutic agent, for use in the treatment of cancer.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: March 22, 2022
    Assignee: Abivax
    Inventors: Sandrine Crabe, Didier Scherrer, Hartmut Ehrlich, Philippe Pouletty
  • Food for improving intestinal environment
    Patent number: 11273169
    Abstract: The present invention provides a food that is effective for improving the intestinal environment by promoting proliferation of intestinal lactic acid bacteria and the like. The present invention provides a food that is effective for improving the intestinal environment, wherein the food includes (1) ?-polyglutamic acid or a composition containing ?-polyglutamic acid, and (2) oligosaccharide or a composition containing oligosaccharide.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: March 15, 2022
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keishi Kameyama, Momoka Tsuneyoshi
  • Compositions of O-glycosyl flavonoids
    Patent number: 11266671
    Abstract: A composition containing L-arginine and a glycosyl compound of formula (I): in which R is a moiety formed of a monosaccharide, a disaccharide, or an oligosaccharide including three to five monosaccharides; and the composition contains the glycosyl compound and L-arginine in a molar ratio of 1:1.6 to 1:3.0. Also disclosed is a method for preparing such a composition, as well as a composition prepared by the method.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: March 8, 2022
    Assignee: ALPS Pharmaceutical Ind. Co., Ltd.
    Inventors: Hiroaki Kida, Naoto Yamaguchi, Mitsunori Ono
  • Use of heparin and carbohydrates to treat cancer
    Patent number: 11266772
    Abstract: The method is described as the removal of mediators that contribute to the pathogenesis of cancer from blood by contacting the blood with a solid, essentially non-micro-porous substrate which has been surface treated with heparin, heparan sulfate and, optionally, other molecules or chemical groups (the adsorbent media or media) having a binding affinity to the mediator, and wherein the size of the interstitial channels within said substrate are balanced with the amount of interstitial substrate surface area such that high flow rates of blood past said substrate creates a flow transport that is characterized by convection transport more than Brownian diffusion transport.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: March 8, 2022
    Assignee: ExThera Medical Corporation
    Inventors: Keith McCrea, Robert Ward, Olle Larm
  • Inhibiting reduction of lean body mass and inhibiting accumulation of liver fat by administering allulose
    Patent number: 11260066
    Abstract: The present invention relates to a composition for inhibiting liver fat accumulation comprising allulose as an active ingredient and a pharmaceutical composition and a food composition using thereof.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: March 1, 2022
    Assignee: SAMYANG CORPORATION
    Inventors: Hye Jung Kim, Chong Jin Park, Kang Pyo Lee
  • Sulfate-grafted nanocrystalline cellulose
    Patent number: 11242411
    Abstract: The invention is directed to a simple and economical method for producing nanocrystalline cellulose from microcrystalline cellulose by contacting frozen concentrated sulfuric acid with microcrystalline cellulose, diluting the mixture in water and hair-shaped ice to hydrolyze the microcrystalline cellulose, and separating the NCC. Another aspect of the invention pertains to an apparatus for conducting this method which includes an acid resistant hydrolysis container having a cooling jacket containing a hollow stirrer each of which may be filled with liquid nitrogen.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: February 8, 2022
    Assignee: King Abdulaziz University
    Inventor: Sherif Shawki Zaki Hindi
  • Urchin-shaped nanocrystalline material
    Patent number: 11242410
    Abstract: The invention is directed to a simple and economical method for producing nanocrystalline cellulose from microcrystalline cellulose by contacting frozen concentrated sulfuric acid with microcrystalline cellulose, diluting the mixture in water and hair-shaped ice to hydrolyze the microcrystalline cellulose, and separating the NCC. Another aspect of the invention pertains to an apparatus for conducting this method which includes an acid resistant hydrolysis container having a cooling jacket containing a hollow stirrer each of which may be filled with liquid nitrogen.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: February 8, 2022
    Assignee: King Abdulaziz University
    Inventor: Sherif Shawki Zaki Hindi
  • Method for treatment of cellular senescence
    Patent number: 11234993
    Abstract: The present invention provides an alcohol extract of Ajuga taiwanensis Nakai ex Murata exhibits significant effects on inhibiting the senescence in human WI-38 lung fibroblasts and human dermal fibroblasts. Moreover, the alcohol extract of A. taiwanensis is able to suppress the expression of the cofilin-1, a protein involved in actin dynamics and cell morphology and found to be increased in senescent cells. Suppression effect of cell senescence by this herb extract is more efficient in mild concentration without over-inhibition of cell viability and growth.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: February 1, 2022
    Assignee: NATIONAL YANG-MING UNIVERSITY
    Inventors: Yi-Jang Lee, Yun-Lian Lin, Chung-Sheng Huang, Cheng-Han Tsai, Chun-Yuan Chang, Bing-Ze Lin, Yuan-Heng Tu, Wei-Hsiang Hsu, Pin-Ho Lo