Patents Examined by Damcron Jones
  • Patent number: 6180082
    Abstract: Administration of a radioisotopic compound by infusion over a period of time greater than two hours, preferably greater than twelve hours, greatly increases the maximum radioactivity that accumulates in the target cell. The efficacy of the administration of the radiolabeled compound can be increased about five times higher than prior bolus injection or short infusion methods. This method enhances the tumor to background ratio by increasing the actual radioligand accumulated inside the target cells. This technique works for any radiolabeled compound whose cellular uptake is limited by a cellular process of either binding to a cellular receptor or to a transport protein. Once the radiolabeled compound is bound and internalized, the ability of an unlabeled compound to compete with the radioligand is markedly decreased. The primary factor governing residence time after internalization is the physical half-life of the radioisotope, not biologic half-life.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: January 30, 2001
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Eugene A. Woltering, Gregory D. Espenan