Patents Examined by Dan C. Jacobson
  • Modified factor VII
    Patent number: 5788965
    Abstract: The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 4, 1998
    Assignees: Novo Nordisk A/S, ZymoGenetics, Inc.
    Inventors: Kathleen L. Berkner, Lars Christian Petersen, Charles E. Hart, Ulla Hedner, Claus Bregengaard