Patents Examined by Daniel E. Kolker
  • Patent number: 12227583
    Abstract: The present invention provides an anti-ox40 antibody, an antigen-binding fragment thereof, and the pharmaceutical use. Further, the present application provides a chimeric antibody and a humanized antibody, the chimeric antibody and the humanized antibody comprising a CDR region from the anti-OX40 antibody and the antigen-binding fragment thereof, and also provides a pharmaceutical composition comprising the anti-OX40 antibody and the antigen-binding fragment thereof, and the use thereof as a drug for treating cancers.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: February 18, 2025
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Cheng Liao, Zupeng Xu, Jiahua Jiang, Xin Ye, Lianshan Zhang
  • Patent number: 12227572
    Abstract: The invention relates to a monoclonal humanized antibody or antigen-binding fragment thereof that specifically bind to the TRBV9 family of the human T cell receptor. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with the human T cell receptor family. The invention is directed to generation of antibodies that can be used for treating, in particular AS, celiac disease and malignant blood diseases, the pathogenesis of which involves the TRBV9 family TCRs.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: February 18, 2025
    Inventors: Olga Vladimirovna Britanova, Dmitry Borisovich Staroverov, Anna Valentinovna Evstrateva, Alexey Konstantinovich Misorin, Timofey Aleksandrovich Nemankin, Mariia Aleksandrovna Shchemeleva, Anna Konstantinovna Vladimirova, Arina Vitalevna Anikina, Roman Alekseevich Ivanov, Dmitry Valentinovich Morozov, Pavel Andreevich Iakovlev, Sergey Anatolievich Lukyanov
  • Patent number: 12209133
    Abstract: The present invention relates to an isolated antibody which specifically binds human CD137, and pharmaceutical compositions and methods of use thereof. The present invention further relates to a nucleic acid comprising a nucleotide sequence encoding said antibody, a vector comprising said nucleic acid, a host cell comprising said nucleic acid or said vector, and a method of producing said antibody.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: January 28, 2025
    Assignee: Numab Therapeutics AG
    Inventors: Tea Gunde, Matthias Brock, Christian Hess, Alexandre Simonin, Stefan Warmuth
  • Patent number: 12202877
    Abstract: The present disclosure provides methods for generating MAGE-B2 specific T cells and compositions comprising engineered MAGE-B2-specific T cell receptors. Further provided are methods of treating cancer comprising administering the MAGE-B2-specific T cells.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: January 21, 2025
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Cassian Yee, Ke Pan
  • Patent number: 12195546
    Abstract: Provided herein are multispecific binding proteins comprising (a) a first antigen binding domain (ABD) comprising an immunoglobulin single variable domain (ISVD) (e.g., VHH) with binding specificity to CD28; and (b) a second ABD comprising an immunoglobulin heavy chain variable domain (VH) and an immunoglobulin light chain variable domain (VL) with binding specificity to OX40. Also provided are methods of treating autoimmune diseases with said multispecific binding proteins.
    Type: Grant
    Filed: December 18, 2023
    Date of Patent: January 14, 2025
    Assignee: SANOFI
    Inventors: Gerald Beste, Yanik Bruynooghe, Klervi Desrumeaux, Jennifer Kuehn, Charlotte Lahoute, Rami Lissilaa, Alessandro Masiero, Sevim Oezguer Bruederle, Benjamin Suratt, Emmanuelle Vigne, Jessica Voss
  • Patent number: 12195538
    Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 14, 2025
    Assignees: ABL BIO INC., I-MAB BIOPHARMA US LIMITED
    Inventors: Eunyoung Park, Yangsoon Lee, Hyejin Chung, Eunsil Sung, Jiseon Yoo, Minji Park, Yong-Gyu Son, Hyoju Choi, Eunjung Kim, Jaeho Jung, Weon-Kyoo You, Sang Hoon Lee, Lei Fang, Wenqing Jiang
  • Patent number: 12193996
    Abstract: Described herein are compositions comprising subsets of monocyte having distinct functional properties and methods for using the same to treat infectious disease.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: January 14, 2025
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Catherine Rhee, David T. Scadden
  • Patent number: 12195543
    Abstract: The present invention provides novel human fins related tyrosine kinase 3 (FLT3) antigen binding proteins, such as antibodies, having improved FLT3 binding affinity, and/or anti-tumor activity. The FLT3 antibodies of the invention were generated by mutation of a parent FLT3 antibody and tested in in vitro in binding assays as well as in vivo in a mouse tumor model and in human patient tumor samples. The antibodies of the invention are provided as monospecific constructs or in a bispecific FLT3×CD3 antibody format and show excellent target affinity and/or tumor cell killing. The present invention also relates methods for producing the antigen binding proteins of the invention as well as nucleic acids encoding them, vectors for and host cells for their expression. The invention further relates to methods of treating or diagnosing a disease such as leukemia using an FLT3 antigen binding protein (ABP) of the invention.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: January 14, 2025
    Assignees: DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES OFFENTLICHEN RECHTS, EBERHARD KARLS UNIVERSITAT TUBINGEN
    Inventors: Gundram Jung, Helmut Salih, Fabian Vogt, Latifa Zekri-Metref, Martin Pflügler, Isabelle Ehnes
  • Patent number: 12187802
    Abstract: The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3R?) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3R?-expressing cell population, the methods comprising contacting a population of IL3R?-expressing cells (e.g., cancer cells and/or cancer stem cells) with an antibody that binds to IL3R?. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3R? chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and/or managing a disorder associated with IL3R?-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3R?.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 7, 2025
    Assignee: Stemline Therapeutics, Inc.
    Inventor: Ivan Bergstein
  • Patent number: 12173075
    Abstract: The present disclosure relates to biotechnology and provides antibodies that specifically bind to IL-5R?. The disclosure also relates to DNA encoding the antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using the antibodies.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: December 24, 2024
    Inventors: Ekaterina Vladimirovna Sofronova, Aleksei Konstantinovich Misorin, Aleksandr Nikolaevich Doronin, Timofey Aleksandrovich Nemankin, Aleksandra Aleksandrovna Sozonova, Galina Stepanovna Zhirivskaia, Sergey Aleksandrovich Legotsky, Anna Konstantinovna Vladimirova, Alina Valerevna Beliasnikova, Mariia Aleksandrovna Shchemeleva, Pavel Andreevich Iakovlev, Valery Vladimirovich Solovyev, Elena Andreevna Krendeleva, Natalia Evgenevna Pestova, Dmitry Valentinovich Morozov
  • Patent number: 12173056
    Abstract: Disclosed is an isolated binding protein including a cardiac troponin I (cTnI) antigen binding domain, and preparation and a use and the like of the binding protein. The antigen binding domain includes at least one complementarity determining region selected from an amino acid sequence defined in this article, or has at least 80% sequence identity with the complementarity determining region of the amino acid sequence and has KD?9.96×10?8 mol/L affinity with cTnI. The binding protein may be used in the detection field of the cTnI protein.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 24, 2024
    Assignee: FAPON BIOTECH INC.
    Inventors: Peng Cui, Zhiqiang He, Yuan Meng, Dongmei Zhong
  • Patent number: 12168694
    Abstract: Isolated anti-human CD45RC antibodies or binding fragments thereof, nucleic acids and expression vector encoding the same, compositions including the same, and uses thereof as medicaments, including for the prevention and/or treatment of CD45RChigh-related diseases (including autoimmune diseases, undesired immune responses, monogenic diseases, and lymphoma or cancer), in particular for use in preventing and/or treating graft-versus-host disease (GVHD).
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: December 17, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), NANTES UNIVERSITE, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
    Inventors: Carole Guillonneau, Ignacio Anegon
  • Patent number: 12158468
    Abstract: Means and methods for determining whether an individual that does not have rheumatoid arthritis, AAV or Sjögren syndrome at the moment of sampling is at risk of developing the disease, the method comprising determining whether an antibody-containing sample of the individual comprises an autoantibody associated with the disease that comprises an N-linked glycosylation at one or more positions in a Fab-portion of the antibody, the method further comprising determining the risk of the individual for developing the disease. The disease is preferably rheumatoid arthritis.
    Type: Grant
    Filed: November 24, 2017
    Date of Patent: December 3, 2024
    Assignee: Academisch Ziekenhuis Leiden h.o.d.n. LUMC
    Inventors: Thomas Willem Johannes Huizinga, Reinaldus Everardus Maria Toes, Leendert Adrianus Trouw, Hans Ulrich Scherer
  • Patent number: 12145987
    Abstract: Provided is a composition for cytotoxic T cell depletion, comprising an anti-LAG-3 antibody or a binding fragment thereof having the properties described in (i) to (iii) below: (i) having in vitro ADCC activity; (ii) reducing, in a low fucose form, the number of LAG-3 positive cells in vivo; and (iii) binding to activated human T cells. Also provided are methods for depleting cytotoxic T cells using the disclosed anti-LAG-3 antibody or binding fragment thereof.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: November 19, 2024
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Ryuta Mukasa, Naoki Kiyosawa, Shinnosuke Yamada
  • Patent number: 12138314
    Abstract: This disclosure relates to anti-cancer antibodies and methods of treatment, detection, and diagnosis using the same.
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: November 12, 2024
    Assignee: Bluefin Biomedicine, Inc.
    Inventors: Hong Ren, Scott Michael Lonning, Nels Eric Pederson, Klarisa Rikova, Aleksandr Tkachev, Tinglei Gu
  • Patent number: 12138313
    Abstract: This disclosure relates to anti-cancer antibodies and methods of treatment, detection, and diagnosis using the same.
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: November 12, 2024
    Assignee: Bluefin Biomedicine, Inc.
    Inventors: Hong Ren, Scott Michael Lonning, Nels Eric Pederson, Klarisa Rikova, Aleksandr Tkachev, Tinglei Gu
  • Patent number: 12139729
    Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (AChE), or a truncation thereof.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: November 12, 2024
    Assignee: NEURO-BIO LTD
    Inventor: Susan Greenfield
  • Patent number: 12138295
    Abstract: A method of treating Crohn's disease in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial intravenous dose and subsequence subcutaneous doses.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: November 12, 2024
    Inventors: Omoniyi Adedokun, Daphne Chan, Yang Chen, Philippe Szapary
  • Patent number: 12139537
    Abstract: The present disclosure provides an antibody for inducing immune tolerance, an induced lymphocyte, and a cell therapy agent therapeutic method using the induced lymphocyte. Specifically, the present disclosure provides an antibody that inhibits the interaction between CD80 and/or CD86 expressed on the surface of a certain cell and CD28 expressed on the surface of another cell, and substantially does not induce immune activation-induced cytokines. In a specific embodiment, the Fc portion of the antibody substantially does not produce the immune activation-induced cytokines.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: November 12, 2024
    Assignee: Junten Bio Co., Ltd.
    Inventors: Ryu Maeda, Masayuki Kawakami, Koichiro Uchida, Kazuyoshi Takeda, Ko Okumura
  • Patent number: 12134657
    Abstract: Monoclonal antibodies that bind, such as specifically bind, blood protein factor XII (FXII) are described. The monoclonal antibodies (including antigen-binding fragments thereof) are capable of forming immune complexes with human FXII and inhibiting FXII activity, resulting in safe anti-inflammatory and anti-thrombotic effects.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: November 5, 2024
    Assignees: Oregon Health & Science University, Aronora, Inc.
    Inventors: Michael Wallisch, Andras Gruber, Erik I. Tucker, Christina U. Lorentz