Abstract: Novel 1-hydroxyaryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart failure and other diseases. The compounds possess .beta.-adrenergic stimulant activity. Representative of the compounds disclosed is 1-p-hydroxyphenyl-2-(.beta.-isobutyramidoethyl)aminoethanol.