Patents Examined by Daniel F Coughlin
  • Patent number: 10758546
    Abstract: The present invention provides a transdermal delivery system, which comprises a drug-containing matrix layer comprising: galantamine or its pharmaceutically acceptable salt as an active ingredient; and a styrene-butadiene-styrene copolymer or a styrene-isoprene-styrene copolymer as an adhesive.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: September 1, 2020
    Assignees: Industry-Academic Cooperation Foundation, TAHO Pharmaceuticals Ltd.
    Inventors: Hoo-kyun Choi, Myung-kwan Chun
  • Patent number: 10744097
    Abstract: The present invention is directed to an immediate release and extended release capsule or capsule fill which mitigates the abuse of abuse-susceptible active pharmaceutical ingredients by direct intravenous injection. The fill comprises a parenteral abuse resistant liquid formulation which when mixed with water and heated, results in a turbid, viscous or bubbling mixture that is not injectable with a standard insulin syringe. The abuse-susceptible active pharmaceutical ingredient is selected from the group consisting of opiates, opioids, tranquillizers, stimulants and narcotics.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: August 18, 2020
    Assignee: R.P. Scherer Technologies, LLC
    Inventor: Simone Wengner
  • Patent number: 10736838
    Abstract: A transdermal drug administration device comprising a drug delivery element (10) defining a contact surface (12) for location, in use, against a patient's skin. The drug delivery element (10) includes a sustained-release pharmaceutical composition. The composition comprises a network of a carrier material having a high mechanical strength and an active pharmaceutical ingredient. The active pharmaceutical ingredient is co-formedly interspersed within pores in the solid, continuous network of the carrier material.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 11, 2020
    Assignee: Emplicure AB
    Inventors: Håkan Engqvist, Susanne Bredenberg, Anders Petterson, Thomas Lundqvist, Anna Dahlgren, Anders Sågström
  • Patent number: 10702584
    Abstract: The present invention provides a method for preparing a bone protein preparation which contains for example growth factors. The present invention also provides a bone protein preparation obtained by the method and paste, putty, pellet, disc, block, granule, osteogenic device or pharmaceutical composition containing said bone protein preparation.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: July 7, 2020
    Inventors: Hanna Tölli, Juha-Matti Närhi, Harri Lumme, Elli Birr, Oili Hietala, Mikko Viitanen, Merja Haikola, Pekka Jalovaara, Bo Kenneth Sandström
  • Patent number: 10695289
    Abstract: A medical device comprising a composition comprising a therapeutically active amount of active agent, a zinc compound, and an array of microneedles. The zinc compound may be selected from the group consisting of zinc, pharmaceutically acceptable salts of zinc, and mixtures thereof. At least a portion of the composition is present as a coating on at least a portion of the microneedles. Methods of delivering a therapeutically active agent to a mammal using compositions of the disclosure are also included.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: June 30, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Kenneth E. Brown, Daniel M. Dohmeier, Joan T. Moseman, Ying Zhang, Alan Harris, Gary Hattersley, Lisa A. Dick
  • Patent number: 10632068
    Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures that alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat, prevent from having, prevent from developing, control, reduce the severity, or reduce the progression of a disease, disorder or condition of a subject.
    Type: Grant
    Filed: July 27, 2019
    Date of Patent: April 28, 2020
    Inventor: Praful Doshi
  • Patent number: 10603403
    Abstract: The embodiments relate to an injectable composition for a bone cement material comprising a dry powder component, a liquid component and a modifier configured to modify a Young's modulus of the bone cement material. The modifier is linoleic acid or a derivative thereof and is present in a concentration of 0.1 to 12 v/v of the liquid component.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: March 31, 2020
    Assignee: INOSSIA AB
    Inventors: Cecilia Persson, Alejandro Lopez
  • Patent number: 10555908
    Abstract: A comestible dosage form article for administration to a target subject, the dosage form comprising: an outer capsule comprising a first cap telescopically engageable with a first body; and an inner capsule, within the outer capsule, comprising a second cap telescopically engageable with a second body, wherein the inner capsule is inverted with respect to the outer capsule such that, in an assembled state, the second cap is proximal to the first body and distal to the first cap.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: February 11, 2020
    Assignee: Capsugel Belgium NV
    Inventor: Stefaan Jaak Vanquickenborne
  • Patent number: 10543275
    Abstract: The present disclosure provides a composition for a non-aqueous patch preparation with excellent adhesibility which can sustainedly release a drug. The patch preparation can improve the adhesibility of the patch preparation and the release property of a drug by the addition of a powder ingredient the long-time sustention of the adhesibility of tape preparations enables an improvement of the transdermal absorbability and the sustained release of a drug.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: January 28, 2020
    Assignee: MEDRX CO., LTD.
    Inventors: Hidetoshi Hamamoto, Katsuhiro Yamanaka, Takahiro Tanimoto
  • Patent number: 10532041
    Abstract: A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate, wherein the co-jet milled glycopyrrolate and magnesium stearate is then subjected to a conditioning step which includes exposure of the co-jet milled glycopyrrolate and magnesium stearate to humidity. A composition made by this method is also disclosed.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: January 14, 2020
    Assignee: Vectura Limited
    Inventor: Fergus Manford
  • Patent number: 10525023
    Abstract: A mesosilicalite nanocarrier having a hierarchical silicalite characterized by a molar ratio of aluminum to silica in a range of 1:3000 to 1:1000. The hierarchical silicalite includes mesopores of a hexagonal structure, and micropores of silicalite structure with a microporous volume in the range of 0.05 cc/g to 0.1 cc/g. The nanocarrier has a mesophase content in the range of 30 wt % to 70 wt %, a microphase content in the range of 30 wt % to 70 wt %, and a mean pore diameter in the range of 1.5 nm to 5.5 nm. A method of preparing the stable mesosilicalite nanocarrier with hierarchical micro/mesopores to load an antioxidant or drug for targeted drug delivery is also described.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: January 7, 2020
    Assignee: Imam Abdulrahman Bin Faisal University
    Inventors: B. Rabindran Jermy, Vijaya Ravinayagam
  • Patent number: 10525099
    Abstract: The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight between 50 and 1,000 mg, said dosage unit consisting of: 1-100 wt. % of particles consisting of: 0.01-10 wt. % of a partus control substance selected from oxytocin, carbetocin, atosiban and combinations thereof; 5-70 wt. % of buffering agent; 20-94 wt. % of branched glucan; 0-70 wt. % of other pharmaceutically acceptable ingredients; 0-95 wt. % of one or more pharmaceutically acceptable excipients; the solid dosage unit comprising at least 5 ?g of the partus control substance and having a pH buffer range of 3.5-5.7. The solid dosage unit of the present invention is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration. Furthermore, the dosage unit does not need to be stored and distributed under temperature controlled conditions.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: January 7, 2020
    Inventors: Johannes Jan Platteeuw, Herman Jan Tijmen Coelingh Bennink
  • Patent number: 10500312
    Abstract: Bioactive porous bone graft implants in various forms suitable for use in bone tissue regeneration and/or repair, as well as methods of use are provided. The implants are formed of bioactive glass and have an engineered porosity. The implants may be contained in polymer for enhanced clinical results and better handling.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: December 10, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steve B. Jung, Hyun W. Bae
  • Patent number: 10499647
    Abstract: The present disclosure relates to use of an encapsulated chlorine bleach to reduce gas evolution when reacted with sodium bromide during dispensing. The compositions include a coated chlorine combined with the sodium bromide which beneficially suppresses the chemical reaction, and therefore gas release, while providing a single, solid, all-in-one composition. Compositions, methods of dispensing and methods of use are disclosed.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: December 10, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Jonathan P. Fast, John Nordling
  • Patent number: 10478528
    Abstract: Synthetic, bioactive ultra-porous bone graft materials having an engineered porosity, and implants formed from such materials are provided. In particular, these implants comprise bioactive glass and incorporate allograft material for osteoinduction. The implants are suitable for bone tissue regeneration and/or repair.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: November 19, 2019
    Assignee: PROSIDYAN, INC.
    Inventors: Charanpreet S. Bagga, Steven B. Jung, Hyun W. Bae
  • Patent number: 10471095
    Abstract: The present invention relates to a water suspension of graphene oxide nanoflakes decorated by nanoparticles of metallic platinum, characterised in that it comprises: • 100 ?g/ml to 500 ?g/ml of graphene oxide nanoflakes, • 5 ?g/ml to 50 ?g/ml of nanoparticles of metallic platinum (Pt°), deposited on the surface of graphene oxide nanoflakes. The invention also relates to a method of preparing such suspension and its use as an antitumor agent.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: November 12, 2019
    Inventors: Ewa Sawosz Chwalibog, Marta Kutwin, Slawomir Jaworski, Mateusz Wierzbicki, Marta Grodzik, Anna Hotowy, Ludwika Lipinska, Joanna Jagiello
  • Patent number: 10463699
    Abstract: Disclosed is a method of reducing the rancid fish odor smell in a topical composition comprised of fish oil which comprises mixing the composition with monolaurin. Also disclosed are various anhydrous topical compositions comprising fish oil. One comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, and monolaurin, another one comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, monolaurin, collagen and sea salt, an a third one comprises fish oil, cetyl ester, palm olein, medium-chain triglyceride(s) of a mixture of C8 and C10 fatty acids, mixture of C8/C10 fatty acids, monolaurin and hydrocolloid. These compositions are useful for treating wounds and skin conditions.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: November 5, 2019
    Assignee: Omeza LLC
    Inventor: Griscom Bettle, III
  • Patent number: 10441687
    Abstract: A product comprising a stent for a human blood vessel which comprises (i) a scaffold which is impregnated with, adsorbed with, or coated with an inhibitor of a Wnt/p-catenin pathway, or (ii) a scaffold coated with a polymer, which polymer is impregnated with, adsorbed with, or coated with an inhibitor of a Wnt/p-catenin pathway, and methods of use to reduce the risk of restenosis.
    Type: Grant
    Filed: November 5, 2014
    Date of Patent: October 15, 2019
    Assignee: Albert Einstein College of Medicine
    Inventors: Nicholas Ernst Smit Sibinga, Dario Fernando Riascos-Bernal
  • Patent number: 10434067
    Abstract: Provided are a solid composite formulation for oral administration, the solid composite formulation including: an ezetimibe granules-part including ezetimibe, said ezetimibe having a particle size distribution wherein the average particle size d(0.9) for the bottom 90% is about 10 ?m or less; and a rosuvastatin mixture-part including rosuvastatin or a pharmaceutically acceptable salt thereof, and a method of preparing the composite formulation.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: October 8, 2019
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Jung Hyun Cho, Jin Cheul Kim, Yong Il Kim, Seung Jun Lee, Jae Hyun Park, Jong Soo Woo
  • Patent number: 10426869
    Abstract: Biodegradable, magnesium alloys and composites, articles produced therefrom, methods of making the same, and methods of using the same are described.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: October 1, 2019
    Assignee: The University of Toledo
    Inventors: Sarit B. Bhaduri, Huan Zhou