Patents Examined by Daniel S. Mytelka
  • Patent number: 6030805
    Abstract: The present invention relates to a new fibronectin binding protein from E. coli in the form of a curli pili. a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from E. coli coding for a protein or polypeptide having fibronectin binding properties. (FIG. 4).
    Type: Grant
    Filed: June 28, 1995
    Date of Patent: February 29, 2000
    Inventors: Staffan Normark, Arne Olsen
  • Patent number: 5888763
    Abstract: The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: March 30, 1999
    Assignee: The Rockefeller University
    Inventors: Hidesaburo Hanafusa, Beatrice S. Knudsen, Stephan M. Feller, John Kuriyan, Xiaodong Wu, Jie Zheng, David Cowburn
  • Patent number: 5856163
    Abstract: A new species of the genus Hyphogyma is disclosed, as are new lipases obtainable therefrom, Also disclosed is a process for obtaining the enzymes.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 5, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Miyoko Hashida, Masanobu Abo, Yukiko Takamura, Ole Kirk, Torben Halkier, Sven Pedersen, Shamkant Anant Patkar, Mogens Trier Hansen
  • Patent number: 5837840
    Abstract: The invention provides novel polypeptides which are associated with the transcription complex NF-AT, polynucleotides encoding such polypeptides, antibodies which are reactive with such polypeptides, polynucleotide hybridization probes and PCR amplification probes for detecting polynucleotides which encode such polypeptides, transgenes which encode such polypeptides, homologous targeting constructs that encode such polypeptides and/or homologously integrate in or near endogenous genes encoding such polypeptides, nonhuman transgenic animals which comprise functionally disrupted endogenous genes that normally encode such polypeptides, and transgenic nonhuman animals which comprise transgenes encoding such polypeptides.
    Type: Grant
    Filed: September 20, 1993
    Date of Patent: November 17, 1998
    Assignee: Board of Trustees of Leland Stanford Jr. University
    Inventors: Gerald R. Crabtree, Jeffrey P. Northrop
  • Patent number: 5824533
    Abstract: Xylanases having high specific activities from Orpinomyces sp. strain PC-2 are provided as well as methods for their purification. DNA sequences encoding these proteins are also provided.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 20, 1998
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Xin-Liang Li, Lars G. Ljungdahl, Huizhong Chen
  • Patent number: 5795763
    Abstract: A means for cleaving a nucleic acid cleavage structure in a site-specific manner is disclosed. A cleaving enzyme having 5' nuclease activity without interfering nucleic acid synthetic ability is employed as the basis of a novel method of detection of specific nucleic acid sequences.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 18, 1998
    Assignee: Third Wave Technologies, Inc.
    Inventors: James E. Dahlberg, Victor I. Lyamichev, Mary Ann D. Brow
  • Patent number: 5759801
    Abstract: A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of transformed yeasts and uses thereof.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: June 2, 1998
    Assignee: Roussel Uclaf
    Inventors: Xavier Chenivesse, Catherine Duport, Eric Lecain, Denis Pompon
  • Patent number: 5723584
    Abstract: Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: March 3, 1998
    Assignee: Affymax Technologies N.V.
    Inventor: Peter J. Schatz
  • Patent number: 5710020
    Abstract: The Bacillus thuringiensis var. kurstaki HD-73 crystal protein gene was cloned into pBR322. E. coli cells harboring this recombinant plasmid produced a 130 kD protoxin that was toxic to Manduca sexta (tobacco hornworm) larvae. Plasmids having the 3'-end of the protoxin gene deleted where also constructed. E. coli cells harboring these deleted plasmids produced an active, soluble 68 kD toxin, provided that the 3'-deletion had not removed sequences encoding the 68 kD toxin. The invention provides methods to produce 68 kD toxin protein by constructing partial protoxin genes encoding the toxin followed by expression of the genes in living cells. Useful plasmids and cells are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 20, 1998
    Assignee: Mycogen Plant Science, Inc.
    Inventor: Michael J. Adang
  • Patent number: 5707839
    Abstract: The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin, of producing a Streptomyces avermitilis bkd mutant and of producing novel avermectins through fermentation.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 13, 1998
    Assignee: Pfizer Inc.
    Inventors: Claudio D. Denoya, Kim J. Stutzman-Engwall
  • Patent number: 5679630
    Abstract: The present invention relates to cleaning compositions comprising subtilisin proteases from Bacillus lentus having the following alterations: N76D, S103A and V104I, where the numbering is based on the corresponding positions in the subtilisin from Bacillus amyloliquefaciens.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: October 21, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Andre Baeck, Chanchal Kumar Ghosh, Thomas Paul Graycar, Richard Ray Bott, Lori Jean Wilson, Philip Frederick Brode, Bobby Lee Barnett, Donn Nelton Rubingh