Abstract: In various embodiments electrical stimulators are provided for transcutaneous and/or epidural stimulation. In certain embodiments the stimulator provides one or more channels configured to provide one or more of the following stimulation patterns: i) monophasic electrical stimulation with a DC offset; ii) monophasic electrical stimulation with charge balance; iii) delayed biphasic electrical stimulation with a DC offset; iv) delayed biphasic electrical stimulation with charge balance; v) amplitude modulated dynamic stimulation; and/or vi) frequency modulated dynamic stimulation.

Abstract: This disclosure is directed to devices, systems, and techniques for delivering electrical stimulation. In some examples, a system includes processing circuitry configured to: receive information representative of a bioelectric brain signal recorded from a brain of a patient; and determine, based on the information, at least one pathological frequency of the bioelectric brain signal. Additionally, the processing circuitry is configured to select, based on the at least one pathological frequency, a sequence of pulse bursts at a pulse burst frequency, the sequence of pulse bursts at least partially defining electrical stimulation deliverable to an area of a brain of a patient, wherein adjacent pulse bursts within the sequence comprise different intra-burst pulse frequencies; and control a medical device to deliver the electrical stimulation comprising the sequence of pulse bursts to the area of the brain of the patient.

Abstract: A leadless biostimulator, such as a leadless pacemaker, including a header assembly having a monolithic controlled release device (MCRD) for therapeutic agent elution, is described. The MCRD is in fluid communication with a space between an insulator and an electrode of the header assembly to elute therapeutic agent into the space when the leadless biostimulator is implanted. The therapeutic agent can elute through the space around the electrode to provide controlled elution of the therapeutic agent to a surrounding environment. The electrode can extend longitudinally through the insulator cavity to a distal tip that provides a stable surface area and controlled impedance for pacing a target tissue. Other embodiments are also described and claimed.

Abstract: Systems and methods are directed to influencing organ function by stimulating the dorsal root ganglion. Systems include at least one electrode to deliver electrical stimulation to the dorsal root ganglion to activate afferent nerves innervating at least one organ, and computing apparatus comprising one or more processors operably coupled to the at least one electrode to control the electrical stimulation.

Abstract: Various embodiments of the present technology generally relate to closed loop deep brain stimulation based on inferred sleep stage from physiological data using machine learning classifiers. Some embodiments, for example, may use subthalamic nucleus (STN) deep brain stimulation (DBS) to treat advanced Parkinson's Disease motor symptoms and improve sleep by identifying sleep stages commensurate with clinician-scored polysomnography (PSG). The DBS may be adapted to include a novel artificial neural network (ANN) that triggers targeted stimulation in response to inferred sleep state from STN local field potentials (LFPs) recorded from implanted DBS electrodes. A feedforward neural network can be trained to prospectively identify sleep stage with PSG-level accuracy. In some embodiments, the machine learning model stored within the DBS may also adapt stimulation during specific sleep stages to treat targeted sleep deficits.

Abstract: The present invention relates to a system and method for replacing an implanted medical device with an implantable medical replacement device, wherein a programming device sends a command signal to the medical device to change an address of the medical device to a new address being different from an address of the replacement device to allow independent communication of the programming device with both the medical device and the replacement device.

Abstract: A surgical system comprises a sterile adapter assembly comprising a mechanical surgical instrument removal lockout and a mechanical sterile adapter assembly removal lockout. The mechanical sterile adapter assembly removal lockout is activated on a condition of a surgical instrument mounted in the sterile adapter assembly. The mechanical surgical instrument removal lockout is activated by a surgical instrument manipulator assembly on a condition of the surgical instrument being mounted in the sterile adapter assembly and movement of the surgical instrument manipulator assembly by a predetermined distance.

Abstract: One aspect is a method of manufacturing a lead connector for an implantable medical device. The method includes connecting proximal ends of a plurality of conductive pins to a corresponding one of a plurality of ring contacts to form a plurality of ring-pin subassemblies, assembling each of the plurality of ring-pin subassemblies on an assembly frame, including inserting the plurality of conductive pins in a corresponding plurality of openings within the assembly frame such that the corresponding plurality of ring contacts are spaced along a longitudinal dimension of the assembly frame, arranging the assembly frame along with the conductive pins and corresponding ring contacts within a mold cavity, filling the mold cavity with a mold material that surrounds the assembly frame, and removing a resulting lead connector from the mold cavity.

Abstract: The invention is a method for processing a phonocardiographic signal characterising fetal breathing movement (FBM), wherein in initial start point (SP) determination (S100) in frequency filtering (S110), bandpass-filtered signals of frequency subbands by first and second bandpass filters are generated from the phonocardiographic signal, and first identified SP of an FBM episode is determined in a frequency subband in SP search (S120), in episode discovering (S130) further SP is searched applying the SP search (S120) in episode search time period, and if found at smaller distance from identified SP than a clustering threshold, it is merged with identified SP, if found at larger distance from identified SP than the clustering threshold, an SP closest to identified SP is identified as second identified SP. The invention is, furthermore, a system for processing a phonocardiographic signal characterising FBM. (FIG.

Abstract: Obstructive sleep apnea from blockage of the upper airway can result in significant daytime drowsiness, with many long-term co-morbidities associated with this disorder such as such as hypertension. A common cause of obstructive sleep apnea is the complete concentric collapse of the soft pallet or retrusion of the genioglossus muscle into the upper airway obstructing breathing. The latter can be due to exhaustion of the muscle due to heightened activation during wake periods, or a greater number of type II muscle fibers can contribute to muscle fatigue. It could also be neurological, whereby the hypoglossal nerve which controls most the upper airway muscles fails to innervate the genioglossus sufficiently to prevent backward movement and pharyngeal block.

Abstract: A multi-electrode ear shell includes an inner surface and an outer surface, the inner surface corresponding to a surface of an ear and being configured to overlap a cymba and a cavum of the ear. The multi-electrode ear shell further includes a first socket to receive a first stimulation electrode and a second socket to receive a second stimulation electrode.

Abstract: Bioelectronic lens (E-lens) systems for inducing neuroprotective changes in neurons, in particular the retina. A system may include a stimulating electrode configured to be placed on an eye or skin around the eye. The system may further include a return electrode configured such that voltage distribution is focalized to the eye and induced electric fields to an area of interest on the eye or on the skin around the eye are maximized. The electric fields provide neuroprotection and reinnervation.

Abstract: Devices, systems, and techniques for identifying electrodes closest to a target region of tissue are described. In one example, a device includes sensing circuitry configured to sense electrical signals from a plurality of electrode combinations. Processing circuitry identifies a first electrode combination of a first subset of electrode combinations. Each electrode combination of the first subset of electrode combination includes electrodes located at different axial positions along a length of the medical lead. The processing circuitry identifies a second electrode combination of a second subset of electrode combinations. Each electrode combination of the second subset of electrode combinations includes electrodes located at a same axial position and different circumferential positions around a perimeter of the medical lead. The processing circuitry then determines a third electrode combination and controls delivery of electrical stimulation via the third electrode combination.

Abstract: A method of determining brain stimulation parameters includes applying Low Frequency Stimulation (LFS) to a contact of a multi-contact electrode implanted in a target structure in an individual's brain. Evoked Compound Activity (ECA) evoked in the target structure by the LFS is measured. A range of frequencies for delivering brain stimulation within a predetermined range based on a phase space extracted from the ECA is determined. Stimulation frequencies are applied to the contact of the multi-contact electrode within the determined range of frequencies. High Frequency Oscillations (HFO) evoked in the target structure by the applied stimulation frequencies within the determined range are measured. A frequency evoking HFO above a predetermined threshold is determined. The determined frequency is selected as a treatment frequency for the target structure.

Abstract: Electrostimulation systems and methods are contemplated in which a high current level, charge balanced alternating current electrical signal is generated for delivery to the cortex region of a patient's brain for treating opioid use disorder and substance use disorder. By stimulating this region of the brain with a charged balanced stimulation current with a stimulation current envelope defining one or more series of pulses at particular frequencies and durations designed to evoke metabolic response in the neurons, significant improvements in efficacy and reductions in patient discomfort may be achieved relative to earlier methods of transcranial electrical stimulation. Further advantages, especially in promoting neural entrainment, may be realized as well via utilizing multiple series of pulses at different frequencies, and via the dynamic adjustment of the stimulation waveform via incorporation of feedback signals in order to maintain charge balance in real-time.

Abstract: An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Abstract: A method of applying tumor treating fields to a subject's body includes: inducing a modulated electric field between a first transducer and a second transducer to treat a tumor of the subject's body, wherein the first transducer is located at a first location of the subject's body, and wherein the second transducer is located at a second location of the subject's body.

Abstract: In various examples, a header of an implantable device includes a first header portion and a second header portion at least partially disengageable from the first header portion. In a closed configuration, the first header portion is fully engaged with the second header portion, and in an open configuration, the first header portion is at least partially disengaged from the second header portion. At least one bore within the header is sized and shaped to accommodate a proximal end of a lead. The bore is split substantially longitudinally to form a first bore portion and a second bore portion. With the proximal end of the lead disposed within the bore and a positioning feature interacting with a lead feature, at least one lead contact aligns with at least one header contact to allow the at least one lead contact to electrically couple to the at least one header contact.

Abstract: Methods and systems for method for acoustic treatment of tissue to disperse vacuoles within the tissue. Some of the present methods and systems comprise: directing pulsed acoustic waves from the acoustic wave generator into the tissue containing the vacuoles. Some of the present methods include identifying the location of tissue containing vacuoles, and/or coupling (e.g., acoustically) an acoustic wave generator to the tissue containing the vacuoles.

Abstract: A subcutaneous implantable active medical device, in particular a subcutaneous cardiac defibrillator, comprising a housing and a subcutaneous implantable lead connected to the housing. The subcutaneous implantable lead comprises a plurality of sensing electrodes forming at least two dipoles from which at least two electrical signals are collected concurrently. The first dipole having a first length less than a second length of the second dipole. The subcutaneous implantable active medical device further comprises a controller configured to determine whether or not tachyarrhythmia is present by determining a criterion of similarity based on the electrical signals collected concurrently via the first dipole and via the second dipole during a defined series of cardiac cycles that is such that detection of a depolarization peak, corresponding to detection of an R wave, is performed via the first dipole.