Abstract: The present invention provides a transforming growth factor-.beta. receptor associated protein (TGFAS) and polynucleotides which identify and encode TGFAS. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of TGFAS.
Abstract: Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil Inhibitory Factors which also which inhibit neutrophil activity. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions and recombinant Neutrophil Inhibitory Factors are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
Type:
Grant
Filed:
December 23, 1993
Date of Patent:
May 5, 1998
Assignee:
Corvas International, Inc.
Inventors:
Matthew Moyle, David L. Foster, George P. Vlasuk