Abstract: Disclosed are human K.sub.+ channel polypeptides and DNA (RNA) encoding such K.sub.+ channel polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques. Agonists for such K.sub.+ channel polypeptides are also disclosed. Such agonists may be used to treat epilepsy, stroke, hypertension, asthma, Parkinson's disease, schizophrenia, anxiety, depression and neurodegeneration. Also disclosed are antagonists against such polypeptides which may be used to treat AIDS, SLE, diabetes, multiple sclerosis and cancer. Also disclosed are diagnostic assays for detecting mutations in the polynucleotide sequences of the present invention.