Patents Examined by DatQuan Lee
  • Patent number: 6123949
    Abstract: The present invention provides a recombinant fowlpox virus designated S-FPV-043 (ATCC Accession No. VR 2395). A vaccine useful for immunizing an animal against fowlpox virus and Newcastle disease virus is provided which comprises an effective immunizing amount of S-FPV-043 and a suitable carrier. A method of immunizing an animal against fowlpox virus and Newcastle disease virus is also provided which comprises administering to the animal an effective immunizing dose of the vaccine.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 26, 2000
    Inventors: Mark D. Cochran, David E. Junker
  • Patent number: 6096016
    Abstract: A topsheet for body exudates absorbent article includes a hydrophilic nonwoven fibrous sheet and a plurality of thermoplastic synthetic resin filaments extending in one direction parallel to one another and continuously bonded to an upper surface of the nonwoven fibrous sheet so that a composite sheet of these sheet and filaments have crests and troughs alternately repeating longitudinally of the filaments and respectively extend transversely of the filaments. An apparatus and a method for manufcturing the topsheet are also disclosed, wherein a pair of mutually engageable embossing rolls are used for forming the crests and the troughs onto the coposite sheet.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: August 1, 2000
    Assignee: Uni-Charm Corporation
    Inventors: Tomoko Tsuji, Hisashi Takai, Hiroki Goda
  • Patent number: 6075139
    Abstract: Sucrose ester and ether products, useful as food or beverage bulking agents, reduced calorie sweeteners, fat replacement agents, stabilizing agents, thickening agents and emulsifying agents; adhesives; biodegradable plastics and films; sizing agents for paper and textiles; ethical pharmaceuticals and new fibers are prepared by using a two-phase reaction system in which sucrose is dissolved in an alkaline, aqueous solution and an acidic reagent such as a bifunctional acid dichloride or epoxide is added to the sucrose in a water-immiscible organic solvent. Several types of products are produced: water-insoluble sucrose ester (ether) copolymers; water-soluble sucrose ester (ether) copolymers; sucrose ester (ether) dimers; and intramolecular, cyclic sucrose esters (ethers). These products can be further varied by using different kinds of acid dichlorides or epoxides that contain different kinds of functional groups.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: June 13, 2000
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: John F. Robyt, Rupendra Mukerjea
  • Patent number: 6042830
    Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: March 28, 2000
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Danny W. Chladek, David E. Gorcyca, Louis L. Harris
  • Patent number: 6027750
    Abstract: The present invention contemplates a system for rapidly isolating nucleic acids. The system comprises an insoluble silica matrix and a buffered aqueous salt solution containing salt at a concentration of at least 3 molar and a buffering agent at a concentration sufficient to provide a buffering capacity corresponding to that which either tris(hydroxymethyl)aminomethane or phosphate ion at a concentration of 0.1 to 1 molar would provide in the solution. Methods of using the system are also contemplated.
    Type: Grant
    Filed: January 25, 1996
    Date of Patent: February 22, 2000
    Inventors: James Gautsch, Mark Brolaski
  • Patent number: 6025141
    Abstract: The present invention relates to the use of insoluble forms of recombinant proteins in a flow cytometric immunofluorescence assay for the detection of given antibodies.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: February 15, 2000
    Assignee: The Canadian Red Cross Society
    Inventor: Yu-Wen Hu
  • Patent number: 6007845
    Abstract: Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently linking a multifunctional compound with one or more hydrophobic polymers and one or more hydrophilic polymers, and contain a biologically active material. The terminal hydroxyl group of the poly(alkylene glycol) can be used to covalently attach onto the surface of the particles biologically active molecules, including antibodies targeted to specific cells or organs, or molecules affecting the charge, lipophilicity or hydrophilicity of the particle. The surface of the particle can also be modified by attaching biodegradable polymers of the same structure as those forming the core of the particles.
    Type: Grant
    Filed: March 25, 1996
    Date of Patent: December 28, 1999
    Assignee: Massachusetts Institute of Technology
    Inventors: Abraham J. Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia, Robert S. Langer
  • Patent number: 6005004
    Abstract: The present invention describes site-specific biomolecular complexes comprising a therapeutic, prophylactic and diagnostic agent, called also biologically active molecule and an omega-3 fatty acid and derivatives thereof. The complexes are further covalently bonded with cationic carriers and permeabilizer peptides for delivery across the blood-brain barrier and with targeting moieties for uptake by target brain cells. Said complexes are particularly useful for delivery of a biologically active agent to the glial tissue of the brain as well as to the cortical, cholinergic and adrenergic neurons. The preferred therapeutic complexes or conjugates comprise an omega-3 fatty acid such as alpha-linolenic acid, eicosapentaenoic acid or docosahexaenoic acid and derivatives thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 21, 1999
    Assignee: Molecular / Structural Biotechnologies, Inc.
    Inventors: Robert Katz, Maria Tomoaia-Cotisel
  • Patent number: 6001255
    Abstract: The invention provides a process for the production and utilization of water-soluble salts selected from the group consisting of water-soluble salts of carboxylic acids and water-soluble salts of amino acids, comprising reacting an aqueous feed solution containing an amino or carboxylic acid or their anions with a water-soluble base, in indirect contact via a semi-permeable membrane, the membrane being permselective to amino acids, carboxylic acids and their anions over cations and non-ionized species, whereby there is formed a salt solution of the acid containing less impurities per anion than the feed solution and utilizing the salt values from the formed salt solution of the acid.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: December 14, 1999
    Inventors: Aharon Eyal, Avraham Baniel, Larry G. Pillard
  • Patent number: 5998601
    Abstract: A nucleotide sequence is provided for the VR-2332 virus, which is capable of causing Porcine Reproductive and Respiratory Syndrome. The nucleotide sequence includes protein coding regions that are inserted into recombinant vectors for the host expression of viral proteins according to a variety of vaccination techniques. Diagnostic assays utilize fragmentary sequences or oligonucleotides to selectively identify the VR-2332 nucleic acids by hybridization or PCR amplification reactions that distinguish VR-2332 nucleotide sequences from other PRRS-causative viruses which are immunologically distinct from VR-2332.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: December 7, 1999
    Assignee: Regents of The University of Minnesota
    Inventors: Michael P. Murtaugh, Margaret R. Elam, Laura T. Kakach
  • Patent number: 5989563
    Abstract: A substantially avirulent vaccine against Porcine Reproductive and Respiratory Syndrome (PRRS) is provided, which effectively immunizes swine against the U.S. and European forms of the disease, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
    Type: Grant
    Filed: August 15, 1996
    Date of Patent: November 23, 1999
    Assignee: Boehringer Ingelheim Vetmedica, Inc.
    Inventors: Danny W. Chladek, David E. Gorcyca, Louis L. Harris
  • Patent number: 5980906
    Abstract: The live recombinant avian vaccine comprises, as vector, an avian herpesvirus comprising at least one nucleotide sequence coding for and expressing an antigenic polypeptide of an avian pathogenic agent, inserted into the region lying between the ATG of ORF UL55 and the junction of U.sub.L with the adjacent repeat region, under the control of the CMV immediate early promoter. The vector is preferably chosen from the group consisting of Marek's disease viruses (MDV and HVT), infectious laryngotracheitis virus ILTV and herpes of ducks. A polyvalent vaccine formula comprises at least two vaccines of this type, with different inserted sequences.
    Type: Grant
    Filed: December 26, 1995
    Date of Patent: November 9, 1999
    Assignee: Rhone Merieux
    Inventors: Jean-Christophe Francis Audonnet, Michel Joseph Marie Bublot, Raphael Jean Darteil, Carole Veronique Duinat, Eliane Louise Fran.cedilla.oise Laplace, Michel Albert Emile Riviere
  • Patent number: 5977263
    Abstract: Thermal transfer articles of the invention comprising a carrier, optionally a release layer, a color layer releaseably adhered thereto, and optionally an adherence layer on the bottom side of the color layer. Also methods for thermal transfer using such articles and signage made by such methods. The transfer articles of the invention 1) exhibit thermoplastic, low cohesive properties during transfer such that good image resolution and transfer is achieved and 2) are thermally crosslinked such that a durable image is formed.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: November 2, 1999
    Assignee: 3M Innovative Properties Company
    Inventor: Nancy H. Phillips
  • Patent number: 5972691
    Abstract: Process for making polyamine-epihalohydrin resin products having very low levels of epihalohydrin or epihalohydrin hydrolyzates, particularly useful in papermaking, which includes, amongst other features, producing a polyamine-epihalohydrin polymer in aqueous solution, terminating the reaction by cooling, adjusting the pH of the polyamine-epihalohydrin solution to from about 7.5 to about 11 and concurrently heating the solution to about 35 to about C., and contacting the aqueous solution with selected microorganisms or an enzyme, and deactivating or removing the enzymes or microbes, cooling to about C. and stabilizing the composition by adjusting the pH to about 2.0 to 5.0 by the addition of acid.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 26, 1999
    Assignee: Hercules Incorporated
    Inventors: Robert Bates, Harvey J. Branton, David J. Hardman, Gary K. Robinson
  • Patent number: 5972324
    Abstract: The present invention relates to a dimeric urethane compounds derived from monohydric alcohols, generally fatty alcohols, and a diisocyanate according to the following reaction scheme: ##STR1## wherein R.sub.1 is selected from the group of saturated or halogen substituted linear, cyclic or branch-chained hydrocarbons and R.sub.2 is a linear, cyclic or branch-chained alkyl or aminoalkyl group ranging from two to 200 carbon atoms, preferably two to 50 carbons, more preferably 6 to 36 carbons, said urethane compound being substantially free from terminal hydroxyl groups.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: October 26, 1999
    Assignee: Alzo, Inco.
    Inventors: Albert Zofchak, Madeline Kenney, John Obeji, Michael Mosquera
  • Patent number: 5968548
    Abstract: Liposome-encapsulated quinolones and specifically liposome-encapsulated ciprofloxacin dramatically enhances macrophage functions, induces NO production and augments the production of cytokines, rendering the composition an immunoprophylactic and immunotherapeutic agent with unique clinical potential. Liposome-encapsulated ciprofloxacin and other quinolones could be extremely useful in antimicrobial, anticancer and AIDS therapies. In such cases, the immunological status of the patient is often compromised or suppressed, making them susceptible to microbial infections and to the development of tumor growth. Selective augmentation of cellular immunity by activation of the microbicidal and tumoricidal activities of macrophages, induction of NO and cytokine production could be of primary importance to such patients in terms of protecting them against microbial infections and inducing their cellular host defense to tumor cells.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: October 19, 1999
    Assignee: Minister of National Defence of Her Majesty's Canadian Government
    Inventors: Jonathan P. Wong, Edward G. Saravolac, Les P. Nagata
  • Patent number: 5948415
    Abstract: The present invention relates to new compounds, which are -substituted ornithine derivatives, having the formula (I)HOOC--CH(NH.sub.2)--(CH.sub.2).sub.3 --NH--(X).sub.h --(CH.sub.2).sub.j --(CHOH).sub.k --(CH.sub.2).sub.m --(O).sub.n --(CH.sub.2).sub.p --Rin which R represents a hydrocarbon alkyl radical or a perfluorinated alkyl radical, X is a divalent radical chosen from --CO--O--, --CO--NH-- and --SO.sub.2 --, h, j, k, m and n are, independently, zero or 1 and p is zero to 4, a salt of a compound of formula (I), an optical isomer of D or L configuration thereof or a mixture thereof. The invention also relates to a process for the preparation of these compounds, to their use, especially in cosmetics, and to compositions, especially cosmetic compositions, comprising them.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: September 7, 1999
    Assignee: L'Oreal
    Inventors: Michel Philippe, Thierry Bordier
  • Patent number: 5948411
    Abstract: Disclosed is a stabilized live vaccine containing a varicella virus and a stabilizer, wherein the vaccine is substantially free of Ca.sup.2+ ions and Mg.sup.2+ ions. This stabilized live vaccine is extremely excellent in storage stability and heat resistance. Also disclosed is an improved stabilizer for a live varicella vaccine, comprising at least one member selected from gelatin and hydrolyzed gelatin, each being substantially free of Ca.sup.2+ ions and Mg.sup.2+ ions. The stabilizer can advantageously be used to stabilize a live vaccine containing a varicella virus. The substantial freedom of Ca.sup.2+ ions and Mg.sup.2+ ions can be attained by masking Ca.sup.2+ ions and Mg.sup.2+ ions present in a live vaccine containing a varicella virus and a stabilizer, with a chelating reagent, or by using as a stabilizer gelatin and/or a gelatin derivative after being purified to remove Ca.sup.2+ ions and/or Mg.sup.2+ ions contained therein.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: September 7, 1999
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Kuniaki Koyama, Juichiro Osame
  • Patent number: 5932516
    Abstract: A reversible thermosensitive coloring composition is provided, which contains (a) an electron-donating coloring compound; and (b) an electron-accepting compound, which is an aromatic carboxylic acid compound comprising at least one hydrocarbon group, which induces color formation in the electron-donating coloring compound. The reversible thermosensitive coloring composition reversibly assumes a color-developed state or a decolorized state, in response to at least one of (1) the temperature thereof when heated and (2) the cooling rate of the reversible thermosensitive coloring composition when cooled after the heating thereof. A reversible thermosensitive recording medium using the coloring composition is also provided.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: August 3, 1999
    Assignee: Ricoh Company, Ltd.
    Inventors: Masafumi Torii, Hiromi Furuya, Masaru Shimada, Kyoji Tsutsui
  • Patent number: 5919461
    Abstract: An Infectious Bursal Disease Virus of the Delaware Variant E type having the characteristics of being able to grow on both VERO cells and CEF cells, reacting with monoclonal antibody BK9 produced by the cell line having ATCC deposit number HB-10157, not causing bursal atrophy after vaccination and not spreading to birds in physical proximity to immunized birds, said virus being identified as Delaware Variant E 89-03.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: July 6, 1999
    Assignee: Akzo Nobel N.V.
    Inventors: Piet van der Marel, Martinus A. J. Thijssen, David Snyder, deceased, Dieter Lutticken, Ruud Hein