Patents Examined by David E. Wheeler
  • Patent number: 4230711
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently alkyl groups containing 1 to 6 carbon atoms; R.sup.3 is a haloalkyl group of the formula C.sub.m Y.sub.(m-1) X.sub.(m+2) wherein X is fluoro, chloro, bromo or iodo and m=1 or 2; Y is hydrogen, fluoro, chloro, bromo or iodo; R.sup.4 is hydrogen, an alkyl group containing 1 to 6 carbon atoms, alkoxy containing 1 to 6 carbon atoms, alkenyl containing 2 to 6 carbon atoms, nitro, hydroxy, alkoxyalkyl containing 2 to 6 carbon atoms, fluoro, bromo, chloro or iodo and n-1, 2, 3 or 4, have fungicidal activity.
    Type: Grant
    Filed: January 31, 1979
    Date of Patent: October 28, 1980
    Assignee: Chevron Research Company
    Inventor: Stephen D. Ziman
  • Patent number: 4225707
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.2 is carboxy or a protected carboxy group,R.sup.4 is hydrogen or lower alkyl andY is a residue of an acid, or a salt.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: September 30, 1980
    Assignee: Fujisawa Pharmaceutical Company, Limited
    Inventors: Takashi Kamiya, Takao Takaya
  • Patent number: 4224049
    Abstract: Compatibility agents were developed for improving the compatibility and stability of mixtures of liquid fertilizers and liquid or wettable powdered pesticides. These compatibility agents contain water, a low alkanol and an alkylaryl polyoxyethylene glycol phosphate ester. The compatibility agent is used at a preferred concentration range of 0.1 to 0.4% of the fertilizer solution. The preferred compatibility agent not only improves the compatibility of liquid fertilizer-pesticide mixtures, but also results in uniform and stable mixtures ensuring accurate pesticide applications. The preferred compatibility agent is a mixture containing about 16% water, about 20% methanol and about 64% of an octylphenol polyoxyethylene glycol phosphate ester.
    Type: Grant
    Filed: November 1, 1978
    Date of Patent: September 23, 1980
    Assignee: Hopkins Agricultural Chemical Co.
    Inventors: Bala N. Devisetty, James R. Hanson
  • Patent number: 4221797
    Abstract: The compounds are amino- or cyano-bearing dihydroquinolines, which have either of the combinations of (a) 2-amino, 3-carboxylic and 4-oxo functions, or (b) 2-oxo, 3-cyano and 4-hydroxy functions, and may be optionally substituted at 1 or 2 of the 5, 6, 7 or 8 positions, eg 1-allyl-2-amino-1,4-dihydro-6,7-dimethoxy-4-oxo-quinoline-3-carboxylic acid ethyl ester, and 1-allyl 3-cyano-1,2-dihydro-4-hydroxy-6,7-dimethoxy-2-oxo-quinoline. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: September 9, 1980
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Patent number: 4220774
    Abstract: The preparation of vincadifformine and some derivatives thereof for use as a starting material for synthesis of the corresponding vincamine derivatives or for synthesis of bisindole alkaloids having clinically important antitumor properties.
    Type: Grant
    Filed: October 26, 1978
    Date of Patent: September 2, 1980
    Assignee: Omnium Chimique
    Inventor: Martin E. Kuehne
  • Patent number: 4220779
    Abstract: Quinoline derivatives, especially those of the formula ##STR1## wherein X represents halogen, nitro or CF.sub.3,Z represents hydrogen, alkyl or aryl,Y represents hydrogen, OH, CN, COR or SO.sub.3 H,R represents alkyl, alkoxy or aryl andn represents an integer from 0 to 4,are obtained in high yields when corresponding aromatic orthodichloromethyl isocyanates are converted by hydrolysis and decarboxylation into the corresponding ortho-aminoaldehydes and these are subjected to a condensation reaction with carbonyl compounds containing an active .alpha.-methylene group.The process products are starting materials for dyestuffs, insecticides and others.
    Type: Grant
    Filed: June 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Volker Ehrig, Hans-Samuel Bien, deceased, Erich Klauke, Detlef-Ingo Schutze
  • Patent number: 4220644
    Abstract: The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted tetrazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: September 2, 1980
    Assignee: SmithKline Corporation
    Inventor: David A. Berges
  • Patent number: 4220761
    Abstract: R.sup.2 is an aliphatic hydrocarbon residue which may be substituted with hydroxy, protected hydroxy or lower alkylthio,R.sup.3 is a heterocyclic group substituted with amino(lower)alkyl, protected amino(lower)alkyl or hydroxy(lower)alkyl, andR.sup.4 is carboxy or functionally modified carboxy, "syn" or "anti" isomer.
    Type: Grant
    Filed: September 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Takao Takaya, Takashi Masugi, Hisashi Takasugi, Hiromu Kochi
  • Patent number: 4220777
    Abstract: Naphthalimide derivatives of the general formula ##STR1## where R.sup.1 is hydrogen or C.sub.1 - to C.sub.4 -alkyl,R.sup.2 is nitrile or a radical containing a carbonyl group or an acetalized carbonyl group andR.sup.3 and R.sup.4 are unsubstituted or substituted alkyl.The compounds are excellent optical brighteners, especially for synthetic fibers.
    Type: Grant
    Filed: November 17, 1978
    Date of Patent: September 2, 1980
    Assignee: BASF Aktiengesellschaft
    Inventors: Jochen Karg, Manfred Patsch, Walter Himmele
  • Patent number: 4219648
    Abstract: This invention is directed to new 7-[[amino(1,3-dihydrobenzo[c]thien-5-yl)acetyl]amino]cephalosporin derivatives useful as antibiotics.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: August 26, 1980
    Assignee: Richardson-Merrell Inc.
    Inventor: Michael L. Edwards
  • Patent number: 4218564
    Abstract: The compounds of this invention are 7.beta.-hydroxy-3-heterocyclicthiomethyl cephalosporins useful as intermediates for the preparation of 7.beta.-acyloxy cephalosporins.
    Type: Grant
    Filed: December 1, 1976
    Date of Patent: August 19, 1980
    Assignee: SmithKline Corporation
    Inventor: John G. Gleason
  • Patent number: 4217348
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, furyl, or pyridyl, or 2-amino-4-thiazolyl; X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, ##STR2## R.sub.3 is hydrogen, ##STR3## --O--lower alkyl, or certain substituted or unsubstituted heterothio groups; are disclosed. These compounds possess useful antibacterial activity.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: August 12, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Hermann Breuer
  • Patent number: 4217450
    Abstract: Compounds having the following formula: ##STR1## wherein X is a radical selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, methyl and amino.Y is a radical selected from the group consisting of hydrogen and hydroxy, andA is an organic compound residue selected from the group consisting of having the formula: ##STR2## wherein Z is a radical selected from the group consisting hydrogen, acyloxy, carbamoyloxy, (heteroaromatic) thio, pyridinium, quinolinium and picolinium; and salts thereof, are useful as anti-bacterial agents active against Pseudomonas aeruginosa.
    Type: Grant
    Filed: June 7, 1978
    Date of Patent: August 12, 1980
    Assignee: Ajinomoto Company, Incorporated
    Inventors: Naohiko Yasuda, Chikahiko Eguchi, Masaru Okutsu, Yoshiteru Hirose
  • Patent number: 4216215
    Abstract: A series of novel 7-(D-.alpha.-acylaminoarylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein the acyl moiety contains an epoxy group immediately adjacent to the carbonyl carbon atom. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-negative and Gram-positive bacteria. Preferred members include 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]-3-(1-meth yl-1,2,3,4-tetrazol-5-ylthiomethyl)-.DELTA..sup.3 -cephem-4-carboxylic acid and 7-[D-.alpha.-(cis-2-carboxyoxiran-3-carboxamido)phenylacetamido]cephalospo ranic acid. Alternate methods of preparation are provided for these compounds and the principal synthetic route is described in detail.
    Type: Grant
    Filed: November 6, 1978
    Date of Patent: August 5, 1980
    Assignee: Pfizer Inc.
    Inventors: Barry C. Ross, Braham Shroot
  • Patent number: 4216324
    Abstract: 1-Difluoromethyl-6,7-methylenedioxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and certain of its alkylaminoalkyl esters, useful in treating bacterial infections in mammals.
    Type: Grant
    Filed: December 26, 1978
    Date of Patent: August 5, 1980
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Kyu T. Lee
  • Patent number: 4211779
    Abstract: Antibacterial 7.alpha.-methoxy-3-cephem derivatives of the formula: ##STR1## [wherein R.sup.1 is hydrogen, or organic or inorganic acyl;R.sup.2 is alkyl; andCOR.sup.3 is carboxy or protected carboxy],methods of production, and pharmaceutical preparations thereof.
    Type: Grant
    Filed: August 2, 1977
    Date of Patent: July 8, 1980
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masayuki Narisada, Teruji Tsuji, Hiromu Matsumura, Wataru Nagata
  • Patent number: 4210584
    Abstract: Vindesine is prepared by converting 4-desacetyl VLB C-3 carboxhydrazide to the corresponding azide with a nitrite such as n-butyl nitrite in THF and then reacting the thus formed azide with triphenylphosphine to yield an intermediate acyl iminophosphorane, which compound is decomposed with acid to yield vindesine of high purity and in good yield.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: July 1, 1980
    Assignee: Eli Lilly and Company
    Inventors: Gloria C. Paschal, Gerald L. Thompson
  • Patent number: 4210750
    Abstract: Alcohols are reacted with certain isocyanate compounds to produce the N-substituted carbamoyloxy derivatives which are cleaved to obtain the carbamate.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: July 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Stephen Marburg, Janos Kollonitsch
  • Patent number: 4208517
    Abstract: Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b, which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together wth the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; R.sup.c and R.sup.d, which may be the same or different, each represents a hydrogen atom or a substituting group e.g. an alkyl group or substituted alkyl group; or R.sup.c and R.sup.d together with the nitrogen atom to which they are attached form a saturated or unsaturated heterocyclic ring which contains 5-7 ring members and which may contain additional hetero atoms, and may be substituted by lower alkyl; R.sup.e represents hydrogen or C.sub.
    Type: Grant
    Filed: November 28, 1977
    Date of Patent: June 17, 1980
    Assignee: Glaxo Operations UK Limited
    Inventors: Michael W. Foxton, Gordon I. Gregory, David M. Rogers
  • Patent number: 4205176
    Abstract: Oxazolines having at least one 3,5-dialkyl-4-hydroxypheny l alkanoic acid ester substituent are provided. Such oxazolines are found to be useful an antioxidants in organic substances normally susceptible to oxidative deterioration.
    Type: Grant
    Filed: October 18, 1978
    Date of Patent: May 27, 1980
    Assignee: Cincinnati Milacron Chemicals Inc.
    Inventors: Mary J. Zestermann, John F. Hussar