Abstract: 6,7-Dimethoxy-4-amino-2-(4-substituted piperazin-1-yl)-quinazolines and 6,7,8-trimethoxy-4-amino-2-(4-substituted piperazin-1-yl)quinazolines are produced by either: (1) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzonitrile with certain 1,4-disubstituted piperazines; or (2) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzamidine with the same 1,4-disubstituted piperazines. The products are known hypotensive agents.

Abstract: Protoberberine derivatives having the general formula: ##SPC1##Wherein R.sub.1 is a lower alkoxy group, i.e. C.sub.1 to C.sub.5 alkoxy; R.sub.2 is a lower alkyl group, i.e. C.sub.1 to C.sub.5 alkyl, pyridyl group, phenyl group substituted by two or three lower alkoxy groups, i.e. C.sub.1 to C.sub.5 alkoxy or a phenylvinyl group substituted by two or three lower alkoxy groups, i.e. C.sub.1 to C.sub.5 alkoxy; having excellent analgesic, vasodilating and hypotensive effects and are prepared from know protoberberines by reaction with carobxylic acids.

Abstract: 9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazoles of the formula ##SPC1##Wherein R.sub.1 is acyl and R.sub.2 is hydrogen or lower alkyl, are described. The end products actively inhibit the growth of transplantable tumors, and are therefore useful as cytostatic agents.

Abstract: Direct production of 1,9-anthrapyrimidine-2-carboxylic acid-1'-anthraquinonylamide in pigmentary form by reaction of 1,9-anthrapyrimidine-2-carboxylic acid chloride with 1-amino-anthraquinone in a polar water-miscible aprotic solvent. The dye is obtained in a high yield and in a very finely divided and pure form. The isolated reaction product may be used direct as a pigment.

Abstract: A class of pyrylium dyes, having at least one rigidized, nitrogen-containing heterocyclic ring fused thereto is described. The rigidized dyes are useful lasing components in lasing media.

Abstract: Dimeric indole alkolids-vinblastine, des-N-methyl-vinblastine and vincristine-are purified by extracting leaves of Vinca rosea with acid, neutralizing the acidic solution, extracting the dimeric alkaloids into an aromatic solvent, optionally subjecting the extracted alkaloids to gel exclusion chromatography, precipitating the dimeric alkaloids as sulfate salts and finally separating the dimeric alkaloids by high-pressure chromatography.

Abstract: Compounds of the general formula (I): ##SPC1##in which R.sub.1, R.sub.2 and R.sub.3 may be the same or different and each represents a hdyrogen atom, an alkyl group, a nitro group, a halogen atom or a group of the formula --NR.sub.4 R.sub.5 or --OR.sub.4 ; in which the groups R.sub.4 and R.sub.5 may be the same or different and each represent a hydrogen atom, or an alkyl, alkenyl or cycloalkyl group (which alkyl group may optionally be substituted by alkoxy, hydroxy, amino, alkylamino, dialkylamino or aryl groups) or R.sub.4 and R.sub.5 together with the nitrogen atom form a heterocyclic ring which may optionally contain additional hetero atoms, e.g. morpholino or piperazinyl; and R.sub.6 represents a hydrogen atom or an alkyl group.These compounds have biological activity, particularly in inhibiting the release of spasmogenic substances arising as a consequence of antigen-antibody reactions.

Abstract: Disclosed are N,N'-Bis(4-Quinazolinyl)alkanediamines, e.g., N,N'-Bis(7-chloro-4-quinazolinyl)-1,9-nonanediamine, having pharmacological activity in animals and useful for example, as anti-obesity agents. Said compounds may be prepared by reacting a 4-haloquinazoline with an alkanediamine.

Abstract: Novel quinoxaline-1,4-dioxides of the formula ##SPC1##Wherein R is hydrogen or methyl;Y is lower alkyl; andn is 0, 1, or 2;Methods for their preparation; and their use as antibacterial agents and agents for promoting growth and improving feed efficiency of animals. Additionally, those compounds wherein n is 0 or 1 serve as intermediates for preparation of compounds wherein n is 1 or 2.