Abstract: Methods and devices to diagnose and treat male urinary incontinence and sexual dysfunction are provided. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and manipulation or positioning of the bladder. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles.

Abstract: Aspects relate to an energy harvesting device adapted for use by an athlete while exercising. The device may utilize a mass of phase-change material to store heat energy, the stored heat energy subsequently converted into electrical energy by one or more thermoelectric generator modules. The energy harvesting device may be integrated into an item of clothing, and such that the mass of phase change material may store heat energy as the item of clothing is laundered.

Abstract: A method of detecting the presence of a person on a bed comprising, receiving movement data in pseudo-real-time, extracting features from the movement data for a time period in pseudo-real-time, recording the user's on-bed and off-bed time segments, and determining a sleep schedule. The method further comprising utilizing a sleep engine to determine sleep stages for the user, and calculating sleep conditions. The method in one embodiment further comprising adjusting the bed when the sleep conditions indicate an event.

Abstract: A perspiration mapping patch according to the present disclosure is attached to skin of a user to absorb sweat, and includes: a sweat absorbing layer in which a plurality of opening units is arranged; a first support layer which is stacked on a first surface of the sweat absorbing layer and includes an opening opened to correspond to each of the plurality of opening units; and a second support layer stacked on a second surface facing an opposite side of the first surface of the sweat absorbing layer.

Abstract: A method, a computer program product, and a computer system provide medications to a patient with a time gap. The method includes determining a dissolving pattern for the patient. The dissolving pattern includes a medication dissolving rate for a first medication prescribed to the patient and a filler dissolving rate for a filler selected so that the time gap is elapsed prior to a second medication being provided after the first medication. The medication dissolving rate and the filler dissolving rate are specific to the patient. The method includes determining dimensions of the first medication to correspond to a dosage of the prescribed first medication and dimensions of the filler to correspond to the time gap. The method includes providing a pill including at least the first medication and the filler, the first medication surrounding the filler such that the first medication is dissolved prior to the filler being dissolved.

Abstract: A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.

Abstract: A bio-vibration device for use by a user having a finger for sensing vibration signals in an individual includes a finger coupler device, a vibration sensor and a communications circuit. The vibration sensor is affixed to the finger coupler device and is configured to be pressed against a selected site of the individual so as to sense a vibration signal therefrom. The communications circuit is responsive to the vibration sensor and is configured to transmit the vibration signal to a remote device.

Abstract: A glucose biosensor encasement includes a first membrane and a second membrane. The first membrane has a first interlocking segment. The second membrane has a second interlocking segment cooperating with the first interlocking segment of the first membrane to provide a cavity between the first membrane and the second membrane configured to receive a glucose sensor. At least one of the first membrane and the second membrane comprises a semi-permeable portion configured to regulate diffusion characteristics of glucose through the membrane to realize a sensitivity for a sensor in the cavity. A method is also provided.

Abstract: A sensor having improved shelf life is provided for determining concentration of a biomarker in a liquid sample. The sensor functions by electrochemical detection and requires use of a biomolecule, e.g., an enzyme that catalyzes an electron transfer reaction specific for the biomarker. The sensor requires use of a quaternary ammonium compound as a bio-linker. It further requires crosslinking of the biomolecule for improved stability.

Abstract: A muscle activity observation apparatus that includes a sensor module and a detection module. The sensor module includes a piezoelectric sensor. Moreover, the piezoelectric sensor has an output that changes in accordance with a tremor of a tendon or a muscle, and an output that changes in accordance with contraction and relaxation of the tendon or the muscle. A detector of the detection module detects an activity state of the tendon or the muscle using a tremor signal and a contraction-relaxation signal output from the piezoelectric sensor.

Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: Glucose prediction using machine learning (ML) and time series glucose measurements is described. Given the number of people that wear glucose monitoring devices and because some wearable glucose monitoring devices can produce measurements continuously, a platform providing such devices may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process and covers a robust number of state spaces unlikely to be covered without the enormous amount of data. In implementations, a glucose monitoring platform includes an ML model trained using historical time series glucose measurements of a user population. The ML model predicts upcoming glucose measurements for a particular user by receiving a time series of glucose measurements up to a time and determining the upcoming glucose measurements of the particular user for an interval subsequent to the time based on patterns learned from the historical time series glucose measurements.

Abstract: An apparatus for inserting a continuous analyte monitoring transmitter that includes an outer member, an inner member configured to telescope relative to the outer member, a transmitter, a bias member, an insertion device, and a pivot member. Force is applied to press the outer member toward an insertion site over the duration of a stroke. During a first portion of the stroke, the pivot member cannot pivot and the motion of the outer member translates to the insertion device until the biosensor is inserted at the insertion site. Over a second portion of the stroke, the continued motion causes a first pivot window in the outer member to overlap with a second pivot window in the inner member, allowing the pivot member to pivot and retract the insertion device from the insertion site, leaving the implanted biosensor.

Abstract: A torque device for gripping and manipulating a guidewire for advancing the guidewire into a patient's vascular system. The torque device is configured for single-handed use and can be opened for repositioning the torque device relative to the guidewire and closed for gripping the guidewire to prevent axial and rotational movement relative to the guidewire. The torque device grips the guidewire at multiple spaced apart locations on the guidewire.

Abstract: A method performed by a computer correlates vesicoelastic pressure data with volume data and calculates vesicoelastic work performed by the bladder, wherein the amount of vesicoelastic work performed by the bladder is determined by calculating an area under said vesicoelastic pressure data when said vesicoelastic pressure data is correlated against the volume data.

Abstract: A method of treatment of a type 2 diabetic patient includes selecting a type 2 diabetic patient having a predetermined comorbidity for treatment, initiating a continuous glucose monitor regimen for the selected type 2 diabetic patient, wherein after six months of initiation of the continuous glucose monitor regimen, a rate of hospitalization for a predetermined diagnostic category of the selected patient having the predetermined comorbidity is reduced by at least 12% relative to an average rate of hospitalization for the predetermined diagnostic category of selected patients having the predetermined comorbidity without the continuous glucose monitor regimen.

Abstract: The present invention provides a technique for judging the reflexivity of an eyeball movement. The judging the reflexivity comprises extracting a first feature value of a saccade appearing in a pupil movement performed by a subject during a task involving moving an eye so as to follow a visual cue and a second feature value of a saccade during a task involving moving the eye in an opposite direction to the visual cue. A judgement result indicates whether an eyeball movement performed by the subject has occurred reflexively based on a degree of difference between the first feature value and the second feature value. The judging further comprises generating, based on the degree of difference between the first and second feature values, a judgement result indicating whether the eyeball movement performed by the subject has occurred reflexively.

Abstract: N-type polymer based electrochemical devices include one or more source electrodes, one or more drain electrodes, one or more channels, a gate electrode, and an electrolyte solution are disclosed. The channels include one or more n-type polymers and one or more enzymes. The gate electrode includes one or more n-type polymers and one or more enzymes. The source and the drain electrodes are electrically connected by the corresponding channel. The electrolyte solution contains one or more metabolites capable of reacting with the one or more enzymes in the channel and the gate electrode and is in electrical contact with the channel and the gate electrode. Saturation current that flows through the channel increases when the metabolites react with the enzymes to produce electrons, which are directly transferred to the n-type polymers at the gate electrode and the channel. Methods of making and using the n-type electrochemical device are also disclosed.

Abstract: A lower limb muscle strength evaluation device acquires an angle of at least one of left and right lower limbs of a user while the user stands up from a sitting state, detects at least one lower limb parameter from among a first lower limb maximum value indicating the angle when the lower limb is initially inclined the most in a first direction, a lower limb minimum value indicating the angle when the lower limb is inclined the most in a second direction, a second lower limb maximum value indicating the angle when the lower limb is again inclined the most in the first direction, a first lower limb elapsed time, a second lower limb elapsed time, and a third lower limb elapsed time, evaluates a lower limb muscle strength of the user using the at least one lower limb parameter, and outputs an evaluation result.