Abstract: A fluid control device includes an inlet configured to be placed directly or indirectly in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has a first state in which a negative pressure differential produced from an external source such as the fluid collection device is applied to the fluid control device to draw an initial volume of bodily fluid from the bodily fluid source, through the inlet, and into a sequestration portion of the fluid control device. The fluid control device has a second state in which (1) the sequestration portion sequesters the initial volume, and (2) the negative pressure differential draws a subsequent volume of bodily fluid, being substantially free of contaminants, from the bodily fluid source, through the fluid control device, and into the fluid collection device.

Abstract: Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

Abstract: Training at the proper level of effort is important for athletes whose objective is to achieve the best results in the least time. In running, for example, pace is often monitored. However, pace alone does not reveal specific issues with regard to running form, efficiency, or technique, much less inform how training should be modified to improve performance or fitness. A sensing system and wearable sensor platform described herein provide real-time feedback to a user/wearer of his power expenditure during an activity. In one example, the system includes an inertial measurement unit (IMU) for acquiring multi-axis motion data at a first sampling rate, and an orientation sensor to acquire orientation data at a second sampling rate that is varied based on the multi-axis motion data.

Abstract: The present disclosure relates to a body attachment unit for continuous blood glucose measurement, in which the body attachment unit is manufactured so as to be assembled in an applicator, thereby minimizing additional work and allowing attachment of the body attachment unit to a body simply by operation of the applicator. In particular, a wireless communication chip is provided in the body attachment unit to enable communication with an external terminal, thereby enabling simple and convenient use without performing additional work of connecting a separate transmitter, and allowing easier maintenance. In addition, activation occurs by a user's operation after the body attachment unit is attached to the body, such that an activation start point in time can be adjusted to an appropriate point in time according to the user's needs, and activation occurs in a stabilized state, thereby providing the body attachment unit allowing more accurate blood glucose measurement.

Abstract: Systems and methods for monitoring heart failure (HF) status in a patient are discussed. An exemplary system includes a gait analyzer circuit than can receive gait or balance information, and generate a gait feature such as gait speed or a gait pattern. The system includes a HF detector circuit that can detect patient HF status, or to predict patient risk of a future worsening heart failure (WHF) event, using the gait feature. In some examples, the system may trigger sensing physiologic information according to the detected gait, and detect patient HF status using the sensed physiologic information. The system can initiate or adjust a heart failure therapy according to the HF status or the WHF risk.

Abstract: A body temperature measuring probe comprises a temperature sensor, a heating assembly and a position control assembly; the position control assembly controls contact or separation between the heating assembly and temperature sensor. A method for measuring body temperature comprises: starting the temperature sensor; preheating the body temperature measuring probe to a preset temperature range; once the body temperature measuring probe is preheated to the preset temperature range, separating the heating assembly from the temperature sensor, and only making the temperature sensor participate in a thermal equilibrium process of the body temperature measurement; the temperature sensor working to obtain body temperature measurement data.

Abstract: A wearable device that is applied to the skin of a user (e.g., patient), samples the user's interstitial fluid (IF), and indicates the presence or absence of a target substance. The device may further include a mechanism to ensure compliance and/or provide tamper resistance.

Abstract: Methods and devices to diagnose and treat male urinary incontinence and sexual dysfunction are provided. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and manipulation or positioning of the bladder. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles.

Abstract: A method of detecting the presence of a person on a bed comprising, receiving movement data in pseudo-real-time, extracting features from the movement data for a time period in pseudo-real-time, recording the user's on-bed and off-bed time segments, and determining a sleep schedule. The method further comprising utilizing a sleep engine to determine sleep stages for the user, and calculating sleep conditions. The method in one embodiment further comprising adjusting the bed when the sleep conditions indicate an event.

Abstract: A method, a computer program product, and a computer system provide medications to a patient with a time gap. The method includes determining a dissolving pattern for the patient. The dissolving pattern includes a medication dissolving rate for a first medication prescribed to the patient and a filler dissolving rate for a filler selected so that the time gap is elapsed prior to a second medication being provided after the first medication. The medication dissolving rate and the filler dissolving rate are specific to the patient. The method includes determining dimensions of the first medication to correspond to a dosage of the prescribed first medication and dimensions of the filler to correspond to the time gap. The method includes providing a pill including at least the first medication and the filler, the first medication surrounding the filler such that the first medication is dissolved prior to the filler being dissolved.

Abstract: Aspects relate to an energy harvesting device adapted for use by an athlete while exercising. The device may utilize a mass of phase-change material to store heat energy, the stored heat energy subsequently converted into electrical energy by one or more thermoelectric generator modules. The energy harvesting device may be integrated into an item of clothing, and such that the mass of phase change material may store heat energy as the item of clothing is laundered.

Abstract: A perspiration mapping patch according to the present disclosure is attached to skin of a user to absorb sweat, and includes: a sweat absorbing layer in which a plurality of opening units is arranged; a first support layer which is stacked on a first surface of the sweat absorbing layer and includes an opening opened to correspond to each of the plurality of opening units; and a second support layer stacked on a second surface facing an opposite side of the first surface of the sweat absorbing layer.

Abstract: A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.

Abstract: A bio-vibration device for use by a user having a finger for sensing vibration signals in an individual includes a finger coupler device, a vibration sensor and a communications circuit. The vibration sensor is affixed to the finger coupler device and is configured to be pressed against a selected site of the individual so as to sense a vibration signal therefrom. The communications circuit is responsive to the vibration sensor and is configured to transmit the vibration signal to a remote device.

Abstract: A glucose biosensor encasement includes a first membrane and a second membrane. The first membrane has a first interlocking segment. The second membrane has a second interlocking segment cooperating with the first interlocking segment of the first membrane to provide a cavity between the first membrane and the second membrane configured to receive a glucose sensor. At least one of the first membrane and the second membrane comprises a semi-permeable portion configured to regulate diffusion characteristics of glucose through the membrane to realize a sensitivity for a sensor in the cavity. A method is also provided.

Abstract: A sensor having improved shelf life is provided for determining concentration of a biomarker in a liquid sample. The sensor functions by electrochemical detection and requires use of a biomolecule, e.g., an enzyme that catalyzes an electron transfer reaction specific for the biomarker. The sensor requires use of a quaternary ammonium compound as a bio-linker. It further requires crosslinking of the biomolecule for improved stability.

Abstract: A muscle activity observation apparatus that includes a sensor module and a detection module. The sensor module includes a piezoelectric sensor. Moreover, the piezoelectric sensor has an output that changes in accordance with a tremor of a tendon or a muscle, and an output that changes in accordance with contraction and relaxation of the tendon or the muscle. A detector of the detection module detects an activity state of the tendon or the muscle using a tremor signal and a contraction-relaxation signal output from the piezoelectric sensor.

Abstract: A method of assessing the balance impairment of a subject includes the steps of presenting the subject with a static scene on a display, collecting a first set of orientation measurements, presenting the subject with an unstable scene on a display, collecting a second set of orientation measurements, storing the first and second sets of orientation measurements on a computing device, referenced to a set of time indices, and calculating a balance score for the subject by comparing the second set of orientation measurements with the first set of orientation measurements. A system for assessing the balance impairment of a subject is also disclosed.

Abstract: Glucose prediction using machine learning (ML) and time series glucose measurements is described. Given the number of people that wear glucose monitoring devices and because some wearable glucose monitoring devices can produce measurements continuously, a platform providing such devices may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process and covers a robust number of state spaces unlikely to be covered without the enormous amount of data. In implementations, a glucose monitoring platform includes an ML model trained using historical time series glucose measurements of a user population. The ML model predicts upcoming glucose measurements for a particular user by receiving a time series of glucose measurements up to a time and determining the upcoming glucose measurements of the particular user for an interval subsequent to the time based on patterns learned from the historical time series glucose measurements.

Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.