Abstract: N-type polymer based electrochemical devices include one or more source electrodes, one or more drain electrodes, one or more channels, a gate electrode, and an electrolyte solution are disclosed. The channels include one or more n-type polymers and one or more enzymes. The gate electrode includes one or more n-type polymers and one or more enzymes. The source and the drain electrodes are electrically connected by the corresponding channel. The electrolyte solution contains one or more metabolites capable of reacting with the one or more enzymes in the channel and the gate electrode and is in electrical contact with the channel and the gate electrode. Saturation current that flows through the channel increases when the metabolites react with the enzymes to produce electrons, which are directly transferred to the n-type polymers at the gate electrode and the channel. Methods of making and using the n-type electrochemical device are also disclosed.

Abstract: Featured are intravaginal devices and methods of using the devices to observe the state of an individual's pelvic floor muscles in order to diagnose, treat, or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms and methods of using the devices to treat or prevent vaginal disorders (e.g., skin laxity) in a subject using an energy transmitter (e.g., a radiofrequency transmitter). Also featured are algorithms to detect pelvic floor movements and physiological indicia from sensor data.

Abstract: A lower limb muscle strength evaluation device acquires an angle of at least one of left and right lower limbs of a user while the user stands up from a sitting state, detects at least one lower limb parameter from among a first lower limb maximum value indicating the angle when the lower limb is initially inclined the most in a first direction, a lower limb minimum value indicating the angle when the lower limb is inclined the most in a second direction, a second lower limb maximum value indicating the angle when the lower limb is again inclined the most in the first direction, a first lower limb elapsed time, a second lower limb elapsed time, and a third lower limb elapsed time, evaluates a lower limb muscle strength of the user using the at least one lower limb parameter, and outputs an evaluation result.

Abstract: The invention relates to a method for gait analysis. In this method, data comprising a ground reaction force curve is first obtained from a force measuring device. Then, a determination of a first approximation of the ground reaction force curve performed by at least a first approximation function defined by a set of coefficients. Then, a determination of a second approximation of the ground reaction force curve is performed by a second approximation function formed on the basis of the set of coefficients of the at least one first approximation function. Further, the invention relates to a gait analysis system.

Abstract: A system includes an actuator couplable to a flexible guide tube, a processor, and memory. The actuator is configured to move the flexible guide tube. The memory stores instructions that, when executed by the processor, cause the system to: identify at least one factor associated with insertion or removal of a tool configured to be inserted through or removed from the flexible guide tube; identify, in a first configuration of the flexible guide tube and based on the at least one factor, a section of the flexible guide tube having a bend that the tool cannot traverse; inform a user that the first configuration includes the section having the bend; and command the actuator to move the flexible guide tube to a second configuration. A distal portion of the flexible guide tube is disposed adjacent a target site in the first configuration. The second configuration does not include the bend.

Abstract: A nerve mapping system includes an elongate medical device, a non-invasive mechanical sensor, and a processor. The elongate medical device includes a distal end portion configured to explore an intracorporeal treatment area of a subject, and the distal end portion includes an electrode. The non-invasive mechanical sensor is configured to provide a mechanomyography output signal corresponding to a monitored mechanical response of a muscle innervated by the nerve. The processor is in communication with the electrode and the sensor, and is configured to provide a plurality of electrical stimuli to the electrode. Each of the plurality of stimuli is provided when the electrode is located at a different position within the intracorporeal treatment area. The processor determines the likelihood of a nerve existing at a particular point using the magnitudes of each of the stimuli and the detected response of the muscle.

Abstract: An external medical device is provided. The device can include monitoring circuitry configured to sense physiological information of a patient and a controller with one or more input components. The controller can be configured to: detect one or more patient events based, at least in part, on the physiological information; notify the patient of the detection of the one or more patient events; and receive a patient response to the notification. The patient response can include a response activity identifiable by the input component, which is configured to test a psychomotor ability of the patient, cognitive ability of the patient, strength, balance, stability, and flexibility of the patient, and/or to substantially confirm that a person performing the activity is the patient.

Abstract: A balloon catheter system has a balloon extending in an axial direction and surrounding a balloon interior. The balloon has an outer side facing away from the balloon interior. A catheter is connected to the balloon and extending in the axial direction, the catheter having a lumen in fluid communication with the balloon interior. First and second annular electrodes are disposed on the outer side, each extending in a circumferential direction of the balloon and being located opposite one another in the axial direction. The electrodes are configured to measure one of more of strain of the balloon in the circumferential direction, strain of the balloon in the radial direction, an impedance of tissue of a patient resting against the electrodes, and a redox potential of tissue of the patient contacting at least one of the electrodes.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: An analyte sensor apparatus including a sensing portion including one or more electrodes including a working electrode and one or more contacts for electrically connecting the sensor portion to control circuitry (e.g., a printed circuit board assembly, PCBA); and a circuit comprising the one or more contacts; wherein the circuit detects an electrical connection between the control circuitry without requiring exposure of the sensing portion to a fluid.

Abstract: A guide wire includes a core shaft and a coil body including a wire wound around the core shaft. The wire includes a long axis and a short axis in a transverse section. The coil body includes an inclined portion where an angle formed by the long axis of the wire and an axial line of the coil body is acute.

Abstract: The present disclosure describes systems and methods of estimating sedation level of a patient using machine learning. For example, the integration of multiple QEEG features into a single sedation level estimation system using machine learning could result in a significant improvement in the predictability of the levels of sedation, independent of the sedative drug used. The present disclosure advantageously allows for the incorporation of large numbers of QEEG features and machine learning into the next-generation monitors of sedation level. Different QEEG features may be selected for different sedation drugs, such as propofol, sevoflurane and dexmedetomidine groups. The sedation level estimation system can maintain a high performance for detecting MOAA/S, independent of the drug used.

Abstract: In the cover for a blood pressure meter according to the invention, a coupling region that is detachably attached to a bottom surface of a main body is provided on one end. A tray region that is disposed so as to face a back surface of the main body and receives an accommodated cuff belt is connected to the coupling region. A panel cover region capable of covering a front panel of the main body is provided on the other end. A storage cover region that connects the tray region and the panel cover region is provided. In a cover-coupled state where the coupling region is detachably attached to the bottom surface of the main body, the panel cover region and the storage cover region are configured to be openable and closable with respect to the front panel and the tray region.

Abstract: Disclosed are systems and methods of a health monitoring device comprising: a flexible circuit, an absorbent product, and, a processing unit. The flexible circuit comprises: an electrochemical biosensor, a color sensor, an LED, and, a moisture sensor. The electrochemical biosensor comprises a plurality of reference electrodes. The processing unit comprises: a GPS antenna, a power unit, a BLUETOOTH® low energy transceiver, a GPS transceiver, a microcontroller, and, an accelerometer. The processing unit is electronically coupled to the flexible circuit. The methods comprise: obtaining health data from health monitoring device; recording the health data on the memory unit; transmitting the health data to a data communication device; and, displaying the health data on the data communication device.

Abstract: A continuous blood glucose measurement body attachment unit is manufactured in an assembled state in an applicator so as to minimize additional operations, such that the body attachment unit can be attached to the body with only a simple operation of the applicator. The body attachment unit has a wireless communication chip so as to be capable of communicating with an external terminal, thereby enabling simple and convenient usage without an additional operation in which a separate transmitter must be connected and enabling maintenance to be more easily performed, and after the body attachment unit is attached to the body, an operation starts by the control of a user, such that an operation start time point can be adjusted to an appropriate time point according to the needs of the user, and an operation can start in a stabilized state, such that blood glucose can be more accurately measured.

Abstract: The present disclosure relates to a device for the measurement of fluids and the prevention of infections caused by probes comprising a module of fluid measurement and a probe infection prevention module. The fluid measurement module comprises an electronic module for the measurement of the body fluids; a disposable container for temporary retention of fluid during measurement; a fluid circulation tube arranged between the probe and the disposable container; and a disposable bag for the final disposal of waste fluids. The probe infection prevention module comprises a sheet equipped with adhesive allowing conformation of a flexible structure to the skin or mucosa of the patient. This module incorporates a gel externally that prevents infections, as well as internal antimicrobial components to inhibit passage of microorganisms through the system. The present invention allows non-invasive measurement of fluids utilizing existing probes while contributing to the reduction of infections in patients.

Abstract: A pressure sensor configured for biological pressure measurement at a distal end portion of an elongated member comprises a dissolvable hydrophilic material coated on a surface of the pressure sensor. A guide wire for biological pressure measurement may include a tube extending along a longitudinal axis of the guide wire; and a pressure sensor for biological pressure measurement, at least a portion of the pressure sensor being mounted within the tube. The pressure sensor comprises a pressure sensor membrane facing a top side of the tube. A circumferential wall of the tube includes at least six openings: a first distal opening, a second distal opening located on a right side of the tube, a third distal opening located on a left side of the tube, a first proximal opening, a second proximal opening located on a right side of the tube, and a third proximal opening located on a left side of the tube.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: A method of testing a subject for impairment includes presenting the subject with a display of a smoothly moving object, repeatedly moving over a tracking path and, while presenting the display to the subject, measuring the subject's right eye positions and measuring the subject's left eye positions. The method further includes generating a disconjugacy metric by comparing the measured right eye positions with the measured left eye positions, comparing the disconjugacy metric with a predetermined baseline to determine whether the disconjugacy metric is indicative of an impairment, and generating a report based on the disconjugacy metric.