Abstract: Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

Abstract: Glucose prediction using machine learning (ML) and time series glucose measurements is described. Given the number of people that wear glucose monitoring devices and because some wearable glucose monitoring devices can produce measurements continuously, a platform providing such devices may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process and covers a robust number of state spaces unlikely to be covered without the enormous amount of data. In implementations, a glucose monitoring platform includes an ML model trained using historical time series glucose measurements of a user population. The ML model predicts upcoming glucose measurements for a particular user by receiving a time series of glucose measurements up to a time and determining the upcoming glucose measurements of the particular user for an interval subsequent to the time based on patterns learned from the historical time series glucose measurements.

Abstract: An apparatus for inserting a continuous analyte monitoring transmitter that includes an outer member, an inner member configured to telescope relative to the outer member, a transmitter, a bias member, an insertion device, and a pivot member. Force is applied to press the outer member toward an insertion site over the duration of a stroke. During a first portion of the stroke, the pivot member cannot pivot and the motion of the outer member translates to the insertion device until the biosensor is inserted at the insertion site. Over a second portion of the stroke, the continued motion causes a first pivot window in the outer member to overlap with a second pivot window in the inner member, allowing the pivot member to pivot and retract the insertion device from the insertion site, leaving the implanted biosensor.

Abstract: A torque device for gripping and manipulating a guidewire for advancing the guidewire into a patient's vascular system. The torque device is configured for single-handed use and can be opened for repositioning the torque device relative to the guidewire and closed for gripping the guidewire to prevent axial and rotational movement relative to the guidewire. The torque device grips the guidewire at multiple spaced apart locations on the guidewire.

Abstract: A method performed by a computer correlates vesicoelastic pressure data with volume data and calculates vesicoelastic work performed by the bladder, wherein the amount of vesicoelastic work performed by the bladder is determined by calculating an area under said vesicoelastic pressure data when said vesicoelastic pressure data is correlated against the volume data.

Abstract: A method of treatment of a type 2 diabetic patient includes selecting a type 2 diabetic patient having a predetermined comorbidity for treatment, initiating a continuous glucose monitor regimen for the selected type 2 diabetic patient, wherein after six months of initiation of the continuous glucose monitor regimen, a rate of hospitalization for a predetermined diagnostic category of the selected patient having the predetermined comorbidity is reduced by at least 12% relative to an average rate of hospitalization for the predetermined diagnostic category of selected patients having the predetermined comorbidity without the continuous glucose monitor regimen.

Abstract: The present invention provides a technique for judging the reflexivity of an eyeball movement. The judging the reflexivity comprises extracting a first feature value of a saccade appearing in a pupil movement performed by a subject during a task involving moving an eye so as to follow a visual cue and a second feature value of a saccade during a task involving moving the eye in an opposite direction to the visual cue. A judgement result indicates whether an eyeball movement performed by the subject has occurred reflexively based on a degree of difference between the first feature value and the second feature value. The judging further comprises generating, based on the degree of difference between the first and second feature values, a judgement result indicating whether the eyeball movement performed by the subject has occurred reflexively.

Abstract: N-type polymer based electrochemical devices include one or more source electrodes, one or more drain electrodes, one or more channels, a gate electrode, and an electrolyte solution are disclosed. The channels include one or more n-type polymers and one or more enzymes. The gate electrode includes one or more n-type polymers and one or more enzymes. The source and the drain electrodes are electrically connected by the corresponding channel. The electrolyte solution contains one or more metabolites capable of reacting with the one or more enzymes in the channel and the gate electrode and is in electrical contact with the channel and the gate electrode. Saturation current that flows through the channel increases when the metabolites react with the enzymes to produce electrons, which are directly transferred to the n-type polymers at the gate electrode and the channel. Methods of making and using the n-type electrochemical device are also disclosed.

Abstract: A lower limb muscle strength evaluation device acquires an angle of at least one of left and right lower limbs of a user while the user stands up from a sitting state, detects at least one lower limb parameter from among a first lower limb maximum value indicating the angle when the lower limb is initially inclined the most in a first direction, a lower limb minimum value indicating the angle when the lower limb is inclined the most in a second direction, a second lower limb maximum value indicating the angle when the lower limb is again inclined the most in the first direction, a first lower limb elapsed time, a second lower limb elapsed time, and a third lower limb elapsed time, evaluates a lower limb muscle strength of the user using the at least one lower limb parameter, and outputs an evaluation result.

Abstract: Featured are intravaginal devices and methods of using the devices to observe the state of an individual's pelvic floor muscles in order to diagnose, treat, or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms and methods of using the devices to treat or prevent vaginal disorders (e.g., skin laxity) in a subject using an energy transmitter (e.g., a radiofrequency transmitter). Also featured are algorithms to detect pelvic floor movements and physiological indicia from sensor data.

Abstract: A nerve mapping system includes an elongate medical device, a non-invasive mechanical sensor, and a processor. The elongate medical device includes a distal end portion configured to explore an intracorporeal treatment area of a subject, and the distal end portion includes an electrode. The non-invasive mechanical sensor is configured to provide a mechanomyography output signal corresponding to a monitored mechanical response of a muscle innervated by the nerve. The processor is in communication with the electrode and the sensor, and is configured to provide a plurality of electrical stimuli to the electrode. Each of the plurality of stimuli is provided when the electrode is located at a different position within the intracorporeal treatment area. The processor determines the likelihood of a nerve existing at a particular point using the magnitudes of each of the stimuli and the detected response of the muscle.

Abstract: The invention relates to a method for gait analysis. In this method, data comprising a ground reaction force curve is first obtained from a force measuring device. Then, a determination of a first approximation of the ground reaction force curve performed by at least a first approximation function defined by a set of coefficients. Then, a determination of a second approximation of the ground reaction force curve is performed by a second approximation function formed on the basis of the set of coefficients of the at least one first approximation function. Further, the invention relates to a gait analysis system.

Abstract: A system includes an actuator couplable to a flexible guide tube, a processor, and memory. The actuator is configured to move the flexible guide tube. The memory stores instructions that, when executed by the processor, cause the system to: identify at least one factor associated with insertion or removal of a tool configured to be inserted through or removed from the flexible guide tube; identify, in a first configuration of the flexible guide tube and based on the at least one factor, a section of the flexible guide tube having a bend that the tool cannot traverse; inform a user that the first configuration includes the section having the bend; and command the actuator to move the flexible guide tube to a second configuration. A distal portion of the flexible guide tube is disposed adjacent a target site in the first configuration. The second configuration does not include the bend.

Abstract: A balloon catheter system has a balloon extending in an axial direction and surrounding a balloon interior. The balloon has an outer side facing away from the balloon interior. A catheter is connected to the balloon and extending in the axial direction, the catheter having a lumen in fluid communication with the balloon interior. First and second annular electrodes are disposed on the outer side, each extending in a circumferential direction of the balloon and being located opposite one another in the axial direction. The electrodes are configured to measure one of more of strain of the balloon in the circumferential direction, strain of the balloon in the radial direction, an impedance of tissue of a patient resting against the electrodes, and a redox potential of tissue of the patient contacting at least one of the electrodes.

Abstract: An external medical device is provided. The device can include monitoring circuitry configured to sense physiological information of a patient and a controller with one or more input components. The controller can be configured to: detect one or more patient events based, at least in part, on the physiological information; notify the patient of the detection of the one or more patient events; and receive a patient response to the notification. The patient response can include a response activity identifiable by the input component, which is configured to test a psychomotor ability of the patient, cognitive ability of the patient, strength, balance, stability, and flexibility of the patient, and/or to substantially confirm that a person performing the activity is the patient.

Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.

Abstract: An analyte sensor apparatus including a sensing portion including one or more electrodes including a working electrode and one or more contacts for electrically connecting the sensor portion to control circuitry (e.g., a printed circuit board assembly, PCBA); and a circuit comprising the one or more contacts; wherein the circuit detects an electrical connection between the control circuitry without requiring exposure of the sensing portion to a fluid.

Abstract: A guide wire includes a core shaft and a coil body including a wire wound around the core shaft. The wire includes a long axis and a short axis in a transverse section. The coil body includes an inclined portion where an angle formed by the long axis of the wire and an axial line of the coil body is acute.

Abstract: The present disclosure describes systems and methods of estimating sedation level of a patient using machine learning. For example, the integration of multiple QEEG features into a single sedation level estimation system using machine learning could result in a significant improvement in the predictability of the levels of sedation, independent of the sedative drug used. The present disclosure advantageously allows for the incorporation of large numbers of QEEG features and machine learning into the next-generation monitors of sedation level. Different QEEG features may be selected for different sedation drugs, such as propofol, sevoflurane and dexmedetomidine groups. The sedation level estimation system can maintain a high performance for detecting MOAA/S, independent of the drug used.

Abstract: In the cover for a blood pressure meter according to the invention, a coupling region that is detachably attached to a bottom surface of a main body is provided on one end. A tray region that is disposed so as to face a back surface of the main body and receives an accommodated cuff belt is connected to the coupling region. A panel cover region capable of covering a front panel of the main body is provided on the other end. A storage cover region that connects the tray region and the panel cover region is provided. In a cover-coupled state where the coupling region is detachably attached to the bottom surface of the main body, the panel cover region and the storage cover region are configured to be openable and closable with respect to the front panel and the tray region.