Abstract: A method of stabilizing perfluoro(2-methylene-4-methyl-1,3-dioxolane) (hereinafter simply referred to as a “stabilization method”), including incorporating at least one selected from the group consisting of a hydroxy group-containing fluoroaromatic compound represented by General Formula (1) below and a hydroxy group-containing fluoroaromatic compound represented by General Formula (2) below into a composition containing perfluoro(2-methylene-4-methyl-1,3-dioxolane): (in the formula, R1 to R6 each independently represent one selected from the group consisting of a fluorine atom, a perfluoroalkyl group and a hydroxy group, and at least one of R1 to R6 is a hydroxy group); (in the formula, R7 to R14 each independently represent one selected from the group consisting of a fluorine atom, a perfluoroalkyl group and a hydroxy group, and at least one of R7 to R14 is a hydroxy group).
Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
Type:
Grant
Filed:
October 15, 2020
Date of Patent:
November 28, 2023
Assignee:
AUCKLAND UNISERVICES LIMITED
Inventors:
Brian Desmond Palmer, Lai Ming Ching, Swarnalatha Akuratiya Gamage
Abstract: A compound of formula (I), or a salt thereof that may have an antagonistic action against an NMDA receptor that includes an NR2B subunit and may be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, a symptom peripheral to dementia, or the like.
Abstract: Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.
Type:
Grant
Filed:
January 5, 2022
Date of Patent:
November 21, 2023
Assignee:
UCB PHARMA GMBH
Inventors:
Christa E. Mueller, Cécile Pegurier, Michael Louis Robert Deligny, Ali El-Tayeb, Joerg Hockemeyer, Marie Ledecq, Joël Mercier, Larurent Provins, Nader M. Boshta, Sanjay Bhattarai, Vigneshwaran Namasivayam, Mario Funke, Lukas Schwach, Sabrina Gollos, Daniel Von Laufenberg, Anaïs Barré
Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.
Type:
Grant
Filed:
January 27, 2022
Date of Patent:
November 21, 2023
Assignee:
Vandria SA
Inventors:
Christopher L. Rinsch, Penelope Andreux, Jonathan Mark Sutton, Eileen Mary Seward, Jamie D. Knight, Ian Linney, Peter C. Sennhenn, Said Oumouch, Florent Beaufils, Thomas Christian Fessard
Abstract: The present invention relates to a new class of compounds having an antiviral effect and the uses thereof.
Type:
Grant
Filed:
March 18, 2022
Date of Patent:
November 7, 2023
Assignee:
ENYO PHARMA
Inventors:
Eric Meldrum, Benoît De Chassey, Laëtitia Lines, Jérôme Amaudrut, Benaissa Boubia, Vincent Derain, Fabrice Guillier, Christian Montalbetti, Calum Macleod, Karine Fabienne Malagu, David Robert Vesey, Paul Colin Michael Winship
Abstract: In some embodiments, provided herein is a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof, as disclosed herein.
Type:
Grant
Filed:
August 13, 2021
Date of Patent:
November 7, 2023
Assignees:
Loxo Oncology Inc., Array BioPharma Inc.
Inventors:
Charles Todd Eary, Stacey Spencer, Zack Crane, Katelyn Chando, Sylvie Asselin, Weidong Liu, Mike Welch, Adam Cook, Gabrielle R. Kolakowski, Andrew T. Metcalf, David A. Moreno, Tony P. Tang
Abstract: The present disclosure provides a compound of Formula (I) or pharmaceutically acceptable salt, stereoisomers thereof, a pharmaceutical composition comprising the compound, and a method to treat or prevent neurodegenerative diseases using the compound.
Type:
Grant
Filed:
July 12, 2021
Date of Patent:
October 31, 2023
Assignee:
1ST Biotherapeutics, Inc.
Inventors:
Jinhwa Lee, Suyeon Jo, Keonseung Lim, A Yeong Park, Jae Eun Kim, Misoon Kim, Seung Mook Lim
Abstract: This disclosure relates to lipid disulfide prodrugs and in particular to lipid disulfide phosphodiester nucleosides and derivatives thereof, pharmaceutical compositions, and uses related thereto. According to one embodiment of the disclosure there is provided a compound of Formula I, or pharmaceutically acceptable salts or derivatives thereof, wherein substitutents are disclosed herein.
Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).
Abstract: Compounds and compositions for modulating fibroblast activation protein (FAP) are described. The compounds and compositions may find use as therapeutic agents for the treatment of diseases, including hyperproliferative diseases.
Type:
Grant
Filed:
December 14, 2018
Date of Patent:
October 10, 2023
Assignee:
PRAXIS BIOTECH LLC
Inventors:
Jennifer Alfaro, Sebastian Belmar, Sebastian Bernales, Brahmam Pujala, Dayanand Panpatil, Bhawana Bhatt
Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
October 10, 2023
Assignee:
Array BioPharma Inc.
Inventors:
Ronald Jay Hinklin, Shelley Allen, Patrick Barbour, Adam Cook, Joshua Dahlke, John Gaudino, Ellen Laird, Oren T. McNulty, Qian Zhao
Abstract: There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-I with respect to poly (ADP-ribose) polymerase P ARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
Abstract: The present invention relates to four crystal forms of crisaborole in free form and the preparation method thereof. The present invention also relates to the pharmaceutical composition containing the crystal forms and the use thereof.
Abstract: The present invention relates to a novel cathode buffer layer material and an organic photoelectric device including the same. When the novel compound of the present invention is applied to a cathode buffer layer of an organic photoelectric device, for example, an organic solar cell or an organic photodiode, there is an effect in which the surface characteristics of an electron transport layer are improved through the high dipole moment of the novel compound to thereby facilitate electron extraction from a photoactive layer to a cathode electrode and to reduce series resistance and leakage current, and accordingly, the performance of an organic optoelectronic device (organic solar cell, organic photodiode, etc.) to be manufactured can be remarkably improved, which is industrially advantageous.
Type:
Grant
Filed:
July 17, 2018
Date of Patent:
September 26, 2023
Assignee:
Korea Research Institute of Chemical Technology
Inventors:
Sung Cheol Yoon, Chang Jin Lee, Jaemin Lee, Seung Hun Eom
Abstract: Acenes, such as aza-acenes are attractive materials for organic semiconductors, specifically for n-type materials. There are disclosed new derivatives of acenes that are fabricated using novel synthesis. For example, the disclosed fabrication strategies have allowed for the first time new aza-tetracene and aza-pentacene derivatives. The HOMO and LUMO energy levels of these materials are tunable through appropriate substitution and as predicted, deepened. There are also disclosed organic photosensitive devices comprising at least one aza-acene such as aza-tetracene and aza-pentacene.
Type:
Grant
Filed:
October 20, 2020
Date of Patent:
August 29, 2023
Assignee:
University of Southern California
Inventors:
Mark E. Thompson, Jonathan R. Sommer, Andrew Bartynski
Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.
Type:
Grant
Filed:
September 20, 2021
Date of Patent:
August 22, 2023
Assignee:
Minoryx Therapeutics S.L.
Inventors:
Ana Maria García Collazo, Wolter Ten Hoeve, Johannes Nicolaas Koek, Johannes B. M. Rewinkel, Sander De Wilde
Abstract: This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
Type:
Grant
Filed:
August 10, 2021
Date of Patent:
August 15, 2023
Assignee:
Centrexion Therapeutics Corporation
Inventors:
Doris Riether, Florian Paul Christian Binder, Henri Doods, Stephan Georg Mueller, Janet Rachel Nicholson, Achim Sauer