Patents Examined by David Lukton
  • Methods for the treatment of X-linked hypophosphatemia and related disorders
    Patent number: 8993720
    Abstract: The disclosure provides methods of treating X-linked hypophosphatemia, related bone demineralization and renal phosphate wasting disorders in a mammalian subject. The methods comprise administering to the subject an effective amount of a polyarginine peptide.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: March 31, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marc K. Drezner, Baozhi Yuan
  • Protocells and their use for targeted delivery of multicomponent cargos to cancer cells
    Patent number: 8992984
    Abstract: Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: March 31, 2015
    Assignees: STC.UNM, Sandia Corporation
    Inventors: C. Jeffrey Brinker, Carlee Erin Ashley, Xingmao Jiang, Juewen Liu, David S. Peabody, Walker Richard Wharton, Eric Carnes, Bryce Chackerian, Cheryl L. Willman
  • Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes
    Patent number: 8986700
    Abstract: The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 24, 2015
    Assignee: The Council of the Queensland Institute of Medical Research
    Inventors: David Jackson, Weiguang Zeng
  • Method of hydrolysis of peptide bond
    Patent number: 8969516
    Abstract: This invention relates to a method of hydrolysis of the peptide bond between R1 and B in a specific designed amino acid sequence R1BXJZR3R2, where R1 represents a polypeptide of interest, R2 represents a sequence capable of specific binding to another component or molecule or another domain which needs to be cleaved, R3 represents an optional short peptide sequence, B represents a residue capable of accepting an acyl group, J represents a residue capable of metal ion binding, and X and Z represent amino acid residues, wherein the said method is based on a novel molecular mechanism of peptide bond hydrolysis, occurring in a specific complex of this metal ion with the BXJZ sequence. This method can be used to remove BXJZR3R2 domains in recombinant polypeptides, such as sequences capable of specific binding to another component or molecule to yield pure, unmodified R1 polypeptides of interest.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: March 3, 2015
    Assignee: Instytut Biochemii I Biofizyki Pan
    Inventors: Wojciech Bal, Edyta Kopera, Artur Krezel, Aleksandra Wyslouch-Cieszynska
  • Method for repairing DNA damage in keratinocytes
    Patent number: 8962571
    Abstract: A method for repairing DNA damage in human keratinocytes by applying to the keratinocytes a composition comprising at least one CLOCK or PER1 gene activator and at least one DNA repair enzyme.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: February 24, 2015
    Assignee: ELC Management
    Inventors: Daniel H. Maes, Nadine A. Pernodet, Lenny Slutsky, Donald F. Collins, Kerri Goldgraben, Edward Pelle, James Timothy McCarthy
  • Peptide fragments for inducing synthesis of extracellular matrix proteins
    Patent number: 8962798
    Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: February 24, 2015
    Assignee: Helix BioMedix, Inc.
    Inventors: Scott M. Harris, Timothy J. Falla, Lijuan Zhang
  • Method of treating degenerative diseases
    Patent number: 8952129
    Abstract: Agonists of a non-proteolytically activated receptor can be used in methods for treating a disease or disorder in a subject. The methods comprise administering to the subject a therapeutically effective amount of an agonist, wherein the disease or disorder is scleroderma, macular degeneration, diabetic retinopathy, Huntington's disease, Parkinson's disease, closed head trauma, glaucoma, optic neuritis or allograft vasculopathy.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: February 10, 2015
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Darrell H. Carney, Randolph C. Steer
  • Synthetic conjugates and uses thereof
    Patent number: 8940690
    Abstract: The present disclosure provides a cross-linked material comprising conjugates which include two or more separate affinity ligands bound to a non-polymeric framework, wherein the molecular weight of the non-polymeric framework is less than 10,000 Da; and multivalent cross-linking agents that non-covalently bind the affinity ligands of the conjugates and thereby cross-link the conjugates to form a cross-linked material, wherein the non-covalent bonds between the multivalent cross-linking agents and the affinity ligands are competitively dissociated in the presence of excess amounts of a target molecule. The present disclosure also provides methods of making and methods of using these materials. In other aspects, the present disclosure provides exemplary conjugates including conjugates for use in glucose responsive cross-linked materials.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: January 27, 2015
    Assignees: National Institutes of Health (NIH), The United States of America Dept. of Health and Human Services (DHHS), The United States of America as represented by NIH Division of Extramural Inventions and Technology Resources (DEITR)
    Inventors: Todd C. Zion, Thomas M. Lancaster
  • Myocardial peptide, preparation method and uses thereof
    Patent number: 8940865
    Abstract: Disclosed are two myocardial peptides, whose amino acid sequences are Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe and Lys-Gly-Ala-Trp-Ser-Asn-Val-Leu-Arg-Gly-Met-Gly-Gly-Ala-Phe respectively, wherein the latter can be obtained by extracting from myocardial peptides solution. The myocardial peptides can be used in the produce of a medicament for preventing and/or treating myocardial ischemia.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: January 27, 2015
    Assignee: Dalian Zhen-Ao Pharmaceutical Co, Ltd.
    Inventors: Yusong Chen, Shu Li, Risheng Wang, Qiang Liang, Zheng Zeng, Xiaohong Qian, Dong Cao, Huimin Liang
  • Liquid formulations of tumor necrosis factor-binding proteins
    Patent number: 8937045
    Abstract: The invention relates to a stable, pharmaceutically acceptable, aqueous formulation of TNF-binding protein, comprising a TNF-binding protein, a buffer and an isotonicity agent.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: January 20, 2015
    Assignee: Ares Trading S.A.
    Inventors: Fabrizio Samaritani, Alessandra Del Rio, Rita Agostinetto
  • Method of making an (alkyl)acryloyl polycarbonate
    Patent number: 8927196
    Abstract: The invention relates to a method for making a polymer wherein during the polymerization is incorporated in the polymer chain by ring opening polymerization a cyclic (alkyl)acryloyl carbonate having the formula (4): wherein R1 and R2 each independently are hydrogen, methyl or ethyl. Preferable the polymer is an (alkyl)acryloyl polycarbonate such that at least one first monomer a cyclic (alkyl)acryloyl carbonate having the formula (4). The (alkyl)acryloyl polyester may be modified and used in biodevices.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: January 6, 2015
    Assignee: SSENS B.V.
    Inventors: Wei Chen, Fenghua Meng, Rong Wang, Ru Cheng, Zhiyuan Zhong
  • One pot desialylation and glycopegylation of therapeutic peptides
    Patent number: 8911967
    Abstract: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: December 16, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Shawn DeFrees, David A. Zopf, Susann Taudte, Walter Scott Willett, Robert J. Bayer, Matthew Kalo
  • Method of regulating proliferation and differentiation of keratinocyes
    Patent number: 8912142
    Abstract: Provided are methods of regulating keratinocytes proliferation and differentiation by subjecting keratinocytes to an agent capable of modulating activity or expression of IGFBP7, thereby regulating keratinocytes proliferation and differentiation. Also provided are methods of treating pathologies characterized by hyperproliferative keratinocytes by administering IGFBP7 polypeptide or a polynucleotide encoding IGFBP7 polypeptide to a subject.
    Type: Grant
    Filed: February 28, 2010
    Date of Patent: December 16, 2014
    Assignees: The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center, Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Eli Sprecher, Janna Nousbeck
  • Mucin hypersecretion inhibitors and methods of use
    Patent number: 8907056
    Abstract: Peptides are provided that comprise less than 24 amino acids. The peptides have an amino acid sequence selected from the group consisting of: (a) an amino acid sequence having from 4 to 6 contiguous amino acids of a reference sequence PEPTIDE 1; (b) an amino acid sequence substantially identical to the sequence defined in (a); and (c) a variant of the amino acid sequence defined in (a). Also provided is a non-myristoylated MANS peptide. Various methods of using the peptides are also provided.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: December 9, 2014
    Assignee: Biomarck Pharmaceuticals, Ltd.
    Inventor: Indu Parikh
  • Crystalline insulin-conjugates
    Patent number: 8906850
    Abstract: The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that encompass these crystalline insulin-conjugates.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: December 9, 2014
    Assignee: Smartcells, Inc.
    Inventors: Todd C. Zion, Thomas M. Lancaster
  • Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
    Patent number: 8895695
    Abstract: Template-fixed ?-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 12, 14 or 18 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Gly, NMeGly, Pro or Pip, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: November 25, 2014
    Assignees: Polyphor Ltd., Universität Zürich
    Inventors: Jürg Zumbrunn, Steven J. Demarco, Sergio Lociuro, Jan Wim Vrijbloed, Frank Gombert, Reshmi Mukherjee, Kerstin Moehle, Daniel Obrecht, John Anthony Robinson, Heiko Henze, Barbara Romagnoli, Christian Ludin
  • Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases
    Patent number: 8889827
    Abstract: The present invention relates to modified opiorphin peptides as new inhibitors of metallo-ectopeptidases.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: November 18, 2014
    Assignee: Institut Pasteur
    Inventor: Catherine Rougeot
  • Methods for separating proteins from connective tissue
    Patent number: 8871291
    Abstract: Methods and systems for separating muscle tissue from connective tissue are provided, in which animal tissue containing both muscle tissue and connective tissue is subjected to stress, and muscle proteins are separated from the connective tissue. Slurries of separated myofibrillar protein are also provided.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: October 28, 2014
    Assignee: M.P.F., Inc.
    Inventors: Christopher Riley, Stanley H. Hultin
  • Macrocyclic derivative and assemblies formed therefrom
    Patent number: 8852895
    Abstract: The present invention is directed to a macrocyclic derivative which is formed by modification of a macrocycle. The invention further relates to assemblies formed by the self-assembly of such macrocyclic derivatives in aqueous solvent, and includes bilayer vesicles, micelles, monolayers, nanoparticles, colloidal assemblies and surface-coated assemblies.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: October 7, 2014
    Assignees: University College Dublin, National University of Ireland, University College Cork, National University of Ireland
    Inventors: Raphael Darcy, Caitriona O'Driscoll
  • Heat stable protein ingredients
    Patent number: 8846863
    Abstract: The subject invention pertains to methods of making crosslinked protein-carbohydrate conjugates (CPCCs) and uncrosslinked protein-carbohydrate conjugates (PCCs) that are heat, pH and salt stable. Methods of stabilizing CPCCs and PCCs are also provided. The PCCs and CPCCs formed according to the methods disclosed herein are useful in the food industry and for loading with substances of interest.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: September 30, 2014
    Assignee: University of Tennessee Research Foundation
    Inventor: Qixin Zhong