Patents Examined by David Naff
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Patent number: 8227238Abstract: A large amount of entrapping immobilization pellets with highly stable quality are produced inexpensively by high-speed treatment. There is provided a process for producing entrapping immobilization pellets in which microorganisms are entrapped and immobilized in an immobilizing agent, the process comprising polymerizing a mixture containing the microorganisms and a solution of the immobilizing agent in a forming frame into a gel to prepare a pellet block.Type: GrantFiled: March 13, 2009Date of Patent: July 24, 2012Assignee: Hitachi Plant Technologies, Ltd.Inventors: Naoki Abe, Koutarou Aoyama, Tatsuo Sumino, Hiroyoshi Emori, Takayuki Kouno
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Patent number: 8227582Abstract: The present invention provides an improved process for the direct and selective metallization of nucleic acids via metal nanoparticles produced in-situ in which a nucleic acid specific metal complex is reacted with a nucleic acid to produce a metal complex-nucleic acid conjugate, non-conjugated metal complex and/or non-conjugated by-products are removed, and the metal complex-nucleic acid conjugate is reacted with a reducing agent to produce a metal nanoparticle-nucleic acid composite. The metal nanoparticle-nucleic acid composites may be used, e. g., in the formation of nanowires, for electronic networks and circuits allowing a high density arrangement.Type: GrantFiled: November 21, 2001Date of Patent: July 24, 2012Assignee: Sony Deutschland GmbHInventors: William Ford, Jurina Wessels, Oliver Harnack, Akio Yasuda
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Patent number: 8227224Abstract: A method of making a molded part, including forming a liquid aggregate. A fungal inoculum and the liquid aggregate are inserted into a mold cavity. A portion of an object is inserted into the mold cavity. The fungal inoculum is grown into live mycelium that operably couples with the object. The mycelium is heated to terminate further growth and develop a composite part made of mycelium and the object.Type: GrantFiled: June 9, 2010Date of Patent: July 24, 2012Assignee: Ford Global Technologies, LLCInventors: Raymond Edward Kalisz, Charles Alan Rocco
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Patent number: 8227233Abstract: A method of making a molded part, including forming a liquid aggregate from a mixture of finely ground aggregate and a fluid. A mixture of a fungal inoculum and the liquid aggregate is formed. Nanoparticles are homogenously distributed throughout the mixture. The mixture is inserted into a mold cavity. Live mycelium is grown to fill the mold cavity. The live mycelium is heated to terminate further growth and develop a formed part.Type: GrantFiled: June 9, 2010Date of Patent: July 24, 2012Assignee: Ford Global Technologies, LLCInventors: Raymond Edward Kalisz, Charles Alan Rocco
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Patent number: 8227225Abstract: A method of making a plasticized mycelium structure, including dissolving a soluble polymer in a liquid thereby forming a polymer solution of polymer particles. The polymer solution is combined with a fungal inoculum capable of growing hyphae in the presence of an aggregate. The resulting mixture is allowed to grow into a mycelium network. The mycelium network is made up of hyphae which bond with the polymer particles found in the polymer solution forming a structure substantially made up of mycelium that has a plasticizer homogenously distributed throughout the structure. The structure is cured to terminate mycelium growth.Type: GrantFiled: June 9, 2010Date of Patent: July 24, 2012Assignee: Ford Global Technologies, LLCInventors: Charles Alan Rocco, Raymond Edward Kalisz
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Patent number: 8216549Abstract: A quantum dot (QD) conjugate comprises a QD and a ligand conjugated with the QD, in which the ligand has at least one thiol and at least one other functional group. The QD conjugate may further comprise a bioactive agent covalently coupled to the ligand to form a bioactive agent-tagged QD conjugate. A method for preparing a QD conjugate comprises the steps of: (1) providing a solution comprising a QD encapsulated within a dendrimer; (2) adding into the solution a ligand; and (3) allowing an exchange between the ligand and the dendrimer for the QD to obtain a ligand-QD conjugate, in which the ligand is covalently conjugated to the surface of the QD. The method may further comprise the step of coupling the ligand-QD conjugate to a bioactive agent to obtain a bioactive agent-tagged ligand-QD conjugate.Type: GrantFiled: June 17, 2009Date of Patent: July 10, 2012Assignee: National Health Research InstitutesInventors: Shu-Yi Lin, Leu-Wei Lo, Chung-Shi Yang
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Patent number: 8211682Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: October 3, 2008Date of Patent: July 3, 2012Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Patent number: 8206982Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: October 14, 2008Date of Patent: June 26, 2012Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Patent number: 8206958Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: December 5, 2007Date of Patent: June 26, 2012Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Tapan K. Dey, Carlos Filipe, Raja Ghosh, Marcus Y. Kim, Elena N. Komkova, Alicja M. Mika, Jinsheng Zhou
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Patent number: 8202833Abstract: The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.Type: GrantFiled: November 26, 2003Date of Patent: June 19, 2012Assignee: Surmodics, Inc.Inventors: Dale G. Swan, Stephen J. Chudzik, Ronald F. Ofstead
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Patent number: 8198055Abstract: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for producing liquid products such as ethanol, butanol and other chemicals. The gas fed on the membrane's gas contact side transports through the membrane to form a biofilm of anaerobic microoganisms that converted the syngas to desired liquid products. A liquid impermeable layer of the membrane assists in establishing direct gas phase contact syngas components with the microorganisms. The system can sustain production with a variety of microorganisms and membrane configurations.Type: GrantFiled: September 5, 2008Date of Patent: June 12, 2012Assignee: Coskata, Inc.Inventors: Rathin Datta, Shih-Perng Tsai, Rahul Basu, Seong-Hoon Yoon
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Patent number: 8192971Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: September 16, 2008Date of Patent: June 5, 2012Assignee: Natrix Separations Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Patent number: 8192970Abstract: The method for treating microcystin-containing water which detoxifies microcystin in the microcystin-containing water, the method comprises the step of: bringing the microcystin-containing water into contact with a Sphingomonas bacterium to degrade biologically the microcystin in the microcystin-containing water, wherein: the Sphingomonas bacterium is a strain FERM P-19480 which is deposited as strain MDB1 with International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology.Type: GrantFiled: December 31, 2007Date of Patent: June 5, 2012Assignee: Hitachi Plant Technologies, Ltd.Inventors: Tatsuo Sumino, Takako Ogasawara, Ho-Dong Park
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Patent number: 8187851Abstract: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein mixture and using a mold to form a protein into a desired shape and size.Type: GrantFiled: July 24, 2008Date of Patent: May 29, 2012Assignee: Medtronic Minimed, Inc.Inventors: Rajiv Shah, Bahar Reghabi, Rudy Montalvo, Yanan Zhang
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Patent number: 8187880Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.Type: GrantFiled: April 23, 2008Date of Patent: May 29, 2012Assignee: Natrix Separations, Inc.Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
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Patent number: 8178314Abstract: The invention relates to pyrimidines suitable as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula (I) wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O6-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins.Type: GrantFiled: April 25, 2006Date of Patent: May 15, 2012Assignee: Covalys Biosciences AGInventors: Maik Kindermann, Markus Schwab
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Patent number: 8173419Abstract: Equipment for treating wastewater by anaerobic ammonium oxidation includes an anaerobic ammonium oxidation vessel to receive water to be treated containing ammonium and nitrite and to denitrify ammonium and nitrite in the water by anaerobic ammonium oxidizing bacteria, forming denitrified treated water, an acclimatization vessel downstream from the anaerobic ammonium oxidation vessel to receive the denitrified treated water from the anaerobic ammonium oxidation vessel, the acclimization vessel containing an immobilizing material that collects the anaerobic ammonium oxidizing bacteria in the denitrified treated water as immobilized microorganisms attached to the immobilizing material, wherein the acclimatization vessel has a structure such that the immobilizing material is prevented from flowing out of the acclimatization vessel, and a pipe connecting the acclimatization vessel to the anaerobic ammonium oxidation vessel.Type: GrantFiled: July 11, 2008Date of Patent: May 8, 2012Assignee: Hitachi Plant Technologies, Ltd.Inventors: Kazuichi Isaka, Tatsuo Sumino
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Patent number: 8173149Abstract: A porous ?-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 ?m, preferably 50-125 ?m. The porous ?-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous ?-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous ?-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous ?-TCP material and inducing bone formation are also provided.Type: GrantFiled: February 21, 2008Date of Patent: May 8, 2012Assignee: Stryker CorporationInventors: Paresh S. Dalal, Godofredo R. Diamaano, Shailesh C. Kulkarni
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Patent number: 8168431Abstract: A tissue engineering scaffold for cell, tissue or organ growth comprises a biocompatible porous polyurethane cellular material comprising a plurality of substantially spherical voids of diameter from 20 to 300 microns, preferably 80 to 200 microns, interconnected by generally elliptically shaped pores. The cellular material has a void content of from 85% to 98% and a surface area to volume of from 5 to 400 mm2/mm3, ideally from 20 to 80 mm2/mm3.Type: GrantFiled: November 14, 2008Date of Patent: May 1, 2012Assignee: Cellology LimitedInventors: Eamon Brady, Ann Marie Cannon, Fergal Farrell, Gerard McCaffrey
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Patent number: 8168423Abstract: A device for detecting nitrosothiol content in a solution includes at least two electrodes disposed in a housing, wherein one of the at least two electrodes is a working electrode having a platinized tip and the other of the at least two electrodes is a counter electrode. A filter membrane is disposed at an end of the housing and is configured to come in contact with the solution. The filter membrane and at least a portion of the working electrode have a material coated thereon. The material includes a polymer and a source of copper dispersed within the material. The material and the platinized tip are configured to come into contact with the solution containing nitrosothiols to convert the nitrosothiols to nitric oxide in order to detect the nitrosothiol content.Type: GrantFiled: April 2, 2008Date of Patent: May 1, 2012Assignee: The Regents of The University of MichiganInventors: Mark E. Meyerhoff, Wansik Cha