Abstract: The invention relates to an antimicrobial silicate glass with the following weight composition in wt. % based on oxides: SiO2 20 to 70, Na2O 5 to 30, K2O 0 to 5, P2O5 1 to 15, B2O3 0 to 10, CaO 4 to 30, AgO 0 to 2, ZnO 0 to 8, CuO 0 to 5, MgO 0 to 8, Al2O3 0 to 7, CeO2 0 to 5, Fe2O3 0 to 2 whereby the sum of the components AgO, CuO, CeO2 is >10 ppm, preferably ?100 ppm and <8 wt. %.
Abstract: Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
Type:
Grant
Filed:
March 24, 2004
Date of Patent:
January 30, 2007
Assignee:
Medtronic, Inc.
Inventors:
Keith R. Hildebrand, Linda M. Page, Deanna S. Lane, Dennis D. Elsberry, David A. Clarahan, Jayantha H. Ratnayake
Abstract: The present invention relates to a phthalamide derivative represented by the general formula (I): wherein R1, R2, R3, X, Y, m, and n are as defined in the disclosure, which can be used as the active ingredient in an agricultural or horticultural insecticide that exhibits an excellent insecticidal effect even when used in a small active-ingredient amount.
Abstract: A pesticidal composition comprising an oxadiazine compound given by formula (A): and an ester compound given by formula (B): as active ingredients, wherein the weight ratio of the oxadiazine compound given by formula (A) to the ester compound given by formula (B) is within the range of 50:1 to 1:10, has an excellent efficacy for controlling pests.
Abstract: Described herein are novel indicator molecules of general formula (1): wherein Q, F, N, Nuc, X1 and X2 are as defined herein, including their tautomeric forms and their additive salts. The present invention also concerns methods for the use of these molecules to monitor nucleic acid amplification in real time and their applications as diagnostics.
Abstract: Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
Type:
Grant
Filed:
March 18, 2002
Date of Patent:
April 18, 2006
Assignee:
Novartis AG
Inventors:
John David Rothermel, Horst F. Schran, Diane Greeley, TianLing Chen