Patents Examined by David Saunder
  • Specific detection of cell surface receptor leukocyte adhesion molecule-1
    Patent number: 5389520
    Abstract: A shed form of leukocyte adhesion molecule-1 (LAM-1, L-selectin) is present in high levels in human plasma. Quantitative methods of detecting shed LAM-1 (sLAM-1) by Western blot and ELISA analysis are disclosed. Also disclosed are methods for the specific detection of cell-surface bound LAM-1 in the presence of shed LAM-1 and for immunotherapy using monoclonal antibodies reactive with cell-surface bound LAM-1 but not reactive with shed LAM-1.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: February 14, 1995
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Thomas F. Tedder, Boris Schleiffenbaum, Olivier Spertini