Patents Examined by David Schmickel
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Patent number: 5643791Abstract: A biologically pure DNA sequence which encodes an endo 1,4-.beta.-glucanase, useful for the efficient conversion of cellulose to glucose, is disclosed. Also disclosed are recombinant DNA cloning vehicles (vectors) that contain nucleotide sequences that encode for the aforesaid endoglucanase, proteins that exhibit endoglucanase activity, expression-controlling DNA sequences, microorganisms that contain recombinant DNA cloning vehicles, as well as messenger RNA sequences complementary to a DNA strand of the aforesaid DNA nucleotide sequences.Type: GrantFiled: January 19, 1994Date of Patent: July 1, 1997Assignee: University of British ColumbiaInventors: R. Anthony J. Warren, Douglas G. Kilburn, Robert C. Miller, Jr.
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Patent number: 5589451Abstract: The invention relates to the use of hepatocyte and keratinocyte growth factors for controlling the proliferation and motility of corneal cells in vivo and in vitro. It also relates to the use of these factors for maintaining the viability of the corneal cells during or after ocular surgery and during corneal preservation in storage medium prior to transplant. Polymerase chain reaction amplification has demonstrated that corneal epithelial and endothelial cells in vitro and ex vivo corneal epithelium produce messenger RNA coding for hepatocyte growth factor, hepatocyte growth factor receptor, keratinocyte growth factor, and keratinocyte growth factor receptor. Additionally, it was demonstrated that hepatocyte growth factor and keratinocyte growth factor stimulate the proliferation of corneal epithelial cells and corneal endothelial cells in vitro in a dose response manner.Type: GrantFiled: September 21, 1992Date of Patent: December 31, 1996Assignee: Board of Regents, The University of Texas SystemInventor: Steven E. Wilson
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Patent number: 5556956Abstract: Disclosed are methods and compositions, including antisense and antigene constructs and pharmaceutical formulations thereof, for use in regulating androgen receptor gene expression. The promoter activity of the androgen receptor gene is herein shown to include a critical upstream acting domain with a unique sequence, the unique nucleic acid sequence corresponding to positions 1697 and 2084, particularly between positions 1697 and 1717, as defined in SEQ ID NO:1. The AR gene promoter sequence, herein characterized as having a a particular nucleotide sequence defined between nucleotides 1697 and 2084 of SEQ ID NO:1, is characterized as important in the regulation of androgen receptor gene expression.Type: GrantFiled: November 4, 1993Date of Patent: September 17, 1996Assignee: Board of Regents, The University of Texas SystemInventors: Arun K. Roy, Bandana Chatterjee
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Patent number: 5543297Abstract: The invention discloses a human cyclooxygenase-2 cDNA, a human cyclooxygenase-2 and assays for preferentially and independently measuring cyclogenase-2 or cyclooxygenase-1 activity present in a given sample.Type: GrantFiled: May 6, 1993Date of Patent: August 6, 1996Assignee: Merck Frosst Canada, Inc.Inventors: Wanda A. Cromlish, Brian P. Kennedy, Gary O'Neill, Philip J. Vickers, Elizabeth Wong, Joseph A. Mancini
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Patent number: 5508032Abstract: The subject invention concerns novel materials and methods for the control of cockroaches. Cockroaches are common house pests, and they create problems in hospitals, the food industry and in agriculture. According to the subject invention, activated toxins of Bacillus thuringiensis var. israelensis (B.t.i.) are used to control cockroaches. In one embodiment, the subject invention also concerns the use of B.t. PS123D1 to control cockroaches. A truncated form of a toxin obtained from PS123D1 having particular activity to cockroaches is also claimed for use in controlling the pest.Type: GrantFiled: June 30, 1994Date of Patent: April 16, 1996Assignee: Mycogen CorporationInventors: H. Ernest Schnepf, John B. Randall, Jewel M. Payne
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Patent number: 5492817Abstract: A method for coupling transcription and translation from DNA using a solution comprising a eukaryotic cell-free extract comprising adding a sufficient amount of a magnesium compound to the extract to raise the magnesium concentration to a level where RNA is transcribed from DNA and RNA translates into protein.Type: GrantFiled: June 27, 1994Date of Patent: February 20, 1996Assignee: Promega CorporationInventors: David V. Thompson, Thomas R. Van Oosbree, Gregory S. Beckler, John F. Van Herwynen
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Patent number: 5482847Abstract: The present invention relates to a DNA fragment containing a nucleotide sequence that encodes an amino acid sequence of esterase, said esterase asymmetrically hydrolyzing carboxylic acid esters represented by the formula (I); ##STR1## (wherein R.sub.1 is alkyl, aralkyl or aryl, R.sub.2 and R.sub.3 are alkyl, and n is 1 or 2) an esterase encoded by the DNA fragment, a recombinant plasmid containing the DNA fragment, a microorganism transformed with the recombinant plasmid and methods of producing optically active carboxylic acids and their enantiomeric esters.Type: GrantFiled: January 14, 1994Date of Patent: January 9, 1996Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Eiji Ozaki, Akihiro Sakimae, Ryozo Numazawa
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Patent number: 5482850Abstract: The present invention relates to the use of these cyclophilins, hereinafter referred to as "cyclophilin-like proteins (CLP)", in a method for identifying compounds capable of binding to and/or inhibiting the enzymatic activity of these proteins. Such compounds may be further screened for their ability to inhibit parasites which are not susceptible to the anti-parasitic effects of CsA.Type: GrantFiled: October 29, 1993Date of Patent: January 9, 1996Assignee: New England Biolabs, Inc.Inventors: Clotilde K. S. Carlow, Antony Page
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Patent number: 5480972Abstract: The present invention provides a nucleic acid having a nucleotide sequence coding for Sor h I, a major allergen of Sorghum halepense, and fragments thereof. The present invention also provides purified Sor h I or at least one fragment thereof, produced in a host cell transformed with a nucleic acid sequence coding for Sor h I, or at least one fragment thereof and fragments of Sor h prepared synthetically. Sor h I and fragments thereof are useful for diagnosing, treating, and preventing allergy to Johnson grass pollen.Type: GrantFiled: October 30, 1992Date of Patent: January 2, 1996Assignees: The University of Melbourne, ImmuLogic Pharmaceutical CorporationInventors: Asil Avjioglu, Mohan B. Singh, Robert B. Knox
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Patent number: 5439821Abstract: The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.Type: GrantFiled: July 7, 1994Date of Patent: August 8, 1995Assignees: University of Florida Research Foundation, The United States of America as represented by the United States Department of AgricultureInventors: Dov Borovsky, David A. Carlson
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Patent number: 5426044Abstract: A novel human protein, minactivin, can be produced by recombinant DNA technology, Biologically active native minactivin, peptides derived from minactivin, and their amino acid sequences can also be purified.Type: GrantFiled: April 30, 1991Date of Patent: June 20, 1995Assignees: Biotechnology Australia, Pty., Ltd., Australian National UniversityInventors: Toni M. Antalis, Thomas M. Barnes, Michelle A. Clark, Peter L. Devine, Neil H. Goss, Philip R. Lehrbach
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Patent number: 5418162Abstract: Isolated DNA encoding a serotonin transporter is disclosed. Also disclosed are vectors and host cells containing the aforesaid DNA, methods of using the same, purified protein by the same, and oligonucleotides and antibodies which bind thereto. Specific embodiments are cDNAs encoding rat and human serotonin transporter.Type: GrantFiled: October 14, 1992Date of Patent: May 23, 1995Assignees: Duke University, Emory UniversityInventors: Randy D. Blakely, Marc G. Caron, Robert T. Fremeau, Jr.
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Patent number: 5408037Abstract: Methods for detecting glucagon antagonists through the use of recombinant DNA techniques are provided. Briefly, subsequent to the expression of glucagon analogs within suitable host cells, the analogs are exposed to a glucagon receptor coupled to a response pathway in the presence of native glucagon. A reduction in the stimulation of the response pathway resulting from the binding of the glucagon analog to the glucagon receptor relative to the stimulation of the response pathway by native glucagon alone indicates the presence of a glucagon antagonist. Glucagon antagonists identified and isolated through the methods are also provided.Type: GrantFiled: August 8, 1991Date of Patent: April 18, 1995Assignee: ZymoGenetics, Inc.Inventors: Robert A. Smith, James R. Piggott
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Patent number: 5393527Abstract: Stabilized microspherical particles having hydrophobic liquid cores prepared as oil-in-water microemulsions. The particles are stabilized by a surface layer comprising an amphiphilic compound and may be functionalized to allow covalent coupling of a ligand to the surface of the particle. When used as tracers in assays, a water insoluble dye may be incorporated in the core liquid of the microparticles.Type: GrantFiled: January 4, 1993Date of Patent: February 28, 1995Assignee: Becton, Dickinson and CompanyInventors: Adrien Malick, Hans H. Feindt
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Patent number: 5382518Abstract: The invention concerns a new urate oxidase activity protein which has the following sequence:______________________________________ Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val Tyr Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu Met Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr Lys Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr Ile Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe Gly Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His Ala Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile Asp Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys Arg Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys Ser Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe Trp Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp Arg Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe Ser Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr Trp Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp AsnType: GrantFiled: July 28, 1992Date of Patent: January 17, 1995Assignee: SanofiInventors: Daniel Caput, Pascual Ferrara, Jean-Claude Guillemot, Mourad Kaghad, Richard Legoux, Gerard Loison, Elisabeth Larbre, Johannes Lupker, Pascal Leplatois, Marc Salome, Patrick Laurent
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Patent number: 5340716Abstract: Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises providing (1) a medium suspected of containing the analyte, (2) a label reagent comprising a first specific binding pair (sbp) member associated with a photochemically activatable chemiluminescent compound wherein the first sbp member is capable of binding to the analyte or to a second sbp member to form a complex related to the presence of the analyte. The method further comprises photochemically activating the chemiluminescent compound. The amount of luminescence generated by the chemiluminescent compound is detected. The amount thereof is related to the amount of analyte in the medium. Compositions and kits are also disclosed.Type: GrantFiled: June 20, 1991Date of Patent: August 23, 1994Assignee: Snytex (U.S.A.) Inc.Inventors: Edwin F. Ullman, Hrair Kirakossian, John S. Pease, Yuri Daniloff, Daniel B. Wagner
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Patent number: 5273746Abstract: Methods and compositions for the control of lice are described. Specifically, Bacillus thuringiensis (B.t.) isolates having anti-lice activity are disclosed. Also described are recombinant hosts which express B.t. genes coding for pesticidal toxins. The B.t. isolates and recombinant proteins are shown to be useful in a method for controlling lice including the sheep louse.Type: GrantFiled: January 29, 1992Date of Patent: December 28, 1993Assignee: Mycogen CorporationInventors: Jewel M. Payne, Leslie A. Hickle
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Patent number: 5232849Abstract: A bacteriocin or polypeptide (LL-2 SEQ ID NO:2) derived from Lactococcus lactis subspecies lactis NRRL-B-18809 is described. Sequenced DNA and polypeptide precursor encoded thereby (SEQ ID NO: 1) are described. Methods of use and production of the polypeptide LL-2 are described.Type: GrantFiled: May 14, 1992Date of Patent: August 3, 1993Assignee: Quest International Flavors & Food Ingredients Company division of Indopco, Inc.Inventors: Ebenezer R. Vedamuthu, James T. Henderson, John D. Marugg, Pieter D. van Wassenaar
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Patent number: 5196316Abstract: The invention concerns a peptidylhydroxyglycine N-C lyase (PHL) catalyzing the reactionR-GlyOH.fwdarw.R-NH.sub.2wherein R represents a peptide residue, and GlyOH represents an .alpha.-hydroxyglycine residue linked to the C-terminus of said peptide R by an amide bond, a recombinant DNA molecule coding for a PHL, a method for the preparation of such a recombinant DNA molecule, processes for the preparation of PHL from a natural source or by means of the said recombinant DNA molecule, and the use of PHL for the preparation of an amidated peptide R-NH.sub.2.Type: GrantFiled: May 30, 1991Date of Patent: March 23, 1993Assignee: Japat Ltd.Inventors: Yasuno Iwasaki, Yoshiki Nishikawa