Abstract: A device is disclosed usable for low level laser therapy to induce a photochemical reaction (non-heating) which is used in the treatment of conditions like tendonitis and other soft tissue injuries, wound healing and pain relief. The arrangement proposed will allow the device to be a Class I laser device thus providing long term minimization of the running costs of the device. The device includes a laser generating means (10) for generating a laser beam (14), the laser generating means (10) having an apparent source size and homogenising means (12) for modifying the laser beam (14) for modifying the apparent source size of the laser beam (14).

Abstract: A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and/or a surgical procedure in the peritoneal cavity can be conducted via the wall of the digestive tract with the use of a flexible endoscope. As presently proposed, the technique is particularly adapted to transgastric peritoneoscopy. However, access in addition or in the alternative through the intestinal wall is contemplated and described as well. Transgastric and/or transintestinal peritoneoscopy will have an excellent cosmetic result as there are no incisions in the abdominal wall and no potential for visible post-surgical scars or hernias.

Abstract: Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.

Abstract: In accordance with the present invention, methods and structures are provided for the treatment of functional spinal unit injuries through the use of light activated gene therapy to induce bone fusion through the introduction of a desired gene into a patient's spinal tissue. Methods and structures are also provided for the utilization of ultraviolet light activated gene therapy to repair/rebuild an injured intervertebral disc through the introduction of a desired gene into a patient's spinal tissue. An implant system including a light probe and an implant with which r-AAV is integrated is also provided.

Abstract: Methods for the creation of microspheres treat the clear, intact crystalline lens of the eye with energy pulses, such as from lasers, for the purpose of correcting presbyopia, other refractive errors, and for the retardation and prevention of cataracts. Microsphere formation in non-contiguous patterns or in contiguous volumes works to change the flexure, mass, or shape of the crystalline lens in order to maintain or reestablish the focus of light passing through the ocular lens onto the macular area, and to maintain or reestablish fluid transport within the ocular lens.

Abstract: A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.

Abstract: A device and method for steering a laser beam to a focal point in target tissue requires generating a laser beam. Diversions of the laser beam from a central beam path are minimized by a sequential arrangement of optical steering components. In order, the beam is first directed to the center of a z-scanning apparatus which will move the focal point in the medium in a z-direction. The beam is then passed to the center of a first galvanometric mirror which introduces focal point movements in the x-direction. A second galvanometric mirror then compensates for the x-direction movement by redirecting the beam to the center of a third galvanometric mirror where focal point movements in the y-direction are introduced.

Abstract: Systems, methods and apparatus for performing selective ablation of a corneal surface of an eye to effect a desired corneal shape, particularly for correcting a hyperopic/astigmatic condition by laser sculpting the corneal surface to increase its curvature. In one aspect of the invention, a method includes the steps of directing a laser beam onto a corneal surface of an eye, and changing the corneal surface from an initial curvature having hyperopic and astigmatic optical properties to a subsequent curvature having correctively improved optical properties. Thus, the curvature of the anterior corneal surface is increased to correct hyperopia, while cylindrical volumetric sculpting of the corneal tissue is performed to correct the astigmatism. The hyperopic and astigmatic corrections are preferably performed by establishing an optical correction zone on the anterior corneal surface of the eye, and directing a laser beam through a variable aperture element designed to produce a rectangular ablation (i.e.

Abstract: A method and system to create and acoustically manipulate without destroying a microbubble which, in biological applications, can manipulate structures such as cells and subcellular structures at a nanoscopic scale.

Abstract: In accordance with the present invention, methods are provided for treating a patient through the use of ultraviolet light activated gene therapy. Embodiments of the present invention include methods for the utilization of light activated gene therapy to repair and/or rebuild damaged cartilage by introducing a desired gene into a patient's tissue.

Abstract: Efficient ablation with multiple prong electrodes is obtained by electrically isolating the prongs from each other and rapidly switching electric power between the prongs, between a prong and a ground pad, or both. In this way, power distribution to a tumor can be controlled efficiently without the need to change probe geometry.

Abstract: Devices, systems, and methods for measuring and determining positions of light energy having wavelengths of less than (as well as equal to or greater than) 200 nm, and are particularly well suited for measuring pulsed light at ultraviolet and other wavelengths using position sensing diode (PSD) technology. An integrator may sum a total charge of a signal from the PSD. Correlations between a distribution of integrated charges among electrodes of the PSD may be non-linear, and may benefit from adjustment for different overall pulse light quantities and/or spot sizes.

Abstract: An ophthalmic surgery light transmitting apparatus has an optic fiber having a flexible length with a light source connector mounted on one end of the optic fiber and the opposite end of the optic fiber being adapted to be mounted to an ophthalmic surgery instrument to provide illumination for the instrument. The cross-sectional area of the optic fiber transitions as it extends from the end connected to the light source connector to the opposite end of the optic fiber. The optic fiber transitions from a larger cross-sectional area of the optic fiber at the light source connector to a smaller cross-sectional area of the optic fiber at the opposite end.

Abstract: A dermatologic treatment apparatus is disclosed which includes one or more housings with at least one housing configured for manipulation in a dermatologic treatment procedure, a light source, and an electrical circuit. The circuit energizes the light source to produce output light pulses. A light path includes an aperture through which eye-safe light pulses are propagated having properties sufficient for providing efficacious treatment. An optical diffuser is disposed along the light path to reduce the integrated radiance to an eye-safe level. The apparatus produces an output fluence not less than 4 J/cm2.

Abstract: The present invention intends to provide a laser corneal surgery apparatus in which an optical system for directing and irradiating a laser beam onto a cornea can be protected from water droplets and the like. The laser corneal surgery apparatus for ablating a cornea of a patient's eye by a laser beam comprises an observation optical system for observing the patient's eye, an irradiation optical system for irradiating the laser beam onto the cornea, and a protection plate which is disposed on an irradiation optical path between the cornea and an optical member included in the irradiation optical system and disposed in a position nearest to the cornea, and which is insertable in and removable from the optical path.

Abstract: A selective aperture for a laser delivery system for providing incision, ablation and coagulation. A laser crystal disposed between two reflective surfaces forms a laser beam. An aperture member positioned between the laser crystal and one of the reflective surfaces includes a substantially circular aperture for passing the laser beam. The size of the aperture is selectively adjustable. The aperture member has a plurality of apertures of various different sizes and is rotatable about an axis of rotation. The axis of rotation is parallel to the longitudinal axis of the laser crystal. By appropriately rotating the aperture member, a selected one of the apertures is positioned to pass the laser beam. A stepper motor and flexible shaft are utilized for rotating the aperture member. At least one of the apertures is surrounded by a beveled portion of the rotatable member. Alternatively, two lasers with different size fixed apertures could be utilized and directed to a common surface.

Abstract: A method of performing photorefractive keratectomy (PRK) wherein the surface smoothness is enhanced. The present invention minimizes the ablation zone dimension including central ablation depth, reducing the need for overcorrection. The present invention reduces regression and scarring (haze) providing enhanced clinical outcomes with faster rehabilitation, greater refractive stability, and improved corneal clarity. Moreover, improved clinical outcomes are achieved by adjusting the initial corneal correction to take into account the effects of regression based upon non-linear predictive formulas which vary with the square of the slope of ablation smoothness (roughness) per micron of ablation depth.

Abstract: A laser photo optic breakdown probe and handpiece system especially suited for small-incision cataract removal including an optical fiber through which a pulsed source of laser energy is delivered to a target spaced from the distal end of the fiber. The fiber is routed through a first guide tube with the target mounted at an angle on the end thereof. Holes are provided in the guide tube for the flow of infusion fluid therethrough. A second aspiration tube surrounds and provides rigidity to the guide tube, shields the distal end of the fiber and target, and serves as a channel for aspirated fluids and dislodged cataractous material. The guide tube is affixed to a transfer housing to which infusion and aspiration connections are made. The aspiration tube forms part of a handle assembly which is detachably coupled to the transfer housing.

Abstract: A noninvasive method is described for performing accurate and controlled reshaping of the anterior surface of the cornea in order to correct ocular refractive errors such as myopia (nearsightedness), hyperopia (farsightedness), and astigmatism. The invention uses a light source emitting a wavelength or wavelengths with correct optical penetration depth(s) to induce changes in corneal stromal collagen without damaging the corneal endothelium, together with a light delivery and control means for producing the required irradiance, exposure time, and geometric pattern, in order to achieve the desired change in corneal shape. Corneal shape is monitored before, during, and after the procedure by a corneal topography system. Anterior corneal surface cooling by a transparent heat sink is used to prevent damage to the epithelium and to Bowman's layer.

Abstract: Near-infrared selective photothermolysis for the treatment of ectatic blood vessels, for example, blood vessels of a portwine stain birthmark. This technique is especially applicable to deeper lying blood vessels in view of the better penetration of the near infrared light. Consequently, vessels are below a dermal/epidermal boundary can be reached. Near-infrared is defined as a range of approximately 700 to 1,200 nm. The optimal colors are near 760 or between 980 to 990 nm for most populations.