Abstract: The invention relates to a structured mixed phase formed by the incorporation of a biological macromolecule into a liquid-crystal phase of amphiphiles, preferably a lamellar phase, wherein said biological macromolecule is present in said structured mixed phase in an amount of at least 5% by weight, based on the amphiphilic compounds constituting said liquid-crystal phase of amphiphiles, and wherein at least one of the two entities consisting of the biological macromolecules, on the one hand, and all the amphiphilic compounds, on the other, is of an uncharged nature. The biological macromolecules incorporated into the structured mixed phases of the invention are preferably selected from polynucleotides, particularly DNA or RNA, proteins and polysaccharides. The invention further relates to vesicles obtained by dispersion of the above structured mixed phases.

Abstract: Improved starch-metal derivatives are provided which have excellent dry flow characteristics and ready dispersability in hot or cold water. The preferred derivatives comprise granules of starch which have been expanded or preswelled and cross-linked, followed by reaction with a polyvalent metal salt, especially salts of Ca, Mg, Zn Cu and Al.

Abstract: A multi-layer coating is particularly useful for the coating of implants such as orthopedic and dental implants, particularly metallic implants. The first layer comprises a bond coating of a dense material insoluble and inert in body fluids. The second layer comprises apatite and a binder. The first layer protects the metallic implants from corrosion, apatite dissolution, and interfacial reaction with apatite and the binder. The apatite in the second layer is a bioactive agent that can osteobond to tissue. The binder allows adjustment of the thermal expansion coefficient between the coating and the metallic substrate. This multi-layer coating has both high bond strength to implants and excellent bioactivity with the surrounding body tissue.

Abstract: The invention concerns a conditioned composition comprising at least a liquid absorbed on a support containing a precipitated silica, said silica being in the form of substantially spherical pellets and having: an average pellet size greater than 150 ?m; a filling density in compacted state (DRT) less than 0.29; an oversize rate for a sieve with aperture size of 75 ?m of at least 88% wt. %; a porous volume (Vd1), consisting of pores with diameter less than 1 ?m, greater than 2.0 cm3/g. The invention also concerns the use of said silica as a support for liquid.

Abstract: Device for applying at least one active principle, consisting of a material wherein one or several capsules or microcapsules containing the active principle(s) are distributed in a binder having a sponge-like consistency so that the active principle(s) is/are released when pressure is exerted on the material. The device consists of a first part (10) and a second part (12), separated by a tear-off portion (14), the capsule or most of the capsules or microcapsules being located in the first part close to the tear-off portion, the first part being detached from the second part by tearing the tear-off portion so as to obtain, at the breakage interface, a surface for applying the active principle(s) contained in the first part when pressure is exerted thereon.

Abstract: A gel formulation is combined with a fungicidal concentrate which is a liquid mixture of about 1.2 to 16 ml parts by volume of ultra pure water having an electrical resistance of 16–26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 16 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943, together with one liter of a gel formulation ingredient containing 10% by weight urea, based on the weight of the gel formulation. The fungicidal liquid concentrate is applied directly to a fungal nail to soften the fungal nail and control the growth of fungi.

Abstract: This invention provides an industrially advantageous process for preparing a composition containing urea and salicylic acid in a water-washable ointment of a non-aqueous emulsion type that exfoliates and moisturizes skin.

Abstract: The invention relates to a method of preventing gel formation of a hydrophobic peptides by contacting the hydrophobic peptide with a counter-ion in an amount and at a molar ratio with the peptide that are sufficient to provide a fluid, milky microcrystalline aqueous suspension of the peptide without formation of a gel. The invention also relates to a fluid, milky microcrystalline aqueous suspension of a hydrophobic peptide and a counter-ion in water, wherein the peptide and counter-ion are present in amounts and at a molar ratio sufficient to form, upon mixing, the suspension without formation of a gel.

Abstract: A shampoo/conditioner that repels lice and aids in the removal of head lice and nits is presented. It is a formulation comprising at least one homeopathic louse insecticide included with acetic acid in association with a gentle wetting agent and shampoo and conditioner and softener components, all tested for low dermal irritation with a final pH below 4.5 and a viscosity of 1200 to 2000 CPS. The product reduces or eliminates the activity of live lice and makes it significantly easier to comb out nits. The product creates an environment repulsive to head lice thereby acting to prevent re-infestation. It is suited for the daily use that is necessary to insure permanent removal of all lice and nits by combing and serves to beautify the hair.

Abstract: An improved composition and method for protecting both natural and artificial hair color from the harmful effects of ultraviolet radiation is provided. The composition includes melanin, an ultraviolet absorber, and a cationic surfactant. The composition may also include other ingredients such as additional cationic surfactants, hair conditioning agents, dispersing agents, rheology modifiers, emulsifiers, antioxidants, film formers, and water. A method of protecting hair color from ultraviolet radiation includes applying the composition to natural or artificial hair.

Abstract: Multiple myeloma and other hematologic tumors and/or malignancies can be treated by administration of a G1 and/or S phase drug, which is preferably ?-lapachone, or a derivative or analog thereof, combined with a G2/M phase drug such as a taxane derivative, which is advantageously paclitaxel. This combination of the G1 and/or S phase drug with the G2/M phase drug results in an unexpectedly greater than additive (i.e., synergistic) apoptosis in multiple myeloma cells. The invention includes methods of treating multiple myeloma by administering the combination of the G1 and/or S phase drug and the G2/M phase drug, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.

Abstract: The invention provides a method and product for mitigating or eliminating pet malodor(s) with an aqueous liquid deodorizing composition, the composition containing about at least 0.01% to about 10% of an dialkali metal tetraborate n-hydrate (with n being an integer from 0 to 10), 0.1–3% water soluble/dispersible polymer, 1–25% water soluble/dispersible volatile solvent, at least 75% water.

Abstract: A method and nutrient supplement composition for nocturnal administration to human subjects where the nutrient supplement composition includes both a sustained timed release portion and a rapid release portion, both portions containing a mixture of edible food proteins and edible amino acid building blocks with a portion of these key components being micro encapsulated for sustained timed release in a the human body during the growth hormone spikes that generally occur during nocturnal sleep.

Abstract: A hair covering which comprises a woven or nonwoven substrate comprising synthetic or natural materials, which are impregnated, or coated, or both, with a mutable dye is described.

Abstract: A hair care formulation is disclosed that enhances visual and/or tactile qualities of the hair. Embodiments of the formulation include a pyridoxine hydrochloride (vitamin B6), a glycyrrhizinic acid, a pantothenic acid, a pyrrolidone, an antimicrobial agent, zinc, and an antioxidant. The formulation may be included in separate hair care products, such as a shampoo, conditioner and scalp serum. In a particular embodiment, the formulation is included in a daily shampoo, a deep cleansing shampoo, a daily conditioner, a deep conditioner, and a scalp serum. In some of these examples, each of the hair care products contain at least 10 vitamins, minerals, and herbs, such as swertia extract, ginseng extract, saw palmetto extract, pyridoxine hydrochloride (vitamin B6), zinc pyrrolidone carboxylic acid, superoxide dismutase, dipotassium glycyrrhizate, green tea extract, and tea tree oil.

Abstract: The invention relates to a moisture and oxygen stable composition comprising inert core particles and a partial or complete coating thereon of at least one active compound encapsulated in a carbohydrate matrix, which matrix is characterized by: 5 to 95 wt. % high molecular weight film forming carbohydratre; 5 to 30 wt. % mono, di and trisaccharides; and 0 to 30 wt. % maltodextrin, based on the total weight of the carbohydrate matrix. The active compound to be encapsulated in the carbohydrate matrix can be selected from the group consisting of flavorants, fragrances, pharmaceuticals and wash-active components.

Abstract: Personal care compositions, particularly hair care products, include a polymer mixture made from (A) a derivatized polymer of maleic anhydride having defined repeat units of a monomer (e.g. ?-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and maleimide, and (B) a compound or polymer having a carboxylic acid functionality. These compositions exhibit excellent high humidity curl retention properties, as well as an advantageous blend of toughness and cohesiveness, and a strong affinity to natural fibers such as keratin-based fibers, e.g. hair, skin, or textiles, such as cotton or wool; and they are also water-soluble and water-resistant.

Abstract: Personal care products, particularly hair care products, are made herein by mixing (A) a polymer having defined repeat units of a monomer (e.g. ?-olefin) maleic anhydride alkyl half-ester or full acid, maleamic acid and maleimide, which is derivatized with an amine, and (B) a compound or polymer having a carboxylic acid functionality. These products exhibit excellent high humidity curl retention properties, as well as an advantageous blend of toughness and cohesiveness, and a strong affinity to natural fibers, when applied to keratin-based fibers, e.g. hair, skin, or textiles, e.g. cotton, wool; and also they are water-soluble and water-resistant.

Abstract: A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g.