Patents Examined by David Vanore
  • Patent number: 12211668
    Abstract: Provided is a charged particle beam device capable of detecting signal charged particles in a wide range of elevation angles from a large elevation angle to a small elevation angle and distinguishing detection signals between backscattered charged particles and secondary charged particles regardless of distribution of the signal charged particles. The charged particle beam device according to the disclosure includes a first detector that detects the secondary charged particles or the backscattered charged particles and a second detector that detects tertiary charged particles generated from the first detector, and generates an observation image of a sample using a signal value obtained by subtracting at least a part of a second detection signal output by the second detector from a first detection signal output by the first detector, or subtracting at least a part of the first detection signal from the second detection signal.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: January 28, 2025
    Assignee: Hitachi High-Tech Corporation
    Inventors: Kohei Suzuki, Shunsuke Mizutani, Yuji Kasai
  • Patent number: 12211681
    Abstract: A method for determining the integrity of at least one complex based on at least one biological sample and at least one matrix, including at least the following steps:—acquiring at least one image,—analyzing the image sent by extracting light intensity values representative of at least one spectral band,—relating the light intensity values to one another to obtain representative spectral data,—determining a state of integrity of the complex by comparing each of the representative spectral data by similarity grouping with a determined similarity threshold,—triggering at least one first alert, by the analysis unit, when the representative data are similar to the first state of integrity or to the second state of integrity.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: January 28, 2025
    Assignee: BIOMERIEUX
    Inventors: Denis Leroux, Jean-Philippe Charrier, Régis Montvernay, Philippe Wandels
  • Patent number: 12196765
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: January 14, 2025
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Patent number: 12196692
    Abstract: Systems and methods of providing a probe spot in multiple modes of operation of a charged-particle beam apparatus are disclosed. The method may comprise activating a charged-particle source to generate a primary charged-particle beam and selecting between a first mode and a second mode of operation of the charged-particle beam apparatus. In the flooding mode, the condenser lens may focus at least a first portion of the primary charged-particle beam passing through an aperture of the aperture plate to form a second portion of the primary charged-particle beam, and substantially all of the second portion is used to flood a surface of a sample. In the inspection mode, the condenser lens may focus a first portion of the primary charged-particle beam such that the aperture of the aperture plate blocks off peripheral charged-particles to form the second portion of the primary charged-particle beam used to inspect the sample surface.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: January 14, 2025
    Assignee: ASML Netherlands B.V.
    Inventors: Weiming Ren, Xuedong Liu, Zhong-wei Chen, Xiaoyu Ji, Xiaoxue Chen, Weimin Zhou, Frank Nan Zhang
  • Patent number: 12198892
    Abstract: A sample holder HL capable of efficiently applying a pressure to an observation surface of a sample SAM is provided. The sample holder HL includes a fixed electrode 4b, a movable electrode 5, and a pressure applying member 6 attached to the movable electrode 5 and having a function to move the movable electrode 5 in a horizontal direction. When the sample SAM is held between a side surface of the fixed electrode 4b and a side surface of the movable electrode 5, an upper surface of the sample SAM is located within a range of a width of the pressure applying member 6 at a position where the pressure applying member 6 is in contact with the movable electrode 5 in the Z direction.
    Type: Grant
    Filed: May 27, 2019
    Date of Patent: January 14, 2025
    Assignee: Hitachi High-Tech Corporation
    Inventors: Shigeru Haneda, Junzo Azuma
  • Patent number: 12186141
    Abstract: A cleaning chamber for cleaning a vein viewing device, includes a housing with an access door having an open position and a shut position, wherein when the access door is in the open position the vein viewing device can be placed inside the housing. When the access door is in the closed position the housing and access door together envelop the vein viewing device. A detector detects when the vein viewing device is contained within the housing. A light source is contained within the housing and is arranged to illuminate the exterior surfaces of the vein viewing device when the vein viewing device is detected within the housing.
    Type: Grant
    Filed: March 21, 2022
    Date of Patent: January 7, 2025
    Inventors: Vincent P. Luciano, Ron Goldman
  • Patent number: 12191134
    Abstract: A set of acceleration electrodes for the acceleration of charged particles in a vacuum ion optical system, wherein each acceleration electrode comprises a conical section and at least an elongated leg protruding from the conical section, the elongated leg and any further elongated leg each being configured as a mechanical support and as an electrical connection between the conical section and an intended source of electric potential.
    Type: Grant
    Filed: October 22, 2020
    Date of Patent: January 7, 2025
    Assignee: Spacetek Technology AG
    Inventors: Jürg Jost, Lukas Hofer
  • Patent number: 12183539
    Abstract: Various approaches are provided for transferring samples within an inert gas environment to and from a beam system. In one example, a sample transfer capsule includes a container configured to store a sample during transport, wherein the container is adjustable between a closed configuration and an open configuration, an inert gas storage chamber coupled to the container and configured to store an inert gas, and a valve coupled to the inert gas storage chamber and the container and configured to selectively allow the inert gas to flow from the inert gas storage chamber to the container when the container is in the closed configuration. In this way, samples may be maintained in an inert gas environment during transport and while beam system vacuum chambers are vented, thereby reducing exposure of the samples and subsequently reducing the rate of a chemical reaction, such as oxidation or nitridation, of the samples.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: December 31, 2024
    Assignee: FEI Company
    Inventors: Libor Novák, Petr Glajc, Marek Uncovský
  • Patent number: 12183557
    Abstract: Embodiments of the present disclosure generally relate to apparatus and methods for controlling an ion energy distribution during plasma processing. In an embodiment, the apparatus includes a substrate support that has a body having a substrate electrode for applying a substrate voltage to a substrate, and an edge ring electrode embedded for applying an edge ring voltage to an edge ring. The apparatus further includes a substrate voltage control circuit coupled to the substrate electrode, and an edge ring voltage control circuit coupled to the edge ring electrode. The substrate electrode, edge ring electrode, or both are coupled to a power module configured to actively control an energy distribution function width of ions reaching the substrate, edge ring, or both. Methods for controlling an energy distribution function width of ions during substrate processing are also described.
    Type: Grant
    Filed: September 11, 2023
    Date of Patent: December 31, 2024
    Assignee: Applied Materials, Inc.
    Inventors: Linying Cui, James Rogers
  • Patent number: 12176174
    Abstract: An electron tube includes a housing that is internally held in a vacuum and has a window transmitting an electromagnetic wave, an electron emitting unit that is disposed in the housing and has a meta-surface emitting electrons in response to incidence of the electromagnetic wave, an electron multiplying unit that is disposed in the housing and multiplies the electrons emitted from the electron emitting unit, and an electron collecting unit that is disposed in the housing and collects the electrons multiplied by the electron multiplying unit. The window contains at least one selected from quartz, silicon, germanium, sapphire, zinc selenide, zinc sulfide, magnesium fluoride, lithium fluoride, barium fluoride, calcium fluoride, magnesium oxide, and calcium carbonate.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: December 24, 2024
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Tetsuya Fujita, Takahiro Suzuki, Yasuhide Miyazaki, Naoya Kawai, Peter Uhd Jepsen, Simon Lehnskov Lange
  • Patent number: 12176121
    Abstract: A nanotweezer and method of trapping and dynamic manipulation thereby are provided. The nanotweezer comprises a first metastructure including a first substrate, a first electrode, and a plurality of plasmonic nanostructures arranged in an array, and a trapping region laterally displaced from the array; a second metastructure including a second substrate and a second electrode; a microfluidic channel between the first metastructure and the second metastructure; a voltage source configured to selectively apply an electric field between the first electrode and the second electrode; and a light source configured to selectively apply an excitation light to the microfluidic channel at a first location corresponding to the array, thereby to trap a nanoparticle at a second location corresponding to the trapping region.
    Type: Grant
    Filed: October 2, 2023
    Date of Patent: December 24, 2024
    Assignee: Vanderbilt University
    Inventor: Justus C. Ndukaife
  • Patent number: 12176196
    Abstract: Devices and methods for surface-induced association are disclosed herein. According to one embodiment, a device for surface-induced dissociation (SID) includes a collision surface and a deflector configured to guide precursor ions from a pre-SID region to the collision surface. In some embodiments, an extractor extracts ions off the collision surface after collision with the collision surface. In some embodiments, an RF device can collect and/or transmit the extracted ions. In some embodiments, an ion funnel guides product ions resulting from collision with the collision surface to a post-SID region. Some aspects of the disclosure are directed to methods for surface-induced dissociation, which may in some embodiments include using of a split lens or an ion funnel.
    Type: Grant
    Filed: December 15, 2019
    Date of Patent: December 24, 2024
    Assignee: Ohio State Innovation Foundation
    Inventors: Vicki Wysocki, Dalton Snyder, Benjamin Jones, Alyssa Stiving, Joshua Gilbert, Zachary Vanaernum, Sophie Harvey-Bernier
  • Patent number: 12176066
    Abstract: Embodiments of a method and/or system for facilitating characterization of one or more conditions can include: generating a set of target-associated molecules; generating a reference-associated set of molecule; facilitating generation of at least one spike-in mixture; determining one or more abundance metrics based on an analysis of the at least one spike-in mixture; and facilitating the characterization of the one or more conditions based on the one or more abundance metrics.
    Type: Grant
    Filed: March 24, 2023
    Date of Patent: December 24, 2024
    Assignee: BILLIONTOONE, INC.
    Inventors: David Tsao, Oguzhan Atay
  • Patent number: 12167929
    Abstract: The present invention relates to positioning a medical imaging system in relation to an object. In order to provide improved positioning possibilities which facilitate the workflow during an intervention, a medical imaging apparatus (10) is provided with an image acquisition arrangement (12), which is positionable in relation to an object (16) to acquire image data (18) of the object from different directions. An output unit (14) is arranged to provide the image data. According to the invention, first movement direction indicators (22) are provided to indicate possible movement directions of the image acquisition arrangement in relation to the object.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: December 17, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Peter Belei, Bart Carelsen
  • Patent number: 12168148
    Abstract: A neutron capture therapy system is provided, including a neutron generating device and a beam shaping assembly. The neutron capture therapy system further includes a concrete wall forming a space for accommodating the neutron generating device and the beam shaping assembly and shielding radiations generated by the neutron generating device and the beam shaping assembly. A support module is disposed in the concrete wall, the support module is capable of supporting the beam shaping assembly and is used to adjust the position of the beam shaping assembly, and the support module includes concrete and a reinforcing portion at least partially disposed in the concrete. The neutron capture therapy system designs a locally adjustable support for the beam shaping assembly, so that the beam shaping assembly can meet the precision requirement, improve the beam quality, and meet an assembly tolerance of the target.
    Type: Grant
    Filed: October 18, 2023
    Date of Patent: December 17, 2024
    Assignee: NEUBORON THERAPY SYSTEM LTD.
    Inventors: Tao Jiang, Wei-lin Chen
  • Patent number: 12168617
    Abstract: In one aspect, a sterilization apparatus is provided to include a flow channel body comprising an inflow unit configured to provide an inflow channel through which water flows in one direction, a discharge unit configured to provide a discharge channel through which water is discharged, and a bypass channel unit configured to provide a bypass channel through which water bypasses in a different direction from the direction of the water flowing in the inflow unit; a mounting unit formed on the flow channel body and configured to provide an installation space connected to the bypass channel, a UV light emitting unit disposed in the installation space and configured to emit UV light towards the bypass channel; and a holder coupled to the mounting unit and securing the UV light emitting unit inside the mounting unit.
    Type: Grant
    Filed: October 2, 2023
    Date of Patent: December 17, 2024
    Assignee: SEOUL VIOSYS CO., LTD.
    Inventors: Woong Ki Jung, Sang Hyun Chang
  • Patent number: 12170183
    Abstract: Provided is a method for adjusting a field-of-view of a charged particle microscope device, in which reference data for a sample is set, a plurality of regions of interest are set for the reference data, a rough sampling coordinate group is set for each of the plurality of regions of interest, the sample is irradiated with charged particles based on the sampling coordinate group to obtain a corresponding pixel value group, a plurality of reconstructed images corresponding to the plurality of regions of interest are generated based on the pixel value group, a correspondence relationship among the plurality of regions of interest is estimated based on the plurality of reconstructed images, and the plurality of regions of interest are adjusted based on the correspondence relationship. Here, the sampling coordinate group is set based on the reference data.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: December 17, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Mitsutoshi Kobayashi, Atsushi Miyamoto, Yoshinobu Hoshino
  • Patent number: 12168078
    Abstract: Embodiments of the disclosure include an uncovered ultraviolet light emitting panel for use in supporting instruments in an operating room. The panel fits inside an autoclave for sterilization and can be utilized without a sterile cover. In use, the panel irradiates surgical instruments and the nearby air continuously.
    Type: Grant
    Filed: September 5, 2023
    Date of Patent: December 17, 2024
    Inventor: John Mansell
  • Patent number: 12165839
    Abstract: Systems and method for the preparation and delivery of biological samples for charged particle analysis are disclosed herein. An example system at least includes an ion filter coupled to select a sample ion from an ionized sample supply, the ion filter including a quadrupole filter to select the sample ion from the sample supply, an energy reduction cell coupled to receive the selected sample ion and reduce a kinetic energy of the sample ion, a validation unit coupled to receive the sample ion and determine whether the sample ion is a target sample ion, a substrate coupled to receive the sample, wherein the substrate is electron transparent, an ion transport module coupled to receive the sample ion from the ion filter and transport the sample ion to the substrate, and an imaging system arranged to image, with a low energy charged particle beam, the sample located on the substrate, wherein the substrate is arranged in an analysis location.
    Type: Grant
    Filed: July 18, 2023
    Date of Patent: December 10, 2024
    Assignee: FEI Company
    Inventors: Marcus Straw, Dmitry Grinfeld, Alexander Makarov, Alan Bahm, Aaron Torok, Kun Liu, Joseph Christian, Josh Gilbert, Tom Nichols, Jeff Kosmoski
  • Patent number: 12158474
    Abstract: A method for characterizing or quantifying one or more proteins in visible and/or sub-visible particles formed in a sample by detecting the at least one visible or sub-visible particle in the sample, isolating and capturing the at least one visible or sub-visible particle to identify a presence of a protein, and using a mass spectrometer to characterize the protein.
    Type: Grant
    Filed: May 8, 2023
    Date of Patent: December 3, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Xiaobin Xu