Patents Examined by David W Berke-Schlessel
  • Patent number: 11401492
    Abstract: The disclosure relates to methods, systems and compositions for use in the production of milk. More specifically, the disclosure is directed to systems, compositions and methods for in-vitro production of milk using an array of mammary organoids seeded on tertiary-branched, resilient duct scaffolding.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: August 2, 2022
    Assignee: Biomilk Ltd.
    Inventor: Sharon Fima
  • Patent number: 11401540
    Abstract: Disclosed is a method for producing algae-derived polyunsaturated fatty acids, comprising the steps of a) contacting dry algae with ethanol; b) removing ethanol to obtain crude oil; c) subjecting the crude oil to a transesterification reaction with a lower alcohol to generate fatty acid alkyl esters; d) extracting the fatty acid alkyl esters to result in a phase containing fatty acid alkyl esters; e) collecting the phase containing fatty acid alkyl esters; and f) contacting the collected phase with silica gel. Also disclosed is a method for effectively removing impurities, including chlorophyll, fucoxanthin and beta-carotene, from crude algal fatty acid alkyl esters, comprising contacting the crude algal fatty acid alkyl esters with silica gel in hexane.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: August 2, 2022
    Assignee: GUANGXI XIAOZAO AGRICULTURE TECHNOLOGY CO., LTD.
    Inventors: Wei Yu, WeiFang Xi, XiaoLi Wu, HongJia Zhang, Lei Wang
  • Patent number: 11401491
    Abstract: The disclosure relates to methods, systems and compositions for use in the production of milk. More specifically, the disclosure is directed to systems, compositions and methods for in-vitro production of milk using an array of mammary organoids seeded on tertiary-branched, resilient duct scaffolding.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: August 2, 2022
    Assignee: Biomilk Ltd.
    Inventor: Sharon Fima
  • Patent number: 11389565
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: July 19, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
  • Patent number: 11376312
    Abstract: Provided herein is a composition and a method for treating nucleic acid-related eye disease.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: July 5, 2022
    Assignee: The Board of Trustees of The University of Illinois
    Inventor: Sandeep Jain
  • Patent number: 11369716
    Abstract: Methods are described for generating autologous tissue grafts, including generating grafts at the point of care, which include isolated cell populations that are enriched with stem cells and are mixed with biological fillers including hyaluronic acid and derivatives thereof. The hyaluronic acid localizes the cells to a desired injection site and stimulates collagen production thus enhancing the viability and the longevity of the graft.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: June 28, 2022
    Assignees: INGENERON, INC., Board of Regents, The University of Texas System
    Inventors: Andrew M Altman, Eckhard U. Alt, Michael E. Coleman
  • Patent number: 11371071
    Abstract: A structure for culturing cells includes growth medium regions on a surface of the structure. Each of the growth medium regions includes a growth medium surface configured to receive and promote growth in a cell that is being cultured. The structure includes a non-growth medium. The non-growth medium includes a non-growth medium surface configured to receive the cell that is being cultured.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: June 28, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Amos Cahan, Guy M. Cohen, Theodore G. van Kessel, Sufi Zafar
  • Patent number: 11357798
    Abstract: The present invention relates to mesenchymal stem cell-derived microparticles having activity that promotes the growth of corneal epithelial stem cells and/or corneal epithelial cells, activity that maintains corneal epithelial stem cells in an undifferentiated state or promotes the formation of colonies thereby, and function that protects corneal epithelium.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: June 14, 2022
    Assignees: OSAKA UNIVERSITY, ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Kohji Nishida, Ryuuhei Hayashi, Yoichi Honma, Toru Okubo, Shun Shibata
  • Patent number: 11359179
    Abstract: The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 14, 2022
    Assignee: FRED HUTCHINSON CANCER CENTER
    Inventor: Irwin D. Bernstein
  • Patent number: 11345884
    Abstract: The present invention is drawn, in part, to biocompatible compositions comprising a biocompatible polymer matrix and conditioned cell medium comprising i) a cell culture medium and ii) one or more agents synthesized by and secreted from one or more cells cultured in the cell culture medium, as well as therapeutic uses thereof, particularly in modulating bone and/or gum tissue growth.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: May 31, 2022
    Assignee: Cellum Biomedical, Inc.
    Inventor: Richard C. Jin
  • Patent number: 11332768
    Abstract: A method for producing a partially hydrolysed lignocellulosic material is provided including treating a lignocellulosic material with an acid and/or an alkali and then a polyol. Also provided are methods of producing a fermentable sugar, or a fermentable sugar and a fermentation product from said partially hydrolysed lignocellulosic material. A partially hydrolysed lignocellulosic material, a fermentable sugar, and fermentation product produced by such methods are also provided. Also provided is an apparatus for producing a partially hydrolysed lignocellulosic material, such as by the aforementioned method.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: May 17, 2022
    Assignee: LEAF SCIENCES PTY LTD
    Inventors: Alex Baker, Leslie Alan Edye
  • Patent number: 11332771
    Abstract: The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine can be added to serum-free media or chemically defined media to improve viable cell density, to reduce cell doubling time, and to increase the production of a protein of interest.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: May 17, 2022
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Shadia Abike Oshodi, Amy S. Johnson, Shawn M. Lawrence
  • Patent number: 11326154
    Abstract: The present invention relates to fusion proteins comprising an N-intein polypeptide and an N-intein solubilization partner, and affinity chromatography matrices comprising such fusion proteins, as well as methods of using same.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: May 10, 2022
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Joe Orlando
  • Patent number: 11326149
    Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: May 10, 2022
    Assignee: EMULATE, INC.
    Inventors: S. Jordan Kerns, Norman Wen, Carol Lucchesi, Christopher David Hinojosa, Jacob Fraser, Jefferson Puerta, Geraldine Hamilton, Robert Barrett, Clive Svendsen, Daniel Levner, Stephen R Targan, Michael Workman, Dhruv Sareen, Uthra Rajamani, Magdalena Kasendra
  • Patent number: 11319561
    Abstract: The present invention discloses a method for producing a long chain dicarboxylic acid by fermentation as well as a fermentation broth, a treated fermentation broth and a wastewater. The salt content in the fermentation broth is controlled to be below 20% by the fermentation method of the present invention. The method for producing a long chain dicarboxylic acid by fermentation provided by the present invention can effectively reduce the amount of alkali used in the fermentation process and the amount of acid used in the subsequent extraction of the long chain dicarboxylic acid, thereby reducing the amount of salt in the whole production process of the long chain dicarboxylic acid. At the same time, the method of the present invention also has many advantages such as shortening the fermentation time, increasing the acid production, reducing the amount of medium, and suitable for the production of various types of long-chain dicarboxylic acids, etc.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: May 3, 2022
    Assignees: CATHAY BIOTECH INC., CIBT AMERICA INC.
    Inventors: Min Xu, Chen Yang, Bingbing Qin, Naiqiang Li, Xiucai Liu
  • Patent number: 11318228
    Abstract: The invention relates to crosslinked soft tissue grafts and methods of use thereof. The invention also relates to methods of preparing the same.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: May 3, 2022
    Assignee: LifeNet Health
    Inventor: Eran Rosines
  • Patent number: 11304977
    Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: April 19, 2022
    Assignee: ImmunityBio. Inc.
    Inventors: Hans G. Klingemann, Barry J. Simon
  • Patent number: 11304941
    Abstract: The present invention concerns a method for modulating the enzymatic activity of an enzyme, wherein said enzyme interacts with BMP, said method comprising the step of administering or inducing Hsp70, or a functional fragment or variant thereof, in a form suitable for allowing interaction between BMP and Hsp70, or said functional fragment or variant thereof, and thereby modulating the enzymatic activity of an enzyme interacting with BMP.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: April 19, 2022
    Assignee: Orphazyme A/S
    Inventors: Thomas Kirkegaard Jensen, Marja H. Jaattela
  • Patent number: 11291161
    Abstract: Systems and methods for growing vegetation are provided. The disclosed systems (100) and methods (1100, 1200) use rotating growth mats (102) and a cutting device (112). The rotating growth mats and cutting device can be coupled to an anaerobic digester (402) to generated methane gas using vegetation grown on the growth mats. The systems and methods may further use C artificial light sources (108) and a nutrients delivery system (110) to assist growth.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: April 5, 2022
    Assignee: BENNAMANN SERVICES LTD
    Inventors: Christopher Mann, Michael Bennett, Derek William Kenneth Jenkins, Thomas William Bradshaw, Matthew Charles Seabrook Heritage
  • Patent number: 11291686
    Abstract: The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: April 5, 2022
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Suzanne T. Ildstad, Mary Jane Elliott