Patents Examined by David Weisz
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Patent number: 8003398Abstract: The present invention provides various methods and compositions which allow for determining the presence or amount of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphoric acid (AMPA) and its various metabolites in a variety of test matrices. In one method, determining the presence or amount of N-acetylglyphosate and/or N-acetyl AMPA in a test sample comprises providing the test sample suspected of containing N-acetylglyphosate and/or N-acetyl AMPA; extracting the N-acetylglyphosate and/or N-acetyl AMPA from the test sample; and, detecting the N-acetylglyphosate and/or N-acetyl AMPA in the extract. In other methods, the presence or amount of at least one of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphonic acid (AMPA) or a metabolite thereof in a test sample is determined.Type: GrantFiled: March 19, 2008Date of Patent: August 23, 2011Assignee: E.I. de Pont de Nemours and CompanyInventors: Frederick Q. Bramble, Jr., Anne M. Pentz
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Patent number: 8003395Abstract: Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.Type: GrantFiled: June 21, 2006Date of Patent: August 23, 2011Assignee: Trace Bio Analytics, LLCInventors: Poguang Wang, Guodong Li, Roger W. Giese
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Patent number: 7993931Abstract: Provided are methods and compositions for quantitatively measuring the amount of an unlabeled organic acid in a sample. Oxygen-18 labeled organic acids are used as internal standards to adjust for the loss of a structurally similar or identical unlabeled organic acid through processing required for its detection, such as by mass spectrometry. The methods of the invention are useful for diagnosing inborn errors of metabolism in an individual by quantitating signature organic acids in body fluids such as urine or plasma.Type: GrantFiled: October 28, 2003Date of Patent: August 9, 2011Assignee: Quest Diagnostics Investments IncorporatedInventor: Su Chen
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Patent number: 7981688Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.Type: GrantFiled: March 8, 2007Date of Patent: July 19, 2011Assignee: University of WashingtonInventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
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Patent number: 7972864Abstract: A method of measuring concentration of a fuel is provided. First, a fuel cell unit having at least an anode, a cathode, and a membrane electrode assembly (MEA) is provided. Next, a fuel is supplied to the anode, while a reactive gas is supplied to the cathode. Then, the amount of the reactive gas supplied to the cathode is adjusted and the concentration of the fuel is estimated in accordance with the consumption rate of the reactive gas in the fuel cell unit.Type: GrantFiled: May 20, 2008Date of Patent: July 5, 2011Assignee: Industrial Technology Research InstituteInventors: Ku-Yen Kang, Pei-Fang Huang, Chiou-Chu Lai
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Patent number: 7972859Abstract: A method of determining authenticity of an ingestible product purportedly from a batch of saccharide-marked ingestible product is provided. The ingestible product is a food, beverage, or pharmaceutical, for example. The method includes identifying a sample of the ingestible product to be tested; and testing the sample for a marked presence of the saccharide using a saccharide-specific binding protein. The ingestible product is not authentic when the testing demonstrates an unexpected change in the marked presence of the saccharide, and the ingestible product is authentic when the testing demonstrates no unexpected change in the marked presence of the saccharide.Type: GrantFiled: June 26, 2007Date of Patent: July 5, 2011Assignee: Authentix, Inc.Inventors: Ian Eastwood, Jared Cartwright, Erwin Dorland, Mark Saw
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Patent number: 7968343Abstract: A chemical sensor including a substrate having at least two faces, at least one of the faces being covered by a thin film that includes a sensitive material, and a means for measuring a change in a physical property of the sensitive material; and, methods of detecting the presence of a nitro compound with the chemical sensor.Type: GrantFiled: October 3, 2005Date of Patent: June 28, 2011Assignee: Commissariat a l'Energie AtomiqueInventors: Didier Poullain, Eric Pasquinet, Lionel Hairault
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Patent number: 7964410Abstract: A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a compound containing a moiety capturing the sugar chain and/or the sugar derivative from the sugar chain capture agent after the completion of the sugar chain capture reaction and releasing the compound.Type: GrantFiled: March 13, 2007Date of Patent: June 21, 2011Assignees: Sumitomo Bakelite Company, Ltd., National University Corporation Hokkaido UniversityInventors: Hideyuki Shimaoka, Hiromitsu Kuramoto, Shinichiro Nishimura, Yasuro Shinohara, Yoshiaki Miura, Jun-ichi Furukawa
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Patent number: 7955861Abstract: The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties.Type: GrantFiled: December 2, 2008Date of Patent: June 7, 2011Assignee: University of Virginia Patent FoundationInventors: Cassandra L. Fraser, Guoqing Zhang, Jianbin Chen
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Patent number: 7923261Abstract: This invention is directed to a method for determining a source of carbon feed used in manufacturing product produced from the carbon feed. The invention further provides a method for tracking products, particularly MTO products, derived from a particular carbon feed. In general, the method involves a variety of steps that include one or more of determining, comparing, inventorying, and tracking the 13C:12C ratio (or HD:H2 ratio) of the product that is being tracked to the measured or predetermined 13C:12C ratio (or HD:H2 ratio) of the feed used to make the product.Type: GrantFiled: June 6, 2008Date of Patent: April 12, 2011Assignee: ExxonMobil Chemical Patents Inc.Inventor: Thomas H. Colle
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Patent number: 7910058Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: GrantFiled: April 6, 2010Date of Patent: March 22, 2011Assignee: NDSU—Research FoundationInventors: Johnson Thomas, Philip Boudjouk
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Patent number: 7901694Abstract: Methods and apparatus are disclosed for determining a new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. New anticoagulant therapy factors maybe based upon the time to maximum acceleration from the time of reagent injection (TX) into a plasma sample, Embodiments include methods and apparatus for determining an anticoagulant therapy factor without requiring use of a mean normal prothrombin time determination or ISI, and may be carried out with the patient sample and a coagulation reagent.Type: GrantFiled: February 14, 2009Date of Patent: March 8, 2011Inventors: Wallace E. Carroll, R. David Jackson
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Patent number: 7897402Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.Type: GrantFiled: April 6, 2010Date of Patent: March 1, 2011Assignee: NDSU-Research FoundationInventors: Johnson Thomas, Philip Boudjouk
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Patent number: 7892846Abstract: According to the present invention, a matrix reagent prepared by adding methylenediphosphonic acid (MDPNA) having two phosphonic acid groups as an additive to a matrix of 2,5-dihydroxybenzoic acid (DHBA) is used for the preparation of a sample. By using the sample according to the present invention, it is possible to achieve a higher peak intensity of phosphopeptide as compared with a sample in which DHBA is solely used as a matrix without using an additive, or a sample in which phosphoric acid (PA) is used as an additive in addition to DHBA. Further, use of the sample according to the present invention enables the detection of peptides that cannot be detected in a case of the phosphoric acid-added sample.Type: GrantFiled: November 12, 2008Date of Patent: February 22, 2011Assignee: Shimadzu CorporationInventors: Hiroki Kuyama, Kazuhiro Sonomura, Osamu Nishimura
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Patent number: 7892739Abstract: The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one can determine a nucleic acid sequence or the presence of an oligonucleotide in a sample.Type: GrantFiled: March 27, 2008Date of Patent: February 22, 2011Assignee: Lehigh UniversityInventor: Dmitri Vezenov
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Patent number: 7871823Abstract: Data on a secular change of each denitration catalyst is managed based on data obtained by a periodic maintenance and a daily management. Management of a secular change and prediction on performance variations that occur until a next periodic check is performed. It is determined whether the denitration catalyst is deteriorated such that an exhaust-gas denitration system cannot maintain its performance. When the denitration catalyst is deteriorated, regeneration, replacement, or addition of the denitration catalyst is performed, and the denitration catalyst is altered as necessary. When the denitration catalyst is usable, the denitration catalyst is not replaced nor regenerated.Type: GrantFiled: March 26, 2009Date of Patent: January 18, 2011Assignee: The Chugoku Electric Power Co., Inc.Inventors: Hiroshi Shimada, Yousuke Oka
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Patent number: 7862775Abstract: The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.Type: GrantFiled: January 26, 2010Date of Patent: January 4, 2011Assignee: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, Trisha L. Andrew, Samuel W. Thomas, III, Jean Bouffard
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Patent number: 7858381Abstract: Improved process for preparing high-purity, halogen-free o-phthalaldehyde, in which a) tetrahalo-o-xylene is hydrolyzed at a temperature of 155-160° C. and a pressure of from 2 to 5 bar, where appropriate in the presence of a phase-transfer catalyst, to o-phthalaldehyde, which b) is converted in an acidic alcoholic solution at a temperature of from 0 to the reflux temperature into the corresponding dialkoxyphthalane and, subsequently, c) an acetal cleavage is effected by acid hydrolysis at a pH >1.5 to pH 7, resulting in high-purity, halogen-free o-phthalaldehyde.Type: GrantFiled: June 27, 2006Date of Patent: December 28, 2010Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KGInventors: Karlheinz Giselbrecht, Klaus Reiter, Rudolf Hermanseder
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Patent number: 7838302Abstract: The present invention generally relates to sub-diffraction limit image resolution. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc.Type: GrantFiled: February 1, 2008Date of Patent: November 23, 2010Assignee: President and Fellows of Harvard CollegeInventors: Xiaowei Zhuang, Wilfred M. Bates, Michael J. Rust, Bo Huang
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Patent number: 7829342Abstract: A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3 C—H bond oxidation. The tetradentate ligand may include a N-heterocyclic-N,N?-bis(pyridyl)-ethane-1,2-diamine group or a N,N?-bis(heterocyclic)-N,N?-bis(pyridyl)-ethane-1,2-diamine group. The composition can be used in combination with H2O2 to effect highly selective oxidations of unactivated sp3 C—H bonds over a broad range of substrates. The site of oxidation can be predicted, based on the electronic and/or steric environment of the C—H bond. In addition, the oxidation reaction does not require the presence of directing groups in the substrate.Type: GrantFiled: October 3, 2008Date of Patent: November 9, 2010Assignee: The Board of Trustees of the Universiy of IllinoisInventors: M. Christina White, Mark S. Chen