Abstract: One or more embodiments of the disclosure are related, generally, to a reusable accessory for a manual medication delivery device. Such a reusable accessory may include a wireless communication interface, a detection circuitry, and a recommendation system. In one or more embodiments, an adapter may be configured to reversibly couple such a reusable accessory to a manual medication delivery device. Dosing events may be detected that are associated with dosing at the manual medication delivery device. Dose recommendations may be provided responsive to analyte measurements and/or dosing events.

Abstract: The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

Abstract: The present invention pertains to a flexible universal catheter securement device for use with, e.g. Foley catheters and other catheters. The flexible universal catheter securement device preferably comprises a cover attached to a base at a longitudinal articulation point. The cover has a top cover surface and a bottom cover surface and the bottom cover surface has an adhesive foam padding. The base has a top base surface and a bottom base surface and the top base surface has an adhesive foam padding. The articulation point is foldable such that the cover can be placed on the base. The base and the cover preferably have a centerline and the articulation point is offset there from. The base further comprises a catheter placement axis and the longitudinal articulation point is located parallel to the catheter placement axis. The cover preferably has less surface area than the base.

Abstract: Diabetes management systems include an insulin delivery device and a monitoring device for detecting at least one characteristic relating to the insulin delivery device. Monitoring devices may comprise pen caps.

Abstract: A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

Abstract: The present invention provides improved devices for removing energy and fluid from body fluid containing spaces and surfaces of a mammal, and new uses for such devices, including fluid removal, energy removal, increasing metabolic rate; promoting weight loss; preventing esophageal burn-through, reducing beta-amylase accumulation in the brain, delaying or inhibiting the onset of Alzheimer's and other senile dementia.

Abstract: One or more embodiments of the disclosure relate, generally, to a pen cap for a manual insulin delivery device. Such a pen cap may include a wireless communication interface, a detection circuit, a user interface, and a processor and memory. The detection circuit may be configured to detect cappings and decappings of the pen cap from a manual insulin delivery device. Timing information and recommendations related to capping and decapping of the pen cap may be presented to a user.

Abstract: A device and method are described for aspirating within a patient during the delivery of a drug-coated treatment device to help remove drug coating dislodged in a patient's blood. The drug treatment device can be a drug-coated balloon, a drug-coated stent, or similar devices. The device can include an occlusion balloon to help contain the dislodged drug coating and aspiration can be applied proximally, distally, or both proximally and distally of the drug coated balloon during a procedure.

Abstract: A catheter is disclosed, which includes an inner tube, and a coil tube disposed on an outer peripheral side of the inner tube, the inner tube being a coil obtained by winding a wire. In addition, in the coil tube, a first coil and a second coil are arranged concentrically with each other. The first coil and the second coil have mutually different winding directions of the wire. Then, the inner tube and the coil tube are rotatable relative to each other around a central axis of the coil tube. In addition, in a natural state where no external force is applied to the catheter, a gap is formed between the inner tube and the coil tube.

Abstract: Methods for treating fluid overload in a subject comprise shifting fluids directly and non-invasively from an interstitial compartment of the subject to skin of the subject through controlled local sweating. Methods of the invention allow for removal of excess fluid from the interstitial compartment of the subject and treat fluid overload in the subject. Sweat stimulation systems comprise a chamber and first and second relative humidity sensors. The chamber is sized to fit around a body part of a subject, comprises an inlet and an outlet, and is configured such that air flows through the chamber from the inlet to the outlet. The first relative humidity sensor is operably located inside the inlet, and the second relative humidity sensor is operably located proximate the outlet.

Abstract: A driving structure and an injection machine are disclosed. The driving structure includes: a driving device, a first swinging assembly and a second swinging assembly, the first swinging assembly and the second swinging assembly both comprise a swinging block and a moving block, the swinging block is in contact with the moving block, the swinging block of the first swinging assembly and the swinging block of the second swinging assembly are both connected with an output end of the driving device, the swinging block in the same swinging assembly is configured to drive the moving block to move, and a working stroke of the moving block in the first swinging assembly and a working stroke of the moving block in the second swinging assembly are carried out at intervals.

Abstract: According to some embodiments, there is disclosed an aerosol generating device which includes: a main body including a controller and a battery; and a cartridge detachably coupled to the main body, wherein the controller periodically detects whether the cartridge is coupled to the main body while the aerosol generating device operates in a first mode, determines whether a preset period of time has elapsed based on the cartridge being determined to have been separated from the main body, and switches the aerosol generating device from the first mode to a second mode based on whether the cartridge is coupled to the main body before the preset period of time elapses.

Abstract: A handle device for use with a hand held portable skin care device has a gas emitting portion that is configured to be proximate to the head of the skin care device during use with the skin care device. The gas emitting portion of the handle device has one or more gas openings. The handle device also includes an inlet that is fluidly coupled to the one of more gas openings through a channel in the handle device. During use, oxygen can be provided to the inlet, and emitted through the one or more gas openings as the skin care device is used to provide therapeutic light to the user's skin.

Abstract: The present disclosure relates to a measurement probe for measuring a mechanical load. The measurement probe includes: an elongated body comprising a tubular portion configured for insertion into a cartridge holder of an injection device, a sensor tab arranged on or integrated into the elongated body, wherein the sensor tab comprises an outside surface portion, an inside surface portion and an outer abutment section, wherein the outer abutment section is configured to abut with an inside of a sidewall of the cartridge holder and wherein the sensor tab is deformable in a radial direction, a sensor element mechanically connected to the at least one sensor tab and configured to measure a deformation of the at least one sensor tab.

Abstract: Various arrangements of fluidics systems are disclosed. In one arrangement, an aspiration circuit for a fluidics system is disclosed that selectively controls aspiration. The aspiration circuit comprises an aspiration line operatively connected to a surgical instrument, an aspiration exhaust line operatively connected to a waste receptacle; an aspiration vent line connected at a first end to the aspiration line; and a selectively variable vent valve operatively connected to the aspiration vent line. The variable vent valve may be selectively moved to vary aspiration pressure within the aspiration line. Other fluidics systems are disclosed that include a selectively positionable irrigation valve that may also be incorporated into a fluidics system that includes a variable vent valve.

Abstract: An apparatus that is ?m- or nm-scale in size and can include integrated circuitry logic based on sub 10 nm SIA transistor nodes, a sensing subsystem, a deciding subsystem, an effecting subsystem, and a power harvesting system is described. The sensing subsystem can identify pathogenic entities, including disease associated cells (for example, cancer cells, autoimmune cells, or pathological microbes) or viruses. The sensing subsystem can include at least one pad constructed of an electrically conductive material and linkers attached to the at least one pad. Each linker can also be attached to a targeting agent (for example, an antibody fragment) or a reference agent. Upon the binding of a targeting agent with an entity of interest, the information is transferred to the logic circuitry, which processes the binding event information and decides whether the entity is disease associated (e.g., a disease associated cell or virus) and requires delivery of therapeutic agents or other treatment.

Abstract: Various exemplary methods, systems, and devices for joint to pump elevation level user interfaces, autocalibration for joint elevation, and joint pressure estimation are provided. In general, an arthroscopic pump can be configured to estimate fluid pressure at a surgical site, e.g., at a joint, to provide an accurate indication of fluid pressure to users. In an exemplary embodiment, the fluid pressure estimation is based on a fluid pressure measurement at the pump that is adjusted at the pump, e.g., by a processor at the pump that executes instructions stored in a memory at the pump, using one or more control algorithms that adjust for one or more factors, such as pressure loss in tubing and sheath through which fluid flows between the pump and the surgical site and elevation difference between the pump and the surgical site.

Abstract: A system for infusing a gas into a vascular access device may include a catheter interface, which may include a distal end, a proximal end, and a lumen extending between the distal end and the proximal end. The system may also include a connector disposed on an outer surface of the catheter interface. The connector may be configured to couple to a reservoir. The reservoir may include a housing, which may include an opening and an impermeable wall. The opening may be configured to couple to the connector of the catheter interface. The reservoir may also include a molecular precursor to a gaseous agent that is suspended in a hydrogel and disposed within the housing. The gaseous agent may be antimicrobial, antithrombogenic, or both antimicrobial and antithrombogenic.

Abstract: Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.

Abstract: An implantable vascular access port has a main port body with one or more hollow internal chambers formed therein each with a floor at the base of the internal chamber. The port body has an outlet aperture formed in a sidewall there of the internal chamber. One or more parallel, lateral, or angled-access apertures, relative to the port floor and associated septa are located opposite the outlet aperture in the main port body in a sidewall there of (parallel or lateral or angled-access aperture or septum), with at least a one perpendicular-access aperture and septum located opposite the floor of the internal chamber(s). The port chamber in the area of the outlet aperture has an at least partially conical shape directionally aligned with the parallel or lateral or angled-access aperture and septum, with said outlet aperture in contiguity a reversible outlet tube or port body needle locking mechanism.