Patents Examined by Deborah C. Lambkin
  • ?-thioamino acids
    Patent number: 6846843
    Abstract: Thio-alpha-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, methods for producing them, and medicaments containing these compounds. The invention also provides methods for treating pain and other diseases using the pharmaceutical compositions comprising the thioamino acids.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: January 25, 2005
    Assignee: Gruenenthal GmbH
    Inventors: Boris Chizh, Matthias Gerlach, Michael Haurand, Claudia Puetz, Gero Gaube, D. Enders
  • Modifications of the trometamol salt of R-thioctic acid as well as a process for their production
    Patent number: 6844449
    Abstract: The invention relates to new modifications of the trometamol salt of R-thioctic acid of the formula I, processes for their production, pharmaceutical preparations containing these modifications, and their medical application.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 18, 2005
    Assignee: Viatris GmbH & Co. KG
    Inventors: Gunter Laban, Wolfgang Sauer, Annegret Jannasch
  • Carbamates of 2-heterocyclic-1,2-ethanediols
    Patent number: 6841569
    Abstract: Carbamate compounds of 2-heteroaryl-1,2-ethanediol are described. The compounds are effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: January 11, 2005
    Assignee: SK Corporation
    Inventors: Yong-Moon Choi, Ki-Ho Lee
  • Phosphorescent material and electroluminescent device using thereof
    Patent number: 6838019
    Abstract: A phosphorescent light emitting material, the material is a complex compound comprises a beta-diketonate ligand, a sulfoxide ligand and a triple charge rare earth group metal ion, the phosphorescent light emitting material has a following structure: wherein M is a triple charge rare earth group metal ion, R2 is hydrogen, R1 and R3 are selected from the group consisting of, hydrogen, C1 to C8 straight chain alkyl groups, C3 to C8 branch chain alkyl groups, heterocyclic groups and C6 to C14 aryl groups, and R4 and R5 are selected from the group consisting of substituted alkyl group, an unsubstituted alkyl group, an aryl group and a heterocyclic group.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: January 4, 2005
    Assignee: Ritek Corporation
    Inventors: Chao-Nan Kuo, Mei-Jung Hu, Sung-Kuei Chiang
  • Acrylic esters and use thereof
    Patent number: 6835844
    Abstract: The present invention provides an acrylic ester compound represented by formula (1), a polymerizable composition containing the acrylic ester compound, and a cured product and an optical component obtained by polymerizing the polymerizable composition: (wherein “a” is an integer of 0 to 4; R1 is a directly bonded single bond, an alkylene group, an aralkylene group or arylene group which may have a substituent, or a —Y3—S—R4—S—Y4— group (R4 is an alkylene group, an aralkylene group or an arylene group; and Y3 and Y4 are each an alkylene group); R2 and R3 are each a hydrogen atom or an alkyl group; X1 and X2 are each an oxygen atom or a sulfur atom; and Y1 and Y2 are each an alkylene group which may contain an oxygen atom or a sulfur atom).
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: December 28, 2004
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Mitsuo Nakamura, Masao Imai, Atsuo Otsuji
  • Immunomodulatory compounds and methods of use thereof
    Patent number: 6835721
    Abstract: The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 28, 2004
    Assignee: Eisai Co., Ltd.
    Inventors: Lynn D. Hawkins, Sally T. Ishizaka, Michael Lewis, Pamela McGuinness, Jeffrey Rose
  • Phenyl substituted thiophenes as estrogenic agents
    Patent number: 6835745
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: December 28, 2004
    Assignee: Wyeth
    Inventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Preparation and use of gamma-butyrolactones as cross-linking agents
    Patent number: 6833460
    Abstract: The rate of aminolysis of butyrolactones is predictably adjusted by attaching a substituent having a known field effect value (F) to the alpha position before reacting the substituted buytrolactone with an amine. The aminolysis product is a gamma-hydroxy amide. The resulting materials are useful as the cross-linking agents in a variety of coatings and coatings processes.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: December 21, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: Albert Gordon Anderson
  • Deacetylase inhibitors
    Patent number: 6833384
    Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: December 21, 2004
    Assignee: Novartis AG
    Inventors: Stacy William Remiszewski, Kenneth Walter Bair, Richard William Versace, Lawrence Blas Perez, Michael Alan Green, Lidia Cristina Sambucetti, Sushil Sharma
  • Inhibitors of neuraminidases
    Patent number: 6831096
    Abstract: Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: December 14, 2004
    Assignee: Abbott Laboratories
    Inventors: Clarence J. Maring, Yu Gui Gu, Hui-Ju Chen, Yuanwei Chen, David A. Degoey, William J. Flosi, Vincent L. Giranda, David J. Grampovnik, Warren M. Kati, Dale J. Kempf, April Kennedy, Larry L. Klein, Allan C. Krueger, Zhen Lin, Darold L. Madigan, Keith F. McDaniel, Steven W. Muchmore, Hing L. Sham, Kent D. Stewart, Vincent S. Stoll, Minghua Sun, Noah P. Tu, Frank L. Wagenaar, Gary T. Wang, Sheldon Wang, Paul E. Wiedeman, Yibo Xu, Ming C. Yeung, Chen Zhao, Stephen Hanessian, Malken Bayrakdarian, Xuehong Luo
  • In Vivo stain compounds and methods of use to identify dysplastic tissue
    Patent number: 6830743
    Abstract: Compounds having the structural formula (A) wherein X is hydrogen, methyl, or Y; Y is —NH—R or hydrogen; and R is methyl or formula (B) are useful as in vivo stains for the detection of dysplastic tissue.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 14, 2004
    Assignee: Zila Biotechnology, Inc.
    Inventor: Douglas D. Burkett
  • Vitamin D analogues
    Patent number: 6831106
    Abstract: The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in carcinology and in the field of autoimmune diseases and that of organ or tissue transplants in particular), or alternatively in cosmetic compositions.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: December 14, 2004
    Assignee: Galderma Research & Development, S.N.C.
    Inventors: Jean-Michel Bernardon, Thibaud Biadatti
  • Process for preparation of sulfonamide derivatives and crystals thereof
    Patent number: 6831178
    Abstract: A process for the preparation of a compound of the formula (I′): which comprises reacting in a solvent a compound of the formula (III): wherein X is halogen, with p-tolylacetylene, a copper (I) salt, a catalyst, and a base, and then treating the resulting reaction mixture with an acid.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: December 14, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshiro Konoike, Akira Okuyama, Yoshiyuki Masui, Teruo Sakata
  • Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
    Patent number: 6831093
    Abstract: The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of using non-steroidal ligands and compositions of non-steroidal ligands of the glucocorticoid receptor for treating or preventing diseases (e.g., obesity, diabetes, depression, neurodegeneration or an inflammatory disease) associated with glucocorticoid binding to the glucocorticoid receptor.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: December 14, 2004
    Assignee: The Regents of the University of California
    Inventors: Thomas S. Scanlan, Nilesh Shah
  • O-substituted 6-methyltramadol derivatives
    Patent number: 6828345
    Abstract: The invention relates to O-substituted 6-methyl-tramadol derivatives, to methods for producing them, to medicaments containing these compounds, to the use of O-substituted 6-methyl-tramadol derivatives for producing medicaments for treating pain and other symptoms or diseases, and to methods of treatment using the medicaments.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: December 7, 2004
    Assignee: Gruenenthal GmbH
    Inventors: Helmut Buschmann, Babette-Yvonne Koegel, Elmar Friderichs, Dagmar Kaulartz
  • Therapeutic uses of depsipeptides and congeners thereof
    Patent number: 6828302
    Abstract: Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: December 7, 2004
    Assignee: Xcyte Therapies, Inc.
    Inventor: Søren Skov
  • Benzodioxinothiophenes, their preparation and use
    Patent number: 6825357
    Abstract: The invention relates to substituted or unsubstituted benzodioxinothiophenes, their preparation and their use for preparing electrically conductive oligomers or polymers, also oligomers or polymers comprising these thiophene derivatives as repeating unit.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: November 30, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Günter Rauchschwalbe, Alexander Klausener, Stephan Kirchmeyer, Knud Reuter
  • Benzothiophene compounds having antiinfective activity
    Patent number: 6825228
    Abstract: Benzothiophene compounds such as are DNA binding compounds exhibiting antibacterial activity.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: November 30, 2004
    Assignee: Genesoft Pharmaceuticals, Inc.
    Inventors: Roland W. Bürli, Eldon E. Baird, Matthew J. Taylor, Jacob A. Kaizerman, Wenhao Hu
  • Quinomethane compounds
    Patent number: 6825359
    Abstract: Quinomethane compounds having a structure represented by the general formula (1): wherein R1 to R4 and R9 to R12 are the same or different and each represents a hydrogen atom, an alkyl group having 1 to 12 carbon atoms, a cyclic alkyl group, an aryl group, or an alkoxy group having 1 to 6 carbon atoms; R5 and R6 are the same or different and each represents an alkyl group having 1 to 12 carbon atoms, an aryl group, or a heterocyclic group; R7 and R8 each represents a hydrogen atom; and optional substituents are each a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, an aryl group, or a heterocyclic group. Since these compounds transport electrons efficiently, they are useful in electrophotographic photoreceptors and/or organic electroluminescence applications.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: November 30, 2004
    Assignee: Fuji Electric Imaging Device Co., Ltd.
    Inventors: Kenichi Ohkura, Yoshihiro Ueno, Masami Kuroda, Nobuyuki Sekine
  • Synthesis of soluble derivatives of sexithiophene and their use as the semiconducting channels in thin-film field-effect transistors
    Patent number: 6825358
    Abstract: In accordance with the first object of this invention soluble derivatives of sexithiophene in which terminal carbons are substituted with various polar groups such as phosphonic esters, phosphonic acids, phosphonates, carboxylic acids, carboxylates, amines, amides, carbamates, and alcohols, each separated from the terminal thiophene rings by one or more methylene groups, are synthesized. An TFT device in accordance with the second objective of this invention employs films of the above sexithiophene derivatives as the semiconducting component. These organic semiconductors are dissolved in common organic solvents and applied to the surface of a substrate using inexpensive, low-temperature solution-based processing such as spin-coating, dip-coating, drop-casting, or microcontact printing.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: November 30, 2004
    Assignee: International Business Machines Corporation
    Inventors: Ali Afzali-Ardakani, Tricia Lynn Breen, Cherie Renee Kagan