Abstract: Various embodiments of this disclosure concern a lead end containing a slotted member. A slotted member can have a plurality of slots extending along at least a portion of the length of the slotted member, each of the slots having a respective positioning feature, the plurality of slots having a plurality of positioning features at different longitudinal positions along the length of the slotted member. The lead end can further include a plurality of conductors at least partially within the plurality of slots, each slot of the plurality of slots containing at least a respective one of the plurality of conductors, the plurality of conductors electrically connecting exposed electrical elements of both ends of the lead.

Abstract: An electrosurgical system includes an electrosurgical generator configured to provide electrosurgical energy to an electrosurgical device coupled thereto which, in turn, delivers electrosurgical energy to tissue. The electrosurgical device may include a plurality of sensors configured to detect one or more tissue properties and output a detected tissue property signal relating thereto. One or more multiplexers having a plurality of channels are electrically connected to each of the corresponding plurality of sensors. The multiplexer(s) may be configured to receive the detected tissue property signal from each sensor of the plurality of sensors and output at least one output signal along a signal line. The signal line is configured to connect to the electrosurgical generator to control a power output of the electrosurgical generator. A channel select algorithm is configured to automatically select channels from the plurality of channels.

Abstract: A method includes displaying, on a display coupled to a computer processor, a two-dimensional representation of an arrangement of electrodes of a lead having one or more segmented electrodes; displaying, by the computer processor and on the display, a three-dimensional clinical effects map with two of the dimensions of the clinical effects map corresponding to the two-dimensional representation of the arrangement of the electrode and a third dimension corresponding to a stimulation parameter; and displaying, by the computer processor and on the display, at least one marking on the clinical effects map. Each marking represents a stimulation instance and is displayed at a position corresponding to the electrode used for stimulation in the stimulation instance and a value of the stimulation parameter used for stimulation in the stimulation instance. Each marking has a graphical characteristic representing a therapeutic effect or a side-effect resulting from the stimulation instance.

Abstract: Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.

Abstract: The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally, power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium, or on the dura, or on or in the brain.

Abstract: Adaptive methods for initiating charging of the high power capacitors of an implantable medical device for therapy delivery after the patient experiences a non-sustained arrhythmia, and devices that perform such methods. The adaptive methods and devices adjust persistence criteria used to analyze an arrhythmia prior to initiating a charging sequence to deliver therapy. Some embodiments apply a specific sequence of X-out-of-Y criteria, persistence criteria, and last event criteria before starting charging for therapy delivery.

Abstract: Methods and apparatus are provided for pulsed electric field neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, the ITEV PEF system comprises an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly.

Abstract: A biological state estimating apparatus includes a pair of electrocardiographic electrodes, a photoplethysmographic sensor, and a controller that includes a peak detecting section, a pulse transmission time measuring section, a correlation information storing section, and a biological state estimating section. The electrocardiographic electrodes detect an electrocardiogram signal and the photoplethysmographic sensor, which has light-emitting and light-receiving elements, detects a photoplethysmogram signal. The controller detects peaks of the electrocardiogram and photoplethysmogram signals and determines a pulse transmission time from the time difference between the respective peaks of the photoplethysmogram and the electrocardiogram signal. Memory stores information determined in advance based on the relationship between pulse transmission time and biological state.

Abstract: The invention relates to headphones and a method for listening to music or some other audio signal, which headphones comprise at least one sound source such as a an earphone to be placed in the vicinity of the ear, for producing sound, and a galvanic conductor for feeding an electrical signal from a signal source, such as a music player or similar, to the sound source. In accordance with the invention at least one sound source is equipped with means for measuring heart rate, as well as means for forwarding heart-rate information wirelessly.

Abstract: An improved self-testing method is described which is incorporated into a defibrillator (20). The method performs a self-testing protocol which operates on a first frequency until a threshold condition is reached. When the threshold condition is reached, the self-testing protocol switches to a second frequency. Such a method enables quicker identification of a failure mode in a population of defibrillators, while maintaining acceptable battery life in the device.

Abstract: The present invention relates to methods and devices for characterizing wounds, and in particular to the use of Raman spectroscopy to characterize the state of healing of a wound.

Abstract: A topical nerve stimulator patch and system are provided comprising a dermal patch; an electrical signal generator associated with the patch; a signal receiver to activate the electrical signal generator; a power source for the electrical signal generator associated with the patch; an electrical signal activation device; and a nerve feedback sensor.

Abstract: A device and method for desynchronizing a patient's neuronal brain activity in which the neuron population is firing in a pathologically synchronized manner. The device includes a stimulation unit that generates an acoustic stimulation signal that includes both a first tone and a second tone. The first tone is provided to shift the phase of the neuronal brain activity of a first subpopulation of the neuron population relative to the phase of the neuronal brain activity of a second subpopulation of the neuron population when the first tone is acoustically received by the patient. Further, the second tone is provided to shift the phase of the neuronal brain activity of the second subpopulation relative to the phase of the neuronal brain activity of the first subpopulation when the second tone is acoustically received by the patient. As a result, the acoustic stimulation signal desynchronizes the stimulated neuron population.

Abstract: A method utilizing computer processing for detecting, within a cardiac cycle, the earliest onset of global, Q-onset, ventricular depolarization in the presence of an operating pacemaker. The method, in general terms, features (a) gathering a plurality of ECG-obtained QRS heart-cycles waveforms, (b) identifying and categorizing of evidences and specific timings therein of intrinsic Q-onset and pacemaker spike events, (c) looking in a single, selected QRS waveform, between specific, defined first and second time marks, for the most significant slope change appearing in that waveform, and (d) designating to be the correct Q-onset that event which immediately precedes that slope change.

Abstract: The present invention provides for a computer system including at least one server having software stored on a non-transient computer readable medium; where, upon execution of the software, the at least one server is at least configured to: i) receiving physiological data representative of a first physiological measurement of at least one physiological characteristic of an epileptic user; ii) receiving physiological data representative of a second physiological measurement of at least one physiological characteristic of the epileptic user; iii) comparing the first physiological measurement of the epileptic user to the second physiological measurement of the epileptic user; iv) based on the comparing, determining that a difference between the first physiological measurement of the epileptic user and the second physiological measurement is: a) higher than a predetermined threshold value, or b) smaller than the predetermined threshold value; and v) generating at least one alert; vi) transmitting the at least one

Abstract: Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

Abstract: A medical system for delivering treatment or therapy to a patient has a kill switch for interrupting the delivery. The kill switch, which can disrupt the delivery directly or can cause an error message to be generated that disrupts the delivery, can be activated by the operator or remotely. In an ablation catheter system, a kill switch mechanism immediately and abruptly terminates delivery of ablation treatment or therapy.

Abstract: Sensors are applied to the heart and sensor data is supplied to a rules engine. The rules engine applies rules that reflect a CRM pharmaceutical regime of the patient to the sensor data to determine whether an electrical waveform should be applied to the heart. When electrical stimulation is warranted, the drug “awareness” rules are used by the rules engine to instruct a multi-phase cardiac stimulus generator to generate an electrical waveform that improves the performance of the drugs administered to the patient, allow the patient to be administered a lower dose of a particular drug, and/or reduce or eliminate side effects from the drugs.

Abstract: A medical system for delivering treatment or therapy to a patient has a kill switch for interrupting the delivery. The kill switch, which can disrupt the delivery directly or can cause an error message to be generated that disrupts the delivery, can be activated by the operator or remotely. In an ablation catheter system, a kill switch mechanism immediately and abruptly terminates delivery of ablation treatment or therapy.

Abstract: The presence of disordered breathing is detected using an implantable medical device. A cardiac condition is detected that is indicative of the patient's cardiac status. Based on the presence of disordered breathing and the cardiac condition, the patient is identified as suitable for a cardiac resynchronization therapy.