Abstract: Provided is a method of improving resistance to a substrate analog of nitric acid in a microalga, comprising deleting a gene encoding the following protein (A) or (B) present in the genome of the microalga, or downregulating expression of a gene encoding the following protein (A) or (B): wherein protein (A) is a protein consisting of the amino acid sequence set forth in SEQ ID NO:41; and wherein protein (B) is a protein consisting of an amino acid sequence having 70% or more identity with the amino acid sequence of protein (A), and having nitrate transporter activity.

Abstract: A Lactobacillus paracasei strain deposited at the CNCM under reference number CNCM I-5369. A mixture of the peptides having the following sequences: (SEQ ID NO 1), (SEQ ID NO 2), (SEQ ID NO 3), (SEQ ID NO 4) and (SEQ ID NO 5) and to one of the above-mentioned peptides in combination with at least one component chosen among: essential oils and particularly among essential oil of mint, essential oil of thyme, essential oil of pine tree, menthol, thymol, pinene, vitamin C, formic acid, propionic acid, citric acid, sorbic acid and lactic acid and/or a nanoparticle which may be loaded with said active ingredients.

Abstract: The present invention relates to a recombinant yeast strain having sterol productivity, a preparation method therefor and a use thereof, and more specifically, to a recombinant yeast strain capable of producing cholesterol and cholesterol precursors in a high yield through the deletion of ERG5 and ERG6 genes and the introduction of DHCR24 and DHCR7 genes by codon-optimizing same in multiple or with a codon context method; and a production method therefor and a use thereof. In addition, disclosed are: a method for producing a recombinant yeast strain with increased production yields of cholesterol and cholesterol precursors by the additional introduction of gene tHMG1, ERG2, ERG3, ERG27, or UPC2-1 in the prepared recombinant yeast strain; and a use thereof.

Abstract: The present invention relates to a novel Lactococcus lactis GEN3033 strain and a composition for preventing or treating cancers, comprising the same. Specifically, the Lactococcus lactis GEN3033 strain of the present invention exhibits effects of directly inhibiting the proliferation of cancer cells and enhancing immunity, thereby having effects of preventing or treating cancers. In particular, the strain has an excellent anticancer effect by secreting metabolites having an anticancer effect while being established in the gut. In addition, when used in combination with an anticancer chemotherapeutic agent or an anticancer immunotherapeutic agent, the Lactococcus lactis GEN3033 strain of the present invention exhibits a better anticancer effect.

Abstract: Modified probiotics, pharmaceutical compositions thereof, and methods of modulating and treating disorders are disclosed.

Abstract: The present invention relates to a novel strain of Trichoderma comprising genetic modifications that enable the improved production of an enzyme cocktail, involving at least upregulation of the transcription factor Xyr1 according to SEQ ID No. 1; disruption of the gene ACE1 according to SEQ ID No. 2; disruption of the gene SLP1 according to SEQ ID No. 3; and expression of the gene Cel3a from Rasamsonia emersonii according to SEQ ID No. 4.

Abstract: Provided is a means for preparing a free ceramide (Cer) from a glycosyl inositol phospho ceramide (GIPC). Specifically provided is a composition for digesting a glycosyl inositol phospho ceramide (GIPC) or a glucosylceramide for producing a free ceramide, the composition comprising a mushroom self-digestion liquid or purified product thereof.

Abstract: Disclosed herein are methods for promoting healthy neural development in an unborn baby, which include administering to a maternal subject gestating the unborn baby a composition or a bacterial composition. Compositions can include trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof, and the bacterial compositions can include bacteria of the order Clostridiales. Also disclosed are methods for conditioning a female subject for bringing about offspring with healthy neural development. Additionally disclosed are methods for reducing adverse effects of antibiotic treatment on an unborn baby in a pregnant subject. Also disclosed are methods for selecting a female subject for conditioning to foster healthy neural development in offspring.

Abstract: Disclosed are compositions and methods for their use that can be used in cosmetic applications. The composition can include an effective amount of a Centella asiatica stem cells to reduce the activity of hyaluronidase in skin, an effective amount of tetradecyl aminobutyroylvalylamino butyric urea trifluoroacetate or Alpinia galanga leaf extract to promote the production of hyaluronic acid in skin, an effective amount of tripeptide-1 to promote the production of fibronectin and laminin in skin, and a dermatologically acceptable vehicle.

Abstract: The present invention relates to novel isolated bacterial strains of the Dolosigranulum pigrum species and variants thereof having at least 99% sequence identity in its 16S rRNA gene to said novel strains. The present invention further relates to the use of these bacterial strains, and compositions comprising said strains for use as a probiotic, such as for improving or restoring the flora/microbiota of the respiratory tract and skin. The present invention further relates to the use of these bacterial strains as an antibacterial agent; for use in human or veterinary medicine; for use in the treatment of human or veterinary diseases; or for use in personal hygiene industry, food industry, cleaning industry, pharma industry, or biocontrol applications.

Abstract: Various methods, devices, and systems for preparing an output sample of a defined concentration are disclosed. The output sample can be used for downstream tests such as downstream anti-infective or antibiotic susceptibility testing (AST). The method can comprise diluting an aliquot of a source sample comprising an infectious agent to yield a diluted sample; exposing one or more sensors to the diluted sample, wherein at least a part of each of the one or more sensors is in fluid communication with the diluted sample; incubating the diluted sample at an incubation temperature; monitoring a change in a solution characteristic of the diluted sample using a parameter analyzer or a computing device coupled to the one or more sensors; and cooling the diluted sample to a cooling temperature when the concentration of infectious agents within the diluted sample reaches the defined concentration to yield the output sample.

Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

Abstract: Provided herein are compounds of Formulas (la), (lb), (II) to (VIII), and salts thereof, and methods of making the same. Also provided herein are recombinant proteins useful in the production of compounds disclosed herein, polynucleotides encoding the same, and cells comprising the same.

Abstract: An object of the present invention is to a method for producing a functional substance utilizing a reaction requiring hydrogen, which production method is safe and efficient; and this object is achieved by a method for producing a functional substance utilizing a reaction requiring hydrogen, the method comprising: supplying the hydrogen by culturing of a hydrogen-producing microorganism.

Abstract: The present disclosure provides improved genome editing compositions and methods for editing a TCR? gene.

Abstract: The present invention relates to the strain of Holdemanella biformis CECT 9752, its cellular components, metabolites, and secreted molecules, and to compositions comprising the aforementioned products, in addition to the use of said strain, but also to the genus Holdemanella, and to the species H. biformis for preventing alterations in energy homeostasis and glucose metabolism, including, glucose intolerance, insulin resistance, metabolic syndrome and diabetes.

Abstract: Disclosed herein is a yeast strain capable of fermenting high maltose syrups into ethanol in the presence of glucose. In commercially important fuel ethanol yeast strains, the presence of glucose prevents robust maltose fermentation. This invention causes enhanced co-fermentation of maltose and glucose in strains otherwise identical to commercial fuel ethanol yeast strains.

Abstract: A mutant of a trichoderma filamentous fungus has a mutation that results in lost or lowered function of a beta-adaptin large subunit, or a mutation in an amino acid sequence that forms the beta-adaptin large subunit. A method produces a protein while maintaining a low viscosity in a culture solution during culturing by using the mutant.

Abstract: Methods and kits for quantifying adenosine-containing molecules within an aqueous composition. Particularly, the methods utilize a competitive fluorescence-polarization and FRET-based assays that directly measure the production of adenosine-containing compounds, particularly S-adenosylhomocysteine (AdoHcy) compounds produced by MTases. The generation of AdoHcy can be quantified by displacing a novel fluorescent probe comprising a 5-carboxytetramethylrhodamine fluorophore covalently bound to an adenosine scaffold from a catalytically inert 5?-methylthioadenosine nucleosidase (MTAN) variant. One or more of the reaction materials can be pre-loaded into wells within multi-well reaction plates as a kit, which can be used to determine the enzymatic activity of MTases or conduct drug screening for potential inhibitors in a high-throughput format.

Abstract: The present invention provides a protein having pentosidine oxidase activity, a method for measuring pentosidine comprising: contacting the protein with a specimen; and detecting a change caused by the contact, and the like.