Patents Examined by Deepak R. Rao
  • Process for preparing spiro derivatives
    Patent number: 11149039
    Abstract: The invention relates to a novel process for preparing Spiro derivatives, in particular 7-methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 19, 2021
    Assignee: Biogen Inc.
    Inventors: Gerard M. Giblin, David T. MacPherson, Osama Suleiman, Michael Williams, David R. Witty, Thierry Bonnaud, Richard Edwards
  • Salts of IJAK inhibitors and methods of using the same
    Patent number: 11149029
    Abstract: The present disclosure relates to salts of compounds of Formula (I) prepared as a xinafoate (1-hydroxy-2-naphthoate) salt (Formula (Ia)), pharmaceutically acceptable compositions comprising same and methods of using the same.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: October 19, 2021
    Assignee: AstraZeneca AB
    Inventors: Anna Matilda Angelica Pettersen, James McCabe, Carl-Johan Aurell
  • Imidazo[1,5-a]pyrazine derivatives as PI3K ? inhibitors
    Patent number: 11136323
    Abstract: Disclosed is a compound of Formula (I), or a stereoisomer thereof or a pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3K? related disorders or diseases by using the compound disclosed herein.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: October 5, 2021
    Assignee: BEIGENE, LTD.
    Inventors: Jing Li, Haibo Zhao, Zhiwei Wang
  • Anti-infective heterocyclic compounds and uses thereof
    Patent number: 11130741
    Abstract: The present invention relates to heterocyclic compounds of Formula I useful as anti-infective agents. The present invention further relates to a method of treating an infection by administering such compounds, and to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: September 28, 2021
    Assignee: Bioimics AB
    Inventors: Leif Kirsebom, Ram Shankar Upadhayaya, Raghava Reddy Kethiri, Anders Virtanen
  • Aryl heterocyclic piperidinone formyl peptide 2 receptor and formyl peptide 1 receptor agonists
    Patent number: 11124494
    Abstract: The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, and related diseases.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: September 21, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Pravin Sudhakar Shirude, Amit Kumar Chattopadhyay, Nicholas R. Wurtz
  • Pyrimidine compounds and pyrimido indole compounds and methods of use
    Patent number: 11111252
    Abstract: The present invention discloses a compound of the formula: and optionally comprising a pharmaceutically acceptable salt or hydrate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt or hydrate thereof.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: September 7, 2021
    Assignee: Duquesne University of The Holy Spirit
    Inventor: Aleem Gangjee
  • Tyrosine kinase inhibitors
    Patent number: 11110082
    Abstract: Disclosed are imidazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, Y and Z are as described herein. In certain embodiments, a compound disclosed herein inhibits a cellular TAM receptor, and can be used to treat disease mediated by or involving the TAM receptor family.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: September 7, 2021
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sacha Holland, Rajinder Singh, Somasekhar Bhamidipati, Pingyu Ding, Rao Kolluri, Ihab Darwish, Esteban Masuda, Jiaxin Yu
  • Biphenyl amides with modified ether groups as Hsp90 inhibitors and Hsp70 inducers
    Patent number: 11098008
    Abstract: Provided herein are compounds of the formulas: wherein: n, X2, R3, R3?, R4, R4?, R5, R5?, R6, and R6? are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases, including diabetic peripheral neuropathy or cancer.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: August 24, 2021
    Assignee: UNIVERSITY OF KANSAS
    Inventors: Brian S. J. Blagg, Rick T. Dobrowsky, Mercy Anyika
  • Methods of inhibiting MMP-9
    Patent number: 11098095
    Abstract: Methods of inhibiting MMP-9 are provided. The methods of inhibiting MMP-9 include methods of inhibiting IL-6/TNF-? crosstalk mediated expression and/or secretion of MMP-9. The inhibition of the IL-6/TNF-? crosstalk pathway may be accomplished using an IL-6 signaling inhibitor, such as AG490 or SC-144. The methods may also include the treatment of dieses through the inhibition of IL-6/TNF-? crosstalk mediated production of MMP-9. In an embodiment the methods may include preventing the progression of cancer or cardiovascular disease through the inhibition of the IL-6/TNF-? crosstalk pathway.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: August 24, 2021
    Assignee: DASMAN DIABETES INSTITUTE
    Inventors: Rasheed Ahmad, Fahd Al Mulla
  • Small molecule N-(?-peroxy) carbazole compounds and methods of use
    Patent number: 11098013
    Abstract: The invention relates to novel N-(?-peroxy)carbazole compounds of Formula I and methods for use. The N-(?-peroxy)carbazole compounds described herein are useful for treating or preventing parasitic infections, bacterial infections, and cancer in subjects. The methods include administering an N-(?-peroxy)carbazole compound as described herein to a subject. Also described herein are methods for synthesizing N-(?-peroxy)carbazole compounds.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: August 24, 2021
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Xinbo Wang, Zhiping Lai, Yupeng Pan, Kuowei Huang
  • Protein kinase inhibitors, preparation method and medical use thereof
    Patent number: 11091476
    Abstract: The embodiments disclosed herein provide compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, or a pharmaceutically acceptable salt or solvate of the compounds as shown in formula I or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer, a deuterated compound, a prodrug or a mixture thereof, wherein R1 to R7 are as defined in the description. This application also provides a preparation method and a medical use of the compounds. The compounds of this disclosure have an activity superior or equivalent to the candidate drug LY2835219 currently under phase III clinical trial, and some of the compounds exhibit better selectivity. Moreover, the preferred compounds exhibit good absorption and good blood-brain distribution when administered orally.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: August 17, 2021
    Assignee: Gan & Lee Pharmaceuticals
    Inventors: Lei Yin, Wenjian Liu, Heng Li, Dianxi Zhu
  • Crystalline form of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
    Patent number: 11091469
    Abstract: The present invention relates to a new crystalline form of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide, process for its preparation, its utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing it.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: August 17, 2021
    Assignee: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Ilaria Candiani, Giovanni Ottaiano, Attilio Tomasi
  • Crystalline brexpiprazole
    Patent number: 11072605
    Abstract: The present invention relates to crystalline brexpiprazole having a particle size distribution (PSD) characterized by a d(90) of 30 ?m to 100 ?m, by a d(10) of at least 1.0 ?m, and by a d(4,3) of at least 15.0 ?m. The present invention also relates to a pharmaceutical composition comprising a crystalline brexpiprazole having a PSD characterized by a d(90) of 30 ?m to 100 ?m, by a d(10) of at least 1.0 ?m, and by a d(4,3) of at least 15.0 ?m, and to an aqueous suspension comprising said crystalline brexpiprazole. The present invention also relates to a composition comprising a crystalline brexpiprazole having a PSD characterized by a d(90) of 30 ?m to 100 ?m, by a d(10) of at least 1.0 ?m, and by a d(4,3) of at least 15.0 ?m, wherein said composition is essentially free from secondary particles of brexpiprazole.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: July 27, 2021
    Assignee: Hexal AG
    Inventors: Andreas Krekeler, Michael Sedlmayr
  • Dimethylaminoethanol salt of a GLP-1 receptor modulator
    Patent number: 11066395
    Abstract: Crystalline 2-hydroxy-N,N-dimethylethanaminium 1-(2-(5-(tert-butyl)-thiophene-2-carboxamido)-3-(4-(5-(4?-ethyl-[1,1?-bi(cyclohexan)]-3-en-4-yl)pyrimidin-2-yl)phenyl)propanoyl)azetidine-3-carboxylate salt, and methods related to synthesis and therapeutic use of the same.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 20, 2021
    Assignee: RECEPTOS LLC
    Inventors: Ephraim Vidal, Roger Bakale, Philip Turnbull, David Moser, Andrew Robbins, Craig Grant
  • 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
    Patent number: 11066396
    Abstract: The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of aryl and heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: July 20, 2021
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Abbas Walji, Richard Berger, Craig A. Stump, Kelly-Ann S. Schlegel, James J. Mulhearn, Thomas J. Greshock, Deping Wang, Mark E. Fraley, Kristen G. Jones
  • Dihydrotetrabenazine for the treatment of anxiety and psychoses
    Patent number: 11065232
    Abstract: This invention relates to pharmaceutical compositions containing (?)-?-dihydrotetrabenazine, processes for making them and their therapeutic uses.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: July 20, 2021
    Assignee: ADEPTIO PHARMACEUTICALS LIMITED
    Inventors: Andrew John Duffield, Anant Pandya
  • Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
    Patent number: 11066383
    Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: July 20, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: David K. Williams, Weifang Shan, Liping Zhang, Emily Charlotte Cherney, James Aaron Balog
  • Pteridinone compounds and uses thereof
    Patent number: 11059826
    Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: July 13, 2021
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: David J. Lauffer, Guy Bemis, Michael Boyd, David Deininger, Hongbo Deng, Warren Dorsch, Wenxin Gu, Russell R. Hoover, Mac Arthur Johnson, Jr., Mark Willem Ledeboer, Brian Ledford, Francois Maltais, Marina Penney, Darin Takemoto, Nathan D. Waal, Tiansheng Wang, Pan Li
  • Protein kinase C inhibitors and methods of their use
    Patent number: 11059804
    Abstract: PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: July 13, 2021
    Assignee: Novartis AG
    Inventors: Michael Joseph Luzzio, Julien Papillon, Michael Scott Visser
  • Pyrrolo[1,2-b]pyridazine derivatives
    Patent number: 11053250
    Abstract: A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: July 6, 2021
    Assignee: Gilead Sciences, Inc.
    Inventors: Stephen Ammann, Elizabeth M. Bacon, Gediminas Brizgys, Elbert Chin, Chienhung Chou, Jeromy J. Cottell, Marilyn Ndukwe, James G. Taylor, Nathan E. Wright, Zheng-Yu Yang, Sheila M. Zipfel