Abstract: CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
August 18, 1998
Assignee:
Neurocrine Biosciences, Inc.
Inventors:
James R. McCarthy, Yun Feng Xie, Jeffrey P. Whitten, Thomas R. Webb, Chen Chen, John Y. Ramphal