Patents by Examiner Dennis M White

Patent number: 8999264
Abstract: A coating formula and method for surface coating non-porous surfaces. Microfluidic devices including said coating achieve desired properties including increased hydrophilicity, improved adhesion, stability and optical clarity.
Type: Grant
Filed: September 26, 2011
Issued: April 7, 2015
Assignee: Siemens Healthcare Diagnostics Inc.
Inventor: Michael J. Pugia
Patent number: 8999262
Abstract: A time indicating label for attachment to a tube, the label comprising: (A) An impermeable facesheet optionally adapted to accepting a graphic before or after attachment of the label to a tube, (B) An activation layer comprising a polymer matrix and an activating agent, the activation layer in contact with the facesheet, (C) A release liner impermeable to the activating agent and in contact with the activation layer, (D) A timing layer comprising a film-forming polymer and a pigment, the timing layer in contact with the release liner, (E) A dye layer comprising a film-forming polymer and an organic solvent soluble dye and in contact with the timing layer, and (F) A base layer comprising a material impermeable to the activating agent and dye and in contact with both the dye layer and the activation layer.
Type: Grant
Filed: March 15, 2013
Issued: April 7, 2015
Assignee: Brady Worldwide, Inc.
Inventors: Richard S. Roehr, Matthew M. Kasper, Adam D. Scheuer
Patent number: 8992860
Abstract: The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to a waste channel, and non-diffused regions of fluid may be preferentially pulled off the channel that contains the segmented flow. Multiple fluid samples that are not contaminated via diffusion may be collected for analysis and measurement in a single channel. The systems and methods for minimizing or eliminating diffusion effects may be used to minimize or eliminate diffusion effects in a microfluidic system for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules.
Type: Grant
Filed: April 14, 2014
Issued: March 31, 2015
Assignee: Canon U.S. Life Sciences, Inc.
Inventors: Brian Murphy, Scott Corey, Alex Flamm, Ben Lane, Conrad Laskowski, Chad Schneider
Patent number: 8986611
Abstract: A sample analysis apparatus configured to automatically press a start button upon installation of a sample tube is provided. The sample analysis apparatus includes: a body of the sample analysis apparatus; a door housing which may be provided in an opened state or a closed state, and configured to be coupled to the body of the sample analysis apparatus by a hinge; a tube accommodating unit included in the door housing and configured to accommodate the sample tube; a start button included in the body of the sample analysis apparatus and configured to start analysis of the sample; and an operating member positioned at a first position which is distant from the start button the sample tube is not installed in the tube accommodating unit, and a second position which is configured to operate the start button when a sample tube is installed and the door housing is closed.
Type: Grant
Filed: August 2, 2012
Issued: March 24, 2015
Assignee: Samsung Electronics Co., Ltd.
Inventors: Yong Koo Lee, Tae Soo Kim, In Duk Hwang, Seock Woo Jang, Chul Ho Yun
Patent number: 8986625
Abstract: A method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of the hydrogen sulphide by forming a sulphur-containing solid product which is different in color from the solid reagent, and recovering the sulphur-containing solid product. The invention also relates to a device suitable for the implementation of this method.
Type: Grant
Filed: August 27, 2013
Issued: March 24, 2015
Assignee: Total S.A.
Inventors: Daniel Dessort, Robert Le Van Loï, Nadine Loubere
Patent number: 8974751
Abstract: Sample liquid is collected in a chamber downstream of a separating device. Adjoining the chamber are a plurality of channels which guide the sample liquid to one or more investigating regions.
Type: Grant
Filed: July 5, 2011
Issued: March 10, 2015
Assignee: Boehringer Ingelheim Microparts GmbH
Inventors: Tobias Rodenfels, Gert Blankenstein
Patent number: 8968677
Abstract: An improved apparatus and method for dispersion of a labeling conjugate in a diagnostic assay, the result being a one-step assay. By eliminating a conjugate pad as in conventional lateral diagnostic devices, and forming a frazil ice pellicle (FIP), rehydration and flow are improved resulting in better reproducibility, improved sensitivity, and reduced costs of individual assay devices. The formation of a frazil ice film formed on a super cooled surface of a sample receiving means simplifies assay assembly. Lyophilization of the FIP improves the release of a sample/analyte/label matrix into a macro channel as in a direct flow assay, while at the same time allowing reagents to mix and flow, thereby optimizing the assay performance. The reagents of the conjugate and the formation of the FIP stabilize the conjugate proteins and provide extended shelf life to the diagnostic assay device.
Type: Grant
Filed: January 22, 2013
Issued: March 3, 2015
Assignee: Quantum Design International, Inc.
Inventors: Ronald T. LaBorde, Nicholas J. Neild
Patent number: 8961898
Abstract: The present invention provides a bilayer membrane produced using a microchannel capable of easily forming bilayer membranes such as planar lipid bilayer membranes in large quantities, and a production method thereof. A process for producing a bilayer membrane of the present invention comprises forming a state where two liquid phases or liquid and gaseous phases each containing amphipathic molecules are alternately arranged in a microchannel, discharging one of the two liquid phases or the gaseous phase of the liquid and gaseous phases through branch minichannels formed in the wall on one side or in the walls on both sides to contact the remaining liquid phases adjacent to each other, and thereby forming a side-by-side arrangement of bilayer membranes comprising the amphipathic molecules.
Type: Grant
Filed: March 28, 2008
Issued: February 24, 2015
Assignee: Tokyo Institute of Technology
Inventors: Takasi Nisisako, Takahiro Baba
Patent number: 8945472
Abstract: The present invention provides a biosensor system comprising a light source, a cartridge adapted to be illuminated by said light source, a light detector adapted for detecting a signal originating from the cartridge, an illumination control means adapted to vary the illumination of the cartridge between at least two different states, a means for generating a first oscillation with a first frequency, and a means for generating a second oscillation with a second frequency, wherein the frame rate of the light detector is triggered by the first oscillation and the illumination control means is triggered by the second oscillation.
Type: Grant
Filed: December 18, 2008
Issued: February 3, 2015
Assignee: Koninklijke Philips N.V.
Inventors: Josephus Arnoldus Henricus Maria Kahlman, Bart Michiels
Patent number: 8945939
Abstract: The invention is directed towards methods and compositions for identifying the amount of hydrofluoric acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of hydrofluoric acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of hydrofluoric acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the hydrofluoric acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Type: Grant
Filed: November 18, 2013
Issued: February 3, 2015
Assignee: Ecolab USA Inc.
Inventors: Amy M. Tseng, Brian V. Jenkins, Robert Mack
Patent number: 8945486
Abstract: A microwell device is provided. The device includes a plate having a upper surface. The upper surface has first and second recesses formed therein. Each recess has an outer periphery. First and second portions of microwells are formed in upper surface of the plate. The first portion of microwells are spaced about the outer periphery of the first recess and the second portion of microwells spaced about the outer periphery of the first recess. A first barrier is about a first portions of the microwells for fluidicly isolating the first portion of the microwells and a second barrier about a second portions of microwells for fluidicly isolating the second portion of the microwells.
Type: Grant
Filed: March 8, 2013
Issued: February 3, 2015
Assignee: Wisconsin Alumni Research Foundation
Inventors: Jay W. Warrick, John Yin, Stephen M. Lindsay
Patent number: 8940234
Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
Type: Grant
Filed: April 11, 2012
Issued: January 27, 2015
Assignee: Intel Corporation
Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
Patent number: 8940237
Abstract: An optic light guide test sensor comprises a light guide, a reagent-coated membrane, and a mesh layer. The reagent-coated membrane and the mesh layer are attached to the light guide at an output end of the light guide. The light guide test sensor is adapted to be used to test the level of an analyte in a biological fluid sample when used with a readhead. A method of manufacturing the light guide test sensor involves providing a plurality of light guides, providing a strip of reagent-coated membrane, and providing a strip of mesh layer. The reagent-coated membrane and mesh layer are attached to the light guides by ultrasonic welding. The reagent-coated membrane and mesh layer may also be attached to the light guides by adhesive.
Type: Grant
Filed: January 22, 2013
Issued: January 27, 2015
Assignee: Bayer HealthCare LLC
Inventors: Jeffery S. Reynolds, Steven C. Charlton, Sung-Kwon Jung, Suny J. George

Kit

Patent number: 8940248
Abstract: A kit comprising a carrier and vessels arranged on the carrier, wherein different reagents are contained in different vessels, the vessels are arranged with an openable closing device on top of the carrier, the carrier has a footprint on the bottom side for being placed on a base, and the carrier has bottom positioning means for being positioned on at least one workplace of an automated laboratory system for microtiter plates according to the SBS standard.
Type: Grant
Filed: April 29, 2013
Issued: January 27, 2015
Assignee: Eppendorf AG
Inventors: Judith Lucke, Jens-Peter Kroog, Helmut Knofe
Patent number: 8932874
Abstract: The invention is directed towards methods and compositions for identifying the amount of ammonium acid in a buffered oxide etching composition. In buffered oxide etching compositions it is very difficult to measure the amount of ammonium acid because it has varying equilibriums and it is toxic so it hard to handle and sample. When used to manufacture microchips however, incorrect amounts of ammonium acid will ruin those chips. The invention utilizes a unique method of spectrographically measuring the ammonium acid when in contact with added chromogenic agents to obtain exact measurements that are accurate, immediate, and safe.
Type: Grant
Filed: July 2, 2014
Issued: January 13, 2015
Assignee: Nalco Company
Inventors: Amy M. Tseng, Brian V. Jenkins, Robert M. Mack
Patent number: 8920749
Abstract: A microchip capable of sending liquid in a micro flow channel to a predetermined place irrespective of the pressure difference and sending a mixture of two or more liquid masses to a predetermined place even if the channel structure is simple. The microchip comprises an intermediate reservoir portion provided in a micro flow channel and adapted for temporarily holding liquid sent through the micro flow channel. The microchip is characterized in that the intermediate reservoir portion has a side channel, the volume of the intermediate reservoir portion is smaller than the total volume of the liquid sent into the intermediate reservoir portion, the side channel is provided for communication of a micro flow channel on the upstream side of the intermediate reservoir portion with a micro flow channel on the downstream side thereof, and the cross-section area of the side channel is smaller than that of the micro flow channel.
Type: Grant
Filed: August 14, 2013
Issued: December 30, 2014
Assignee: Konica Minolta Medical & Graphic, Inc.
Inventors: Youichi Aoki, Akihisa Nakajima, Kusunoki Higashino, Yasuhiro Sando, Yoshikazu Kurihara
Patent number: 8920723
Abstract: A sample support structure comprising a sample support manufactured from a semiconductor material and having one or more openings therein. Methods of making and using the sample support structure.
Type: Grant
Filed: November 16, 2007
Issued: December 30, 2014
Assignee: Protochips, Inc.
Inventors: John Damiano, Jr., Stephen E. Mick, David P. Nackashi
Patent number: 8916110
Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.
Type: Grant
Filed: July 5, 2011
Issued: December 23, 2014
Assignee: Boehringer Ingelheim Microparts GmbH
Inventors: Tobias Rodenfels, Gert Blankenstein
Patent number: 8911681
Abstract: A wetness indicator material may be used on a substrate to form a wetness sensor. The sensor may show either the presence or absence of an aqueous-based fluid or water-containing medium, such as vaginal fluid or urine in a personal hygiene article. The wetness sensor may be incorporated into the article. The wetness indicator material includes a standard colorant that does not change color when wetted. The standard colorant increases the range of hues exhibited by the wetness indicator material.
Type: Grant
Filed: September 12, 2011
Issued: December 16, 2014
Assignee: Kimberly-Clark Worldwide, Inc.
Inventors: Xuedong Song, Karen Meloy Goeders, Ning Wei
Patent number: 8900515
Abstract: The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.
Type: Grant
Filed: November 25, 2011
Issued: December 2, 2014
Assignee: Health & Life Co., Ltd.
Inventor: Meng Yi Lin
1 2 3 4 5 next