Patents Examined by Dennis M White
  • Patent number: 9937496
    Abstract: A method of constructing a point-of-care diagnostic apparatus and fluid storage and delivery apparatus therefor is provided. The method of constructing the fluid storage and delivery apparatus includes providing a flexible upper layer having a reservoir; providing a flexible lower layer having a valve member; providing a rigid substrate having an upper surface, a lower surface and a through port; disposing a fluid in the reservoir; and sandwiching the rigid substrate between the upper and lower layers and bonding the upper layer to the upper surface of the rigid substrate with the reservoir registered with the through port and bonding the lower layer to the lower surface of the rigid substrate with the valve member registered with the through port. The method of constructing the point-of-care diagnostic apparatus includes fixing the fluid storage and delivery apparatus to a rigid base in selective fluid communication with a reaction chamber.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: April 10, 2018
    Inventor: David W. Wright
  • Patent number: 9901928
    Abstract: The present disclosure relates to a calibration cartridge for an in vitro medical diagnostic device. The device also includes a removable assay cartridge containing a polymer body with channels for fluid movement.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: February 27, 2018
    Assignee: EDAN DIAGNOSTICS
    Inventors: Chao Lin, Paul Swanson, Zhixiang Jason Zhao
  • Patent number: 9891217
    Abstract: In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: February 13, 2018
    Assignee: ALVERIX, INC.
    Inventors: Patrick T. Petruno, John F. Petrilla, Michael J. Brosnan, Rong Zhou, Daniel B. Roitman
  • Patent number: 9878324
    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: January 30, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Jason Taylor, Vincent Linder
  • Patent number: 9851310
    Abstract: A three-dimensional porous photonic structure, whose internal pore surfaces can be provided with desired surface properties in a spatially selective manner with arbitrary patterns, and methods for making the same are described. When exposed to a fluid (e.g., via immersion or wicking), the fluid can selectively penetrate the regions of the structure with compatible surface properties. Broad applications, for example in security, encryption and document authentication, as well as in areas such as simple microfluidics and diagnostics, are anticipated.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: December 26, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Ian Burgess, Lidiya Mishchenko, Benjamin Hatton, Marko Loncar
  • Patent number: 9828598
    Abstract: Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: November 28, 2017
    Assignee: LUMINEX CORPORATION
    Inventors: Jesus Ching, David Hsiang Hu, Steve Jia Chang Yu, Phillip You Fai Lee
  • Patent number: 9829451
    Abstract: A reconfigurable microfluidics multiplexing device for biological and chemical sample analysis which comprises: a cartridge comprising one or more sample fluid tracks (both horizontal and vertical) in a single plane, an array comprising one or more electronically programmable valves capable of being configured to alter fluid steering in the fluid tracks; a means for the array to interface with the fluid tracks; a means to control fluid flow in the fluid tracks; and a user interface to direct control of valves via control logic within the device; wherein, by the interface, valve positions are controllable and alterable.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: November 28, 2017
    Assignee: Simon Fraser University
    Inventors: Bonnie L. Gray, Lesley Shannon
  • Patent number: 9829426
    Abstract: Provided is a fluid analysis cartridge configured to analyze a fluid specimen, a fluid analysis sheet forming the same and a method of manufacturing the fluid analysis cartridge. The fluid analysis sheet includes at least one cut out part configured to form an intermediate layer of an inspection substrate, the cut out part including a flow passage structure including an inlet part in which a fluid is introduced and an inspection part in which the fluid is introduced to react with a reagent; and wherein the cut out part is further configured to include a first end adjacent to the inspection part and a second end adjacent to the inlet part, and wherein a minimum distance between the first end and the flow passage structure is at least 1 mm.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: November 28, 2017
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Seung Jun Lee, Jung Ki Min, Seung Hoon Kim, Ji Young Park, Hyun-Suk Kang
  • Patent number: 9822356
    Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 21, 2017
    Assignees: California Institute of Technology, SlipChip Corporation
    Inventors: Rustem F. Ismagilov, Feng Shen, Liang Li, Yu-Hsiang Hsu, Stefano Begolo, Mikhail Karymov, David Selck, Stephanie McCalla, Philip James Homewood
  • Patent number: 9823243
    Abstract: An object of the present invention is to provide a highly sensitive immunoanalysis method and analysis apparatus. The invention relates to an analysis method and an analysis apparatus which are constituted in such a way that a component to be measured is reacted with capture component specifically reacting thereto and the reactant is labeled when the component to be measured is present and which are characterized by analyzing the component to be measured with single-molecule sensitivity and resolution by arranging the labeled reactant in a spatially separated certain position and detecting the label of the labeled reactant.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: November 21, 2017
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Kyoko Imai, Toshiro Saito, Kazumichi Imai
  • Patent number: 9816924
    Abstract: The present invention relates to the use of amphipathic polymers to enhance lateral flow and reagent mixing on assay devices. More specifically, the invention relates to use of an amphipathic polymer in assay methods including a device for determining the concentration of lipids in blood serum or plasma.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 14, 2017
    Assignee: L3 Technology Limited
    Inventors: Anthony Nicholls, Laura Garcia, Mark Hudson, Gareth Jones, David Clarke
  • Patent number: 9808804
    Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: November 7, 2017
    Assignee: CUE INC.
    Inventors: Ayub Khattak, Clinton Sever, Paul Nelson, Ryan Cooper, Thomas Congdon, Justin Demartino, Raphael Shapiro, Mark Duncan
  • Patent number: 9808798
    Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: November 7, 2017
    Assignee: California Institute of Technology
    Inventors: Rustem F. Ismagilov, Qichao Pan, Stefano Begolo
  • Patent number: 9804091
    Abstract: The present invention relates to the use of surfaces that exhibit different surface energies wherein the difference in surface energies is configured to disrupt capillary laminar flow of a fluid travelling between the two surfaces. The invention further relates to the use of such surfaces in assay methods including a device utilising same.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: October 31, 2017
    Assignee: L3 Technology Limited
    Inventors: Anthony Nicholls, Laura Garcia, Mark Hudson, Gareth Jones, David Clarke
  • Patent number: 9791151
    Abstract: The invention relates to a controlled combustion system for the simultaneous analysis of the thermodynamic efficiency of combustion and total polluting emissions in solids with combustible potential, including: a pre-chamber, a combustion chamber, a heat transfer unit which includes a connection for a device that analyses combustion gases to determine the performance of combustion and burning, and a unit for storing the combustion emissions, which comprises a container for storing the sample and a means of collecting samples for the simultaneous collection of gases and particulate matter for analyzing the combustion emissions.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: October 17, 2017
    Inventors: Francisco Javier Cereceda Balic, Mario Gonzalo Toledo Torres
  • Patent number: 9784686
    Abstract: An aquatic environment water parameter testing system and related methods and chemical indicator elements. The aquatic environment water parameter testing system includes an electronics portion having an optical reader element and a sample chamber portion having a chemical indicator element which may be removably connected. A chemical indicator element may include an information storage and communication element used, in part, to provide identification of a chemical indicator of the chemical indicator element. Conductivity and/or temperature may be utilized to calibrate readings by the optical reader element. A chemical indicator element may also include a thin film material having particular optical characteristics tied to the light from a light source, such as a light source of an optical reader element.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: October 10, 2017
    Assignee: Step Ahead Innovations, Inc.
    Inventor: James E. Clark
  • Patent number: 9776186
    Abstract: A slot extender includes a reservoir. The reservoir includes a reservoir floor defining a drain opening, a continuous reservoir sidewall extending from the reservoir floor, and a concave fillet running along at least a portion where the reservoir sidewall joins the reservoir floor. The concave fillet has a variable radius.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: October 3, 2017
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Dennis R Esterberg, Frank D Derryberry, Richard W Seaver, Christie Dudenhoefer
  • Patent number: 9759716
    Abstract: A single device to collect, transfer, and measure salivary nitric oxide analyte and metabolite, nitrite, a biomarker for nitric oxide, as well as, a method to assess the effects of diet and exercise on changing an individual's nitric oxide status and health.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: September 12, 2017
    Assignee: Berkeley NOX Limited
    Inventors: Natalie Green, Juliana Green
  • Patent number: 9759842
    Abstract: The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising polyethylene glycol. The bottom surface of the nanoaperture can be functionalized with at least one second molecule comprising polyethylene glycol, for example, a silane-PEG molecule. The second molecule can further include a moiety, such as biotin, which is capable of binding a target biomolecule, which in turn can bind to a biomolecule of interest for single molecule fluorescence imaging analysis. Fabrication techniques of the nanoaperture are also provided.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: September 12, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Colin Kinz-Thompson, Ruben L. Gonzalez, Jr., James C. Hone, Matteo Palma, Alexander Alexeevich Godarenko, Daniel Alexandre Chenet, Samuel J. Wind
  • Patent number: 9759688
    Abstract: A gas sensor utilizing carbon nanotubes (CNTs) is disclosed. The sensor can include a patch antenna, a feed line, and a stub line. The stub line can include a carbon nanotube (CNT) thin-film layer for gas detection. The CNTs can be functionalized to detect one or more analytes with specificity designed to detect, for example, environmental air contaminants, hazardous gases, or explosives. The sensor can provide extremely sensitive gas detection by monitoring the shift in resonant frequency of the sensor circuit resulting from the adsorption of the analyte by the CNT thin-film layer. The sensor can be manufactured using inkjet printing technologies to reduce costs. The integration of an efficient antenna on the same substrate as the sensor enables wireless applications of the sensor without additional components, for wireless standoff chemical sensing applications including, for example, defense, industrial monitoring, environmental sensing, automobile exhaust analysis, and healthcare applications.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 12, 2017
    Assignee: Georgia Tech Research Corporation
    Inventors: Krishna Naishadham, Xiaojuan Song, Brent Wagner