Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.

Abstract: The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhance and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.

Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

Abstract: A three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body components bonded to each other and made from component materials comprising about 40 to about 90 wt % B2O3, and two or more other oxides, wherein the scaffold body has a porosity between about 15 and about 90 vol %.

Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.

Abstract: An antibacterial agent composed of silver-containing aluminum sulfate hydroxide particles represented by the following formula (X-I) or (Y-I). (AgaBb-a)bAlcAx(SO4)y(OH)z.pH2O??(X-I) [AgaBb-a]b[Ti3-cAlc](SO4)y(OH)z.pH2O??(Y-I) The above antibacterial agent of the present invention provides antibacterial molded articles and further antifungal agents, cosmetics, antibacterial paper, antibacterial deodorizing sprays and agricultural chemicals when it is mixed with a resin.

Abstract: A two-part disinfecting system, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous acidic disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid, and wherein the first part, the second part, or both the first and second parts further comprise a nitrogenous stabilizer having a nitrogen group substituted with at least one hydrogen.

Abstract: The invention provides compositions and methods for inhibiting nematode damage to plants. The compositions comprise acid extracts or alcohol extracts from juglone-producing members of the Juglandaceae. The methods comprise applying the compositions of the invention to soil contacting roots of nematode-susceptible plants.

Abstract: Disclosed is a layered double hydroxide capable of delamination in water comprising a plurality of basal layers of a double hydroxide of Formula: M(II)1-xM(III)x(OH)2 wherein M(II) is Mg, Zn or a combination thereof, M(III) is Al, and x is 0.2 to 0.33 and a plurality of intercalated layers between each adjacent basal layers of Mg acetate, Zn acetate or Ce acetate and water of intercalation. A process for producing the layered double hydroxide is also disclosed. The layered double hydroxide find use as an vehicle component or an anti-corrosive pigment of water-based protective coatings for metallic substrates, and as a humectant or a stabilizing agent for cosmetic preparations such as lotions, creams or foundations.

Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.

Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.

Abstract: Compositions and methods for the treatment of pain in a mammal are described. More specifically, a dosage form designed for release of acetaminophen and an opioid is described, wherein the dosage form provides delivery of the drugs to the upper gastrointestinal tract (“GI”) of a mammal for an extended period of time.

Abstract: The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhance and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.

Abstract: A liquid preservative composition comprises (a) an alkanol fatty monoester; and (b) an aqueous isothiazolinone solution, an alkanol-substituted aromatic compound, or a combination thereof; and is free from formaldehyde, formaldehyde-releasing compounds, and paraben compounds. Preferred compositions comprise glyceryl caprylate, together with either phenethyl alcohol or an aqueous 2-methyl-4-isothiazolin-3-one solution.

Abstract: A method for directing vessel growth toward a blood-deficient site in a mammal comprising implanting into the mammal an assembly of at glass fibers to form a vascular bridge with a first end of the vascular bridge in contact with the blood-deficient site and a second end of the vascular bridge remote from the blood-deficient site. Over time the bridge biodegrades and promotes vascularity in the direction of the bridge.

Abstract: A liquid aqueous formulation for the intranasal administration of apomorphine includes: (a) at least about 15 mg/ml of apomorphine; and (b) a solubilising agent selected from (i) at least one polyoxyethylene-polyoxypropylene copolymer (poloxamer); (ii) at least one cyclodextrin; and (iii) at least one cyclodextrin together with chitosan. The formulations of the invention can be used in the treatment or management of Parkinson's disease and erectile dysfunction.

Abstract: The invention is directed to providing a compound for treating cancer, the compound comprising a metal complex having predetermined characteristics, and which may be incorporated into a polymeric nanoparticle or other delivery system for delivering the metal complex for action on tumor cells. The metal complex for treating cancer wherein the metal complex is a silver(I) salt, a silver(I) macrocyclic metal complex, a silver(I) N-heterocyclic carbene or mixtures thereof. The invention is also directed to a silver(I) macrocyclic metal complex and a silver(I) N-heterocyclic carbine, and methods of treating cancerous cells in a mammal including the steps of administering an effective amount of a silver(I) metal salt, such as by incorporating the material into a biodegradable polymeric nanoparticle.

Abstract: A highly aqueous liquid acidic hard surface treatment composition having a pH of about 3.5 or less which necessarily comprises: 0.001-3.5% wt.

Abstract: The present invention provides a moisturizer comprising, as an active ingredient, a saccharide having 3-O-?-D-glucopyranosyl-D-glucose as a structural unit. The moisturizer of the present invention improves the water retention capacity of the stratum corneum, and is useful for prevention and improvement of rough skin.

Abstract: The present invention relates to methods and compositions for reducing distress dysfunction, including emotional and physical distress. The invention entails co-administration of at least one Receptor Switcher and at least one Endorphin Enhancer. Additionally, at least one Synergistic Enhancer and/or at least one Exogenous Opioid are also administered to enhance or prolong the therapeutic effects.