Patents Examined by Devesh Srivastava
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Patent number: 7871633Abstract: The anhydrous cosmetic composition of the present invention provides a durable film after application that resists degradation over time. The anhydrous cosmetic composition includes an aminosilicone, an organosiloxane resin, a diorganopolysiloxane polymer and a volatile carrier. The anhydrous cosmetic composition can also be packaged with a topcoat product.Type: GrantFiled: April 14, 2004Date of Patent: January 18, 2011Assignee: The Procter & Gamble CompanyInventors: Haimanot Bekele, Claire Davison, Qadira Tayyiba Wagstaff, Catherine Joyce Noell
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Patent number: 6258561Abstract: The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g.Type: GrantFiled: October 20, 1999Date of Patent: July 10, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Suenaga Masato, Moriya Takeo, Tanaka Yoko, Nishimura Osamu
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Patent number: 6258578Abstract: The invention provides HIS5 polypeptides and DNA (RNA) encoding HIS5 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing HIS5 polypeptides to screen for antibacterial compounds.Type: GrantFiled: October 17, 1997Date of Patent: July 10, 2001Assignee: SmithKline Beecham CorporationInventors: Sanjoy Biswas, Martin Karl Russel Burnham, Michael Arthur Lonetto, Patrick Vernon Warren, Richard Lloyd Warren
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Patent number: 6248558Abstract: The invention describes a membrane-translocating peptide sequence (MTS) which facilitates entry of polypeptides and proteins into cells. Also described is an isolated nucleotide sequence encoding the membrane-translocating peptide and a method of using this sequence to genetically engineer proteins with cell membrane permeability. The MTS, and the method of genetically engineering proteins with cell membrane permeability, are useful for polypeptide and protein delivery for human and veterinary applications such as vaccine delivery and cancer therapy.Type: GrantFiled: November 4, 1998Date of Patent: June 19, 2001Assignee: Vanderbilt UniversityInventors: Yao-Zhong Lin, John P. Donahue, Mauricio Rojas, Zhong-Jia Tan
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Patent number: 6242214Abstract: The invention provides human GTPase-associated proteins (GPAP) and polynucleotides which identify and encode GPAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GPAP.Type: GrantFiled: April 21, 1998Date of Patent: June 5, 2001Assignee: Incyte Pharmaceuticals, Inc.Inventors: Olga Bandman, Preeti Lal, Karl J. Guegler, Neil C. Corley, Chandra Patterson
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Patent number: 6235882Abstract: This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention further provides a Pseudomonas mendocina strain deficient in this gene. This strain is unable to grow in the presence of chloramphenicol and, compared to the wildtype strain, grows slowly in the presence of high concentrations of PHBA.Type: GrantFiled: June 15, 1999Date of Patent: May 22, 2001Assignee: E. I. du Pont de Nemours and CompanyInventor: Kevin Keqin Chen
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Patent number: 6232108Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.Type: GrantFiled: October 22, 1999Date of Patent: May 15, 2001Assignee: New York UniversityInventor: Mark R. Philips
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Patent number: 6228591Abstract: The present invention provides a purified and isolated wild type PKD2 gene, as well as mutated forms of this gene. The present invention also provides one or more single-stranded nucleic acid probes which specifically hybridize to the wild type PKD2 gene or the mutated PKD2 gene, and mixtures thereof, which may be formulated in kits, and used in the diagnosis of ADPKD associated with the mutated PKD2 gene. The present invention also provides a method for diagnosing ADPKD caused by a mutated PKD2 gene, as well as a method for treating autosomal dominant polycystic kidney disease caused by a mutated PKD2 gene.Type: GrantFiled: August 30, 1999Date of Patent: May 8, 2001Assignee: Albert Einstein College of Medicine of Yeshiva UniversityInventors: Stefan Somlo, Toshio Mochizuki
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Patent number: 6228632Abstract: This invention relates to a recombinant deoxyribonucleic acid (DNA) which can be isolated from Aspergillus soyae, characterised in that it codes for a leucine aminopeptidase (LAP) and comprises a nucleotide sequence corresponding to the nucleotide sequence given in SEQ ID NO: 1 for the mature LAP or to a nucleotide sequence derived therefrom which hybridises under stringent conditions with the nucleotide sequence given in SEQ ID NO: 1 for the mature LAP. The invention further relates to vectors and transformed host organisms, and also relates to methods of producing LAP. Enzyme products for the production of protein hydrolysates, as well as protein hydrolysates which are produced correspondingly, also form part of the invention.Type: GrantFiled: April 20, 1998Date of Patent: May 8, 2001Assignee: Roehm GmbHInventors: Erwin Schuster, Bruno Sproessler, Kornelia Titze, Michael Gottschalk, Nguyen Quoc Khanh, Sabine Wolf, Hermann Plainer
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Patent number: 6225089Abstract: This invention relates to the isolation of a novel putative efflux gene from Pseudomonas mendocina. The putative efflux gene is useful for probing an organism's efflux system to gain an understanding of the mechanisms of solvent tolerance. The invention further provides a Pseudomonas mendocina strain deficient in this gene. This strain is unable to grow in the presence of chloramphenicol and, compared to the wildtype strain, grows slowly in the presence of high concentrations of PHBA.Type: GrantFiled: June 15, 1999Date of Patent: May 1, 2001Assignee: E. I. du Pont de Nemours and CompanyInventor: Kevin Keqin Chen
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Patent number: 6218125Abstract: A region of the Chlamydia trachomatis cryptic plasmid has been identified which is useful for performing amplification assays to determine specifically whether C. trachomatis is present in the sample being tested. Oligonucleotides useful for performing thermal Strand Displacement Assay (tSDA) reactions on this gene are disclosed. The disclosed oligonucleotides can be used in an assay which is specific for all strains of C. trachomatis and which does not show crossreactivity with the genomes of other microorganisms or with human DNA.Type: GrantFiled: January 12, 2000Date of Patent: April 17, 2001Assignee: Becton, Dickinson and CompanyInventors: Paul A. Foxall, Dolores M. Berger
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Patent number: 6207390Abstract: The present invention relates to methods for contacting biological targets using a mutated streptavidin protein having a reduced affinity for biotin.Type: GrantFiled: October 3, 1997Date of Patent: March 27, 2001Assignee: The Trustees of Boston UniversityInventors: Charles R. Cantor, Takeshi Sano
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Patent number: 6204042Abstract: The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.Type: GrantFiled: May 10, 1999Date of Patent: March 20, 2001Assignee: SMithKline Beecham CorporationInventors: Christine Debouck, Deborah Dee Jaworski, Jeffrey L Mooney, Lisa Kathleen Shilling, Nicola Gail Wallis, Min Wang, Yi Yi Zhong
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Patent number: 6200776Abstract: The hNBC3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hNBC3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: July 15, 1998Date of Patent: March 13, 2001Assignees: Yale University School of Medicine, SmithKline Beecham Corporation P.L.C., SmithKline Beecham Laboratories PharmaceutiquesInventors: Walter F Boron, Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Steven Charles Jupe, Christopher John Rawlings, Trudy Rachel Doe
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Patent number: 6197747Abstract: The invention relates to genetically engineered plant-colonizing microorganisms which proliferate in symbiotic or non-detrimental relationships with the plant in the plant environment. Such microorganisms contain DNA derived from Bacillus thuringiensis which codes for the insecticidal crystal protein toxin. The engineered plant-colonizing microorganisms of the invention and their progency are active against a variety of lepidopterous pests. The invention further relates to the use of such plant-colonizing microorganisms in a method of killing or inhibiting lepidopterous pests and to insecticidal compositions containing the plant-colonizing microorganism as the active insecticidal agent.Type: GrantFiled: June 30, 1999Date of Patent: March 6, 2001Assignee: Monsanto CompanyInventors: Lidia S. Watrud, Frederick J. Perlak
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Patent number: 6194385Abstract: The present invention provides a human calcium-binding protein (HCBP) and polynucleotides which identify and encode HCBP. The invention also provides expression vectors and host cells, agonists, antibodies, and antagonists. In addition, the invention provides methods for producing HCBP and for treating or preventing disorders associated with the expression of HCBP.Type: GrantFiled: December 7, 1998Date of Patent: February 27, 2001Assignee: Incyte Genomics, Inc.Inventors: Jennifer L. Hillman, Surya K. Goli
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Patent number: 6184016Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.Type: GrantFiled: June 11, 1998Date of Patent: February 6, 2001Assignee: New York UniversityInventor: Mark R. Philips
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Patent number: 6180760Abstract: An actin filament-binding protein 1-Afadin having the amino acid sequence of SEQ ID NO: 1 or having an amino acid sequence substantially the same as that of SEQ ID NO: 1, a cDNA sequence encoding the protein, a genomic DNA sequence to which the cDNA sequence or a partial sequence thereof is hybridized, and an antibody specifically recognizing 1-Afadin are provided. The protein is a novel actin filament-binding protein localized at the cadherin based cell-to-cell adherens junction and the other products are useful as the genetic materials for industrially utilizing the protein.Type: GrantFiled: September 21, 1998Date of Patent: January 30, 2001Assignees: Japan Science and Technology Corp., Manabu Wada, Hiroshi ObaishiInventors: Yoshimi Takai, Hiroyuki Nakanishi, Kenji Mandai, Manabu Wada, Hiroshi Obaishi
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Patent number: 6180775Abstract: The subject invention concerns the discovery of Bacillus thuringiensis isolates with advantageous activity against weevils. In preferred embodiments of the invention, B.t. isolates, or toxins therefrom, are used to control alfalfa weevils, boll weevils, and/or rice water weevils. The toxins can be administered to the pests through a variety of methods including the transformation of bacteria or plants to produce the weevil-active toxins.Type: GrantFiled: September 23, 1999Date of Patent: January 30, 2001Assignee: Mycogen CorporationInventors: Gregory A. Bradfisch, H. Ernest Schnepf, Leo Kim
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Patent number: 6174672Abstract: A method, and kit for carrying out the method, is provided for the non-radioactive and enzymatic detection of reverse transcriptase.Type: GrantFiled: February 10, 1998Date of Patent: January 16, 2001Assignee: Retro-Tech GmbH Gesellschaft fur Retrovirale TechnologieInventors: Ortwin Faff, Alois Gabriel Hisem