Abstract: Embodiments include medical devices comprising a handle assembly including a wire tensioner component and an adjustment knob, the adjustment knob configured to rotate about a longitudinal axis of the handle assembly; an elongate shaft coupled to the handle assembly, the elongate shaft defining a lumen and including a deflectable section; a first wire coupled to the adjustment knob and extending from the adjustment knob through the lumen to at least a distal end portion of the deflectable section; and a second wire coupled to the wire tensioner component and extending from the wire tensioner component to at least the distal end portion of the deflectable section, the second wire having a deflectable extraluminal section configured to deflect independently of the deflectable section.

Abstract: A device includes an EMG processing application operable with a processing module to receive an output signal from EMG testing, wherein the output signal represents electrical activity of at least one muscle. The EMG processing application is operable to process the output signal to detect at least one type of waveform of a plurality of types of waveforms from the output signal and display the detected at least one type of waveform.

Abstract: A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. A controller may be physically connected to the monitoring system from the sterile field to allow the user to control the monitoring system.

Abstract: Systems and methods are disclosed for generating fluence maps for a radiotherapy treatment plan that uses machine learning prediction. The systems and methods include identifying image data that indicates treatment constraints for target dose areas and organs at risk areas in an anatomy of the subject, generating anatomy projection images that represent a view of the subject from respective beam angles, using a trained neural network model to generate the computer-simulated fluence map representations based on the anatomy projection images, where the fluence maps indicate a fluence distribution of the radiotherapy treatment at each of the beam angles.

Abstract: Devices, systems and methods are disclosed which relate to using wet foam elution for removal of particles from swabs and wipes. This allow users to capture particles from surfaces and recover them by elution into small sample volumes for subsequent detection for human clinical, veterinary, food safety, pharmaceutical, outbreak investigations, forensics, biodefense and bioterrorism response, environmental monitoring, and other applications where collection of samples from surfaces and humans or animals is required. More specifically, the swabs or wipes are used to collect samples in the standard ways that commercially available swabs and wipes are in use today; from, for instance, food preparation surfaces in food plants, from production equipment in pharmaceutical facilities, for collection of dry powders during bioterrorism event response, and for collection of clinical samples such as nasal, throat, nasopharyngeal, and wounds.

Abstract: Systems, methods, and apparatuses for enabling a plurality of non-invasive, physiological sensors to obtain physiological measurements from the same tissue site. Each of a plurality of sensors can be integrated with or attached to a multi-sensor apparatus. The multi-sensor apparatus can orient the plurality of non-invasive, physiological sensors such that each of the plurality of non-invasive, physiological sensors obtains physiological data from the same or a similar location.

Abstract: A wearable device for a noninvasive measurement of a user's body temperature can include a housing, a first substrate coupled to the housing and having an opening, a second substrate coupled to the first substrate and configured to secure to skin of a user, a mounting frame enclosed by the housing and the first substrate, a circuit board secured by the mounting frame, a temperature sensor coupled to the circuit board and configured to determine a body temperature of the user, and a thermally conductive probe. The thermally conductive probe is secured by the mounting frame and positioned proximate to the first temperature sensor. The thermally conductive probe extends at least partially through the opening in the first substrate and transmits a thermal energy from a portion of the user's skin to the first temperature sensor.

Abstract: Systems, devices, and methods are disclosed herein for monitoring physiological data of subjects urinating or defecating into an excretion collection device, including systems, devices, and methods for monitoring temperature of objects (e.g., urine or feces) received through the opening of the excretion collection device. In some embodiments, systems, devices, and methods disclosed herein include a temperature sensor that can generate a temperature profile associated with a urination or defecation event, and determine a core body temperature of a subject based on the temperature profile.

Abstract: The disclosure provides a system and method for a programmable medical wire that can be preprogrammed, and controlled and reshaped upon command. The system can include a power supply, a controller, and a multilayered wire assembly. The wire assembly includes a core conductor, actuator conductors coupled to the core conductor, selective conductors formed adjacent the core conductor and the actuator conductors, and a protective biocompatible shield around the layers. The selective conductors can be energized to activate the actuator conductors and cause the actuator conductors to bend or twist in a preprogrammed manner. By selectively controlling the direction of movement of the actuator conductors, the wire assembly can be remotely guided through body passageways to the target. Auxiliary equipment such as sensors, micro cameras, detectors, cutters, and other equipment can also be coupled to the wire assembly, and controlled and communicated with through one or more of the selective conductors.

Abstract: Breath sensor calibration methods and apparatus are described herein where a breath sensor device may generally comprise a sampling unit having a housing configured to receive a sample breath from a user and a sensor positioned within the housing. A processor in electrical communication with the sensor may be configured to determine a dissipation time when the sensor is exposed to a near-constant concentration level of CO detected from the breath sample down to an ambient level of CO detected. The processor may also be configured to calculate a time constant based on the dissipation time and a reduction from the near-constant concentration level to the ambient level. Furthermore, the processor may also be configured to apply the time constant to a transient response of the sensor to account for drift in calibrating the sensor.

Abstract: Systems and methods are provided for providing a standardized pressure value representing a transient pressure event within a region of interest within a living body. An air-charged catheter is configured to record pressure data representing the region of interest. A measurement assembly includes a parameter calculation component configured to calculate at least a peak pressure representing the transient pressure event and a time to peak pressure, representing the time necessary to reach the peak pressure, from the recorded pressure data. A standardization component is configured to calculate the standardized pressure value as a function of the peak pressure and the time to peak pressure. A user interface is configured to display at least the standardized pressure value at an associated display.

Abstract: A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover. The sizer cover can be formed from a continuous sheet of material configured to surround at least a portion of the sizing element of the heart valve sizer so as to guard against entanglement of the sizing element with structures of a human heart.

Abstract: Disclosed are steerable needles having a shaft that can be controllably buckled, a steering head positioned at a distal end of the shaft, a transmission for controlling the orientation of the steering head, and a base at the end of the shaft, the base optionally comprising a controller for controlling the transmission. Also disclosed are methods of using the disclosed steerable needles.

Abstract: In an embodiment, a method includes: generating a displacement signal indicative of a distension of a surface of a skin; determining a temperature of the skin using a temperature sensor; during a calibration time interval, collecting a plurality of distension values from the displacement signal, the plurality of distension values associated with a respective plurality of temperature values determined using the temperature sensor, the plurality of temperature values being indicative of a temperature change of the skin; determining compensation coefficients associated with the plurality of temperature values; and after the calibration time interval, collecting a first distension value from the displacement signal, determining a first temperature value using the temperature sensor, and determining a blood pressure based on the first distension value, the first temperature value, and the determined compensation coefficients.

Abstract: Some implementations of the disclosure describe a blood pressure measurement apparatus and method that enable continuous, non-invasive blood pressure measurement using sound and ultrasound transducers. In one implementation, a blood pressure measurement device includes: a first transducer configured to emit multiple soundwaves having multiple frequencies, the soundwaves configured to cause a blood vessel of a subject to vibrate; a second transducer configured to capture one or more ultrasound images of the blood vessel; and a processing device configured to: determine, based on the one or more ultrasound images, a wall thickness, a radius, and a resonant frequency of the blood vessel; and calculate, based on the wall thickness, the radius, and the resonant frequency, a blood pressure of the subject.

Abstract: A pulse diagnostic device and a system of pulse diagnosis are provided. The pulse diagnostic device includes a cuff and a main monitor. The cuff includes a tube and an air bag arranged with an air path interface. A gas medium is received in the air bag. The tube is connected to the air path interface. The main monitor includes a pressure sensor and a controller. The tube extends to reach the main monitor and is connected to the pressure sensor, and the pressure sensor further connects to the controller. When the pulse diagnostic device is working, the cuff contacts an artery, the pressure sensor senses a pressure of the gas medium in the tube. The pressure sensor transmits the pressure of the gas medium to the controller. The controller obtains the pulse information and the blood pressure information based on the pressure of the gas medium.

Abstract: A pressure-sensing device includes a device frame, a flexible membrane, a pressure sensor, and device electronics. The device frame includes a base surface that rests on a supporting structure and a frame attachment region located opposite to the base surface such that the frame attachment region is raised from the supporting structure when the base surface is resting on the supporting structure. The device frame also includes a seating surface. The flexible membrane is attached to the frame attachment region such that the device frame and the flexible membrane enclose a pressure chamber. The seating surface extends outward around the flexible membrane and the flexible membrane protrudes above the seating surface. The pressure sensor is configured to generate a pressure signal. The device electronics are configured to determine the pressure in the pressure chamber based on the pressure signal.

Abstract: Methods and devices monitor oxygen saturation levels in tissue. According to one aspect of the invention, a device is a sensor panel comprising a flexible substrate and a plurality of oximeter sensor units coupled to the substrate. In another aspect of the invention, the device is a sensor panel comprising a flexible substrate and a plurality of oximeter sensor units and a plurality of pressure sensors coupled to the substrate. Embodiments of the invention can be used to simultaneously measure oxygen saturation levels in many locations of a large tissue. Embodiments of the invention can be applied in diagnosing a medical condition involving a large tissue area where the oxygen saturation level is unstable.

Abstract: An implantable device for controlling electrical conditions of body tissue. A feedback sense electrode and a compensation electrode are positioned proximal to the tissue to make electrical contact with the tissue. A feedback amplifier is referenced to ground, and takes as an input a feedback signal from the feedback sense electrode. The output of the feedback amplifier is connected to the compensation electrode. The feedback amplifier thus drives the neural tissue via the compensation electrode in a feedback arrangement which seeks to drive the feedback signal to ground, or other desired electrical value.

Abstract: Many treatments of skin cancer need an accurate assessment of the margins of the tumor. Spectrally-encoded optical polarization imaging improves upon the demarcation of skin cancer such as keratinocytic carcinomas. When the clinician can outline the clinical boundary of each lesion, surgery and other treatments can be more efficient and effective. Optical images of the lesions are acquired at various wavelengths, then spectrally-encoded. Spectral-encoding of the images minimizes the impact of background pigmentation and vascularization so that the tumor can be accurately visualized.